DE60327765D1 - Verfahren zur herstellung von n-(2,6-dimethylphenyl)-2-piperazin-1-ylacetamid - Google Patents
Verfahren zur herstellung von n-(2,6-dimethylphenyl)-2-piperazin-1-ylacetamidInfo
- Publication number
- DE60327765D1 DE60327765D1 DE60327765T DE60327765T DE60327765D1 DE 60327765 D1 DE60327765 D1 DE 60327765D1 DE 60327765 T DE60327765 T DE 60327765T DE 60327765 T DE60327765 T DE 60327765T DE 60327765 D1 DE60327765 D1 DE 60327765D1
- Authority
- DE
- Germany
- Prior art keywords
- piperazine
- solvent
- xylidine
- haloacetyl
- piperazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02077749 | 2002-06-24 | ||
PCT/EP2003/050241 WO2004000824A1 (en) | 2002-06-24 | 2003-06-19 | Process for the production of n-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60327765D1 true DE60327765D1 (de) | 2009-07-09 |
Family
ID=29797257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60327765T Expired - Lifetime DE60327765D1 (de) | 2002-06-24 | 2003-06-19 | Verfahren zur herstellung von n-(2,6-dimethylphenyl)-2-piperazin-1-ylacetamid |
Country Status (13)
Country | Link |
---|---|
US (1) | US8541578B2 (de) |
EP (1) | EP1517900B1 (de) |
JP (1) | JP4846234B2 (de) |
CN (1) | CN1326846C (de) |
AT (1) | ATE432267T1 (de) |
AU (1) | AU2003255511B2 (de) |
BR (1) | BRPI0312001B1 (de) |
CA (1) | CA2487141C (de) |
DE (1) | DE60327765D1 (de) |
ES (1) | ES2326800T3 (de) |
HK (1) | HK1081966A1 (de) |
IL (1) | IL165916A (de) |
WO (1) | WO2004000824A1 (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101747294B (zh) * | 2008-12-10 | 2011-09-28 | 上海医药工业研究院 | 一种n-(2,6-二甲苯基)-2-(1-哌嗪基)乙酰胺的纯化方法 |
EP3233814A4 (de) | 2015-03-10 | 2018-07-18 | Unichem Laboratories Limited | Neuartiges verfahren zur herstellung von ranolazin |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US458129A (en) * | 1891-08-18 | papin | ||
GB840358A (en) | 1957-10-11 | 1960-07-06 | British Drug Houses Ltd | Improvements in or relating to the manufacture of n-mono-substituted piperazines |
US3953448A (en) * | 1972-12-07 | 1976-04-27 | Delmar Chemicals Limited | Piperazino-anilido compounds |
IT1054961B (it) * | 1976-01-23 | 1981-11-30 | Corvi Camillo Spa | Derivati della piperazina adatti come agenti anti ulcera |
US4567264A (en) | 1983-05-18 | 1986-01-28 | Syntex (U.S.A.) Inc. | Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry |
US4558129A (en) * | 1983-05-18 | 1985-12-10 | Syntex (U.S.A.) Inc. | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade |
DE69322707T2 (de) * | 1992-07-31 | 1999-08-19 | Bristol Myers Squibb Co | Diphenyl Oxazole-, Thiazole- und Imidazole-Derivate als Inhibitoren der Wiederaufnahme des Adenosins |
EP0775128A1 (de) * | 1995-06-07 | 1997-05-28 | Dade Chemistry Systems Inc. | Verfahren zur herstellung von immunogenen und anderen arzneimittelkonjugaten |
NZ321575A (en) | 1995-10-30 | 1999-05-28 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives |
-
2003
- 2003-06-19 AT AT03760705T patent/ATE432267T1/de not_active IP Right Cessation
- 2003-06-19 DE DE60327765T patent/DE60327765D1/de not_active Expired - Lifetime
- 2003-06-19 AU AU2003255511A patent/AU2003255511B2/en not_active Expired
- 2003-06-19 BR BRPI0312001-5A patent/BRPI0312001B1/pt not_active IP Right Cessation
- 2003-06-19 CN CNB038146673A patent/CN1326846C/zh not_active Expired - Lifetime
- 2003-06-19 CA CA2487141A patent/CA2487141C/en not_active Expired - Lifetime
- 2003-06-19 EP EP03760705A patent/EP1517900B1/de not_active Expired - Lifetime
- 2003-06-19 ES ES03760705T patent/ES2326800T3/es not_active Expired - Lifetime
- 2003-06-19 WO PCT/EP2003/050241 patent/WO2004000824A1/en active Application Filing
- 2003-06-19 JP JP2004514875A patent/JP4846234B2/ja not_active Expired - Fee Related
- 2003-06-19 US US10/518,887 patent/US8541578B2/en active Active
-
2004
- 2004-12-22 IL IL165916A patent/IL165916A/en active IP Right Grant
-
2006
- 2006-02-22 HK HK06102356A patent/HK1081966A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US8541578B2 (en) | 2013-09-24 |
CA2487141C (en) | 2011-08-02 |
JP4846234B2 (ja) | 2011-12-28 |
BR0312001A (pt) | 2005-03-22 |
HK1081966A1 (en) | 2006-05-26 |
WO2004000824A1 (en) | 2003-12-31 |
IL165916A (en) | 2012-12-31 |
ES2326800T3 (es) | 2009-10-20 |
IL165916A0 (en) | 2006-01-15 |
JP2005530837A (ja) | 2005-10-13 |
CN1662517A (zh) | 2005-08-31 |
ATE432267T1 (de) | 2009-06-15 |
EP1517900B1 (de) | 2009-05-27 |
CN1326846C (zh) | 2007-07-18 |
AU2003255511A1 (en) | 2004-01-06 |
EP1517900A1 (de) | 2005-03-30 |
CA2487141A1 (en) | 2003-12-31 |
US20050240018A1 (en) | 2005-10-27 |
BRPI0312001B1 (pt) | 2015-04-07 |
AU2003255511B2 (en) | 2009-02-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent |