ITMI971523A0 - - Google Patents

Info

Publication number
ITMI971523A0
ITMI971523A0 ITMI971523A ITMI971523A ITMI971523A0 IT MI971523 A0 ITMI971523 A0 IT MI971523A0 IT MI971523 A ITMI971523 A IT MI971523A IT MI971523 A ITMI971523 A IT MI971523A IT MI971523 A0 ITMI971523 A0 IT MI971523A0
Authority
IT
Italy
Application number
ITMI971523A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ITMI971523A0 publication Critical patent/ITMI971523A0/it
Priority to IT97MI001523A priority Critical patent/IT1292426B1/it
Priority to AT98938668T priority patent/ATE230393T1/de
Priority to JP50529499A priority patent/JP2002506456A/ja
Priority to IL13269198A priority patent/IL132691A/en
Priority to CNB988062763A priority patent/CN1205186C/zh
Priority to PCT/EP1998/003946 priority patent/WO1999000361A1/en
Priority to HU0003133A priority patent/HUP0003133A3/hu
Priority to CA002292794A priority patent/CA2292794A1/en
Priority to SI9830175T priority patent/SI1019370T1/xx
Priority to RU2000100825/04A priority patent/RU2194037C2/ru
Priority to ES98938668T priority patent/ES2190095T3/es
Priority to KR10-1999-7011984A priority patent/KR100512892B1/ko
Priority to BRPI9810459-4A priority patent/BR9810459A/pt
Priority to DE69810498T priority patent/DE69810498T2/de
Priority to AU87300/98A priority patent/AU740411B2/en
Priority to EP98938668A priority patent/EP1019370B1/en
Priority to US09/423,287 priority patent/US6218417B1/en
Priority to DK98938668T priority patent/DK1019370T3/da
Publication of ITMI971523A1 publication Critical patent/ITMI971523A1/it
Application granted granted Critical
Publication of IT1292426B1 publication Critical patent/IT1292426B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0217—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -C(=O)-C-N-C(=O)-N-C-C(=O)-
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
IT97MI001523A 1997-06-27 1997-06-27 Sali nitrati di ace-inibitori IT1292426B1 (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IT97MI001523A IT1292426B1 (it) 1997-06-27 1997-06-27 Sali nitrati di ace-inibitori
SI9830175T SI1019370T1 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts
ES98938668T ES2190095T3 (es) 1997-06-27 1998-06-24 Sales nitricas de inhibidores del enzima de conversion.
IL13269198A IL132691A (en) 1997-06-27 1998-06-24 Ace-inhibitor nitrate salts and pharmaceutical compositions containing them
CNB988062763A CN1205186C (zh) 1997-06-27 1998-06-24 Ace－抑制剂硝酸盐
PCT/EP1998/003946 WO1999000361A1 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts
HU0003133A HUP0003133A3 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts and use of them for producing pharmaceutical compositions
CA002292794A CA2292794A1 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts
AT98938668T ATE230393T1 (de) 1997-06-27 1998-06-24 Ace-inhibitoren stickstoffsalze
RU2000100825/04A RU2194037C2 (ru) 1997-06-27 1998-06-24 Нитрат асе-ингибитора
JP50529499A JP2002506456A (ja) 1997-06-27 1998-06-24 Ａｃｅ（アンギオテンシン変換酵素）阻害剤硝酸塩
KR10-1999-7011984A KR100512892B1 (ko) 1997-06-27 1998-06-24 에이스저해제 질산염
BRPI9810459-4A BR9810459A (pt) 1997-06-27 1998-06-24 sais nìtricos dos inibidores de ace
DE69810498T DE69810498T2 (de) 1997-06-27 1998-06-24 Ace-inhibitoren stickstoffsalze
AU87300/98A AU740411B2 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts
EP98938668A EP1019370B1 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts
US09/423,287 US6218417B1 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts
DK98938668T DK1019370T3 (da) 1997-06-27 1998-06-24 Nitratsalte af ACE-inhibitorer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI001523A IT1292426B1 (it) 1997-06-27 1997-06-27 Sali nitrati di ace-inibitori

Publications (3)

Publication Number Publication Date
ITMI971523A0 true ITMI971523A0 (it) 1997-06-27
ITMI971523A1 ITMI971523A1 (it) 1998-12-27
IT1292426B1 IT1292426B1 (it) 1999-02-08

Family

ID=11377450

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97MI001523A IT1292426B1 (it) 1997-06-27 1997-06-27 Sali nitrati di ace-inibitori

Country Status (17)

Country Link
US (1) US6218417B1 (it)
EP (1) EP1019370B1 (it)
JP (1) JP2002506456A (it)
KR (1) KR100512892B1 (it)
CN (1) CN1205186C (it)
AT (1) ATE230393T1 (it)
AU (1) AU740411B2 (it)
BR (1) BR9810459A (it)
CA (1) CA2292794A1 (it)
DE (1) DE69810498T2 (it)
DK (1) DK1019370T3 (it)
ES (1) ES2190095T3 (it)
HU (1) HUP0003133A3 (it)
IL (1) IL132691A (it)
IT (1) IT1292426B1 (it)
RU (1) RU2194037C2 (it)
WO (1) WO1999000361A1 (it)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1301759B1 (it) * 1998-06-19 2000-07-07 Nicox Sa Sali nitrati di farmaci antiipertensivi
IT1303672B1 (it) * 1998-07-28 2001-02-23 Nicox Sa Sali nitrati di farmaci attivi nei disordini ossei
WO2001017528A1 (en) 1999-09-08 2001-03-15 Nitromed, Inc. Methods of treating and preventing congestive heart failure with hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
US7708989B2 (en) * 1999-10-29 2010-05-04 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
DE60042611D1 (de) 1999-10-29 2009-09-03 Nitromed Inc Verfahren zur behandlung von gefässerkrankungen, dxid auszeichnen
US7235237B2 (en) 1999-10-29 2007-06-26 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US7537785B2 (en) 1999-10-29 2009-05-26 Nitromed, Inc. Composition for treating vascular diseases characterized by nitric oxide insufficiency
EP1406608B1 (en) 2001-05-02 2009-07-29 Nitromed, Inc. Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use
GB0111872D0 (en) * 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
US7968605B2 (en) * 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
EP2319518A1 (en) * 2002-02-04 2011-05-11 ALFAMA-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda. Use of CO-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases
US20060247216A1 (en) * 2002-10-25 2006-11-02 Haj-Yehia Abdullah I Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
GB2395432B (en) * 2002-11-20 2005-09-14 Northwick Park Inst For Medica Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
US20070207217A1 (en) * 2003-02-03 2007-09-06 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Method for treating a mammal by administration of a compound having the ability to release CO
US7169805B2 (en) * 2003-05-28 2007-01-30 Nicox S.A. Captopril derivatives
JP2008506716A (ja) * 2004-07-16 2008-03-06 ニトロメッド インコーポレーティッド 心不全に関連する組成物および方法
DE602005020314D1 (de) 2004-08-25 2010-05-12 Actelion Pharmaceuticals Ltd Bicyclononen-derivate als renin-inhibitoren
EP1679072B9 (en) * 2005-01-06 2009-09-02 IPCA Laboratories Limited Process for for synthesis of (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indole-2- carboxylic acid derivatives and use in the synthesis of perindopril
WO2006121853A1 (en) * 2005-05-05 2006-11-16 Keryx Biopharmaceuticals, Inc. Combination therapy with sulodexide and a blood pressure reducing agent in the treatment of diabetic nephropathy
EP1893578A2 (en) * 2005-05-27 2008-03-05 Actelion Pharmaceuticals Ltd. Novel piperidine carboxylic acid amide derivatives
JP2009514809A (ja) * 2005-10-18 2009-04-09 ニコックス エス エイ レニン阻害剤のニトロ誘導体
GB0601394D0 (en) 2006-01-24 2006-03-01 Hemocorm Ltd Therapeutic delivery of carbon monoxide
AU2007210813A1 (en) 2006-02-02 2007-08-09 Actelion Pharmaceuticals Ltd Secondary amines as renin inhibitors
EP1984010A4 (en) * 2006-02-17 2010-09-08 Nitromed Inc METHOD FOR USE OF HYDRALAZIN COMPOUNDS AND ISOSORBIDE DINITRATE OR ISOSORBIDE MONONITRATE
JP2009529033A (ja) * 2006-03-08 2009-08-13 アクテリオン ファーマシューティカルズ リミテッド 新規アミン
WO2007136626A1 (en) * 2006-05-16 2007-11-29 Nitromed, Inc. Solid dosage formulations of hydralazine compounds
CN102015682B (zh) 2008-05-05 2014-07-16 埃科特莱茵药品有限公司 作为肾素抑制剂的3,4-取代的哌啶衍生物
ES2656237T3 (es) 2011-04-19 2018-02-26 Alfama, Inc. Moléculas liberadoras de monóxido de carbono y usos de las mismas
WO2013013179A1 (en) 2011-07-21 2013-01-24 Alfama, Inc. Ruthenium carbon monoxide releasing molecules and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE463851B (sv) 1988-09-02 1991-02-04 Amsu Ltd Komposition foer behandling av erektil dysfunktion via uretra
US5352708A (en) 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5328933A (en) 1992-10-28 1994-07-12 Allergan, Inc. Cyclopentane heptenylnitro and heptanylnitro-2-aliphatic or aryl aliphatic derivatives and homologues
KR100387359B1 (ko) 1994-05-10 2003-08-27 니콕스 에스. 에이. 항-염증성,비알러지성및항-혈전성을가지는니트로화합물들과그들의조성물들
US5625083A (en) 1995-06-02 1997-04-29 Bezuglov; Vladimir V. Dinitroglycerol esters of unsaturated fatty acids and prostaglandins
US5645839A (en) * 1995-06-07 1997-07-08 Trustees Of Boston University Combined use of angiotensin inhibitors and nitric oxide stimulators to treat fibrosis
CN1141771A (zh) * 1995-08-02 1997-02-05 贾力 巯-亚硝基化合物及其医学用途

Also Published As

Publication number Publication date
EP1019370B1 (en) 2003-01-02
RU2194037C2 (ru) 2002-12-10
EP1019370A1 (en) 2000-07-19
HUP0003133A2 (en) 2001-03-28
US6218417B1 (en) 2001-04-17
CN1260780A (zh) 2000-07-19
ITMI971523A1 (it) 1998-12-27
BR9810459A (pt) 2006-10-03
ATE230393T1 (de) 2003-01-15
KR20010013958A (ko) 2001-02-26
IL132691A0 (en) 2001-03-19
CA2292794A1 (en) 1999-01-07
ES2190095T3 (es) 2003-07-16
DE69810498D1 (de) 2003-02-06
IL132691A (en) 2004-06-01
DE69810498T2 (de) 2003-10-30
CN1205186C (zh) 2005-06-08
DK1019370T3 (da) 2003-05-05
IT1292426B1 (it) 1999-02-08
AU8730098A (en) 1999-01-19
AU740411B2 (en) 2001-11-01
KR100512892B1 (ko) 2005-09-07
WO1999000361A1 (en) 1999-01-07
HUP0003133A3 (en) 2002-10-28
JP2002506456A (ja) 2002-02-26

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Legal Events

Date Code Title Description
0001 Granted