FR2973378B1 - Derives d'acide hydroxybisphosphonique bifonctionnels - Google Patents
Derives d'acide hydroxybisphosphonique bifonctionnelsInfo
- Publication number
- FR2973378B1 FR2973378B1 FR1152546A FR1152546A FR2973378B1 FR 2973378 B1 FR2973378 B1 FR 2973378B1 FR 1152546 A FR1152546 A FR 1152546A FR 1152546 A FR1152546 A FR 1152546A FR 2973378 B1 FR2973378 B1 FR 2973378B1
- Authority
- FR
- France
- Prior art keywords
- bifunctional
- acid derivatives
- hydroxybisphosphonic acid
- hydroxybisphosphonic
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000002253 acid Substances 0.000 title 1
- 230000001588 bifunctional effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/548—Phosphates or phosphonates, e.g. bone-seeking
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3869—Polyphosphonic acids containing carboxylic acid or carboxylic acid derivative substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
- C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1152546A FR2973378B1 (fr) | 2011-03-28 | 2011-03-28 | Derives d'acide hydroxybisphosphonique bifonctionnels |
US14/008,986 US9173946B2 (en) | 2011-03-28 | 2012-03-28 | Bifunctional hydroxy-bisphosphonic acid derivatives |
ES12711632T ES2743276T3 (es) | 2011-03-28 | 2012-03-28 | Derivados de ácido hidroxibisfosfónico bifuncionales |
PCT/EP2012/055569 WO2012130911A1 (fr) | 2011-03-28 | 2012-03-28 | Derives d'acide hydroxybisphosphonique bifonctionnels |
EP12711632.5A EP2691402B1 (fr) | 2011-03-28 | 2012-03-28 | Derives d'acide hydroxybisphosphonique bifonctionnels |
JP2014501606A JP6026499B2 (ja) | 2011-03-28 | 2012-03-28 | 二機能性ヒドロキシ−ビスホスホン酸誘導体 |
CA2831713A CA2831713C (fr) | 2011-03-28 | 2012-03-28 | Derives d'acide hydroxybisphosphonique bifonctionnels et leur utilisation dans la vectorisation de molecules d'interet therapeutique ou diagnostique |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1152546A FR2973378B1 (fr) | 2011-03-28 | 2011-03-28 | Derives d'acide hydroxybisphosphonique bifonctionnels |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2973378A1 FR2973378A1 (fr) | 2012-10-05 |
FR2973378B1 true FR2973378B1 (fr) | 2013-10-04 |
Family
ID=45926557
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR1152546A Active FR2973378B1 (fr) | 2011-03-28 | 2011-03-28 | Derives d'acide hydroxybisphosphonique bifonctionnels |
Country Status (7)
Country | Link |
---|---|
US (1) | US9173946B2 (fr) |
EP (1) | EP2691402B1 (fr) |
JP (1) | JP6026499B2 (fr) |
CA (1) | CA2831713C (fr) |
ES (1) | ES2743276T3 (fr) |
FR (1) | FR2973378B1 (fr) |
WO (1) | WO2012130911A1 (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3028762B1 (fr) * | 2014-11-20 | 2017-01-06 | Atlanthera | Derives hydroxybisphosphoniques hydrosolubles de la doxorubicine |
EP3085390B1 (fr) * | 2015-04-20 | 2020-02-26 | Taiwan Hopax Chems. Mfg. Co., Ltd. | Composé pour exploration osseuse et son utilisation |
US11679099B2 (en) * | 2020-05-13 | 2023-06-20 | Seoul National University R&Db Foundation | Use of HIF-2α inhibitors for treating chondrosarcoma, or preventing recurrence and metastasis thereof |
FR3122427A1 (fr) | 2021-04-30 | 2022-11-04 | Atlanthéra | Derives hydroxybisphosphoniques de meloxicam pour traitement des maladies inflammatoires osteoarticulaires |
WO2023107909A1 (fr) * | 2021-12-10 | 2023-06-15 | Ppg Industries Ohio, Inc. | Composé à fonction carbazate |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2558373A1 (de) | 1974-12-26 | 1976-07-08 | Yoshida Kogyo Kk | Aussenfenstereinheit |
US4830847A (en) * | 1985-06-28 | 1989-05-16 | The Procter & Gamble Company | Diphosphonate-derivatized macromolecules |
PH26923A (en) * | 1989-03-08 | 1992-12-03 | Ciba Geigy | N-substituted amino alkanediphosphonic acids |
IT1303672B1 (it) * | 1998-07-28 | 2001-02-23 | Nicox Sa | Sali nitrati di farmaci attivi nei disordini ossei |
EP1615639A2 (fr) * | 2003-04-03 | 2006-01-18 | Semafore Pharmaceuticals, Inc. | Agents de protection cibles de la moelle osseuse |
WO2007096703A2 (fr) * | 2005-08-11 | 2007-08-30 | Targanta Therapeutics Inc. | Rifamycines phosphonatées et utilisation pour la prévention des infections des os et des articulations |
US8133311B2 (en) * | 2007-04-30 | 2012-03-13 | Cabot Corporation | Pigment dipsersions comprising functionalized non-polymeric dispersants |
FR2926080B1 (fr) * | 2008-01-03 | 2010-04-02 | Univ Nantes | Procede de synthese de derives d'acide hydroxy-bisphosphonique |
FR2926081B1 (fr) | 2008-01-03 | 2010-02-19 | Univ Nantes | Derives d'acide hydroxy-bisphosphonique comme vecteur ciblant le tissu osseux |
EP2289558A1 (fr) * | 2009-08-25 | 2011-03-02 | KTB Tumorforschungsgesellschaft mbH | Promédicaments à base de bisphosphonate |
-
2011
- 2011-03-28 FR FR1152546A patent/FR2973378B1/fr active Active
-
2012
- 2012-03-28 ES ES12711632T patent/ES2743276T3/es active Active
- 2012-03-28 WO PCT/EP2012/055569 patent/WO2012130911A1/fr active Application Filing
- 2012-03-28 CA CA2831713A patent/CA2831713C/fr active Active
- 2012-03-28 JP JP2014501606A patent/JP6026499B2/ja active Active
- 2012-03-28 US US14/008,986 patent/US9173946B2/en active Active
- 2012-03-28 EP EP12711632.5A patent/EP2691402B1/fr active Active
Also Published As
Publication number | Publication date |
---|---|
EP2691402B1 (fr) | 2019-05-08 |
JP2014514288A (ja) | 2014-06-19 |
JP6026499B2 (ja) | 2016-11-16 |
CA2831713A1 (fr) | 2012-10-04 |
US20140086843A1 (en) | 2014-03-27 |
WO2012130911A1 (fr) | 2012-10-04 |
FR2973378A1 (fr) | 2012-10-05 |
ES2743276T3 (es) | 2020-02-18 |
EP2691402A1 (fr) | 2014-02-05 |
CA2831713C (fr) | 2020-09-15 |
US9173946B2 (en) | 2015-11-03 |
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