DE60039533D1 - Verbessertes verfahren zur herstellung von 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamid hydrochlorid und anderen derivaten von 2-hydroxy-1,3-diamin - Google Patents

Verbessertes verfahren zur herstellung von 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamid hydrochlorid und anderen derivaten von 2-hydroxy-1,3-diamin

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Publication number
DE60039533D1
DE60039533D1 DE60039533T DE60039533T DE60039533D1 DE 60039533 D1 DE60039533 D1 DE 60039533D1 DE 60039533 T DE60039533 T DE 60039533T DE 60039533 T DE60039533 T DE 60039533T DE 60039533 D1 DE60039533 D1 DE 60039533D1
Authority
DE
Germany
Prior art keywords
hydroxy
phenylbutyl
isobutyl
amino
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60039533T
Other languages
English (en)
Inventor
Aslam A Malik
Hasan Palandoken
Joy A Stringer
Roland P Carlson
John Leach
Thomas G Archibald
Robert G Miotke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aerojet Fine Chemicals LLC
Original Assignee
Aerojet Fine Chemicals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aerojet Fine Chemicals LLC filed Critical Aerojet Fine Chemicals LLC
Application granted granted Critical
Publication of DE60039533D1 publication Critical patent/DE60039533D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60039533T 1999-12-23 2000-12-22 Verbessertes verfahren zur herstellung von 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamid hydrochlorid und anderen derivaten von 2-hydroxy-1,3-diamin Expired - Lifetime DE60039533D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17204399P 1999-12-23 1999-12-23
PCT/US2000/035335 WO2001046120A1 (en) 1999-12-23 2000-12-22 Improved preparation of 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines

Publications (1)

Publication Number Publication Date
DE60039533D1 true DE60039533D1 (de) 2008-08-28

Family

ID=22626131

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60039533T Expired - Lifetime DE60039533D1 (de) 1999-12-23 2000-12-22 Verbessertes verfahren zur herstellung von 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamid hydrochlorid und anderen derivaten von 2-hydroxy-1,3-diamin

Country Status (5)

Country Link
EP (6) EP2194038A3 (de)
AT (1) ATE401298T1 (de)
AU (1) AU2739201A (de)
DE (1) DE60039533D1 (de)
WO (1) WO2001046120A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4818124B2 (ja) 2003-12-23 2011-11-16 テイボテク・フアーマシユーチカルズ・リミテツド （３Ｒ，３ａＳ，６ａＲ）−ヘキサヒドロフロ〔２，３−ｂ〕フラン−３−イル（１Ｓ，１Ｒ）−３−〔〔（４−アミノフェニル）スルホニル〕（イソブチル）アミノ〕−１−ベンジル−２−ヒドロキシプロピルカルバマートの製造方法
SI1999133T1 (sl) 2006-03-29 2013-10-30 Gilead Sciences, Inc. Postopek za pripravo HIV proteaznih inhibitorjev
MX2009011574A (es) * 2007-04-27 2009-11-09 Tibotec Pharm Ltd Metodos para la preparacion de derivados de n-isobutil-n-(2-hidrox i-3-amino-4-fenilbutil)-p-nitrobencensulfonilamida.
WO2018081292A1 (en) 2016-10-27 2018-05-03 Gilead Sciences, Inc. Crystalline forms of darunavir free base, hydrate, solvates and salts
JOP20180009A1 (ar) 2017-02-06 2019-01-30 Gilead Sciences Inc مركبات مثبط فيروس hiv
TWI829205B (zh) 2018-07-30 2024-01-11 美商基利科學股份有限公司 抗hiv化合物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE520156C (de) * 1927-09-01 1931-03-09 Ici Ltd Verfahren zur Herstellung von Morpholin und seinen Homologen
FR2557101B1 (fr) * 1983-12-21 1986-06-27 Pharmascience Lab Nouveau procede de preparation de diamine-alcools
DE4220758A1 (de) 1992-06-24 1994-01-05 Inst Genbiologische Forschung DNA-Sequenz und Plasmide zur Herstellung von Pflanzen mit veränderter Saccharose-Konzentration
US5783701A (en) * 1992-09-08 1998-07-21 Vertex Pharmaceuticals, Incorporated Sulfonamide inhibitors of aspartyl protease
US5723490A (en) 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
ATE174587T1 (de) * 1993-08-24 1999-01-15 Searle & Co Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
US5705500A (en) * 1995-03-10 1998-01-06 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US5776971A (en) * 1995-03-10 1998-07-07 G.D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
EP0774453B1 (de) * 1995-11-17 2002-02-06 Ajinomoto Co., Inc. Verfahren zur Herstellung von 3-Amino-2-oxo-1-Halogenpropan-Derivaten
SE9602646D0 (sv) * 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
GB9805898D0 (en) * 1998-03-20 1998-05-13 Glaxo Group Ltd Process for the sythesis of hiv protease inhibitors
WO2000047551A2 (en) * 1999-02-12 2000-08-17 Vertex Pharmaceuticals Incorporated Inhibitors of aspartyl protease

Also Published As

Publication number Publication date
EP2314562A3 (de) 2012-03-21
EP2314564A3 (de) 2012-04-04
EP2314562A2 (de) 2011-04-27
EP2314563A2 (de) 2011-04-27
EP2194038A2 (de) 2010-06-09
AU2739201A (en) 2001-07-03
EP2319824A3 (de) 2012-04-11
EP1244610B1 (de) 2008-07-16
EP1244610A4 (de) 2005-02-02
EP2314563A3 (de) 2012-04-04
ATE401298T1 (de) 2008-08-15
EP1244610A1 (de) 2002-10-02
EP2319824A2 (de) 2011-05-11
WO2001046120A1 (en) 2001-06-28
EP2194038A3 (de) 2010-09-01
EP2314564A2 (de) 2011-04-27

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DE60039533D1 (de) Verbessertes verfahren zur herstellung von 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamid hydrochlorid und anderen derivaten von 2-hydroxy-1,3-diamin
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