ES2164665T3 - Inhibidores de proteasas retrovirales. - Google Patents
Inhibidores de proteasas retrovirales.Info
- Publication number
- ES2164665T3 ES2164665T3 ES93914694T ES93914694T ES2164665T3 ES 2164665 T3 ES2164665 T3 ES 2164665T3 ES 93914694 T ES93914694 T ES 93914694T ES 93914694 T ES93914694 T ES 93914694T ES 2164665 T3 ES2164665 T3 ES 2164665T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- inhibitors
- retroviral proteases
- sec
- date
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000035195 Peptidases Human genes 0.000 title abstract 2
- 108091005804 Peptidases Proteins 0.000 title abstract 2
- 239000004365 Protease Substances 0.000 title abstract 2
- 230000001177 retroviral effect Effects 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3241—Esters of arylalkanephosphinic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/48—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof
- C07F9/4808—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof the acid moiety containing a substituent or structure which is considered as characteristic
- C07F9/4816—Acyclic saturated acids or derivatices which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A UN COMPUESTO DE LA FORMULA (I) DONDE Q REPRESENTA UN RESTO DE LA FORMULA (IIA) O (IIB), Y ES OXIGENO O AZUFRE Y A, R2, R3, R4, R5, R6, R7, ASI COMO LOS RESTOS PROVISTOS CON EL CORRESPONDIENTE ASTERISCO SE DEFINEN COMO EN LA DESCRIPCION, UN PROCESO PARA SU ELABORACION, ASI COMO SU UTILIZACION PARA LA INHIBICION DE PROTEASAS RETROVIRALES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4220566A DE4220566A1 (de) | 1992-06-24 | 1992-06-24 | Inhibitoren retroviraler Proteasen |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2164665T3 true ES2164665T3 (es) | 2002-03-01 |
Family
ID=6461647
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93914694T Expired - Lifetime ES2164665T3 (es) | 1992-06-24 | 1993-06-22 | Inhibidores de proteasas retrovirales. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5663139A (es) |
EP (1) | EP0649426B1 (es) |
AT (1) | ATE206127T1 (es) |
DE (2) | DE4220566A1 (es) |
DK (1) | DK0649426T3 (es) |
ES (1) | ES2164665T3 (es) |
PT (1) | PT649426E (es) |
WO (1) | WO1994000461A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102007032669A1 (de) | 2007-07-13 | 2009-01-15 | Clariant International Limited | Alkylphosphonigsäuren, -salze und -ester, Verfahren zu deren Herstellung und ihre Verwendung |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0428849A3 (en) * | 1989-09-28 | 1991-07-31 | Hoechst Aktiengesellschaft | Retroviral protease inhibitors |
EP0435059B1 (de) * | 1989-12-16 | 1997-11-05 | Hoechst Aktiengesellschaft | Inhibitoren retroviraler Proteasen |
-
1992
- 1992-06-24 DE DE4220566A patent/DE4220566A1/de not_active Withdrawn
-
1993
- 1993-06-22 WO PCT/EP1993/001594 patent/WO1994000461A1/de active IP Right Grant
- 1993-06-22 ES ES93914694T patent/ES2164665T3/es not_active Expired - Lifetime
- 1993-06-22 DK DK93914694T patent/DK0649426T3/da active
- 1993-06-22 PT PT93914694T patent/PT649426E/pt unknown
- 1993-06-22 EP EP93914694A patent/EP0649426B1/de not_active Expired - Lifetime
- 1993-06-22 US US08/360,662 patent/US5663139A/en not_active Expired - Lifetime
- 1993-06-22 DE DE59310218T patent/DE59310218D1/de not_active Expired - Lifetime
- 1993-06-22 AT AT93914694T patent/ATE206127T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1994000461A1 (de) | 1994-01-06 |
US5663139A (en) | 1997-09-02 |
PT649426E (pt) | 2002-03-28 |
DE59310218D1 (de) | 2001-10-31 |
EP0649426B1 (de) | 2001-09-26 |
DE4220566A1 (de) | 1994-01-20 |
DK0649426T3 (da) | 2002-01-21 |
EP0649426A1 (de) | 1995-04-26 |
ATE206127T1 (de) | 2001-10-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0810209T3 (da) | Alpha - and beta-aminosyre-hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser | |
DE69831937D1 (de) | Bicyclische protein-farnesyl-transferase inhibitoren | |
GR3021404T3 (en) | Nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid and process for their preparation. | |
IL115903A0 (en) | Use of dioxomorpholines for combating endoparasites new dioxomorpholines and processes for their preparation | |
DK0696270T3 (da) | 4-Aminofluorbenzamider og deres anvendelse som cytotoksiske promedikamenter | |
DE69433984D1 (de) | Arylpiperazinderivate von indol als liganden der rezeptoren 5 ht1-like, 5 ht1b und 5 ht1d | |
DK0689534T3 (da) | Amidderivater som 5-HT1A-ligander | |
DE69623610T2 (de) | Neue heterozyklische chemie | |
ATE148345T1 (de) | Therapeutische verwendung von phosphoryl-l-serin- n-acyl-sphingosin | |
MX9303605A (es) | Derivados de azabicicloheptano n-substituidas, su obtencion y uso. | |
HU9301388D0 (en) | Method for producing hydroxy-ethylene-isoster type compounds of hiv-protease inhibiting effect containing dithiolamine-glycine | |
ES2164665T3 (es) | Inhibidores de proteasas retrovirales. | |
HUT73231A (en) | Pharmaceutical compositions with 17-beta-monosubstituted-carbamoyl-4-aza-5-alpha-androst-1-en-3-ones for treatment of chronic prostatitis | |
DE69405760D1 (de) | 4-aza-pregnan-5-alpha-reductase isozym 1 inhibitoren | |
CA2032303A1 (en) | Inhibitors of retroviral proteases | |
PT100682A (pt) | Agentes anti-helminticos derivados de benzimidazole e processo para a sua preparacao | |
KR960700223A (ko) | C-치환 디에틸렌 트리아민의 제조 방법(Process for the Production of C-Substituted Diethylenetriamines) | |
FI955707A (fi) | Indolijohdannaiset steroidi-5alfa-reduktaasin inhibiittoreina | |
DK0625972T3 (da) | Fremgangsmåde til fremstilling af 2-amino-7-nitrobenzothiazoler | |
MD950234A (ro) | Procedeu de obtinere a amidelor acidului 3,3-diarilacrilic | |
DK0850225T3 (da) | Mellemprodukt til fremstilling af en farmaceutisk aktiv forbindelse |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 649426 Country of ref document: ES |