LTIP378A - Methylpiperazinoazepine derivatives, preparation and use tereof - Google Patents

Methylpiperazinoazepine derivatives, preparation and use tereof

Info

Publication number
LTIP378A
LTIP378A LTIP378A LTIP378A LTIP378A LT IP378 A LTIP378 A LT IP378A LT IP378 A LTIP378 A LT IP378A LT IP378 A LTIP378 A LT IP378A LT IP378 A LTIP378 A LT IP378A
Authority
LT
Lithuania
Prior art keywords
methylpiperazinoazepine
derivatives
preparation
tereof
pharmaceutically acceptable
Prior art date
Application number
LTIP378A
Inventor
Jean-Francois Fernand Liegeois
Jacques Elie Delarge
Original Assignee
Therabel Research Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HK98106195.3A external-priority patent/HK1006970B/en
Application filed by Therabel Research Sa filed Critical Therabel Research Sa
Publication of LTIP378A publication Critical patent/LTIP378A/en
Publication of LT3231B publication Critical patent/LT3231B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D517/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having selenium, tellurium, or halogen atoms as ring hetero atoms
    • C07D517/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having selenium, tellurium, or halogen atoms as ring hetero atoms in which the condensed system contains two hetero rings
    • C07D517/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Methylpiperazinoazepine derivatives of general formula (I), wherein X, R1, R2, N1 and N2 have various meanings, pharmaceutically acceptable salts thereof, and their preparation and use, are described.
LTIP378A 1990-09-26 1993-03-03 Methylpiperazinoazepine derivatives, preparation and use tereof LT3231B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
BE9000914A BE1004596A4 (en) 1990-09-26 1990-09-26 Methylpiperazinoazepine DERIVATIVES, PREPARATION AND USE.
CA002120229A CA2120229C (en) 1990-09-26 1991-10-10 Methylpiperazinoazepine derivatives, their preparation and their use
HK98106195.3A HK1006970B (en) 1991-10-10 Methylpiperazinoazepine derivatives, their preparation and use

Publications (2)

Publication Number Publication Date
LTIP378A true LTIP378A (en) 1994-09-25
LT3231B LT3231B (en) 1995-04-25

Family

ID=27159764

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP378A LT3231B (en) 1990-09-26 1993-03-03 Methylpiperazinoazepine derivatives, preparation and use tereof

Country Status (13)

Country Link
EP (1) EP0607129B1 (en)
AT (1) ATE126799T1 (en)
BE (1) BE1004596A4 (en)
CA (1) CA2120229C (en)
DE (1) DE69112432T2 (en)
DK (1) DK0607129T3 (en)
EE (1) EE02942B1 (en)
ES (1) ES2080336T3 (en)
GR (1) GR3017951T3 (en)
LT (1) LT3231B (en)
LV (1) LV10098B (en)
RU (1) RU2111966C1 (en)
WO (1) WO1993007143A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700445A (en) * 1994-12-12 1997-12-23 Allelix Biopharmaceuticals, Inc. N-methyl piperazine compounds having dopamine receptor affinity
US5561127A (en) * 1994-12-19 1996-10-01 Allelix Biopharmaceuticals, Inc. Muscarinic receptor ligands
FR2850654A1 (en) * 2003-02-03 2004-08-06 Servier Lab NOVEL TRICYCLIC AZEPINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
NZ547911A (en) 2003-12-22 2010-06-25 Acadia Pharm Inc Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
CN1913900B (en) * 2003-12-22 2010-11-24 阿卡蒂亚药品公司 Amino-substituted diaryl [ a, d ] cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric diseases
CN102807574B (en) * 2011-05-30 2015-09-02 长春吉大天元化学技术股份有限公司 New pyridine sulphur nitrogen seven-membered ring derivative as antitumor drug, and its preparation method and application
CN107382907A (en) * 2017-06-21 2017-11-24 温州医科大学 A kind of 11 methyldiphenyls simultaneously [b, f] [1,4] selenium azepine compound and preparation method

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7403657A (en) * 1973-03-23 1974-09-25
US3872122A (en) * 1973-04-16 1975-03-18 Bristol Myers Co 11 H-Pyrimido{8 4,5-b{9 {8 1,4{9 benzodiazepines
GB1587128A (en) 1977-04-07 1981-04-01 Hexachimie Benzothiazepine derivatives
IT7851496A0 (en) * 1977-10-31 1978-10-13 Sandoz Ag PYRAZINOBENZOXAZEPINES THEIR PREPARATION AND THEIR MEDICAL USE
CH643263A5 (en) * 1979-05-11 1984-05-30 Sandoz Ag BENZODIAZEPINE, THEIR PRODUCTION AND USE.
GB8819059D0 (en) * 1988-08-11 1988-09-14 Lilly Industries Ltd Benzodiazepine compounds & their use as pharmaceuticals
US4940704A (en) 1989-08-16 1990-07-10 Hoechst-Roussel Pharmaceutical Inc. Pyrido[3,4-b][1,4]benzoxazepines

Also Published As

Publication number Publication date
DE69112432T2 (en) 1996-02-01
CA2120229A1 (en) 1993-04-15
GR3017951T3 (en) 1996-02-29
CA2120229C (en) 2002-04-09
RU2111966C1 (en) 1998-05-27
EE02942B1 (en) 1996-10-15
DE69112432D1 (en) 1995-09-28
BE1004596A4 (en) 1992-12-22
HK1006970A1 (en) 1999-03-26
WO1993007143A1 (en) 1993-04-15
EP0607129B1 (en) 1995-08-23
LV10098B (en) 1994-10-20
LT3231B (en) 1995-04-25
DK0607129T3 (en) 1995-12-18
LV10098A (en) 1994-05-10
EP0607129A1 (en) 1994-07-27
ATE126799T1 (en) 1995-09-15
ES2080336T3 (en) 1996-02-01

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Legal Events

Date Code Title Description
TK9A Rectifications: patents

Free format text: 1. METILPIPERAZINAZEPINO DARINYS, KURIO BENDRA FORMULE I: I,KURIOJE:X YRA DEGUONIES ATOMAS, SIEROS ATOMAS, SELENO ATOMAS ARBA NH AR NR3 GRUPE, KURIOJE R3 YRA -C , -C GRUPE, ARBA NESAKOTA AR SAKOTA NUO 1 IKI 4 ANGLIES ATOMU TURINTI ALKILO GRUPE;R1 YRA VANDENILIO ATOMAS, HALOGENO ATOMAS ARBA SAKOTA AR NESAKOTA NUO 1 IKI 4 ANGLIES ATOMU TURINTI ALKILO GRUPE;R2 YRA VANDENILIO ATOMAS, HALOGENO ATOMAS ARBA SAKOTA AR NESAKOTA NUO 1 IKI 4 ANGLIES ATOMU TURINTI ALKILO GRUPE; IR N1 YRA BENZENO ZIEDAS IR N2 PIRIDINO ZIEDAS ARBA ATVIRKSCIAI, SU

TK9A Rectifications: patents

Free format text: C07D 241/00, C07D 241/02, C07D 295/00, C07D 295/02, C07D 295/32, 19960616,

PC9A Transfer of patents

Owner name: UNIVERSITE DE LIEGE, BE

Effective date: 20030326

MM9A Lapsed patents

Effective date: 20040303