ATE318264T1 - Laktonisierungsverfahren bei der herstellung von statinen - Google Patents
Laktonisierungsverfahren bei der herstellung von statinenInfo
- Publication number
- ATE318264T1 ATE318264T1 AT02026916T AT02026916T ATE318264T1 AT E318264 T1 ATE318264 T1 AT E318264T1 AT 02026916 T AT02026916 T AT 02026916T AT 02026916 T AT02026916 T AT 02026916T AT E318264 T1 ATE318264 T1 AT E318264T1
- Authority
- AT
- Austria
- Prior art keywords
- present
- simvastatin
- statins
- production
- processing method
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2001-0075991A KR100423892B1 (ko) | 2001-12-03 | 2001-12-03 | 스타틴의 제조에 있어서 새로운 락톤화 방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE318264T1 true ATE318264T1 (de) | 2006-03-15 |
Family
ID=36129249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02026916T ATE318264T1 (de) | 2001-12-03 | 2002-12-03 | Laktonisierungsverfahren bei der herstellung von statinen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6906204B2 (de) |
| EP (1) | EP1316552B1 (de) |
| JP (1) | JP3802481B2 (de) |
| KR (1) | KR100423892B1 (de) |
| CN (1) | CN1197854C (de) |
| AT (1) | ATE318264T1 (de) |
| AU (1) | AU2002311322B8 (de) |
| BR (1) | BR0204943A (de) |
| CA (1) | CA2413235C (de) |
| DE (1) | DE60209289T2 (de) |
| MX (1) | MXPA02011967A (de) |
| WO (1) | WO2003048149A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100502834B1 (ko) * | 2002-03-25 | 2005-07-20 | 보령제약 주식회사 | 개선된 락톤화 반응에 의한 심바스타틴의 제조방법 및이의 정제방법 |
| WO2005095374A1 (en) * | 2004-03-30 | 2005-10-13 | Lupin Ltd. | An improved method for manufacture of 4-hydroxy pyran-2-one derivatives |
| EP2597092A1 (de) | 2011-11-24 | 2013-05-29 | Sterling Biotech Limited | Verfahren zum Reinigen von Lovastatin |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2053000C (en) * | 1990-10-15 | 1995-08-29 | Michael J. Conder | Biosynthetic production of 6(r)-[2-(8(s)-hydroxy-2(s), 6(r)-dimethyl-1,2,6,7,8,8a(r)-hexahydronaphthyl)-ethyl]-4 (r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-one triol acid by enzymatic hydrolysis of lovastatin acid using an enzyme derived from__lonostachys compactiuscula |
| NZ245713A (en) * | 1992-02-10 | 1994-12-22 | Novopharm Ltd | Production of the antibiotic lovastatin from genetically engineered aspergillus strains |
| AU747219C (en) * | 1997-01-28 | 2003-11-20 | Plus Chemicals B.V. | Process for the production of semi synthetic statins via novel intermediates |
| IN186880B (de) * | 1997-10-28 | 2001-12-01 | Ranbaxy Lab Ltd | |
| IN186879B (de) * | 1997-10-28 | 2001-12-01 | Ranbaxy Lab Ltd | |
| US6380401B1 (en) * | 1999-10-27 | 2002-04-30 | Merck & Co., Inc. | Lactonization process |
| EP1294706A1 (de) * | 2001-05-18 | 2003-03-26 | Aurobindo Pharma Limited | Prozess zur herstellung von simvastatin durch lactonisierung |
-
2001
- 2001-12-03 KR KR10-2001-0075991A patent/KR100423892B1/ko not_active IP Right Cessation
-
2002
- 2002-11-11 WO PCT/KR2002/002095 patent/WO2003048149A1/en active Application Filing
- 2002-11-14 US US10/295,300 patent/US6906204B2/en not_active Expired - Fee Related
- 2002-11-29 CA CA002413235A patent/CA2413235C/en not_active Expired - Fee Related
- 2002-11-29 CN CNB021530378A patent/CN1197854C/zh not_active Expired - Fee Related
- 2002-12-02 AU AU2002311322A patent/AU2002311322B8/en not_active Ceased
- 2002-12-02 JP JP2002350255A patent/JP3802481B2/ja not_active Expired - Fee Related
- 2002-12-02 BR BR0204943-0A patent/BR0204943A/pt active Search and Examination
- 2002-12-02 MX MXPA02011967A patent/MXPA02011967A/es active IP Right Grant
- 2002-12-03 EP EP02026916A patent/EP1316552B1/de not_active Expired - Lifetime
- 2002-12-03 DE DE60209289T patent/DE60209289T2/de not_active Expired - Lifetime
- 2002-12-03 AT AT02026916T patent/ATE318264T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60209289T2 (de) | 2006-08-10 |
| JP2003183271A (ja) | 2003-07-03 |
| DE60209289D1 (de) | 2006-04-27 |
| CN1197854C (zh) | 2005-04-20 |
| MXPA02011967A (es) | 2004-07-16 |
| US6906204B2 (en) | 2005-06-14 |
| CA2413235C (en) | 2006-05-30 |
| CN1425661A (zh) | 2003-06-25 |
| US20030109723A1 (en) | 2003-06-12 |
| BR0204943A (pt) | 2004-06-15 |
| EP1316552A1 (de) | 2003-06-04 |
| WO2003048149A1 (en) | 2003-06-12 |
| EP1316552B1 (de) | 2006-02-22 |
| KR100423892B1 (ko) | 2004-03-22 |
| JP3802481B2 (ja) | 2006-07-26 |
| AU2002311322B2 (en) | 2005-06-30 |
| KR20030045340A (ko) | 2003-06-11 |
| AU2002311322B8 (en) | 2005-10-27 |
| CA2413235A1 (en) | 2003-06-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |