EA199800603A1 - Производные 1-(1,2-дизамещенный пиперидинил)-4-(конденсированный имидазол)-пиперидина - Google Patents

Производные 1-(1,2-дизамещенный пиперидинил)-4-(конденсированный имидазол)-пиперидина

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Publication number
EA199800603A1
EA199800603A1 EA199800603A EA199800603A EA199800603A1 EA 199800603 A1 EA199800603 A1 EA 199800603A1 EA 199800603 A EA199800603 A EA 199800603A EA 199800603 A EA199800603 A EA 199800603A EA 199800603 A1 EA199800603 A1 EA 199800603A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
phenyl
formula
piperidine
substituted
Prior art date
Application number
EA199800603A
Other languages
English (en)
Other versions
EA001374B1 (ru
Inventor
Франс Эдуард Жансенс
Йозеф Элизабет Ленартс
Ив Эмиль Мария Ван Росбрук
Original Assignee
Жансен Фармасетика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Жансен Фармасетика Н.В. filed Critical Жансен Фармасетика Н.В.
Publication of EA199800603A1 publication Critical patent/EA199800603A1/ru
Publication of EA001374B1 publication Critical patent/EA001374B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение касается соединений формулы (I)их N-оксидных форм фармацевтически приемлемых солей присоединения и стереохимически изомерных форм, где n равно 0, 1 или 2; m равно 1 или 2, при условии, что если m равно 2, то n равно 1; =Q является =O или =NR; X является ковалентной связью или -O-, -S-, -NR-; Rявляется Ar, ArCалкилом или ди(Ar)Cалкилом, где каждая Cалкильная группа произвольно замещена; Rявляется Ar, ArCалкилом; Het или HetCалкилом; Rявляется водородом или Cалкилом; L является пиперидиновым производным формулы (а-1) или спиропиперидиновым производным формулы (а-2); Arявляется фенилом или замещенным фенилом; Arявляется нафталинилом, фенилом или замещенным фенилом; и Het является моноциклическим или бициклическим гетероциклом; каждый моноциклический или бициклический гетероцикл может быть необязательно замещен по атому углерода в качестве антагонистов вещества P; их получения, содержащих их композиций и их применения в качестве лекарственных препаратов.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800603A 1995-12-27 1996-12-20 Производные 1-(1,2-дизамещенный пиперидинил)-4-(конденсированный имидазол)-пиперидина EA001374B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95203652 1995-12-27
PCT/EP1996/005885 WO1997024356A1 (en) 1995-12-27 1996-12-20 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives

Publications (2)

Publication Number Publication Date
EA199800603A1 true EA199800603A1 (ru) 1998-12-24
EA001374B1 EA001374B1 (ru) 2001-02-26

Family

ID=8221024

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800603A EA001374B1 (ru) 1995-12-27 1996-12-20 Производные 1-(1,2-дизамещенный пиперидинил)-4-(конденсированный имидазол)-пиперидина

Country Status (30)

Country Link
US (1) US6251894B1 (ru)
EP (1) EP0843679B1 (ru)
JP (1) JP4097043B2 (ru)
KR (1) KR100485147B1 (ru)
CN (1) CN1066733C (ru)
AR (2) AR005278A1 (ru)
AT (1) ATE208392T1 (ru)
AU (1) AU716071B2 (ru)
BR (1) BR9612307A (ru)
CA (1) CA2238817C (ru)
CY (1) CY2271B1 (ru)
CZ (1) CZ295861B6 (ru)
DE (1) DE69616802T2 (ru)
DK (1) DK0843679T3 (ru)
EA (1) EA001374B1 (ru)
ES (1) ES2167619T3 (ru)
HK (1) HK1011206A1 (ru)
HU (1) HU229766B1 (ru)
IL (2) IL124641A (ru)
MY (1) MY117680A (ru)
NO (1) NO310916B1 (ru)
NZ (1) NZ325845A (ru)
PL (1) PL183767B1 (ru)
PT (1) PT843679E (ru)
SI (1) SI0843679T1 (ru)
SK (1) SK283540B6 (ru)
TR (1) TR199801210T2 (ru)
TW (1) TW382017B (ru)
WO (1) WO1997024356A1 (ru)
ZA (1) ZA9610889B (ru)

Families Citing this family (22)

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Publication number Priority date Publication date Assignee Title
TW527186B (en) 1996-03-19 2003-04-11 Janssen Pharmaceutica Nv Fused imidazole derivatives as multidrug resistance modulators
AU1146099A (en) 1997-09-18 1999-04-05 Janssen Pharmaceutica N.V. Fused imidazole derivatives for improving oral bioavailability of pharmaceuticalagents
BR9916371A (pt) * 1998-12-19 2001-09-18 Janssen Pharmaceutica Nv Composto de espiro anti-histamìnico
AU7788500A (en) * 1999-10-25 2001-05-08 Janssen Pharmaceutica N.V. Use of substance p antagonists for influencing the circadian timing system
CA2448735C (en) 2001-06-12 2008-10-28 Janssen Pharmaceutica N.V. Novel substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine
US20030083345A1 (en) * 2001-07-10 2003-05-01 Torsten Hoffmann Method of treatment and/or prevention of brain, spinal or nerve injury
DE60231351D1 (de) * 2001-11-23 2009-04-09 Janssen Pharmaceutica Nv Verwendung von Histaminrezeptorantagonisten für die Senkung des intrakranialen Druckes
EP1457493A4 (en) 2001-12-10 2005-11-30 Kyorin Seiyaku Kk CONDENSED, BICYCLIC PYRIDINE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS
AU2003206722B2 (en) 2002-01-16 2008-01-24 Mercury Pharma Group Limited Prucalopride-N-oxide
MXPA04006571A (es) 2002-01-18 2004-10-04 Kyorin Seiyaku Kk Derivado de pirimidina biciclica fusionada.
DE60314238T2 (de) * 2002-03-26 2008-01-31 Kyorin Pharmaceutical Co., Ltd. Kondensierte, bicyclische pyridinderivate als antagonisten des tachykininrezeptors
AU2003298369B2 (en) * 2002-12-23 2009-08-27 Janssen Pharmaceutica N.V. Substituted 4-(4-piperidin-4-yl-piperazin-1-yl)-azepane derivatives and their use as neurokinin antagonists
JO2696B1 (en) 2002-12-23 2013-03-03 شركة جانسين فارماسوتيكا ان. في Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists
JO2676B1 (en) 2004-04-06 2012-06-17 جانسين فارماسوتيكا ان. في Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines
JO2525B1 (en) * 2004-04-08 2010-03-17 شركة جانسين فارماسوتيكا ان. في Derived 4-alkyl-and-4-canoelperidine derivatives and their use as anti-neroquin
MX2007010728A (es) 2005-03-03 2007-10-12 Janssen Pharmaceutica Nv Derivados sustituidos de oxa-diaza-espiro-[5.5]-undecanona y su uso como antagonistas de la neurocinina.
US8604200B2 (en) 2005-03-08 2013-12-10 Janssen Pharmaceutica N.V. Diaza-spiro-{4,4}-nonane derivatives as neurokinin (NK1) antagonists
WO2009009829A1 (en) * 2007-07-19 2009-01-22 Adelaide Research & Innovation Pty Ltd Method for reducing intracranial pressure
UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
NO2729147T3 (ru) 2011-07-04 2018-02-03
WO2019162519A1 (en) 2018-02-26 2019-08-29 Ospedale San Raffaele S.R.L. Nk-1 antagonists for use in the treatment of ocular pain
EP4117673A1 (en) 2020-03-11 2023-01-18 Ospedale San Raffaele S.r.l. Treatment of stem cell deficiency

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4329353A (en) 1980-10-22 1982-05-11 Janssen Pharmaceutica, N.V. 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
ATE124045T1 (de) * 1990-10-10 1995-07-15 Schering Corp Substituierte imidazobenzazepine und imidazopyridoazepine.
IL101850A (en) * 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them
IL101851A (en) * 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition
US5674866A (en) * 1993-07-13 1997-10-07 Janssen Pharmaceutica N.V. Antiallergic imidazoazepines
RU2156763C2 (ru) 1994-07-15 2000-09-27 Мейдзи Сейка Кабусики Кайся Азотсодержащие гетероциклические производные, фармацевтическая композиция на их основе и способ лечения или профилактики тромботических заболеваний
NZ321575A (en) 1995-10-30 1999-05-28 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives

Also Published As

Publication number Publication date
PL183767B1 (pl) 2002-07-31
ES2167619T3 (es) 2002-05-16
NZ325845A (en) 1999-06-29
HUP9903948A3 (hu) 2000-04-28
BR9612307A (pt) 1999-07-13
SK283540B6 (sk) 2003-09-11
SK83098A3 (en) 1999-01-11
CA2238817C (en) 2006-10-17
CZ295861B6 (cs) 2005-11-16
HUP9903948A2 (hu) 2000-03-28
SI0843679T1 (en) 2002-06-30
NO982405D0 (no) 1998-05-27
DE69616802T2 (de) 2002-07-04
JP2000506503A (ja) 2000-05-30
IL124642A (en) 2002-08-14
IL124641A (en) 2001-11-25
EP0843679A1 (en) 1998-05-27
EA001374B1 (ru) 2001-02-26
AR005278A1 (es) 1999-04-28
PL327136A1 (en) 1998-11-23
TR199801210T2 (xx) 1999-10-21
KR19990076715A (ko) 1999-10-15
IL124642A0 (en) 1998-12-06
CZ186598A3 (cs) 1998-11-11
CN1066733C (zh) 2001-06-06
ZA9610889B (en) 1998-06-23
HK1011206A1 (en) 1999-07-09
HU229766B1 (hu) 2014-06-30
PT843679E (pt) 2002-04-29
AU716071B2 (en) 2000-02-17
AU1308697A (en) 1997-07-28
MY117680A (en) 2004-07-31
DK0843679T3 (da) 2002-02-25
JP4097043B2 (ja) 2008-06-04
US6251894B1 (en) 2001-06-26
TW382017B (en) 2000-02-11
IL124641A0 (en) 1998-12-06
EP0843679B1 (en) 2001-11-07
NO982405L (no) 1998-08-19
CY2271B1 (en) 2003-07-04
AR051817A2 (es) 2007-02-14
DE69616802D1 (de) 2001-12-13
KR100485147B1 (ko) 2005-09-13
WO1997024356A1 (en) 1997-07-10
CN1206417A (zh) 1999-01-27
NO310916B1 (no) 2001-09-17
ATE208392T1 (de) 2001-11-15
CA2238817A1 (en) 1997-07-10

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