AR005278A1 - Derivados de 1- (piperidinil 1,2 - disustituido) -4- (imidazol fusionado) -piperidina, proceso para la preparación de los mismos, composición farmacéutica que los contiene y proceso para la preparación de dicha composición. - Google Patents
Derivados de 1- (piperidinil 1,2 - disustituido) -4- (imidazol fusionado) -piperidina, proceso para la preparación de los mismos, composición farmacéutica que los contiene y proceso para la preparación de dicha composición.Info
- Publication number
- AR005278A1 AR005278A1 ARP960105895A ARP960105895A AR005278A1 AR 005278 A1 AR005278 A1 AR 005278A1 AR P960105895 A ARP960105895 A AR P960105895A AR P960105895 A ARP960105895 A AR P960105895A AR 005278 A1 AR005278 A1 AR 005278A1
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- Prior art keywords
- formula
- alkyl
- radical
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- hydrogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Virology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se describen derivados 1-(piperidinil 1,2-disustituido)-4- (imidazolfusionado)-piperidina, que comprende un compuesto de la fórmula (I),en forma N-óxido, una sal de adición farmacéuticamente aceptable o una forma estereoquímicamen te isomérica delmismo, donde n es 0,1o 2; m es 1 o 2, siempreque si m es 2, n sea 1; =Q es =O o =NR3; X es un enlace covalente o un radical bivalente de la fórmula -O-, -S-, NR3-; R1 es Ar1.Ar1 alquilo C1-6 o di(Ar1)alquilo C1-6, donde cada grupo a lquilo C1-C6está optaitvamentte sustituido con hidroxi, alquilox C1-C4, oxo o un sustituyente oxo cetalizado de lafórmula -O-CH2-CH2-O o -O-CH2-CH2-CH2-O-; R2 es Ar2, Ar2 alquilo C1-6, Het o Het alquilo C1-6; R3 es hidrógeno o alquilo C1-C6; L es un radicalde lafórmula (a-1) o (a2),en la cual la línea de puntos es un enlace optativo; cada -A-B es, independientemente, un radical bivalente de la fórmula: Y-CR7=CH-(b-1); -CH=CR7-Y (b-2); -CH=CH-CH=CH- (b-3); -CH=CR7-CH=CH- (b-4); -CH=CH-CR7=CH- (b-5); o-CH=CH-CH=CR7 (b-6) en el cual cada Y esindependientemente , alquilo C1-6, halo, etenilo sustituido con carboxilo o alquiloxicarbonilo C1-C6, hidroxialquilo C1-C6; o R7 es hidrógeno en el casoque -A-B- es un radical de fórmula (b-1)o (b-2); R8 eshidrógeno, alquilo C1-C6 o alquilcarbonilo C1-C6; cada Z es, independientemente, Z1 o Z2; dondeZ1 es un radical bivalente de la fórmula -CH2-, -CH2-CH2-,o -CH=Ch-, siempre que cuando L es un radical de la fórmu la (a-1) y la línea de puntos esunenlace adicional, Z1 no sea -CH2-; Z2 es un radical bivalente de la fórmula -CH2-CHOH, -CH2-O-, -CH2C(=O)- o -CH2-C(=NOH)-, siempre que la porción -CH2- dedichos radicales bivalentes esté conectada al nitrógeno del anillo de imidazol; cada R4 es,independientemente, hidrógeno, alquilo C1-C6, halo, etenilo
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95203652 | 1995-12-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR005278A1 true AR005278A1 (es) | 1999-04-28 |
Family
ID=8221024
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP960105895A AR005278A1 (es) | 1995-12-27 | 1996-12-26 | Derivados de 1- (piperidinil 1,2 - disustituido) -4- (imidazol fusionado) -piperidina, proceso para la preparación de los mismos, composición farmacéutica que los contiene y proceso para la preparación de dicha composición. |
ARP050105316A AR051817A2 (es) | 1995-12-27 | 2005-12-16 | Derivados de piperidina-1-(1,2-piperidinil disustituidos)-4-(imidazol condensados) |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050105316A AR051817A2 (es) | 1995-12-27 | 2005-12-16 | Derivados de piperidina-1-(1,2-piperidinil disustituidos)-4-(imidazol condensados) |
Country Status (30)
Country | Link |
---|---|
US (1) | US6251894B1 (es) |
EP (1) | EP0843679B1 (es) |
JP (1) | JP4097043B2 (es) |
KR (1) | KR100485147B1 (es) |
CN (1) | CN1066733C (es) |
AR (2) | AR005278A1 (es) |
AT (1) | ATE208392T1 (es) |
AU (1) | AU716071B2 (es) |
BR (1) | BR9612307A (es) |
CA (1) | CA2238817C (es) |
CY (1) | CY2271B1 (es) |
CZ (1) | CZ295861B6 (es) |
DE (1) | DE69616802T2 (es) |
DK (1) | DK0843679T3 (es) |
EA (1) | EA001374B1 (es) |
ES (1) | ES2167619T3 (es) |
HK (1) | HK1011206A1 (es) |
HU (1) | HU229766B1 (es) |
IL (2) | IL124641A (es) |
MY (1) | MY117680A (es) |
NO (1) | NO310916B1 (es) |
NZ (1) | NZ325845A (es) |
PL (1) | PL183767B1 (es) |
PT (1) | PT843679E (es) |
SI (1) | SI0843679T1 (es) |
SK (1) | SK283540B6 (es) |
TR (1) | TR199801210T2 (es) |
TW (1) | TW382017B (es) |
WO (1) | WO1997024356A1 (es) |
ZA (1) | ZA9610889B (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW527186B (en) | 1996-03-19 | 2003-04-11 | Janssen Pharmaceutica Nv | Fused imidazole derivatives as multidrug resistance modulators |
US6544979B1 (en) | 1997-09-18 | 2003-04-08 | Janssen Pharmaceuticals, N.V. | Fused imidazole derivatives for improving oral bioavailability of pharmaceutical agents |
HU229406B1 (en) * | 1998-12-19 | 2013-12-30 | Janssen Pharmaceutica Nv | Antihistaminic spiro compounds |
WO2001030348A1 (en) * | 1999-10-25 | 2001-05-03 | Janssen Pharmaceutica N.V. | Use of substance p antagonists for influencing the circadian timing system |
EP1401838B1 (en) | 2001-06-12 | 2014-03-26 | Janssen Pharmaceutica NV | Novel substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine |
US20030083345A1 (en) * | 2001-07-10 | 2003-05-01 | Torsten Hoffmann | Method of treatment and/or prevention of brain, spinal or nerve injury |
NZ550723A (en) * | 2001-11-23 | 2008-06-30 | Janssen Pharmaceutica Nv | The use of anti-histaminics for acute reduction of elevated intracranial pressure |
WO2003050123A1 (fr) * | 2001-12-10 | 2003-06-19 | Kyorin Pharmaceutical Co., Ltd. | Derives bicycliques fusionnes de pyridine en tant qu'antagonistes du recepteur de la tachykinine |
AU2003206722B2 (en) * | 2002-01-16 | 2008-01-24 | Mercury Pharma Group Limited | Prucalopride-N-oxide |
CN1297559C (zh) * | 2002-01-18 | 2007-01-31 | 杏林制药株式会社 | 稠合双环嘧啶衍生物 |
EP1489083B1 (en) * | 2002-03-26 | 2007-06-06 | Kyorin Pharmaceutical Co., Ltd. | Fused bicyclic pyridine derivative as tachykinin receptor antagonist |
WO2004056805A1 (en) * | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Substituted 4-(4-piperidin-4-yl-piperazin-1-yl)-azepane derivatives and their use as neurokinin antagonists |
JO2696B1 (en) | 2002-12-23 | 2013-03-03 | شركة جانسين فارماسوتيكا ان. في | Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists |
JO2676B1 (en) | 2004-04-06 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines |
JO2525B1 (en) * | 2004-04-08 | 2010-03-17 | شركة جانسين فارماسوتيكا ان. في | Derived 4-alkyl-and-4-canoelperidine derivatives and their use as anti-neroquin |
DE602006014531D1 (de) | 2005-03-03 | 2010-07-08 | Janssen Pharmaceutica Nv | Substituierte oxadiazaspiro-ä5.5ü-undecanonderivate und ihre verwendung als neurokininantagonisten |
ES2350647T3 (es) | 2005-03-08 | 2011-01-25 | Janssen Pharmaceutica Nv | Derivados de diaza-espiro-[4.4]-nonano como antagonistas de neuroquininas (nk1). |
AU2008278273A1 (en) * | 2007-07-19 | 2009-01-22 | Adelaide Research & Innovation Pty Ltd | Method for reducing intracranial pressure |
UA105182C2 (ru) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
EP2729147B1 (en) | 2011-07-04 | 2017-09-06 | IRBM - Science Park S.p.A. | Nk-1 receptor antagonists for treating corneal neovascularisation |
US20210015834A1 (en) | 2018-02-26 | 2021-01-21 | Ospedale San Raffaele S.R.L. | Nk-1 antagonists for use in the treatment of ocular pain |
US20230134843A1 (en) | 2020-03-11 | 2023-05-04 | Ospedale San Raffaele S.R.L. | Treatment of stem cell deficiency |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4329353A (en) | 1980-10-22 | 1982-05-11 | Janssen Pharmaceutica, N.V. | 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof |
DE69110685T2 (de) * | 1990-10-10 | 1995-11-09 | Schering Corp | Substituierte imidazobenzazepine und imidazopyridoazepine. |
IL101851A (en) * | 1991-06-13 | 1996-05-14 | Janssen Pharmaceutica Nv | History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition |
IL101850A (en) * | 1991-06-13 | 1996-01-31 | Janssen Pharmaceutica Nv | History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them |
ATE198480T1 (de) * | 1993-07-13 | 2001-01-15 | Janssen Pharmaceutica Nv | Antiallergische imidazoazepine |
TW397831B (en) | 1994-07-15 | 2000-07-11 | Meiji Seika Kaisha | The anti-platelet-agglutination hexahydrogenated pyridine and its derivatives |
NZ321575A (en) | 1995-10-30 | 1999-05-28 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives |
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1996
- 1996-12-13 TW TW085115390A patent/TW382017B/zh not_active IP Right Cessation
- 1996-12-20 AT AT96944693T patent/ATE208392T1/de active
- 1996-12-20 BR BR9612307A patent/BR9612307A/pt not_active IP Right Cessation
- 1996-12-20 EA EA199800603A patent/EA001374B1/ru not_active IP Right Cessation
- 1996-12-20 CN CN96199396A patent/CN1066733C/zh not_active Expired - Fee Related
- 1996-12-20 WO PCT/EP1996/005885 patent/WO1997024356A1/en active IP Right Grant
- 1996-12-20 PL PL96327136A patent/PL183767B1/pl unknown
- 1996-12-20 EP EP96944693A patent/EP0843679B1/en not_active Expired - Lifetime
- 1996-12-20 IL IL12464196A patent/IL124641A/en not_active IP Right Cessation
- 1996-12-20 HU HU9903948 patent/HU229766B1/hu not_active IP Right Cessation
- 1996-12-20 SI SI9630419T patent/SI0843679T1/xx unknown
- 1996-12-20 KR KR10-1998-0704830A patent/KR100485147B1/ko not_active IP Right Cessation
- 1996-12-20 IL IL12464296A patent/IL124642A/en not_active IP Right Cessation
- 1996-12-20 NZ NZ325845A patent/NZ325845A/xx not_active IP Right Cessation
- 1996-12-20 JP JP52403397A patent/JP4097043B2/ja not_active Expired - Fee Related
- 1996-12-20 PT PT96944693T patent/PT843679E/pt unknown
- 1996-12-20 CZ CZ19981865A patent/CZ295861B6/cs not_active IP Right Cessation
- 1996-12-20 DE DE69616802T patent/DE69616802T2/de not_active Expired - Lifetime
- 1996-12-20 AU AU13086/97A patent/AU716071B2/en not_active Ceased
- 1996-12-20 TR TR1998/01210T patent/TR199801210T2/xx unknown
- 1996-12-20 SK SK830-98A patent/SK283540B6/sk unknown
- 1996-12-20 DK DK96944693T patent/DK0843679T3/da active
- 1996-12-20 CA CA002238817A patent/CA2238817C/en not_active Expired - Fee Related
- 1996-12-20 ES ES96944693T patent/ES2167619T3/es not_active Expired - Lifetime
- 1996-12-23 ZA ZA9610889A patent/ZA9610889B/xx unknown
- 1996-12-26 AR ARP960105895A patent/AR005278A1/es active IP Right Grant
- 1996-12-27 MY MYPI96005516A patent/MY117680A/en unknown
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1998
- 1998-05-27 NO NO19982405A patent/NO310916B1/no not_active IP Right Cessation
- 1998-06-22 US US09/102,136 patent/US6251894B1/en not_active Expired - Lifetime
- 1998-11-24 HK HK98112228A patent/HK1011206A1/xx not_active IP Right Cessation
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2002
- 2002-04-25 CY CY0200023A patent/CY2271B1/xx unknown
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2005
- 2005-12-16 AR ARP050105316A patent/AR051817A2/es active IP Right Grant
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