DK153556C - Fremgangsmaade til fremstilling af estere af 9alfa-klor- eller -fluor-16alfa- eller -16beta-metyl-21-desoxyprednisoloner - Google Patents

Fremgangsmaade til fremstilling af estere af 9alfa-klor- eller -fluor-16alfa- eller -16beta-metyl-21-desoxyprednisoloner

Info

Publication number
DK153556C
DK153556C DK129575A DK129575A DK153556C DK 153556 C DK153556 C DK 153556C DK 129575 A DK129575 A DK 129575A DK 129575 A DK129575 A DK 129575A DK 153556 C DK153556 C DK 153556C
Authority
DK
Denmark
Prior art keywords
desoxyprednisolones
9alfa
16alfa
fluoro
beta
Prior art date
Application number
DK129575A
Other languages
English (en)
Other versions
DK153556B (da
DK129575A (da
Inventor
Joao Emerico Villax
Original Assignee
Plurichemie Anstalt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plurichemie Anstalt filed Critical Plurichemie Anstalt
Publication of DK129575A publication Critical patent/DK129575A/da
Priority to DK196776A priority Critical patent/DK146909C/da
Publication of DK153556B publication Critical patent/DK153556B/da
Application granted granted Critical
Publication of DK153556C publication Critical patent/DK153556C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J7/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J17/00Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J7/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/005Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16
    • C07J7/0055Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK129575A 1974-03-27 1975-03-26 Fremgangsmaade til fremstilling af estere af 9alfa-klor- eller -fluor-16alfa- eller -16beta-metyl-21-desoxyprednisoloner DK153556C (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK196776A DK146909C (da) 1974-03-27 1976-05-03 Fremgangsmaade til fremstilling af estere eller aetere af 16-metyl-9alfa-halogenprednisoloner

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
PT6163674 1974-03-27
PT6163774 1974-03-27
PT6163674 1974-03-27
PT6163774 1974-03-27
PT6163675 1975-03-10
PT6163675 1975-03-10

Publications (3)

Publication Number Publication Date
DK129575A DK129575A (da) 1975-09-28
DK153556B DK153556B (da) 1988-07-25
DK153556C true DK153556C (da) 1988-12-05

Family

ID=27354092

Family Applications (1)

Application Number Title Priority Date Filing Date
DK129575A DK153556C (da) 1974-03-27 1975-03-26 Fremgangsmaade til fremstilling af estere af 9alfa-klor- eller -fluor-16alfa- eller -16beta-metyl-21-desoxyprednisoloner

Country Status (8)

Country Link
BE (1) BE827275A (da)
CH (2) CH622811A5 (da)
DK (1) DK153556C (da)
FR (1) FR2274309A1 (da)
GB (2) GB1510617A (da)
IE (2) IE41138B1 (da)
NZ (1) NZ177056A (da)
SE (1) SE440656B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR890000664B1 (ko) * 1981-10-19 1989-03-22 바리 안소니 뉴우샘 미분된 베클로메타손 디프로피오네이트 일수화물의 제조방법
IT1285770B1 (it) 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei
CN102516348B (zh) * 2011-11-10 2013-11-13 中国科学院上海有机化学研究所 一种16s-甲基-20s-羟基孕甾化合物、合成方法及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1070751A (en) * 1964-01-28 1967-06-01 Glaxo Lab Ltd 17-esters of 17-hydroxy-21-desoxy-steroids
GB1139505A (en) * 1965-06-23 1969-01-08 Glaxo Lab Ltd A process for the production of 17-‡-monoesters of 17-‡-hydroxy-20-keto-steroids
CH481085A (de) * 1965-08-30 1969-11-15 Scherico Ltd Verfahren zur Herstellung von 11B-Hydroxy-17 -alkanoyloxysteroiden der Pregnanreihe
US3383394A (en) * 1965-08-30 1968-05-14 Schering Corp Novel 17-acylating process and products thereof
BE788355A (fr) * 1971-09-07 1973-03-05 Merck Patent Gmbh Esters de 9 alpha-fluoro-16-methylene-prednisolone

Also Published As

Publication number Publication date
FR2274309A1 (fr) 1976-01-09
IE41137B1 (en) 1979-10-24
NZ177056A (en) 1978-09-20
DK153556B (da) 1988-07-25
DK129575A (da) 1975-09-28
CH622811A5 (da) 1981-04-30
BE827275A (fr) 1975-07-16
IE41137L (en) 1975-09-27
FR2274309B1 (da) 1978-11-24
SE7803041L (sv) 1978-03-16
GB1511820A (en) 1978-05-24
IE41138B1 (en) 1979-10-24
SE440656B (sv) 1985-08-12
CH625254A5 (da) 1981-09-15
GB1510617A (en) 1978-05-10

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