DE602005020314D1 - Bicyclononen-derivate als renin-inhibitoren - Google Patents

Bicyclononen-derivate als renin-inhibitoren

Info

Publication number
DE602005020314D1
DE602005020314D1 DE602005020314T DE602005020314T DE602005020314D1 DE 602005020314 D1 DE602005020314 D1 DE 602005020314D1 DE 602005020314 T DE602005020314 T DE 602005020314T DE 602005020314 T DE602005020314 T DE 602005020314T DE 602005020314 D1 DE602005020314 D1 DE 602005020314D1
Authority
DE
Germany
Prior art keywords
derivatives
bicyclophone
renin inhibitors
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005020314T
Other languages
English (en)
Inventor
Olivier Bezencon
Christoph Boss
Daniel Bur
Olivier Corminboeuf
Walter Fischli
Corinna Grisostomi
Lubos Remen
Sylvia Richard
Thierry Sifferlen
Thomas Weller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Actelion Pharmaceuticals Ltd
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of DE602005020314D1 publication Critical patent/DE602005020314D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE602005020314T 2004-08-25 2005-08-22 Bicyclononen-derivate als renin-inhibitoren Active DE602005020314D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2004009477 2004-08-25
PCT/EP2005/009049 WO2006021402A1 (en) 2004-08-25 2005-08-22 Bicyclononene derivatives as renin inhibitors

Publications (1)

Publication Number Publication Date
DE602005020314D1 true DE602005020314D1 (de) 2010-05-12

Family

ID=35345116

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005020314T Active DE602005020314D1 (de) 2004-08-25 2005-08-22 Bicyclononen-derivate als renin-inhibitoren

Country Status (11)

Country Link
US (1) US8138340B2 (de)
EP (1) EP1786814B1 (de)
JP (1) JP2008510755A (de)
CN (1) CN101010323B (de)
AT (1) ATE462703T1 (de)
AU (1) AU2005276624B2 (de)
CA (1) CA2577084A1 (de)
DE (1) DE602005020314D1 (de)
ES (1) ES2340696T3 (de)
TW (1) TW200621773A (de)
WO (1) WO2006021402A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1786814B1 (de) 2004-08-25 2010-03-31 Actelion Pharmaceuticals Ltd. Bicyclononen-derivate als renin-inhibitoren
RU2410374C2 (ru) * 2005-05-27 2011-01-27 Актелион Фармасьютикалз Лтд Новые амидные производные пиперидинкарбоновой кислоты
WO2006131884A2 (en) * 2005-06-07 2006-12-14 Actelion Pharmaceuticals Ltd Thiazole substituted diazabicyclononane or-nonene derivatives as renin inhibitors
WO2007088514A1 (en) * 2006-02-02 2007-08-09 Actelion Pharmaceuticals Ltd Secondary amines as renin inhibitors
KR20080100382A (ko) * 2006-03-03 2008-11-17 액테리온 파마슈티칼 리미티드 레닌 저해제로서의 1차 아민
US20090062342A1 (en) * 2006-03-08 2009-03-05 Actelion Pharmaceuticals Ltd. Amines
US8129538B1 (en) 2007-03-28 2012-03-06 Takeda Pharmaceutical Company Limited Renin inhibitors
US8343968B2 (en) 2007-05-24 2013-01-01 Merck Canada Inc. Case of renin inhibitors
US8334308B2 (en) 2007-08-20 2012-12-18 Merck Sharp & Dohme Corp. Renin inhibitors
BRPI0912388A2 (pt) 2008-05-05 2017-09-26 Merck Frosst Canada Ltd composto, forma cristalina, processo para preparar compostos, composição farmacêutica, e, uso de um composto, e, método para o tratamento ou profilaxia de doenças

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225570A (en) 1987-08-13 1993-07-06 Monsanto Company 5-heterocyclic-substituted oxazolidine dihaloacetamides
US5380758A (en) 1991-03-29 1995-01-10 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
US5175179A (en) 1991-09-25 1992-12-29 Pfizer Inc. Method for treating hypertension
US5703073A (en) 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
DK0863875T3 (da) 1995-09-07 2003-12-01 Hoffmann La Roche Hidtil ukendte 4-(oxyalkoxyphenyl)-3-oxy-piperiner til behandling af hjerte- og nyrelidelser
US5994294A (en) 1996-02-02 1999-11-30 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
US5932538A (en) 1996-02-02 1999-08-03 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
JP2001504457A (ja) 1996-11-01 2001-04-03 ニトロメド インコーポレーテッド ニトロソ化およびニトロシル化ホスホジエステラーゼ阻害剤化合物、組成物及びその使用法
IT1295694B1 (it) 1996-11-14 1999-05-27 Nicox Sa Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
IT1292426B1 (it) 1997-06-27 1999-02-08 Nicox Sa Sali nitrati di ace-inibitori
WO2000044746A1 (en) 1999-01-28 2000-08-03 Neurosearch A/S Novel azabicyclo derivatives and their use
WO2002088101A2 (en) 2001-04-27 2002-11-07 Vertex Pharmaceuticals Incorporated Inhibitors of bace
CA2473892C (en) 2001-12-04 2010-09-21 Actelion Pharmaceuticals Ltd Novel quinoline derivatives
JP4041123B2 (ja) 2002-04-29 2008-01-30 アクテリオン ファマシューティカルズ リミテッド 新規なジアザビシクロノネン
PL375214A1 (en) 2002-06-27 2005-11-28 Actelion Pharmaceuticals Ltd. Novel tetrahydropyridine derivatives as renin inhibitors
US20040204455A1 (en) 2003-04-10 2004-10-14 Cody Wayne Livingston Piperidine derivative rennin inhibitors
US20060217371A1 (en) 2003-04-28 2006-09-28 Olivier Bezencon Diazabicyclononene and tetrahydropyriddine derivatives as renin inhibitors
CA2521932A1 (en) 2003-04-29 2004-11-11 Actelion Pharmaceuticals Ltd Novel 3,4-disubstituted 1,2,3,6-tetrahydropyridine derivatives
WO2004096803A1 (en) 2003-04-30 2004-11-11 Actelion Pharmaceuticals Ltd Azabicyclononene derivatives
RU2005137184A (ru) 2003-04-30 2006-03-20 Актелион Фармасьютикалз Лтд. (Ch) Новые производные тропана
CA2521938A1 (en) 2003-04-30 2004-11-11 Actelion Pharmaceuticals Ltd 9-azabicyclo[3.3.1]non-6-ene derivatives with a heteroatom at the 3-position as renin inhibitors
US20060223795A1 (en) 2003-05-02 2006-10-05 Oliver Bezencon Novel diazabicyclononene derivatives
BRPI0409882A (pt) 2003-05-02 2006-05-23 Actelion Pharmaceuticals Ltd compostos, composições farmacêuticas, método para o tratamento ou profilaxia de doenças, e, usos de compostos e de um ou mais compostos em combinação com outros compostos farmacologicamente ativos
WO2004105762A1 (en) 2003-05-30 2004-12-09 Actelion Pharmaceuticals Ltd Medical use of diazabicyclononene derivatives as inhibitors of parasite aspartic proteases
TW200513461A (en) 2003-10-01 2005-04-16 Speedel Experimenta Ag Organische verbindungen
JP2007508260A (ja) 2003-10-09 2007-04-05 アクテリオン　ファマシューティカルズ　リミテッド 新規なテトラヒドロピリジン誘導体
CA2540782A1 (en) 2003-10-13 2005-05-06 Olivier Bezencon Diazabicyclononene derivatives and their use as renin inhibitors
EP1680427A1 (de) 2003-10-23 2006-07-19 Actelion Pharmaceuticals Ltd. Diazabicyclononen- und tetrahydropyridinderivate als renininhibitoren
ES2332053T3 (es) 2003-11-26 2010-01-25 Novartis Ag Derivados 4-fenilpiperidina como inhibidores de renina.
AU2004295091A1 (en) 2003-12-05 2005-06-16 Actelion Pharmaceuticals Ltd Diazabicyclononene derivatives and their use as renin inhibitors
JP2007513107A (ja) 2003-12-05 2007-05-24 アクテリオン　ファマシューティカルズ　リミテッド ジアザビシクロノネンおよび新側鎖を有するテトラヒドロピリジン誘導体
TW200613274A (en) 2004-07-09 2006-05-01 Speedel Experimenta Ag Organic compounds
EP1786814B1 (de) 2004-08-25 2010-03-31 Actelion Pharmaceuticals Ltd. Bicyclononen-derivate als renin-inhibitoren
AR052263A1 (es) 2004-12-08 2007-03-07 Actelion Pharmaceuticals Ltd Derivado de diazabiciclononeno
WO2006079988A1 (en) 2005-01-28 2006-08-03 Actelion Pharmaceuticals Ltd 7- {4- [2- (2 , 6-dichl0r0-4-methylphen0xy) ethoxy] phenyl}-3 , 9-diazabicyclo [3 .3 . 31] non - 6-ene- s- carboxylic acid cyclopropyl- (2 , 3-dimethylbenzyd amide as inhibitors of renin for the treatment of hypertension
TW200716622A (en) 2005-03-31 2007-05-01 Speedel Experimenta Ag Substituted piperidines
RU2410374C2 (ru) 2005-05-27 2011-01-27 Актелион Фармасьютикалз Лтд Новые амидные производные пиперидинкарбоновой кислоты
WO2007088514A1 (en) 2006-02-02 2007-08-09 Actelion Pharmaceuticals Ltd Secondary amines as renin inhibitors
US20090062342A1 (en) 2006-03-08 2009-03-05 Actelion Pharmaceuticals Ltd. Amines

Also Published As

Publication number Publication date
CA2577084A1 (en) 2006-03-02
ATE462703T1 (de) 2010-04-15
TW200621773A (en) 2006-07-01
EP1786814A1 (de) 2007-05-23
US20090306123A1 (en) 2009-12-10
AU2005276624A1 (en) 2006-03-02
AU2005276624B2 (en) 2011-09-29
CN101010323B (zh) 2010-06-16
EP1786814B1 (de) 2010-03-31
US8138340B2 (en) 2012-03-20
WO2006021402A1 (en) 2006-03-02
CN101010323A (zh) 2007-08-01
ES2340696T3 (es) 2010-06-08
JP2008510755A (ja) 2008-04-10

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