ATE102199T1 - 4-amino-3-carboxynaphthyridin-derivate, ihre herstellung und pharmazeutische zusammensetzungen. - Google Patents
4-amino-3-carboxynaphthyridin-derivate, ihre herstellung und pharmazeutische zusammensetzungen.Info
- Publication number
- ATE102199T1 ATE102199T1 AT89401547T AT89401547T ATE102199T1 AT E102199 T1 ATE102199 T1 AT E102199T1 AT 89401547 T AT89401547 T AT 89401547T AT 89401547 T AT89401547 T AT 89401547T AT E102199 T1 ATE102199 T1 AT E102199T1
- Authority
- AT
- Austria
- Prior art keywords
- denote
- carboxynaphthyridine
- derivatives
- amino
- preparation
- Prior art date
Links
- ZIJNKTXIQVXZDF-UHFFFAOYSA-N 4-amino-1,8-naphthyridine-3-carboxylic acid Chemical class C1=CC=C2C(N)=C(C(O)=O)C=NC2=N1 ZIJNKTXIQVXZDF-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8807723A FR2632639B1 (fr) | 1988-06-09 | 1988-06-09 | Derives d'amino-4 carboxy-3 naphtyridines, leur preparation et compositions pharmaceutiques qui les contiennent |
| EP89401547A EP0346207B1 (de) | 1988-06-09 | 1989-06-05 | 4-Amino-3-carboxynaphthyridin-Derivate, ihre Herstellung und pharmazeutische Zusammensetzungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE102199T1 true ATE102199T1 (de) | 1994-03-15 |
Family
ID=9367129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89401547T ATE102199T1 (de) | 1988-06-09 | 1989-06-05 | 4-amino-3-carboxynaphthyridin-derivate, ihre herstellung und pharmazeutische zusammensetzungen. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4996213A (de) |
| EP (1) | EP0346207B1 (de) |
| JP (1) | JP2815614B2 (de) |
| AT (1) | ATE102199T1 (de) |
| DE (1) | DE68913365T2 (de) |
| FR (1) | FR2632639B1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0169813B1 (ko) * | 1995-07-12 | 1999-01-15 | 김종인 | 4-아미노-3-아실나프티리딘 유도체 |
| JPH10242848A (ja) * | 1997-02-27 | 1998-09-11 | Nec Corp | 半導体集積回路 |
| ZA9810490B (en) | 1997-12-03 | 1999-05-20 | Dainippon Pharmaceutical Co | 2-Aryl-8-oxodihydropurine derivative process for the preparation thereof pharmaceutical composition containing the same and intermediate therefor |
| DE60128936T2 (de) * | 2000-10-12 | 2008-04-10 | Merck & Co, Inc. | Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer |
| CA2425625A1 (en) * | 2000-10-12 | 2002-07-18 | Merck & Co., Inc. | Aza-and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
| WO2002030931A2 (en) | 2000-10-12 | 2002-04-18 | Merck & Co., Inc. | Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
| AR036256A1 (es) * | 2001-08-17 | 2004-08-25 | Merck & Co Inc | Sal sodica de un inhibidor de integrasa del vih, procesos para su preparacion, composiciones farmaceuticas que lo contienen y su uso para la manufactura de un medicamento |
| CA2472372C (en) * | 2002-01-17 | 2010-08-17 | Melissa Egbertson | Hydroxynaphthyridinone carboxamides useful as hiv integrase inhibitors |
| JP4567974B2 (ja) | 2002-01-18 | 2010-10-27 | 株式会社アドバンテスト | 試験装置 |
| WO2003077857A2 (en) * | 2002-03-15 | 2003-09-25 | Merck & Co., Inc. | N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors |
| US8575203B2 (en) | 2010-04-21 | 2013-11-05 | Boehringer Ingelheim International Gmbh | Chemical compounds |
| DK2753329T3 (en) | 2012-01-19 | 2017-10-23 | Onco Therapy Science Inc | 1,5-NAPHTHYRIDINE INGREDIENTS AS MILK INHIBITORS |
| CN117430602A (zh) * | 2023-09-26 | 2024-01-23 | 爱斯特（成都）生物制药股份有限公司 | 一种制备6-卤代-4-羟基[1,5]萘啶-3-甲酸酯及其衍生物的方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4324893A (en) * | 1979-04-18 | 1982-04-13 | American Home Products Corporation | 4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives |
| FR2581382B1 (fr) * | 1985-05-06 | 1987-06-26 | Sanofi Sa | Derives n-(quinolyl) glycinamides, leur procede de preparation et leur application therapeutique en tant que psychotropes |
-
1988
- 1988-06-09 FR FR8807723A patent/FR2632639B1/fr not_active Expired - Fee Related
-
1989
- 1989-06-05 DE DE68913365T patent/DE68913365T2/de not_active Expired - Fee Related
- 1989-06-05 EP EP89401547A patent/EP0346207B1/de not_active Expired - Lifetime
- 1989-06-05 JP JP1143955A patent/JP2815614B2/ja not_active Expired - Lifetime
- 1989-06-05 AT AT89401547T patent/ATE102199T1/de active
- 1989-06-06 US US07/362,104 patent/US4996213A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE68913365D1 (de) | 1994-04-07 |
| US4996213A (en) | 1991-02-26 |
| JP2815614B2 (ja) | 1998-10-27 |
| JPH0232078A (ja) | 1990-02-01 |
| DE68913365T2 (de) | 1994-08-11 |
| EP0346207A1 (de) | 1989-12-13 |
| FR2632639B1 (fr) | 1990-10-05 |
| FR2632639A1 (fr) | 1989-12-15 |
| EP0346207B1 (de) | 1994-03-02 |
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