DE3684225D1 - Verfahren zur herstellung von 3-imidazolylmethyltetrahydrocarbazolonen. - Google Patents
Verfahren zur herstellung von 3-imidazolylmethyltetrahydrocarbazolonen.Info
- Publication number
- DE3684225D1 DE3684225D1 DE8686305673T DE3684225T DE3684225D1 DE 3684225 D1 DE3684225 D1 DE 3684225D1 DE 8686305673 T DE8686305673 T DE 8686305673T DE 3684225 T DE3684225 T DE 3684225T DE 3684225 D1 DE3684225 D1 DE 3684225D1
- Authority
- DE
- Germany
- Prior art keywords
- sub
- sup
- alkyl
- cycloalkyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 abstract 1
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000001537 neural effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858518741A GB8518741D0 (en) | 1985-07-24 | 1985-07-24 | Process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3684225D1 true DE3684225D1 (de) | 1992-04-16 |
Family
ID=10582813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8686305673T Expired - Lifetime DE3684225D1 (de) | 1985-07-24 | 1986-07-23 | Verfahren zur herstellung von 3-imidazolylmethyltetrahydrocarbazolonen. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4739072A (de) |
| EP (1) | EP0219929B1 (de) |
| JP (1) | JPH07612B2 (de) |
| KR (1) | KR920001670B1 (de) |
| AT (1) | ATE73451T1 (de) |
| CA (1) | CA1281722C (de) |
| DE (1) | DE3684225D1 (de) |
| ES (1) | ES2000935A6 (de) |
| FI (1) | FI84350C (de) |
| GB (1) | GB8518741D0 (de) |
| GR (1) | GR861926B (de) |
| PT (1) | PT83043B (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8617994D0 (en) * | 1986-07-23 | 1986-08-28 | Glaxo Group Ltd | Heterocyclic compounds |
| GR871809B (en) * | 1986-11-28 | 1988-03-07 | Glaxo Group Ltd | Process for the preparation of tricyclic ketones |
| US5360800A (en) * | 1987-09-03 | 1994-11-01 | Glaxo Group Limited | Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives |
| EP0317088A1 (de) * | 1987-10-22 | 1989-05-24 | Glaxo Group Limited | Ketonderivate |
| US5225431A (en) * | 1987-10-23 | 1993-07-06 | Burroughs Wellcome Co. | Therapeutic substituted indole compounds and compositions thereof |
| JPH02167280A (ja) * | 1988-08-15 | 1990-06-27 | Glaxo Group Ltd | ラクタム誘導体 |
| WO1990012569A1 (en) | 1989-04-21 | 1990-11-01 | Sandoz Ag | Therapeutic use of 5-ht3 receptor antagonists |
| DE4010797A1 (de) * | 1990-04-04 | 1991-10-10 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
| ES2043535B1 (es) * | 1992-03-13 | 1994-08-01 | Vita Invest Sa | Procedimiento para la obtencion de la 1,2,3,9-tetrahidro-9-metil-3-(2-metil-1h-imidazol-1-il)metil*-4h-carbazol-4-ona. |
| HU212934B (en) | 1992-10-14 | 1996-12-30 | Richter Gedeon Vegyeszet | Process for producing novel alkoxalylated carbazolone derivatives |
| YU32003A (sh) * | 2000-10-30 | 2006-05-25 | Teva Pharmaceutical Industries Ltd. | Novi kristalni i solvatni oblici ondansteron hlorovodonika i postupci za njihovo pripremanje |
| US20020115707A1 (en) * | 2001-01-11 | 2002-08-22 | Rami Lidor-Hadas | Process for preparing pure ondansetron hydrochloride dihydrate |
| PL373191A1 (en) * | 2002-04-29 | 2005-08-22 | Teva Gyogyszergyar Reszvenytarsasag | Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1h-imidazol-1-yl)methyl]-4h-carbazol-4-one |
| US20050131045A1 (en) * | 2002-04-30 | 2005-06-16 | Judith Aronhime | Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them |
| FI6164U1 (fi) * | 2003-01-09 | 2004-03-15 | Synthon Bv | Ondansetronmuotoja |
| US7390503B1 (en) | 2003-08-22 | 2008-06-24 | Barr Laboratories, Inc. | Ondansetron orally disintegrating tablets |
| US20090170872A1 (en) * | 2005-07-05 | 2009-07-02 | Orchid Research Laboratories Limited | Compounds and Their Pharmaceutical Use |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3592824A (en) * | 1970-03-12 | 1971-07-13 | Miles Lab | 3-substituted amino-1,2,3,4-tetrahydrocarbazoles |
| US3892766A (en) * | 1974-06-03 | 1975-07-01 | Warner Lambert Co | Process for the preparation of 4-keto-1,2,3,4-tetrahydrocarbazole |
| GR73560B (de) * | 1979-02-24 | 1984-03-15 | Pfizer | |
| EP0073849A1 (de) * | 1981-09-03 | 1983-03-16 | Schering Corporation | Phenyl-1,2,3,4-tetrahydrocarbazole, ihre Herstellung und pharmazeutische Zubereitungen, die sie enthalten |
| FR2561244B1 (fr) * | 1984-01-25 | 1988-03-04 | Glaxo Group Ltd | Composes heterocycliques du type tetrahydrocarbazolone, procede pour leur preparation et composition pharmaceutique les comprenant |
-
1985
- 1985-07-24 GB GB858518741A patent/GB8518741D0/en active Pending
-
1986
- 1986-07-23 DE DE8686305673T patent/DE3684225D1/de not_active Expired - Lifetime
- 1986-07-23 PT PT83043A patent/PT83043B/pt unknown
- 1986-07-23 US US06/888,254 patent/US4739072A/en not_active Expired - Lifetime
- 1986-07-23 GR GR861926A patent/GR861926B/el unknown
- 1986-07-23 EP EP86305673A patent/EP0219929B1/de not_active Expired - Lifetime
- 1986-07-23 AT AT86305673T patent/ATE73451T1/de not_active IP Right Cessation
- 1986-07-23 FI FI863019A patent/FI84350C/fi not_active IP Right Cessation
- 1986-07-23 CA CA000514470A patent/CA1281722C/en not_active Expired - Lifetime
- 1986-07-24 KR KR1019860006010A patent/KR920001670B1/ko not_active IP Right Cessation
- 1986-07-24 ES ES8600565A patent/ES2000935A6/es not_active Expired
- 1986-07-24 JP JP61174683A patent/JPH07612B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FI863019A (fi) | 1987-01-25 |
| GR861926B (en) | 1986-09-05 |
| JPH07612B2 (ja) | 1995-01-11 |
| ATE73451T1 (de) | 1992-03-15 |
| ES2000935A6 (es) | 1988-04-01 |
| FI84350B (fi) | 1991-08-15 |
| EP0219929A1 (de) | 1987-04-29 |
| FI863019A0 (fi) | 1986-07-23 |
| US4739072A (en) | 1988-04-19 |
| CA1281722C (en) | 1991-03-19 |
| PT83043B (pt) | 1989-02-28 |
| JPS6277380A (ja) | 1987-04-09 |
| KR870001198A (ko) | 1987-03-12 |
| EP0219929B1 (de) | 1992-03-11 |
| FI84350C (fi) | 1991-11-25 |
| KR920001670B1 (ko) | 1992-02-22 |
| GB8518741D0 (en) | 1985-08-29 |
| PT83043A (en) | 1986-08-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3684225D1 (de) | Verfahren zur herstellung von 3-imidazolylmethyltetrahydrocarbazolonen. | |
| DE3684235D1 (de) | Verfahren zur herstellung von 3-imidazolylmethyltetrahydrocarbazolonen. | |
| ATE126219T1 (de) | Benzimidazolderivate, verfahren zu deren herstellung und anwendung. | |
| ATE127801T1 (de) | Pyrazolopyridinverbindungen und verfahren zu ihrer herstellung. | |
| ATE246676T1 (de) | Tetrahydrochinolinderivate mit selektive aktivität für retinoid x rezeptoren | |
| KR860009007A (ko) | 피페리딜리덴 디하이드로-디벤조[a,d]-사이클로헵텐의 제조방법 | |
| DE3675226D1 (de) | Triazinderivate, verfahren zur herstellung der derivate und die derivate als wirksamen bestandteil enthaltende herbizide. | |
| AT380471B (de) | Verfahren zur herstellung von neuen 2-oxoazetidin-derivate | |
| ATE285410T1 (de) | Naphthyridinderivate oder salze davon | |
| ATE19773T1 (de) | Nitroaliphatische verbindungen, verfahren zu deren herstellung und deren verwendung. | |
| DE69635057D1 (de) | Verfahren zur herstellung von campothecinderivate | |
| EP0356098A3 (de) | Lactamderivate | |
| DE69324854D1 (de) | Pyridazinone-Derivate und Verfahren zur deren Herstellung | |
| ES2008067T3 (es) | Analogos de prostaciclina (pgi2). | |
| ATE17484T1 (de) | Benzodioxan-imidazolin-verbindungen, verfahren zu deren herstellung und deren anwendung. | |
| ATE202350T1 (de) | Verfahren zur herstellung von sulfonylharnstoffderivaten | |
| KR850001165A (ko) | 중추 신경계 활성을 갖는 피롤리디논의 제조방법 | |
| ATE107657T1 (de) | Verfahren zur herstellung von zwischenprodukten für 11-beta,16-alpha,17-alpha,21- tetrahydroxypregna-3-20-dione 16-alpha,17-alpha- acetal und deren 21-ester. | |
| KR910004632A (ko) | 신규한 1-옥사-2-옥소-8-아자스피로[4,5]데칸 유도체와 그들을 포함하는 약제학적 조성물 및 그 제조방법 | |
| DE69007203D1 (de) | Imidazolderivate, Verfahren zu deren Herstellung und diese enthaltende Antiulkusmittel. | |
| KR920002619A (ko) | 오르가노실란 유도체, 이를 함유하는 약제학적 조성물 및 이의 제조방법 | |
| ATE232884T1 (de) | Verfahren zur herstellung von kondensationsverbindungen | |
| DE3680807D1 (de) | Dioxolobenzisoxazolderivate und verfahren zu ihrer herstellung. | |
| KR830005213A (ko) | 이소퀴놀린유도체의 제조방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |