BR0204943A - Método de processamento de lactonização na preparação de estatinas - Google Patents

Método de processamento de lactonização na preparação de estatinas

Info

Publication number
BR0204943A
BR0204943A BR0204943-0A BR0204943A BR0204943A BR 0204943 A BR0204943 A BR 0204943A BR 0204943 A BR0204943 A BR 0204943A BR 0204943 A BR0204943 A BR 0204943A
Authority
BR
Brazil
Prior art keywords
processing method
lactonization
present
simvastatin
lovastatin
Prior art date
Application number
BR0204943-0A
Other languages
English (en)
Inventor
Kwang-Hyeg Lee
Jin-Wan Kim
Kwang-Do Choi
Sang-Ho Lee
Hong-Suk Cho
Original Assignee
Cj Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cj Corp filed Critical Cj Corp
Publication of BR0204943A publication Critical patent/BR0204943A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"MéTODO DE PROCESSAMENTO DE LACTONIZAçãO NA PREPARAçãO DE ESTATINAS". A presente invenção refere-se a um método de processamento para preparação de lovastatina e simvastatina que compreende as etapas de (1) realização de lactonização de ácido mevínico e seus compostos homólogos em presença de solvente orgânico misto sem um catalisador de ácido através de varredura de nitrogênio; e (2) fabricação de cristais. No processo da presente invenção, lovastatina e simvastatina altamente purificadas podem ser produzidas em alto rendimento e especialmente, heterodímeros formados como um subproduto podem ser notavelmente reduzidos. Portanto, o método de processamento da presente invenção pode ser conveniente e económico.
BR0204943-0A 2001-12-03 2002-12-02 Método de processamento de lactonização na preparação de estatinas BR0204943A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR10-2001-0075991A KR100423892B1 (ko) 2001-12-03 2001-12-03 스타틴의 제조에 있어서 새로운 락톤화 방법

Publications (1)

Publication Number Publication Date
BR0204943A true BR0204943A (pt) 2004-06-15

Family

ID=36129249

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0204943-0A BR0204943A (pt) 2001-12-03 2002-12-02 Método de processamento de lactonização na preparação de estatinas

Country Status (12)

Country Link
US (1) US6906204B2 (pt)
EP (1) EP1316552B1 (pt)
JP (1) JP3802481B2 (pt)
KR (1) KR100423892B1 (pt)
CN (1) CN1197854C (pt)
AT (1) ATE318264T1 (pt)
AU (1) AU2002311322B8 (pt)
BR (1) BR0204943A (pt)
CA (1) CA2413235C (pt)
DE (1) DE60209289T2 (pt)
MX (1) MXPA02011967A (pt)
WO (1) WO2003048149A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100502834B1 (ko) * 2002-03-25 2005-07-20 보령제약 주식회사 개선된 락톤화 반응에 의한 심바스타틴의 제조방법 및이의 정제방법
US7777056B2 (en) * 2004-03-30 2010-08-17 Lupin Ltd. Method for manufacture of 4-hydroxy pyran-2-one derivatives
EP2597092A1 (en) 2011-11-24 2013-05-29 Sterling Biotech Limited A process for purification of lovastatin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2053000C (en) * 1990-10-15 1995-08-29 Michael J. Conder Biosynthetic production of 6(r)-[2-(8(s)-hydroxy-2(s), 6(r)-dimethyl-1,2,6,7,8,8a(r)-hexahydronaphthyl)-ethyl]-4 (r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-one triol acid by enzymatic hydrolysis of lovastatin acid using an enzyme derived from__lonostachys compactiuscula
NZ245713A (en) * 1992-02-10 1994-12-22 Novopharm Ltd Production of the antibiotic lovastatin from genetically engineered aspergillus strains
ES2197465T3 (es) 1997-01-28 2004-01-01 Plus Chemicals B.V. Proceso para la produccion de estatinas semisinteticas a traves de nuevos intermedios.
IN186879B (pt) * 1997-10-28 2001-12-01 Ranbaxy Lab Ltd
IN186880B (pt) * 1997-10-28 2001-12-01 Ranbaxy Lab Ltd
CA2388182A1 (en) 1999-10-27 2001-05-03 Merck & Co., Inc. Lactonization process
JP2004520445A (ja) * 2001-05-18 2004-07-08 オーロビンド ファーマ リミテッド シンバスタチンを生成するためのラクトン化法

Also Published As

Publication number Publication date
EP1316552A1 (en) 2003-06-04
CN1197854C (zh) 2005-04-20
EP1316552B1 (en) 2006-02-22
ATE318264T1 (de) 2006-03-15
DE60209289T2 (de) 2006-08-10
US6906204B2 (en) 2005-06-14
MXPA02011967A (es) 2004-07-16
KR20030045340A (ko) 2003-06-11
CN1425661A (zh) 2003-06-25
JP3802481B2 (ja) 2006-07-26
AU2002311322B2 (en) 2005-06-30
CA2413235A1 (en) 2003-06-03
AU2002311322B8 (en) 2005-10-27
KR100423892B1 (ko) 2004-03-22
JP2003183271A (ja) 2003-07-03
DE60209289D1 (de) 2006-04-27
WO2003048149A1 (en) 2003-06-12
CA2413235C (en) 2006-05-30
US20030109723A1 (en) 2003-06-12

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B25A Requested transfer of rights approved

Owner name: CJ HEALTHCARE CORPORATION (KR)

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time