ES2000935A6 - Un procedimiento para la preparacion de 3-imidazolin-metiltetrahidrocarbazolonas. - Google Patents

Un procedimiento para la preparacion de 3-imidazolin-metiltetrahidrocarbazolonas.

Info

Publication number
ES2000935A6
ES2000935A6 ES8600565A ES8600565A ES2000935A6 ES 2000935 A6 ES2000935 A6 ES 2000935A6 ES 8600565 A ES8600565 A ES 8600565A ES 8600565 A ES8600565 A ES 8600565A ES 2000935 A6 ES2000935 A6 ES 2000935A6
Authority
ES
Spain
Prior art keywords
alkyl
cycloalkyl
phenyl
hydrogen atom
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600565A
Other languages
English (en)
Inventor
Alexander Willi Oxford
Colin David Eldred
Ian Harold Coates
James Angus Bell
David Cedric Humber
George Blanch Ewan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES2000935A6 publication Critical patent/ES2000935A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 3-IMIDAZOLIN-METITETRA-HIDROCARBAZOLONAS DE FORMULA GENERAL (I) DONDE R1 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C1-10 CICLOALQUILO C3-7(CICLOALQUIL C3-7) ALQUILO C1-4 ALQUENILO C3-6, ALQUINILO C3-10 FENILO O FENIL-ALQUILO C1-3 Y UNO DE LOS GRUPOS REPRESENTADOS POR R2, R3 Y R4 ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C1-6, CICLOALQUILO C3-7, ALQUENILO C2-6 O FENIL-ALQUILO C1-3 Y CADA UNO DE LOS OTROS DOS GRUPOS, QUE PUEDEN SER IGUALESO DIFERENTES, REPRESENTAN UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C1-6; O UNA SAL O UN DERIVADO PROTEGIDO DEL MISMO, POR CICLACION DE UN COMPUESTO DE FORMULA (II) DONDE R1, R2, R3 Y R4 SON LOS DEFINIDOS ANTES, O UNA SAL O UN DERIVADO PROTEGIDODE LOS MISMOS. LOS COMPUESTOS DE FORMULA (I) ASI OBTENIDOS SON ANTAGONISTAS POTENTES Y SELECTIVOS DE LOS RECEPTORES DE 5-HIDROXITRIPATMINA (NEURONALES).
ES8600565A 1985-07-24 1986-07-24 Un procedimiento para la preparacion de 3-imidazolin-metiltetrahidrocarbazolonas. Expired ES2000935A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858518741A GB8518741D0 (en) 1985-07-24 1985-07-24 Process

Publications (1)

Publication Number Publication Date
ES2000935A6 true ES2000935A6 (es) 1988-04-01

Family

ID=10582813

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8600565A Expired ES2000935A6 (es) 1985-07-24 1986-07-24 Un procedimiento para la preparacion de 3-imidazolin-metiltetrahidrocarbazolonas.

Country Status (12)

Country Link
US (1) US4739072A (es)
EP (1) EP0219929B1 (es)
JP (1) JPH07612B2 (es)
KR (1) KR920001670B1 (es)
AT (1) ATE73451T1 (es)
CA (1) CA1281722C (es)
DE (1) DE3684225D1 (es)
ES (1) ES2000935A6 (es)
FI (1) FI84350C (es)
GB (1) GB8518741D0 (es)
GR (1) GR861926B (es)
PT (1) PT83043B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2043535A1 (es) * 1992-03-13 1993-12-16 Vita Invest Sa Procedimiento para la obtencion de la 1,2,3,9-tetrahidro-9-metil-3-(2-metil-1h-imidazol-1-il)metil*-4h-carbazol-4-ona.

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8617994D0 (en) * 1986-07-23 1986-08-28 Glaxo Group Ltd Heterocyclic compounds
GR871809B (en) * 1986-11-28 1988-03-07 Glaxo Group Ltd Process for the preparation of tricyclic ketones
US5360800A (en) * 1987-09-03 1994-11-01 Glaxo Group Limited Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives
EP0317088A1 (en) * 1987-10-22 1989-05-24 Glaxo Group Limited Ketone derivatives
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
US5008272A (en) * 1988-08-15 1991-04-16 Glaxo Group Limited Lactam derivatives
ATE97803T1 (de) 1989-04-21 1993-12-15 Sandoz Ag Therapeutische verwendung von 5-ht3-rezeptorantagonisten.
DE4010797A1 (de) * 1990-04-04 1991-10-10 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
HU212934B (en) 1992-10-14 1996-12-30 Richter Gedeon Vegyeszet Process for producing novel alkoxalylated carbazolone derivatives
US20020107275A1 (en) * 2000-10-30 2002-08-08 Ramy Lidor-Hadas Novel crystal and solvate forms of ondansetron hydrochloride and processes for their preparation
US20020115707A1 (en) * 2001-01-11 2002-08-22 Rami Lidor-Hadas Process for preparing pure ondansetron hydrochloride dihydrate
PT1499623E (pt) * 2002-04-29 2007-08-10 Teva Gyogyszergyar Zartkoeruee ''processo papa a preparação de 1, 2, 3, 9-tetra-hidro-9-metil-3- [(2-metil-1h-imidazol-1-il) metil] -4h-carbazol-4-ona''
US20050131045A1 (en) * 2002-04-30 2005-06-16 Judith Aronhime Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them
FI6164U1 (fi) * 2003-01-09 2004-03-15 Synthon Bv Ondansetronmuotoja
US7390503B1 (en) 2003-08-22 2008-06-24 Barr Laboratories, Inc. Ondansetron orally disintegrating tablets
US20090170872A1 (en) * 2005-07-05 2009-07-02 Orchid Research Laboratories Limited Compounds and Their Pharmaceutical Use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3592824A (en) * 1970-03-12 1971-07-13 Miles Lab 3-substituted amino-1,2,3,4-tetrahydrocarbazoles
US3892766A (en) * 1974-06-03 1975-07-01 Warner Lambert Co Process for the preparation of 4-keto-1,2,3,4-tetrahydrocarbazole
GR73560B (es) * 1979-02-24 1984-03-15 Pfizer
EP0073849A1 (en) * 1981-09-03 1983-03-16 Schering Corporation Novel phenyl-1,2,3,4-tetrahydrocarbazoles, their preparation and pharmaceutical compositions containing them
NZ210940A (en) * 1984-01-25 1989-08-29 Glaxo Group Ltd 1,2,3-trihydro-3-(1h-imidazol-1-ylmethyl)-4h-carbazol-4-one derivatives and pharmaceutical compositions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2043535A1 (es) * 1992-03-13 1993-12-16 Vita Invest Sa Procedimiento para la obtencion de la 1,2,3,9-tetrahidro-9-metil-3-(2-metil-1h-imidazol-1-il)metil*-4h-carbazol-4-ona.

Also Published As

Publication number Publication date
FI863019A0 (fi) 1986-07-23
EP0219929A1 (en) 1987-04-29
EP0219929B1 (en) 1992-03-11
JPH07612B2 (ja) 1995-01-11
ATE73451T1 (de) 1992-03-15
GR861926B (en) 1986-09-05
FI84350B (fi) 1991-08-15
GB8518741D0 (en) 1985-08-29
FI84350C (fi) 1991-11-25
PT83043A (en) 1986-08-01
CA1281722C (en) 1991-03-19
KR870001198A (ko) 1987-03-12
KR920001670B1 (ko) 1992-02-22
PT83043B (pt) 1989-02-28
JPS6277380A (ja) 1987-04-09
US4739072A (en) 1988-04-19
DE3684225D1 (de) 1992-04-16
FI863019A (fi) 1987-01-25

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980401

FD1A Patent lapsed

Effective date: 20060725