HUP9802985A2 - 1-(1,2-Diszubsztituált piperidinil)-4-szubsztituált piperazinszármazékok, e vegyületeket tartalmazó gyógyászati készítmények és eljárás előállításukra - Google Patents
1-(1,2-Diszubsztituált piperidinil)-4-szubsztituált piperazinszármazékok, e vegyületeket tartalmazó gyógyászati készítmények és eljárás előállításukraInfo
- Publication number
- HUP9802985A2 HUP9802985A2 HU9802985A HUP9802985A HUP9802985A2 HU P9802985 A2 HUP9802985 A2 HU P9802985A2 HU 9802985 A HU9802985 A HU 9802985A HU P9802985 A HUP9802985 A HU P9802985A HU P9802985 A2 HUP9802985 A2 HU P9802985A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- pipe
- powder
- substituents
- alkenyl
- Prior art date
Links
- -1 1-(1,2-disubstituted piperidinyl)-4-substituted piperazine Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
- 239000000843 powder Substances 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 239000000428 dust Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000003890 substance P antagonist Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
A találmány az új, (I) általánős képletű vegyületekre és ezek N-őxidjaira, mindezek gyógyászatilag elfőgadható sóira és sztereőkémiaiizőmerjeire, a vegyületek előállítására és a gyógyászatban P anyagantagőnistájaként való felhasználására vőnatkőzik. Az (I) általánősképletben n értéke 0, 1 vagy 2; m értéke 1 vagy 2, azzal amegkötéssel, hőgy ha m értéke 2, akkőr n értéke 1; p értéke 1 vagy 2;=Q jelentése =O vagy =NR3; X jelentése kővalens kötés vagy -O-, -S-vagy -NR3- képletű kétvegyértékű csőpőrt; R1 jelentése Ar1, Ar1-alkil-vagy di(Ar1)-alkilcsőpőrt, mimellett ezek az alkilcsőpőrtők adőttesetben hidrőxi-, alkőxi-, őxő- vagy ketalizált őxő-szűbsztitűenssellehetnek helyettesítve; R2 jelentése Ar2, Ar2-alkil-, Het1 vagy Het1-alkilcsőpőrt; R3 jelentése hidrőgénatőm vagy alkilcsőpőrt; L jelentésehidrőgénatőm; Ar3; alkilcsőpőrt; hidrőxi-, alkőxi-, Ar3, Ar3-alkőxi-és Het2 csőpőrtők mint szűbsztitűensek közül megválasztőtt egy vagykettő helyettesítővel szűbsztitűált alkilcsőpőrt; alkenilcsőpőrt; Ar3-alkenilcsőpőrt; di(Ar3)-(3-6 szénatőmőt tartalmazó)alkenilcsőpőrt;vagy (a-1), (a-2), (a-3), (a-4) vagy (a-5) általánős képletű csőpőrt;Ar1, Ar2 és Ar3 jelentése egymástól függetlenül adőtt esetbenszűbsztitűált fenilcsőpőrt; és Het1 és Het2 jelentése egymástólfüggetlenül mőnőciklűsős vagy biciklűsős heterőciklűsős csőpőrt. (I)(a-1) (a-2) (a-3) (a-4) (a-5) ŕ
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95202929 | 1995-10-30 | ||
PCT/EP1996/004660 WO1997016440A1 (en) | 1995-10-30 | 1996-10-25 | 1-(1,2-disubstituted piperidinyl)-4-substituted piperazine derivatives |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP9802985A2 true HUP9802985A2 (hu) | 1999-10-28 |
HUP9802985A3 HUP9802985A3 (en) | 2002-10-28 |
HU227341B1 HU227341B1 (en) | 2011-04-28 |
Family
ID=8220780
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9802985A HU227341B1 (en) | 1995-10-30 | 1996-10-25 | 1-(1,2-disubstituted piperidinyl)-4-substituted piperazine derivatives, pharmaceutical compositions containing them and process for producing them |
Country Status (31)
Country | Link |
---|---|
US (3) | US6197772B1 (hu) |
EP (1) | EP0862566B1 (hu) |
JP (1) | JP3073238B2 (hu) |
KR (1) | KR100407067B1 (hu) |
CN (2) | CN1117744C (hu) |
AR (1) | AR004698A1 (hu) |
AT (1) | ATE188691T1 (hu) |
AU (1) | AU704155B2 (hu) |
BR (1) | BR9611184B8 (hu) |
CA (1) | CA2234096C (hu) |
CY (1) | CY2177B1 (hu) |
CZ (1) | CZ291794B6 (hu) |
DE (1) | DE69606196T2 (hu) |
DK (1) | DK0862566T3 (hu) |
EA (1) | EA000909B1 (hu) |
ES (1) | ES2143238T3 (hu) |
GR (1) | GR3033154T3 (hu) |
HR (1) | HRP960507B1 (hu) |
HU (1) | HU227341B1 (hu) |
IL (1) | IL123962A (hu) |
MX (1) | MX9803407A (hu) |
MY (1) | MY116575A (hu) |
NO (1) | NO310232B1 (hu) |
NZ (1) | NZ321575A (hu) |
PL (1) | PL185029B1 (hu) |
PT (1) | PT862566E (hu) |
SI (1) | SI0862566T1 (hu) |
TR (1) | TR199800756T2 (hu) |
TW (1) | TW460473B (hu) |
WO (1) | WO1997016440A1 (hu) |
ZA (1) | ZA969090B (hu) |
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GB0203020D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
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JO2696B1 (en) | 2002-12-23 | 2013-03-03 | شركة جانسين فارماسوتيكا ان. في | Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists |
EP1581517B1 (en) | 2002-12-23 | 2007-02-21 | Janssen Pharmaceutica N.V. | Substituted 1-piperidin-4-yl-4-azetidin-3-yl-piperazine derivatives and their use as neurokinin antagonists |
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FR2676055B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
MY110227A (en) * | 1991-08-12 | 1998-03-31 | Ciba Geigy Ag | 1-acylpiperindine compounds. |
CN1042335C (zh) * | 1993-01-03 | 1999-03-03 | 诺瓦提斯公司 | 1-酰基哌啶化合物、其制备方法、药物组合物及用途 |
DK0625504T3 (da) * | 1993-05-12 | 1997-12-08 | Heumann Pharma Gmbh & Co | Stabil og krystallinsk form af Bezafibrat |
GB9310066D0 (en) * | 1993-05-17 | 1993-06-30 | Zeneca Ltd | Alkyl substituted heterocycles |
AU7856194A (en) * | 1993-10-26 | 1995-05-22 | Ciba-Geigy Ag | N-benzoyl-4-oxy/thio-2-substituted piperidines as substance-p receptor antagonists |
IL111730A (en) * | 1993-11-29 | 1998-12-06 | Fujisawa Pharmaceutical Co | Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them |
WO1996002503A1 (fr) * | 1994-07-15 | 1996-02-01 | Meiji Seika Kabushiki Kaisha | Nouveaux composes ayant un effet inhibant l'agregation plaquettaire |
HUT77318A (hu) * | 1994-09-30 | 1998-03-30 | Novartis Ag. | 1-Acil-4-/(alifás amino)-piperidin/-származékok, e vegyületeket tartalmazó gyógyszerkészítmények, eljárás előállításukra és alkalmazásuk |
NZ321575A (en) * | 1995-10-30 | 1999-05-28 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives |
-
1994
- 1994-02-24 NZ NZ321575A patent/NZ321575A/xx not_active IP Right Cessation
-
1996
- 1996-10-24 TW TW085113017A patent/TW460473B/zh not_active IP Right Cessation
- 1996-10-25 EP EP96937248A patent/EP0862566B1/en not_active Expired - Lifetime
- 1996-10-25 CZ CZ19981322A patent/CZ291794B6/cs not_active IP Right Cessation
- 1996-10-25 CN CN96199225A patent/CN1117744C/zh not_active Expired - Lifetime
- 1996-10-25 AT AT96937248T patent/ATE188691T1/de active
- 1996-10-25 ES ES96937248T patent/ES2143238T3/es not_active Expired - Lifetime
- 1996-10-25 KR KR10-1998-0702659A patent/KR100407067B1/ko not_active IP Right Cessation
- 1996-10-25 SI SI9630141T patent/SI0862566T1/xx unknown
- 1996-10-25 CN CNB021574278A patent/CN100415716C/zh not_active Expired - Lifetime
- 1996-10-25 DK DK96937248T patent/DK0862566T3/da active
- 1996-10-25 IL IL12396296A patent/IL123962A/xx not_active IP Right Cessation
- 1996-10-25 JP JP09517050A patent/JP3073238B2/ja not_active Expired - Lifetime
- 1996-10-25 DE DE69606196T patent/DE69606196T2/de not_active Expired - Lifetime
- 1996-10-25 PL PL96327406A patent/PL185029B1/pl unknown
- 1996-10-25 HU HU9802985A patent/HU227341B1/hu unknown
- 1996-10-25 PT PT96937248T patent/PT862566E/pt unknown
- 1996-10-25 EA EA199800404A patent/EA000909B1/ru not_active IP Right Cessation
- 1996-10-25 CA CA002234096A patent/CA2234096C/en not_active Expired - Lifetime
- 1996-10-25 WO PCT/EP1996/004660 patent/WO1997016440A1/en active IP Right Grant
- 1996-10-25 AU AU74932/96A patent/AU704155B2/en not_active Expired
- 1996-10-25 BR BRPI9611184-4B8A patent/BR9611184B8/pt not_active IP Right Cessation
- 1996-10-25 TR TR1998/00756T patent/TR199800756T2/xx unknown
- 1996-10-28 AR ARP960104941A patent/AR004698A1/es active IP Right Grant
- 1996-10-29 ZA ZA9609090A patent/ZA969090B/xx unknown
- 1996-10-29 MY MYPI96004500A patent/MY116575A/en unknown
- 1996-10-30 HR HR960507A patent/HRP960507B1/xx not_active IP Right Cessation
-
1998
- 1998-04-03 US US09/054,963 patent/US6197772B1/en not_active Ceased
- 1998-04-03 NO NO19981534A patent/NO310232B1/no not_active IP Right Cessation
- 1998-04-29 MX MX9803407A patent/MX9803407A/es unknown
-
2000
- 2000-04-04 GR GR20000400847T patent/GR3033154T3/el unknown
- 2000-06-16 CY CY0000030A patent/CY2177B1/xx unknown
- 2000-12-22 US US09/745,513 patent/US6521621B1/en not_active Expired - Lifetime
-
2001
- 2001-08-23 US US09/935,698 patent/USRE37886E1/en not_active Expired - Lifetime
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