DE69112432T2 - Derivate von methylpiperazinoazepin, verfahren zu ihrer herstellung und verwendung. - Google Patents

Derivate von methylpiperazinoazepin, verfahren zu ihrer herstellung und verwendung.

Info

Publication number
DE69112432T2
DE69112432T2 DE69112432T DE69112432T DE69112432T2 DE 69112432 T2 DE69112432 T2 DE 69112432T2 DE 69112432 T DE69112432 T DE 69112432T DE 69112432 T DE69112432 T DE 69112432T DE 69112432 T2 DE69112432 T2 DE 69112432T2
Authority
DE
Germany
Prior art keywords
methylpiperazinoazepine
derivatives
production
preparation
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69112432T
Other languages
English (en)
Other versions
DE69112432D1 (de
Inventor
Jean-Francois Fernand Liegeois
Jacques Elie Delarge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UNIVERSITE DE LIEGE LIEGE BE
Original Assignee
Therabel Research NV SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Therabel Research NV SA filed Critical Therabel Research NV SA
Publication of DE69112432D1 publication Critical patent/DE69112432D1/de
Application granted granted Critical
Publication of DE69112432T2 publication Critical patent/DE69112432T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D517/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having selenium, tellurium, or halogen atoms as ring hetero atoms
    • C07D517/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having selenium, tellurium, or halogen atoms as ring hetero atoms in which the condensed system contains two hetero rings
    • C07D517/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
DE69112432T 1990-09-26 1991-10-10 Derivate von methylpiperazinoazepin, verfahren zu ihrer herstellung und verwendung. Expired - Fee Related DE69112432T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
BE9000914A BE1004596A4 (fr) 1990-09-26 1990-09-26 Derives de methylpiperazinoazepine, leur preparation et leur utilisation.
PCT/BE1991/000073 WO1993007143A1 (fr) 1990-09-26 1991-10-10 Derives de methylpiperazinoazepine, leur preparation et leur utilisation
CA002120229A CA2120229C (fr) 1990-09-26 1991-10-10 Derives de methylpiperazinoazepine, leur preparation et leur utilisation
HK98106195A HK1006970A1 (en) 1990-09-26 1998-06-23 Methylpiperazinoazepine derivatives their preparation and use

Publications (2)

Publication Number Publication Date
DE69112432D1 DE69112432D1 (de) 1995-09-28
DE69112432T2 true DE69112432T2 (de) 1996-02-01

Family

ID=27159764

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69112432T Expired - Fee Related DE69112432T2 (de) 1990-09-26 1991-10-10 Derivate von methylpiperazinoazepin, verfahren zu ihrer herstellung und verwendung.

Country Status (14)

Country Link
EP (1) EP0607129B1 (de)
AT (1) ATE126799T1 (de)
BE (1) BE1004596A4 (de)
CA (1) CA2120229C (de)
DE (1) DE69112432T2 (de)
DK (1) DK0607129T3 (de)
EE (1) EE02942B1 (de)
ES (1) ES2080336T3 (de)
GR (1) GR3017951T3 (de)
HK (1) HK1006970A1 (de)
LT (1) LT3231B (de)
LV (1) LV10098B (de)
RU (1) RU2111966C1 (de)
WO (1) WO1993007143A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700445A (en) * 1994-12-12 1997-12-23 Allelix Biopharmaceuticals, Inc. N-methyl piperazine compounds having dopamine receptor affinity
US5561127A (en) * 1994-12-19 1996-10-01 Allelix Biopharmaceuticals, Inc. Muscarinic receptor ligands
FR2850654A1 (fr) * 2003-02-03 2004-08-06 Servier Lab Nouveaux derives d'azepines tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN1913900B (zh) * 2003-12-22 2010-11-24 阿卡蒂亚药品公司 作为毒蕈碱激动剂的氨基取代的二芳基[a，d]环庚烯类似物及神经精神疾病的治疗方法
ES2324713T3 (es) 2003-12-22 2009-08-13 Acadia Pharmaceuticals Inc. Analogos de diaril(a,d)ciclohepteno amino-sustituidos como agonistas muscarinicos y metodos de tratamiento de trastornos neuropsiquiatricos.
CN102807574B (zh) * 2011-05-30 2015-09-02 长春吉大天元化学技术股份有限公司 新型吡啶并硫氮七元环衍生物作为抗肿瘤药物、及其制备方法和应用
CN107382907A (zh) * 2017-06-21 2017-11-24 温州医科大学 一种11‑甲基二苯并[b,f][1,4]硒吖庚因化合物及制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7403657A (de) * 1973-03-23 1974-09-25
US3872122A (en) * 1973-04-16 1975-03-18 Bristol Myers Co 11 H-Pyrimido{8 4,5-b{9 {8 1,4{9 benzodiazepines
GB1587128A (en) 1977-04-07 1981-04-01 Hexachimie Benzothiazepine derivatives
IT7851496A0 (it) * 1977-10-31 1978-10-13 Sandoz Ag Menti pirazinobenzossazepine loro preparazione e loro impiego quali medica
CH643263A5 (de) * 1979-05-11 1984-05-30 Sandoz Ag Benzodiazepine, ihre herstellung und verwendung.
GB8819059D0 (en) * 1988-08-11 1988-09-14 Lilly Industries Ltd Benzodiazepine compounds & their use as pharmaceuticals
US4940704A (en) 1989-08-16 1990-07-10 Hoechst-Roussel Pharmaceutical Inc. Pyrido[3,4-b][1,4]benzoxazepines

Also Published As

Publication number Publication date
LTIP378A (en) 1994-09-25
HK1006970A1 (en) 1999-03-26
LV10098B (en) 1994-10-20
ES2080336T3 (es) 1996-02-01
BE1004596A4 (fr) 1992-12-22
DE69112432D1 (de) 1995-09-28
LV10098A (lv) 1994-05-10
ATE126799T1 (de) 1995-09-15
DK0607129T3 (da) 1995-12-18
LT3231B (en) 1995-04-25
EP0607129A1 (de) 1994-07-27
CA2120229A1 (fr) 1993-04-15
EP0607129B1 (de) 1995-08-23
RU2111966C1 (ru) 1998-05-27
GR3017951T3 (en) 1996-02-29
EE02942B1 (et) 1996-10-15
CA2120229C (fr) 2002-04-09
WO1993007143A1 (fr) 1993-04-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: UNIVERSITE DE LIEGE, LIEGE, BE

8339 Ceased/non-payment of the annual fee