ES2177952T3 - Compuestos codrticoides de esteres de nitrato y su utilizacion farmaceutica. - Google Patents
Compuestos codrticoides de esteres de nitrato y su utilizacion farmaceutica.Info
- Publication number
- ES2177952T3 ES2177952T3 ES97910409T ES97910409T ES2177952T3 ES 2177952 T3 ES2177952 T3 ES 2177952T3 ES 97910409 T ES97910409 T ES 97910409T ES 97910409 T ES97910409 T ES 97910409T ES 2177952 T3 ES2177952 T3 ES 2177952T3
- Authority
- ES
- Spain
- Prior art keywords
- equal
- compounds
- codrticoid
- group
- different
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 150000002823 nitrates Chemical class 0.000 title 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000003246 corticosteroid Substances 0.000 abstract 1
- 239000002699 waste material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA GENERAL B X 1 - NO 2 O A SUS ESTERES O SALES, DONDE B PRESENTA LA ESTRUCTURA (1), DONDE PUEDEN EXISTIR DIVERSOS SUSTITUYENTES EN LUGAR DE LOS HIDROGENOS H DEL GRUPO CH O DE LOS DOS HIDROGENOS H 2 DEL GRUPO CH 2 ; R Y R'' SON IGUALES O DISTINT OS ENTRE SI, Y PUEDEN SER HIROGENO O ALQUILOS LINEALES O RAMIFICADOS DE 1 A 4 ATOMOS DE CARBONO, PREFERIBLEMENTE R = R'' = CH3 ; SINEDO B UN RESIDUO CORTICOSTEROIDE; R'''' ES - (CO L) SUB,T - (X) T1 - DONDE T Y T1 SON ENTEROS IGUALES O DISTINTOS ENTRE SI, E IGUALES A 0 O 1; DONDE L ES UN GRUPO DE CONEXION BIVALENTE; X ES IGUAL A X 0 , DONDE X 0 = O, NH, NR 1C , DONDE R 1C ES UN ALQUILO LINEAL O RAMIFICADO DE 1 A 10 ATOMOS DE C; O IGUAL A X 2 , DONDE X 2 ES IGUAL A OH, CH 3 , CL, N(- CH 2 CH 3 ) 2 , SCH 2 F, SH; X 1 ES UN PUENTE DE CONEXION BIVALENTE YO, CUANDO Y ES UN ALQUILENO C 1 C 20 .
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT96MI002048A IT1285770B1 (it) | 1996-10-04 | 1996-10-04 | Composti corticoidei |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2177952T3 true ES2177952T3 (es) | 2002-12-16 |
Family
ID=11374972
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97910409T Expired - Lifetime ES2177952T3 (es) | 1996-10-04 | 1997-10-02 | Compuestos codrticoides de esteres de nitrato y su utilizacion farmaceutica. |
Country Status (18)
Country | Link |
---|---|
US (8) | US6610676B1 (es) |
EP (1) | EP0929565B1 (es) |
JP (1) | JP4388600B2 (es) |
KR (1) | KR100487898B1 (es) |
CN (1) | CN1142939C (es) |
AT (1) | ATE218142T1 (es) |
AU (1) | AU719250B2 (es) |
BR (1) | BR9711586A (es) |
CA (1) | CA2267630C (es) |
DE (1) | DE69712900T2 (es) |
DK (1) | DK0929565T3 (es) |
ES (1) | ES2177952T3 (es) |
HU (1) | HUP9904149A3 (es) |
IT (1) | IT1285770B1 (es) |
PT (1) | PT929565E (es) |
RU (1) | RU2186781C2 (es) |
SI (1) | SI0929565T1 (es) |
WO (1) | WO1998015568A2 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5824669A (en) | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
IT1285770B1 (it) * | 1996-10-04 | 1998-06-18 | Nicox Sa | Composti corticoidei |
IT1311922B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
IT1314184B1 (it) | 1999-08-12 | 2002-12-06 | Nicox Sa | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
IT1320176B1 (it) * | 2000-12-22 | 2003-11-26 | Nicox Sa | Dispersioni solide di principi attivi nitrati. |
EP1219306A1 (en) | 2000-12-29 | 2002-07-03 | Nicox S.A. | Compositions comprising cyclodextrins and NO- releasing drugs |
US6696592B2 (en) | 2001-05-22 | 2004-02-24 | Nicox-S.A. | Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof |
US7402577B2 (en) | 2001-10-03 | 2008-07-22 | Merck & Co., Inc. | Androstane 17-beta-carboxamides as androgen receptor modulators |
ITMI20020148A1 (it) * | 2002-01-29 | 2003-07-29 | Nicox Sa | Nuovi corticosteroidi |
CN100513415C (zh) * | 2005-08-03 | 2009-07-15 | 中国人民解放军军事医学科学院毒物药物研究所 | 胆汁酸衍生物及其医药用途 |
NZ566128A (en) * | 2005-09-02 | 2011-03-31 | Nicox Sa | Nitrooxy derivatives of glucocorticoids |
US8802726B2 (en) | 2006-02-03 | 2014-08-12 | Nicox S.A. | Use of nitrooxyderivative of drug for the treatment of muscular dystrophies |
US7893058B2 (en) * | 2006-05-15 | 2011-02-22 | Janssen Pharmaceutica Nv | Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases |
WO2008095806A1 (en) * | 2007-02-05 | 2008-08-14 | Nicox S.A. | Nitric oxide releasing steroids |
WO2009037584A2 (en) * | 2007-08-10 | 2009-03-26 | Topigen Pharmaceuticals Inc. | Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease |
WO2009071990A2 (en) * | 2007-08-31 | 2009-06-11 | Topigen Pharmaceuticals Inc. | No-donating cordicosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties |
WO2010012567A1 (en) * | 2008-07-31 | 2010-02-04 | Nicox S.A. | Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology |
US20110130376A1 (en) * | 2008-08-05 | 2011-06-02 | Nicox S.A. | New no releasing steroids derivatives |
US20110130375A1 (en) | 2008-08-05 | 2011-06-02 | Nicox S.A. | New no-releasing steroids for the treatment of retina and macula lutea diseases |
EP2560634A1 (en) | 2010-04-23 | 2013-02-27 | Piramal Enterprises Limited | Nitric oxide releasing prodrugs of therapeutic agents |
US8716268B2 (en) | 2010-06-07 | 2014-05-06 | Chao Liu | Nitrate esters of corticoid compounds useful as diuretics |
CA2897571C (en) | 2013-01-21 | 2018-12-18 | Apparao Satyam | Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group |
CN108191938B (zh) * | 2018-01-11 | 2019-07-05 | 湖南新合新生物医药有限公司 | 9,11烯烃甾族化合物的制备方法 |
CN113069460B (zh) * | 2021-03-24 | 2022-02-08 | 兰州大学 | 哈西奈德及其衍生物用于制备治疗和/或预防脑血管疾病药物中的应用 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2990401A (en) * | 1958-06-18 | 1961-06-27 | American Cyanamid Co | 11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids |
GB1054290A (es) * | 1963-05-01 | |||
US3183252A (en) * | 1963-09-05 | 1965-05-11 | Syntex Corp | 16-nitratoalkyl-pregnanes |
US3494941A (en) * | 1967-12-04 | 1970-02-10 | American Home Prod | Nitrate esters of 17beta-(hydroxyalkoxy)steroid 3-ols,3-ones and 3-amidinohydrazones |
HU164115B (es) * | 1971-05-07 | 1973-12-28 | ||
DK153556C (da) * | 1974-03-27 | 1988-12-05 | Plurichemie Anstalt | Fremgangsmaade til fremstilling af estere af 9alfa-klor- eller -fluor-16alfa- eller -16beta-metyl-21-desoxyprednisoloner |
CA1058161A (en) * | 1975-09-08 | 1979-07-10 | Ravi K. Varma | 3,20-DIKETOPREGNENES HAVING AN 11.beta.-ACETAL GROUP AND DERIVATIVES THEREOF |
IT1256345B (it) | 1992-08-20 | 1995-12-01 | Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione | |
IT1256450B (it) | 1992-11-26 | 1995-12-05 | Soldato Piero Del | Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione |
US5457207A (en) | 1993-10-05 | 1995-10-10 | Regents Of The University Of Minnesota | Spirovesamicols |
ATE168986T1 (de) | 1993-10-06 | 1998-08-15 | Nicox Sa | Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung |
WO1995030641A1 (en) | 1994-05-10 | 1995-11-16 | Nicox S.A. | Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities |
US5824669A (en) * | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
US5837698A (en) * | 1996-05-02 | 1998-11-17 | G. D. Searle & Co. | Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs |
US5985862A (en) * | 1996-05-02 | 1999-11-16 | G.D. Searle & Co. | Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs |
IT1285770B1 (it) * | 1996-10-04 | 1998-06-18 | Nicox Sa | Composti corticoidei |
-
1996
- 1996-10-04 IT IT96MI002048A patent/IT1285770B1/it active IP Right Grant
-
1997
- 1997-10-02 KR KR10-1999-7002942A patent/KR100487898B1/ko not_active IP Right Cessation
- 1997-10-02 RU RU99108661/04A patent/RU2186781C2/ru not_active IP Right Cessation
- 1997-10-02 EP EP97910409A patent/EP0929565B1/en not_active Expired - Lifetime
- 1997-10-02 WO PCT/EP1997/005426 patent/WO1998015568A2/en active IP Right Grant
- 1997-10-02 HU HU9904149A patent/HUP9904149A3/hu unknown
- 1997-10-02 DK DK97910409T patent/DK0929565T3/da active
- 1997-10-02 CN CNB97180284XA patent/CN1142939C/zh not_active Expired - Fee Related
- 1997-10-02 PT PT97910409T patent/PT929565E/pt unknown
- 1997-10-02 DE DE69712900T patent/DE69712900T2/de not_active Expired - Lifetime
- 1997-10-02 JP JP51715498A patent/JP4388600B2/ja not_active Expired - Fee Related
- 1997-10-02 CA CA002267630A patent/CA2267630C/en not_active Expired - Fee Related
- 1997-10-02 AU AU47803/97A patent/AU719250B2/en not_active Ceased
- 1997-10-02 ES ES97910409T patent/ES2177952T3/es not_active Expired - Lifetime
- 1997-10-02 BR BR9711586A patent/BR9711586A/pt not_active Application Discontinuation
- 1997-10-02 US US09/269,729 patent/US6610676B1/en not_active Expired - Fee Related
- 1997-10-02 SI SI9730333T patent/SI0929565T1/xx unknown
- 1997-10-02 AT AT97910409T patent/ATE218142T1/de active
-
2003
- 2003-06-17 US US10/462,637 patent/US7056905B2/en not_active Expired - Fee Related
-
2006
- 2006-03-14 US US11/374,220 patent/US7160871B2/en not_active Expired - Fee Related
- 2006-03-14 US US11/374,219 patent/US7157450B2/en not_active Expired - Fee Related
- 2006-03-14 US US11/374,315 patent/US7196075B2/en not_active Expired - Fee Related
- 2006-06-02 US US11/445,140 patent/US7205288B2/en not_active Expired - Fee Related
-
2007
- 2007-03-07 US US11/714,724 patent/US7368442B2/en not_active Expired - Fee Related
-
2008
- 2008-03-19 US US12/051,434 patent/US7605151B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2177952T3 (es) | Compuestos codrticoides de esteres de nitrato y su utilizacion farmaceutica. | |
NL971014I1 (nl) | Heterocyclische verbindingen. | |
BE855972Q (fr) | Nouvelles compositions de matieres | |
FR2301497A1 (fr) | Composition d'engrais | |
FI943728A0 (fi) | Enkefalinaasin ja ACE:n inhibiittoreina käyttökelpoisia uusia aminoasetyylimerkaptojohdannaisia | |
ES452737A1 (es) | Un procedimiento para preparar compuestos 2-anol-3-fenilben-zotiofeno. | |
MX9302116A (es) | Compuestos azabiciclo. | |
ES2121784T3 (es) | Nuevos derivados de oxazolilo. | |
IT1080242B (it) | Composizione pigmentaria allungata di bivo 4 | |
IT1077453B (it) | Composizione di resina contenente cloro | |
UY25211A1 (es) | Inhibidores de isoquinolinilguanidina uroquinasa | |
DE3776391D1 (de) | Fluessige zubereitungen von 1,2-benzisothiazolin-3-on, ihre herstellung und verwendung. | |
NL7510417A (nl) | Zelfklevende letters of dergelijke tekens. | |
MX9400194A (es) | Materiales fototermograficos. | |
DE69007695D1 (de) | Fucosidase-Inhibitoren. | |
IT1083532B (it) | Composizione poliolefinica particolarmente per la produzione di pellicole resistenti allo strappo | |
FR2631339B1 (fr) | Nouveaux eicosanoides sulfures et leur application en pharmacie et en cosmetique | |
SE7408124L (sv) | Sett att framstella sulfamoylbensoesyraamider. | |
IT1158662B (it) | Procedimento per la produzione di gas di sintesi e di gas contenente co | |
ES8800910A1 (es) | Un procedimiento para la preparacion de nuevas quinazolindionas | |
NZ186686A (en) | Bis long chain amine monofluorophosphates and anticarie compositions | |
MX9700365A (es) | Uso de benzaldehidos para asignar hidrocarburos. | |
ES468361A1 (es) | Un procedimiento para la preparacion de acidos 2-(2'-2'-di- halogenvinil)-ciclopropancarboxilicos y sus esteres. | |
FR2655039B1 (fr) | Synthese des bromures de perfluoroalkyle. | |
FR2308498A1 (fr) | Elements tels que baignoires et analogues, presentant l'aspect du marbre |