FI943728A0 - Enkefalinaasin ja ACE:n inhibiittoreina käyttökelpoisia uusia aminoasetyylimerkaptojohdannaisia - Google Patents

Enkefalinaasin ja ACE:n inhibiittoreina käyttökelpoisia uusia aminoasetyylimerkaptojohdannaisia

Info

Publication number
FI943728A0
FI943728A0 FI943728A FI943728A FI943728A0 FI 943728 A0 FI943728 A0 FI 943728A0 FI 943728 A FI943728 A FI 943728A FI 943728 A FI943728 A FI 943728A FI 943728 A0 FI943728 A0 FI 943728A0
Authority
FI
Finland
Prior art keywords
enkephalinase
ace
inhibitors
aminoacetyl
new
Prior art date
Application number
FI943728A
Other languages
English (en)
Swedish (sv)
Other versions
FI943728A (fi
FI106717B (fi
Inventor
Gary A Flynn
Robert J Cregge
Thomas L Fevig
Shyam Sunder
Patrick W Shum
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI943728A publication Critical patent/FI943728A/fi
Publication of FI943728A0 publication Critical patent/FI943728A0/fi
Application granted granted Critical
Publication of FI106717B publication Critical patent/FI106717B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
FI943728A 1992-02-14 1994-08-12 Menetelmä terapeuttisesti aktiivisten 7-aminoasetyylimerkaptoasetyyliamidioktahydro-6-oksopyridiini[2,1a] [2] - bentsatsepiini- ja heksahydro-6-okso-1H- [1,4] -oksatsiini - [3,4-a] [2]bentsatsepiini-ja heksahydro-6-okso-1H-[1,4] - tiatsiini[3,4-a] [2]bentsatsepiini-4-karboksyylihappojen ja niiden farmaseuttisesti hyväksyttävien suolojen valmistamiseksi FI106717B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US83602892A 1992-02-14 1992-02-14
US83602892 1992-02-14
US98567892A 1992-12-11 1992-12-11
US98567892 1992-12-11
US9300153 1993-01-08
PCT/US1993/000153 WO1993016103A1 (en) 1992-02-14 1993-01-08 Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace

Publications (3)

Publication Number Publication Date
FI943728A FI943728A (fi) 1994-08-12
FI943728A0 true FI943728A0 (fi) 1994-08-12
FI106717B FI106717B (fi) 2001-03-30

Family

ID=27125838

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943728A FI106717B (fi) 1992-02-14 1994-08-12 Menetelmä terapeuttisesti aktiivisten 7-aminoasetyylimerkaptoasetyyliamidioktahydro-6-oksopyridiini[2,1a] [2] - bentsatsepiini- ja heksahydro-6-okso-1H- [1,4] -oksatsiini - [3,4-a] [2]bentsatsepiini-ja heksahydro-6-okso-1H-[1,4] - tiatsiini[3,4-a] [2]bentsatsepiini-4-karboksyylihappojen ja niiden farmaseuttisesti hyväksyttävien suolojen valmistamiseksi

Country Status (18)

Country Link
US (3) US5424425A (fi)
EP (1) EP0625987B1 (fi)
JP (1) JP3460838B2 (fi)
KR (1) KR100276029B1 (fi)
AT (1) ATE164593T1 (fi)
AU (1) AU668707B2 (fi)
CA (1) CA2130116C (fi)
DE (1) DE69317764T2 (fi)
DK (1) DK0625987T3 (fi)
ES (1) ES2117123T3 (fi)
FI (1) FI106717B (fi)
HU (1) HU220596B1 (fi)
IL (1) IL104716A (fi)
MX (1) MX9300777A (fi)
NO (1) NO311524B1 (fi)
NZ (1) NZ246811A (fi)
TW (1) TW225534B (fi)
WO (1) WO1993016103A1 (fi)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ246811A (en) * 1992-02-14 1996-02-27 Merrell Dow Pharma N-[pyrido (and oxazino and thiazino) benzazepine] 1-benzyl-1-(heterocyclyl(alkyl)carbonylthio) acetamide derivatives and pharmaceutical compositions
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
US5654294A (en) * 1993-05-13 1997-08-05 Bristol-Myers Squibb Spiro lactam dual action inhibitors
CA2140553A1 (en) * 1993-06-11 1994-12-22 Hitoshi Oinuma Amino acid derivative
US5508272A (en) * 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam
HUT76479A (en) * 1994-02-14 1997-09-29 Merrell Pharma Inc Novel fused benzazepinone derivatives, process for preparation thereof and pharmaceutical composition containing them
ES2145267T3 (es) * 1994-02-14 2000-07-01 Merrell Pharma Inc Nuevos derivados bisulfuro de mercaptoacetilamido de 1,3,4,5-tetrahidro-benzo(c)azepin-3-ona utiles como inhibidores de la encefalinasa y del enzima de conversion de la angiotensina.
ES2168355T3 (es) * 1994-02-14 2002-06-16 Merrell Pharma Inc Derivados de bisulfuro de indano-2-mercaptoacetilamida utiles como inhibidores de la encefalinasa.
ES2141923T3 (es) * 1994-03-24 2000-04-01 Merrell Pharma Inc Uso hipocolesterolemico, antiaterosclerotico e hipotrigliceridemico de derivados aminoacetilmercapto.
US5616775A (en) * 1994-05-05 1997-04-01 Bristol-Myers Squibb Co. Process for preparing homocystein analogs useful as intermediates for compounds containing a fused bicyclic ring
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US6245764B1 (en) 1995-03-24 2001-06-12 Molecumetics Ltd. β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US6020331A (en) * 1995-03-24 2000-02-01 Molecumetics, Ltd. β-sheet mimetics and use thereof as protease inhibitors
US6699869B1 (en) 1995-03-24 2004-03-02 Myriad Genetics Inc. β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US5877313A (en) 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
US6117896A (en) 1997-02-10 2000-09-12 Molecumetics Ltd. Methods for regulating transcription factors
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
EP1053246B1 (en) * 1998-02-12 2003-01-02 Molecumetics, Ltd. Beta-sheet mimetics and methods relating to the use thereof
WO1999065500A1 (en) 1998-06-17 1999-12-23 Bristol-Myers Squibb Company Preventing cerebral infarction through administration of adp-receptor antiplatelet and antihypertensive drugs in combination
WO2000040578A1 (en) * 1998-12-31 2000-07-13 Aventis Pharmaceuticals Inc. 3-(thio-substituted amido)-lactams useful as inhibitors of matrix metalloproteinase
US6486193B2 (en) 1998-12-31 2002-11-26 Aventis Pharmaceuticals Inc. 3-substituted pyrrolidines useful as inhibitors of matrix metalloproteinases
CA2358955A1 (en) * 1998-12-31 2000-07-13 Aventis Pharmaceuticals Inc. N-carboxymethyl substituted benzolactams as inhibitors of matrix metalloproteinase
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
WO2003068237A1 (en) 2002-02-14 2003-08-21 Myriad Genetics, Inc. Beta-sheet mimetics and composition and methods relating thereto
DE10229180A1 (de) * 2002-06-28 2004-01-29 Aventis Pharma Deutschland Gmbh Verwendung von Vasopeptidase-Inhibitoren bei der Behandlung von metabolischen Erkrankungen, Nephropathie und mit AGE assoziierten Erkrankungen

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3334095A (en) * 1965-02-16 1967-08-01 Sandoz Ag Novel pyrrolo-oxazines and pyrrolo-oxazoles
US3334091A (en) * 1965-03-25 1967-08-01 Sandoz Ag Sedatives
GB1525845A (en) * 1976-07-30 1978-09-20 Ucb Sa 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones
IE50839B1 (en) * 1980-02-26 1986-07-23 Wyeth John & Brother Ltd Novel processes for preparing proline derivatives and analogous compounds
EP0042100A1 (de) * 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
US4320057A (en) * 1980-06-23 1982-03-16 American Home Products Corporation Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones
US4552889A (en) * 1983-06-09 1985-11-12 Eli Lilly And Company 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
KR880001092B1 (ko) * 1985-04-30 1988-06-23 일라이 릴리 앤드 캄파니 7-치환된 바이시클릭 피라졸리디논 및 그의 제조방법
ZA874106B (en) * 1986-06-13 1987-12-08 Merrell Dow Pharmaceuticals Inc. Novel antihypertensive agent
ZA874107B (fi) * 1986-06-13 1987-12-09
US4973585A (en) * 1986-06-13 1990-11-27 Merrell Dow Pharmaceuticals Tricyclic lactams active as antihypertensive agents
GB8629875D0 (en) * 1986-12-15 1987-01-28 Hoffmann La Roche Pyridazodiazepine derivatives
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5208230A (en) * 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
FR2679564A1 (fr) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
CA2119019A1 (en) * 1991-09-16 1993-04-01 Harry R. Davis Pharmaceutical compositions comprising natriuretic peptides or neutral endopeptidase inhibitors for treating or preventing myointimal proliferation
CA2078759C (en) * 1991-09-27 2003-09-16 Alan M. Warshawsky Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
NZ246811A (en) * 1992-02-14 1996-02-27 Merrell Dow Pharma N-[pyrido (and oxazino and thiazino) benzazepine] 1-benzyl-1-(heterocyclyl(alkyl)carbonylthio) acetamide derivatives and pharmaceutical compositions
RU2124503C1 (ru) * 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds

Also Published As

Publication number Publication date
US5488048A (en) 1996-01-30
JP3460838B2 (ja) 2003-10-27
AU668707B2 (en) 1996-05-16
FI943728A (fi) 1994-08-12
CA2130116C (en) 1998-04-07
NO942994D0 (no) 1994-08-12
NZ246811A (en) 1996-02-27
IL104716A0 (en) 1993-06-10
EP0625987A1 (en) 1994-11-30
ES2117123T3 (es) 1998-08-01
ATE164593T1 (de) 1998-04-15
AU3439193A (en) 1993-09-03
NO311524B1 (no) 2001-12-03
HU9402355D0 (en) 1994-10-28
HUT71105A (en) 1995-11-28
DK0625987T3 (da) 1999-01-11
US5424425A (en) 1995-06-13
TW225534B (fi) 1994-06-21
DE69317764D1 (de) 1998-05-07
MX9300777A (es) 1993-08-01
KR100276029B1 (ko) 2000-12-15
US5529995A (en) 1996-06-25
KR950700323A (ko) 1995-01-16
DE69317764T2 (de) 1998-07-30
WO1993016103A1 (en) 1993-08-19
FI106717B (fi) 2001-03-30
EP0625987B1 (en) 1998-04-01
CA2130116A1 (en) 1993-08-19
JPH07503955A (ja) 1995-04-27
NO942994L (no) 1994-10-13
HU220596B1 (hu) 2002-03-28
IL104716A (en) 1997-09-30

Similar Documents

Publication Publication Date Title
FI943728A0 (fi) Enkefalinaasin ja ACE:n inhibiittoreina käyttökelpoisia uusia aminoasetyylimerkaptojohdannaisia
ES2114870T3 (es) Nuevos derivados de mercaptoacetilamida utiles como inhibidores de encefalinasa y eca.
GR3021420T3 (en) 2-Substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
AU657166B2 (en) Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
NO944430L (no) 4-mercaptoacetylamino-[2Åbenzazepinon(3)-derivater, og anvendelse som enkefalinaseinhibitorer
FI950842A0 (fi) Enkefalinaasin inhibiittoreina käyttökelpoisia uusia 2-substituoituja trisyklisiä indaani-2-merkaptoasetyyliamidijohdannaisia
MX9603348A (es) Derivados de disulfuro de amida indano-2-mercaptoacetilica novedosos utiles como inhibidores de encefalinasa.
ES2089281T3 (es) Nuevos derivados de 2-mercaptometileno-tetrahidronaftaleno y 2-carboxamida indanos como inhibidores de la encefalinasa.

Legal Events

Date Code Title Description
MA Patent expired