ATE245157T1 - 3,9-diazabicyclo-(3.3.1)-nonanylderivate, verfahren und intermediate für ihre darstellung und sie enthaltende pharmazeutische zusammensetzungen - Google Patents

3,9-diazabicyclo-(3.3.1)-nonanylderivate, verfahren und intermediate für ihre darstellung und sie enthaltende pharmazeutische zusammensetzungen

Info

Publication number
ATE245157T1
ATE245157T1 AT91916973T AT91916973T ATE245157T1 AT E245157 T1 ATE245157 T1 AT E245157T1 AT 91916973 T AT91916973 T AT 91916973T AT 91916973 T AT91916973 T AT 91916973T AT E245157 T1 ATE245157 T1 AT E245157T1
Authority
AT
Austria
Prior art keywords
alkyl
phenyl
nonanyl
diazabicyclo
intermediates
Prior art date
Application number
AT91916973T
Other languages
English (en)
Inventor
F D King
Julian Anthony Gregory
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Application granted granted Critical
Publication of ATE245157T1 publication Critical patent/ATE245157T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT91916973T 1990-09-26 1991-09-23 3,9-diazabicyclo-(3.3.1)-nonanylderivate, verfahren und intermediate für ihre darstellung und sie enthaltende pharmazeutische zusammensetzungen ATE245157T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909020927A GB9020927D0 (en) 1990-09-26 1990-09-26 Pharmaceuticals
PCT/GB1991/001629 WO1992005174A1 (en) 1990-09-26 1991-09-23 3,9-diazabicyclo (3.3.1) nonan-7-yl derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ATE245157T1 true ATE245157T1 (de) 2003-08-15

Family

ID=10682769

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91916973T ATE245157T1 (de) 1990-09-26 1991-09-23 3,9-diazabicyclo-(3.3.1)-nonanylderivate, verfahren und intermediate für ihre darstellung und sie enthaltende pharmazeutische zusammensetzungen

Country Status (19)

Country Link
EP (1) EP0550550B1 (de)
JP (1) JP2831464B2 (de)
KR (1) KR100200438B1 (de)
AT (1) ATE245157T1 (de)
AU (1) AU652187B2 (de)
CA (1) CA2092431C (de)
CY (1) CY2387B1 (de)
DE (1) DE69133295T2 (de)
DK (1) DK0550550T3 (de)
ES (1) ES2203609T3 (de)
GB (1) GB9020927D0 (de)
HK (1) HK1012356A1 (de)
IE (1) IE913352A1 (de)
MX (1) MX9101236A (de)
NZ (1) NZ239915A (de)
PT (1) PT99028B (de)
TW (1) TW240227B (de)
WO (1) WO1992005174A1 (de)
ZA (1) ZA917606B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9121170D0 (en) * 1991-10-05 1991-11-20 Smithkline Beecham Plc Pharmaceuticals
US5344831A (en) * 1992-01-31 1994-09-06 Nisshin Flour Milling Co., Ltd. Diazabicyclo derivatives
GB9214184D0 (en) * 1992-07-03 1992-08-12 Smithkline Beecham Plc Pharmaceuticals
US5514690A (en) * 1992-11-17 1996-05-07 E. R. Squibb & Sons, Inc. Aminocarbonyl (thiocarbonyl) and cyanoguanidine derivatives of quinoline and indoline
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
GB9721139D0 (en) * 1997-10-07 1997-12-03 Glaxo Group Ltd Medicaments
ES2372931T3 (es) 2002-04-29 2012-01-27 Actelion Pharmaceuticals Ltd. Derivados de 7-aril-3,9-diazabiciclo[3.3.1]non-6-eno y su uso como inhibidores de la renina en el tratamiento de la hipertensión, enfermedades cardiovasculares o renales.
AU2004283821A1 (en) * 2003-10-13 2005-05-06 Actelion Pharmaceuticals Ltd. Diazabicyclononene derivatives and their use as renin inhibitors
US7737163B2 (en) 2004-06-15 2010-06-15 Pfizer Inc. Benzimidazolone carboxylic acid derivatives
AU2005254800B2 (en) 2004-06-15 2010-12-09 Pfizer Inc. Benzimidazolone carboxylic acid derivatives
EP1856110B1 (de) 2005-02-22 2011-06-22 Pfizer Inc. Oxyindol-derivate als 5ht4-rezeptor-agonisten
US8129538B1 (en) 2007-03-28 2012-03-06 Takeda Pharmaceutical Company Limited Renin inhibitors
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3687080T2 (de) * 1985-04-27 1993-03-25 Beecham Group Plc Azabicyclononyl-indazol-carboxamid mit 5-ht-antagonistischer wirkung.
NL8701682A (nl) * 1986-07-30 1988-02-16 Sandoz Ag Werkwijze voor het therapeutisch toepassen van serotonine antagonisten, aktieve verbindingen en farmaceutische preparaten die deze verbindingen bevatten.
US4920227A (en) * 1988-11-29 1990-04-24 Rorer Pharmaceutical Corp. Benzobicyclic carboxamide 5-HT3 antagonists
US4920219A (en) * 1988-11-29 1990-04-24 Rorer Pharmaceutical Corp. Substituted saturated and unsaturated indole quinoline and benzazepine carboxamides and their use as pharmacological agents

Also Published As

Publication number Publication date
KR930702345A (ko) 1993-09-08
GB9020927D0 (en) 1990-11-07
NZ239915A (en) 1993-11-25
TW240227B (de) 1995-02-11
EP0550550A1 (de) 1993-07-14
JPH06501256A (ja) 1994-02-10
CA2092431C (en) 2002-12-10
JP2831464B2 (ja) 1998-12-02
ZA917606B (en) 1992-09-30
EP0550550B1 (de) 2003-07-16
IE913352A1 (en) 1992-04-08
PT99028A (pt) 1993-10-29
HK1012356A1 (en) 1999-07-30
ES2203609T3 (es) 2004-04-16
AU652187B2 (en) 1994-08-18
CA2092431A1 (en) 1992-03-27
WO1992005174A1 (en) 1992-04-02
CY2387B1 (en) 2004-09-10
DE69133295D1 (de) 2003-08-21
KR100200438B1 (ko) 1999-06-15
DK0550550T3 (da) 2003-09-08
PT99028B (pt) 1999-02-26
MX9101236A (es) 1992-05-04
DE69133295T2 (de) 2004-03-18
AU8624491A (en) 1992-04-15

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