EA199800404A1 - Производные 1-(1,2-дизамещенный пиперидинил)-4-замещенного пиперазина - Google Patents

Производные 1-(1,2-дизамещенный пиперидинил)-4-замещенного пиперазина

Info

Publication number
EA199800404A1
EA199800404A1 EA199800404A EA199800404A EA199800404A1 EA 199800404 A1 EA199800404 A1 EA 199800404A1 EA 199800404 A EA199800404 A EA 199800404A EA 199800404 A EA199800404 A EA 199800404A EA 199800404 A1 EA199800404 A1 EA 199800404A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
het
6alkyl
formula
substituted
Prior art date
Application number
EA199800404A
Other languages
English (en)
Other versions
EA000909B1 (ru
Inventor
Франс Эдуард Жансенс
Франсуа Мария Соммен
Доминик Луи Нестор Гилейн Сюрлеро
Йозеф Элизабет Ленартс
Ив Эмиль Мария Ван Росбрук
Original Assignee
Жансен Фармасетика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8220780&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA199800404(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Жансен Фармасетика Н.В. filed Critical Жансен Фармасетика Н.В.
Publication of EA199800404A1 publication Critical patent/EA199800404A1/ru
Publication of EA000909B1 publication Critical patent/EA000909B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Настоящее изобретение относится к соединениям формулы (I)их N-оксидным формам, фармацевтически приемлемым аддитивным солям и стереоизомерным формам, где n равно 0, 1 или 2; m равно 1 или 2, при условии, что если m равно 2, то n равно 1; p равно 1 или 2; =Q представляет =O или =NR; X представляет ковалентную связь или двухвалентный радикал формулы -O-, -S-, -NR-; Rпредставляет Ar, ArCалкил или ди(Ar)Cалкил, где каждая Cалкильная группа необязательно замещена гидрокси, Cалкилокси, оксо или кетализированным оксозаместителем, Rпредставляет Ar, ArCалкил, Hetили HetCалкил; Rпредставляет водород или Cалкил; L представляет водород; Ar; Cалкил; Cалкил, замещенный 1 или 2 заместителями, выбранными из гидрокси, Cалкилокси, Ar, ArCалкилокси и Het; Cалкенил; ArCалкенил; ди(Ar)Cалкенил или радикал формулы (а-1), (а-2), (а-3), (а-4) или (а-5); каждый из Ar, Arи Arпредставляет фенил или замещенный фенил; каждый из Hetи Hetпредставляет моноциклический или бициклический гетероцикл; в качестве антагонистов вещества P; их получению, композициям, содержащим их, и их использованию в качестве лекарственного средства.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800404A 1995-10-30 1996-10-25 Производные 1-(1,2-дизамещенный пиперидинил)-4-замещенного пиперазина EA000909B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP95202929 1995-10-30
EP96937248A EP0862566B1 (en) 1995-10-30 1996-10-25 1-(1,2-disubstituted piperidinyl)-4-substituted piperazine derivatives
PCT/EP1996/004660 WO1997016440A1 (en) 1995-10-30 1996-10-25 1-(1,2-disubstituted piperidinyl)-4-substituted piperazine derivatives

Publications (2)

Publication Number Publication Date
EA199800404A1 true EA199800404A1 (ru) 1998-10-29
EA000909B1 EA000909B1 (ru) 2000-06-26

Family

ID=8220780

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800404A EA000909B1 (ru) 1995-10-30 1996-10-25 Производные 1-(1,2-дизамещенный пиперидинил)-4-замещенного пиперазина

Country Status (31)

Country Link
US (3) US6197772B1 (ru)
EP (1) EP0862566B1 (ru)
JP (1) JP3073238B2 (ru)
KR (1) KR100407067B1 (ru)
CN (2) CN1117744C (ru)
AR (1) AR004698A1 (ru)
AT (1) ATE188691T1 (ru)
AU (1) AU704155B2 (ru)
BR (1) BR9611184B8 (ru)
CA (1) CA2234096C (ru)
CY (1) CY2177B1 (ru)
CZ (1) CZ291794B6 (ru)
DE (1) DE69606196T2 (ru)
DK (1) DK0862566T3 (ru)
EA (1) EA000909B1 (ru)
ES (1) ES2143238T3 (ru)
GR (1) GR3033154T3 (ru)
HR (1) HRP960507B1 (ru)
HU (1) HU227341B1 (ru)
IL (1) IL123962A (ru)
MX (1) MX9803407A (ru)
MY (1) MY116575A (ru)
NO (1) NO310232B1 (ru)
NZ (1) NZ321575A (ru)
PL (1) PL185029B1 (ru)
PT (1) PT862566E (ru)
SI (1) SI0862566T1 (ru)
TR (1) TR199800756T2 (ru)
TW (1) TW460473B (ru)
WO (1) WO1997016440A1 (ru)
ZA (1) ZA969090B (ru)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ321575A (en) * 1995-10-30 1999-05-28 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives
TW382017B (en) 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives
TW429256B (en) * 1995-12-27 2001-04-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(benzimidazolyl- and imidazopyridinyl)-piperidine derivatives
TW531537B (en) 1995-12-27 2003-05-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-substituted piperidine derivatives
WO1999032486A1 (en) * 1997-12-23 1999-07-01 Alcon Laboratories, Inc. Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions
US6391865B1 (en) 1999-05-04 2002-05-21 Schering Corporation Piperazine derivatives useful as CCR5 antagonists
US6689765B2 (en) 1999-05-04 2004-02-10 Schering Corporation Piperazine derivatives useful as CCR5 antagonists
USRE39921E1 (en) 1999-10-07 2007-11-13 Smithkline Beecham Corporation Chemical compounds
GB9923748D0 (en) * 1999-10-07 1999-12-08 Glaxo Group Ltd Chemical compounds
WO2001030348A1 (en) * 1999-10-25 2001-05-03 Janssen Pharmaceutica N.V. Use of substance p antagonists for influencing the circadian timing system
GB0025354D0 (en) 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
PL364560A1 (en) 2001-03-29 2004-12-13 Schering Corporation Ccr5 antagonists useful for treating aids
GB0108594D0 (en) * 2001-04-05 2001-05-23 Glaxo Group Ltd Chemical compounds
GB0203022D0 (en) 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
JP2005522436A (ja) * 2002-02-08 2005-07-28 グラクソ　グループ　リミテッド ピペリジルカルボキシアミド誘導体またはそのタキキニン介在疾患の治療における使用
GB0203020D0 (en) * 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
ES2326800T3 (es) 2002-06-24 2009-10-20 Janssen Pharmaceutica Nv Proceso para la produccion de n-(2,6-dimetil-fenil)-2-piperazin-1-il-acetamida.
MY141736A (en) * 2002-10-08 2010-06-15 Elanco Animal Health Ireland Substituted 1,4-di-piperidin-4-yi-piperazine derivatives and their use as neurokinin antagonists
WO2004056772A1 (en) * 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Substituted 1,4-di-piperidin-4-yl-piperazine derivatives and their use as tachykinin antagonists
CA2501539A1 (en) * 2002-10-17 2004-04-29 Amgen Inc. Benzimidazole derivatives and their use as vanilloid receptor ligands
US7514424B2 (en) 2002-12-23 2009-04-07 Janssen Pharmaceutica N.V. Substituted 4-(4-piperidin-4-yl-piperazin-1-yl)-azepane derivatives and their use as neurokinin antagonists
WO2004056800A1 (en) 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Substituted 1-piperidin-4-yl-4-azetidin-3-yl-piperazine derivatives and their use as neurokinin antagonists
JO2485B1 (en) * 2002-12-23 2009-01-20 شركة جانسين فارماسوتيكا ان. في 1-Piperidine-3-Yl-4-Piperidine-4-Yl-Piperazine derivatives substituted and used as quinine antagonists
JO2696B1 (en) 2002-12-23 2013-03-03 شركة جانسين فارماسوتيكا ان. في Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists
ES2307025T3 (es) * 2003-06-10 2008-11-16 Janssen Pharmaceutica Nv Combinacion de opioides y un derivado de la piperazina para el tratamiento del dolor.
WO2004110415A2 (en) * 2003-06-10 2004-12-23 Janssen Pharmaceutica N.V. Substituted 1, 4-di-piperidin-4-yl-piperazine derivative combined with an opioid analgesic and their use for the treatment of pain and side-effects associated with opioid-based treatments
UY28538A1 (es) * 2003-09-26 2005-04-29 Vertex Pharma Derivados de fenil-piperazina como moduladores de receptores muscarínicos
JO2527B1 (en) * 2004-04-06 2010-03-17 شركة جانسين فارماسوتيكا ان. في Derivatives of second-aza-Spiro- (5,5) -andecan and their use as antihistamines
JO2676B1 (en) * 2004-04-06 2012-06-17 جانسين فارماسوتيكا ان. في Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines
JO2525B1 (en) * 2004-04-08 2010-03-17 شركة جانسين فارماسوتيكا ان. في Derived 4-alkyl-and-4-canoelperidine derivatives and their use as anti-neroquin
EP1734966B1 (en) 2004-04-13 2013-07-31 Incyte Corporation Piperazinylpiperidine derivatives as chemokine receptor antagonists
WO2005123081A2 (en) * 2004-06-22 2005-12-29 Janssen Pharmaceutica N.V. (2-benzyl-4-{4-[1-(tetrahydrofuran-3-carbonyl)-pyrrolidin-3-yl]-piperazin-1-yl}-piperidin-1-yl)-(3,5-trifluoromethyl-phenyl))-methanone for the treatment of schizophrenia
US20060024481A1 (en) * 2004-07-29 2006-02-02 Eastman Kodak Company Jet printing of patterned metal
CA2576166C (en) 2004-08-19 2018-02-20 Monsanto Technology Llc Glyphosate salt herbicidal composition
WO2006071958A1 (en) * 2004-12-29 2006-07-06 Millennium Pharmaceuticals, Inc. Compounds useful as chemokine receptor antagonists
ATE478075T1 (de) 2005-03-08 2010-09-15 Janssen Pharmaceutica Nv Diazaspiro-ä4,4ü-nonanderivate als neurokinin- (nk1)-antagonisten
CN101190330A (zh) 2006-11-30 2008-06-04 深圳市鼎兴生物医药技术开发有限公司 胆碱酯酶在拮抗速激肽药物中的应用
EA200970706A1 (ru) 2007-01-24 2010-02-26 Глэксо Груп Лимитед Новые фармацевтические композиции
WO2010081851A1 (en) 2009-01-14 2010-07-22 Genoscience Pharma Piperidin-4-ylpiperazine compounds for the treatment of hcv infection
CN101913076B (zh) * 2010-06-23 2012-09-05 中国科学院自动化研究所 基于工业机器人的活塞、活塞销和连杆装配方法及装置
GB201106817D0 (en) 2011-04-21 2011-06-01 Astex Therapeutics Ltd New compound
GB201218862D0 (en) 2012-10-19 2012-12-05 Astex Therapeutics Ltd Bicyclic heterocycle compounds and their uses in therapy
GB201218864D0 (en) 2012-10-19 2012-12-05 Astex Therapeutics Ltd Bicyclic heterocycle compounds and their uses in therapy
GB201218850D0 (en) 2012-10-19 2012-12-05 Astex Therapeutics Ltd Bicyclic heterocycle compounds and their uses in therapy
US9980973B2 (en) 2012-10-19 2018-05-29 Astex Therapeutics Limited Bicyclic heterocycle compounds and their uses in therapy
PT2956440T (pt) 2013-02-08 2018-05-08 Gen Mills Inc Produtos alimentares com baixo teor de sódio
SI3083616T1 (sl) 2013-12-20 2021-12-31 Astex Therapeutics Limited Biciklične heterociklične spojine in njihova uporaba pri zdravljenju
DK3377064T3 (da) * 2016-01-08 2019-09-23 Nerre Therapeutics Ltd Orvepitant til behandling af kronisk hoste

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676055B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
MY110227A (en) * 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
CN1042335C (zh) * 1993-01-03 1999-03-03 诺瓦提斯公司 1－酰基哌啶化合物、其制备方法、药物组合物及用途
ES2105003T3 (es) * 1993-05-12 1997-10-16 Heumann Pharma Gmbh & Co Forma estable y cristalina del bezafibrato.
GB9310066D0 (en) * 1993-05-17 1993-06-30 Zeneca Ltd Alkyl substituted heterocycles
WO1995011895A1 (en) * 1993-10-26 1995-05-04 Ciba-Geigy Ag N-benzoyl-4-oxy/thio-2-substituted piperidines as substance-p receptor antagonists
IL111730A (en) * 1993-11-29 1998-12-06 Fujisawa Pharmaceutical Co Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them
CA2171850A1 (en) * 1994-07-15 1996-02-01 Kiyoaki Katano Novel compound having platelet aggregation inhibitor effect
EP0783490B1 (en) * 1994-09-30 2002-02-06 Novartis AG 1-acyl-4-aliphatic aminopiperidine compounds
NZ321575A (en) * 1995-10-30 1999-05-28 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives

Also Published As

Publication number Publication date
JP3073238B2 (ja) 2000-08-07
TR199800756T2 (xx) 1998-07-21
ES2143238T3 (es) 2000-05-01
PL185029B1 (pl) 2003-02-28
NO981534D0 (no) 1998-04-03
ATE188691T1 (de) 2000-01-15
US6197772B1 (en) 2001-03-06
SI0862566T1 (en) 2000-04-30
AU7493296A (en) 1997-05-22
HRP960507B1 (en) 2001-08-31
BR9611184B8 (pt) 2015-02-18
MX9803407A (es) 1998-09-30
CZ132298A3 (cs) 1998-09-16
DE69606196D1 (de) 2000-02-17
ZA969090B (en) 1998-04-29
CN1438220A (zh) 2003-08-27
NO981534L (no) 1998-06-24
PL327406A1 (en) 1998-12-07
DK0862566T3 (da) 2000-06-13
US6521621B1 (en) 2003-02-18
DE69606196T2 (de) 2000-09-21
CN1117744C (zh) 2003-08-13
TW460473B (en) 2001-10-21
AR004698A1 (es) 1999-03-10
PT862566E (pt) 2000-06-30
HU227341B1 (en) 2011-04-28
KR100407067B1 (ko) 2004-06-04
MY116575A (en) 2004-02-28
EP0862566B1 (en) 2000-01-12
HUP9802985A2 (hu) 1999-10-28
GR3033154T3 (en) 2000-08-31
USRE37886E1 (en) 2002-10-15
WO1997016440A1 (en) 1997-05-09
HRP960507A2 (en) 1998-02-28
JPH11514634A (ja) 1999-12-14
CA2234096C (en) 2005-06-14
CZ291794B6 (cs) 2003-05-14
EP0862566A1 (en) 1998-09-09
CY2177B1 (en) 2002-08-23
IL123962A (en) 2001-01-11
CN1205699A (zh) 1999-01-20
CA2234096A1 (en) 1997-05-09
CN100415716C (zh) 2008-09-03
NO310232B1 (no) 2001-06-11
HUP9802985A3 (en) 2002-10-28
NZ321575A (en) 1999-05-28
EA000909B1 (ru) 2000-06-26
KR19990064178A (ko) 1999-07-26
BR9611184A (pt) 1999-03-30
AU704155B2 (en) 1999-04-15

Similar Documents

Publication Publication Date Title
EA199800404A1 (ru) Производные 1-(1,2-дизамещенный пиперидинил)-4-замещенного пиперазина
EA199800604A1 (ru) Производные 1-(1,2-дизамещенный пиперидинил)-4-замещенного пиперидинина как антагонисты рецепторов тахикинина
DE69431974T2 (de) Benzamid-Derivate und ihre Verwendung als Vasopressin-Antagonisten
FI882081A0 (fi) 2-substituerade e-fusionerade (1,2,4) triazolo(1,5-c) pyrimidiner, farmaceutiska kompositioner och deras anvaendning.
EA200100553A1 (ru) Замещенные бициклические производные, полезные в качестве противораковых агентов
NO986055D0 (no) Nye heterocykliske forbindelser, deres fremstilling, farmas÷ytiske preparat
ES2044836T3 (es) Derivado de la piperidina, su utilizacion y compuesto farmaceutico que lo contiene.
EA199800603A1 (ru) Производные 1-(1,2-дизамещенный пиперидинил)-4-(конденсированный имидазол)-пиперидина
EA200000400A1 (ru) Галогензамещенные тетрациклические производные тетрагидрофурана
IL77452A0 (en) Derivatives of arylcyclobutylalkylamines,their preparation and pharmaceutical compositions containing them
MX9306310A (es) Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
TR199801218T2 (xx) Takikinin antagonistleri olarak N-asil-2-ikameli-4-(Benzimidazolil-ya da imidazopiridinil-ikameli art�klar)-piperidinler.
DE69133295D1 (de) 3,9-diazabicyclo-[3.3.1]-nonanylderivate, verfahren und intermediate für ihre darstellung und sie enthaltende pharmazeutische zusammensetzungen
AR007108A1 (es) Agentes antitumorales y antivirales alquilantes, procedimiento para su preparacion, utilizacion de los mismos para la fabricacion de un medicamento y composicion farmaceutica que contiene a dichos agentes.
NO892295L (no) Fremgangsmaate for fremstilling av nye cefemforbindelser.
RU96102842A (ru) Применение кумаринов и карбостирилов в качестве pla2-ингибиторов, новые кумарины и карбостирилы, способ их получения и лекарственные средства
AR008168A1 (es) Compuestos etilamino arilamida aril substituidos de pirrolidinilo y pirrolinilo, composicion farmaceutica que lo contiene, compuesto util para susintesis, procedimiento para su preparacion
SE8303913L (sv) Heterocykliska foreningar
AR027454A1 (es) Derivados de beta-alanina, utiles como antagonistas de receptores, las composiciones farmaceuticas que las contienen y el uso de los mismos para lapreparacion de medicamentos
FR2778404B1 (fr) Derives du dihydro ou tetrahydronaphtalene, et les compositions pharmaceutiques les renfermant
GB1028234A (en) New pharmaceutical compositions comprising 5-aminodibenzocycloheptene derivatives
NO165593C (no) Analogifremgangsmaate ved fremstilling av nye tetracykliske indolderivater.
NO982549L (no) 5-naftalen-1-yl-1,3-dioksan-derivater, fremstilling og terapeutisk anvendelse derav
ES8207543A1 (es) Un procedimiento para la preparacion de nuevos derivados heterotriciclicos jaula.
ECSP972156A (es) Inhibidores de metaloproteinasas, composiciones farmaceuticas que los contienen y sus usos farmaceuticos y los metodos e intermedios utiles para su preparacion

Legal Events

Date Code Title Description
MK4A Patent expired

Designated state(s): AM AZ BY KZ KG MD TJ TM RU