HUP0002528A2 - Xa faktort gátló hatású heterociklusos vegyületek - Google Patents
Xa faktort gátló hatású heterociklusos vegyületekInfo
- Publication number
- HUP0002528A2 HUP0002528A2 HU0002528A HUP0002528A HUP0002528A2 HU P0002528 A2 HUP0002528 A2 HU P0002528A2 HU 0002528 A HU0002528 A HU 0002528A HU P0002528 A HUP0002528 A HU P0002528A HU P0002528 A2 HUP0002528 A2 HU P0002528A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- atom
- nitrogen
- phenyl
- independently represent
- Prior art date
Links
- 108010074860 Factor Xa Proteins 0.000 title abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 title abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 239000003146 anticoagulant agent Substances 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 229940127090 anticoagulant agent Drugs 0.000 abstract 1
- 229960004676 antithrombotic agent Drugs 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/18—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/08—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
A találmány (I) általános képletű vegyületekre és gyógyászatilagalkalmazható sóikra vonatkozik - a képletben A adott esetbenszubsztituált, öt- vagy hattagú, 1, 2 vagy 3 nitrogén-, oxigén-és/vagy kén-heteroatomot tartalmazó monociklusos aromás gyűrűt jelent;B1, B2, B3 és B4 egymástól függetlenül -CH= csoportot vagynitrogénatomot jelent, azzal a feltétellel, hogy B1, B2, B3 és B4legalább egyike nitrogénatomot képvisel, és a Bl, B2, B3 és B4csoportot tartalmazó gyűrű adott esetben szubsztituált lehet; T1 és T2-CH= csoportot vagy nitrogénatomot jelent, azzal a feltétellel, hogylegalább egyikük nitrogénatomot képvisel; X1 SO, SO2- C(R4)2 vagy COcsoportot jelent, vagy ha T1 -CH= csoportot képvisel, akkor X1 mégoxigénatom vagy kénatom is lehet, és a C(R4)2 csoportban szereplő kétR4 csoport egymástól függetenül hidrogénatomot vagy 1-4 szénatomosalkilcsoportot jelent; L1 1-4 szénatomos alkiléncsoportot vagy (1-3szénatomos alkilén)-karbonil-csoportot jelent; R2 és R3 egymástólfüggetlenül hidrogénatomot vagy 1-4 szénatomos alkilcsoportot jelent,vagy együtt 1-4 szénatomos alkiléncsoportot vagy -CH2CO- csoportotalkothatnak, és ebben az esetben a T1, R2, R3, T2 és L1 által alkotottgyűrű adott esetben szubsztituált lehet; X2 S(O)y, C(R5)2 vagy COcsoportot jelent, és ezekben a képletekben y értéke 1 vagy 2, míg akét R5 csoport egymástól függetlenül hidrogénatomot vagy 1-4szénatomos alkilcsoportot jelent; és Q fenil-, naftil-, fenil-(1-4szénatomos alkil)-, fenil-(2-4 szénatomos alkenil)- vagy fenil-(2-4szénatomos alkinil)-csoportot vagy legföljebb 4 nitrogén-, oxigén-és/vagy kén-heteroatomot tartalmazó heterociklusos csoportot jelent,és a felsorolt csoportok adott esetben szubsztituáltak lehetnek. Ezeka vegyületek gátolják az Xa faktor működését, és a gyógyászatbanelsősorban trombózisellenes és antikoaguláns szerekként használhatók. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9715894.3A GB9715894D0 (en) | 1997-07-29 | 1997-07-29 | Heterocyclic derivatives |
| PCT/GB1998/002210 WO1999006371A1 (en) | 1997-07-29 | 1998-07-23 | Heterocyclic derivatives which inhibit factor xa |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0002528A2 true HUP0002528A2 (hu) | 2001-06-28 |
| HUP0002528A3 HUP0002528A3 (en) | 2002-09-30 |
Family
ID=10816578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0002528A HUP0002528A3 (en) | 1997-07-29 | 1998-07-23 | Heterocyclic derivatives which inhibit factor xa |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US6458793B1 (hu) |
| EP (2) | EP1367054A1 (hu) |
| JP (1) | JP2001512103A (hu) |
| KR (1) | KR20010022108A (hu) |
| CN (1) | CN1265098A (hu) |
| AT (1) | ATE266007T1 (hu) |
| AU (1) | AU754747B2 (hu) |
| BR (1) | BR9811055A (hu) |
| CA (1) | CA2295945A1 (hu) |
| DE (1) | DE69823665T2 (hu) |
| DK (1) | DK1000033T3 (hu) |
| ES (1) | ES2219894T3 (hu) |
| GB (1) | GB9715894D0 (hu) |
| HU (1) | HUP0002528A3 (hu) |
| IL (1) | IL133516A0 (hu) |
| NO (2) | NO317419B1 (hu) |
| NZ (1) | NZ501778A (hu) |
| PL (1) | PL338355A1 (hu) |
| PT (1) | PT1000033E (hu) |
| RU (1) | RU2225404C2 (hu) |
| SK (1) | SK1272000A3 (hu) |
| TR (1) | TR200000223T2 (hu) |
| WO (1) | WO1999006371A1 (hu) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| GB9602166D0 (en) * | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
| EP1051176B1 (en) | 1998-01-27 | 2006-11-22 | Aventis Pharmaceuticals Inc. | SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS |
| GB9809349D0 (en) * | 1998-05-02 | 1998-07-01 | Zeneca Ltd | Heterocyclic derivatives |
| JP2002513790A (ja) * | 1998-05-02 | 2002-05-14 | アストラゼネカ アクチボラグ | Ｘａ因子を阻害する複素環誘導体 |
| GB9902989D0 (en) * | 1999-02-11 | 1999-03-31 | Zeneca Ltd | Heterocyclic derivatives |
| DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| TWI290136B (en) | 2000-04-05 | 2007-11-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
| US6670362B2 (en) | 2000-09-20 | 2003-12-30 | Pfizer Inc. | Pyridazine endothelin antagonists |
| DE10105989A1 (de) | 2001-02-09 | 2002-08-14 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| DE10129725A1 (de) | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
| WO2003000657A1 (fr) | 2001-06-20 | 2003-01-03 | Daiichi Pharmaceutical Co., Ltd. | Derives de diamine |
| DE10134482A1 (de) | 2001-07-16 | 2003-01-30 | Bayer Ag | Substituierte Isoindole und ihre Verwendung |
| DE10137163A1 (de) | 2001-07-30 | 2003-02-13 | Bayer Ag | Substituierte Isoindole und ihre Verwendung |
| PT1569912E (pt) | 2002-12-03 | 2015-09-15 | Pharmacyclics Llc | Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia |
| DE10300111A1 (de) * | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
| DE102004062475A1 (de) * | 2004-12-24 | 2006-07-06 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung |
| EP1685841A1 (en) | 2005-01-31 | 2006-08-02 | Bayer Health Care Aktiengesellschaft | Prevention and treatment of thromboembolic disorders |
| DE102005045518A1 (de) * | 2005-09-23 | 2007-03-29 | Bayer Healthcare Ag | 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung |
| DE102005047561A1 (de) | 2005-10-04 | 2007-04-05 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
| SG166126A1 (en) | 2005-10-04 | 2010-11-29 | Bayer Schering Pharma Ag | Novel polymorphous form and the amorphous form of 5-chloro-n-({(5s)-2-oxo- 3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidine-5-yl}-methyl)-2-thiophene carboxamide |
| DE102005047558A1 (de) * | 2005-10-04 | 2008-02-07 | Bayer Healthcare Ag | Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen |
| GB0813142D0 (en) | 2008-07-17 | 2008-08-27 | Glaxo Group Ltd | Novel compounds |
| GB0813144D0 (en) | 2008-07-17 | 2008-08-27 | Glaxo Group Ltd | Novel compounds |
| BR112021026410A2 (pt) | 2019-07-01 | 2022-02-08 | Tonix Pharma Ltd | Anticorpos anti-cd154 e usos dos mesmos |
| EP4274587A1 (en) | 2021-01-06 | 2023-11-15 | Tonix Pharma Limited | Methods of inducing immune tolerance with modified anti-cd154 antibodies |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8905526D0 (en) * | 1989-03-10 | 1989-04-19 | Fujisawa Pharmaceutical Co | N-containing heterocyclic compounds,processes for the preparation thereof and composition comprising the same |
| US5541330A (en) * | 1991-12-10 | 1996-07-30 | Eastman Kodak Company | Ion-sensitive compounds |
| IL115420A0 (en) * | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| GB9602166D0 (en) * | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
| UA56197C2 (uk) * | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
-
1997
- 1997-07-29 GB GBGB9715894.3A patent/GB9715894D0/en active Pending
-
1998
- 1998-07-23 SK SK127-2000A patent/SK1272000A3/sk unknown
- 1998-07-23 EP EP03018010A patent/EP1367054A1/en not_active Withdrawn
- 1998-07-23 PL PL98338355A patent/PL338355A1/xx not_active Application Discontinuation
- 1998-07-23 RU RU2000104829/04A patent/RU2225404C2/ru not_active IP Right Cessation
- 1998-07-23 KR KR1020007000678A patent/KR20010022108A/ko not_active Application Discontinuation
- 1998-07-23 BR BR9811055-1A patent/BR9811055A/pt not_active Application Discontinuation
- 1998-07-23 EP EP98935208A patent/EP1000033B1/en not_active Expired - Lifetime
- 1998-07-23 CA CA002295945A patent/CA2295945A1/en not_active Abandoned
- 1998-07-23 TR TR2000/00223T patent/TR200000223T2/xx unknown
- 1998-07-23 WO PCT/GB1998/002210 patent/WO1999006371A1/en not_active Application Discontinuation
- 1998-07-23 NZ NZ501778A patent/NZ501778A/en unknown
- 1998-07-23 IL IL13351698A patent/IL133516A0/xx unknown
- 1998-07-23 AU AU84557/98A patent/AU754747B2/en not_active Ceased
- 1998-07-23 US US09/463,625 patent/US6458793B1/en not_active Expired - Fee Related
- 1998-07-23 DK DK98935208T patent/DK1000033T3/da active
- 1998-07-23 PT PT98935208T patent/PT1000033E/pt unknown
- 1998-07-23 CN CN98807641A patent/CN1265098A/zh active Pending
- 1998-07-23 AT AT98935208T patent/ATE266007T1/de not_active IP Right Cessation
- 1998-07-23 DE DE69823665T patent/DE69823665T2/de not_active Expired - Lifetime
- 1998-07-23 HU HU0002528A patent/HUP0002528A3/hu unknown
- 1998-07-23 JP JP2000505130A patent/JP2001512103A/ja active Pending
- 1998-07-23 ES ES98935208T patent/ES2219894T3/es not_active Expired - Lifetime
-
2000
- 2000-01-28 NO NO20000448A patent/NO317419B1/no unknown
-
2002
- 2002-06-27 US US10/180,337 patent/US20020193375A1/en not_active Abandoned
-
2004
- 2004-02-05 NO NO20040520A patent/NO20040520L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2295945A1 (en) | 1999-02-11 |
| AU754747B2 (en) | 2002-11-21 |
| WO1999006371A1 (en) | 1999-02-11 |
| CN1265098A (zh) | 2000-08-30 |
| NO20000448D0 (no) | 2000-01-28 |
| TR200000223T2 (tr) | 2000-07-21 |
| GB9715894D0 (en) | 1997-10-01 |
| NO20040520L (no) | 2004-02-05 |
| BR9811055A (pt) | 2000-09-05 |
| JP2001512103A (ja) | 2001-08-21 |
| HUP0002528A3 (en) | 2002-09-30 |
| DK1000033T3 (da) | 2004-08-02 |
| PL338355A1 (en) | 2000-10-23 |
| SK1272000A3 (en) | 2000-06-12 |
| RU2225404C2 (ru) | 2004-03-10 |
| PT1000033E (pt) | 2004-08-31 |
| ATE266007T1 (de) | 2004-05-15 |
| EP1000033B1 (en) | 2004-05-06 |
| ES2219894T3 (es) | 2004-12-01 |
| NO317419B1 (no) | 2004-10-25 |
| US6458793B1 (en) | 2002-10-01 |
| KR20010022108A (ko) | 2001-03-15 |
| EP1000033A1 (en) | 2000-05-17 |
| IL133516A0 (en) | 2001-04-30 |
| DE69823665D1 (de) | 2004-06-09 |
| DE69823665T2 (de) | 2005-04-28 |
| EP1367054A1 (en) | 2003-12-03 |
| US20020193375A1 (en) | 2002-12-19 |
| NZ501778A (en) | 2001-09-28 |
| NO20000448L (no) | 2000-03-16 |
| AU8455798A (en) | 1999-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |