DE60226203D1 - Laktonisierung im Verfahren zur Herstellung von Statinen - Google Patents

Laktonisierung im Verfahren zur Herstellung von Statinen

Info

Publication number
DE60226203D1
DE60226203D1 DE60226203T DE60226203T DE60226203D1 DE 60226203 D1 DE60226203 D1 DE 60226203D1 DE 60226203 T DE60226203 T DE 60226203T DE 60226203 T DE60226203 T DE 60226203T DE 60226203 D1 DE60226203 D1 DE 60226203D1
Authority
DE
Germany
Prior art keywords
present
lactonization
simvastatin
lovastatin
statins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60226203T
Other languages
English (en)
Other versions
DE60226203T2 (de
Inventor
Kwang-Hyeg Lee
Jin-Wan Kim
Myeong-Sik Yoon
Kwang-Do Choi
Sang-Ho Lee
Hong-Suk Cheil Jedang Cho
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CJ Corp
Original Assignee
CJ Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CJ Corp filed Critical CJ Corp
Publication of DE60226203D1 publication Critical patent/DE60226203D1/de
Application granted granted Critical
Publication of DE60226203T2 publication Critical patent/DE60226203T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D309/06—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
DE60226203T 2001-08-27 2002-07-10 Laktonisierung im Verfahren zur Herstellung von Statinen Expired - Lifetime DE60226203T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR2001051796 2001-08-27
KR10-2001-0051796A KR100407758B1 (ko) 2001-08-27 2001-08-27 스타틴의 제조에 있어서 락톤화 방법

Publications (2)

Publication Number Publication Date
DE60226203D1 true DE60226203D1 (de) 2008-06-05
DE60226203T2 DE60226203T2 (de) 2009-05-14

Family

ID=19713589

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60226203T Expired - Lifetime DE60226203T2 (de) 2001-08-27 2002-07-10 Laktonisierung im Verfahren zur Herstellung von Statinen

Country Status (8)

Country Link
US (1) US6649775B2 (de)
EP (1) EP1288212B1 (de)
JP (1) JP2003096071A (de)
KR (1) KR100407758B1 (de)
CN (1) CN1193022C (de)
AT (1) ATE393151T1 (de)
DE (1) DE60226203T2 (de)
WO (1) WO2003018570A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002094803A1 (en) * 2001-05-18 2002-11-28 Aurobindo Pharma Limited A process for lactonization to produce highly pure simvastatin
US6995277B2 (en) 2003-02-11 2006-02-07 Plus Chemicals, B.V. Process for preparing simvastatin having controlled ranges of simvastatin dimer content
DE04758696T1 (de) * 2003-04-01 2005-12-29 Plus Chemicals B.V. Amorhes simvastatin calcium und verfahren zur herstellung davon
AU2004317826A1 (en) * 2004-03-30 2005-10-13 Lupin Ltd An improved method for manufacture of 4-hydroxy pyran-2-one derivatives
US20060084817A1 (en) * 2004-06-30 2006-04-20 Chenault Henry K Synthesis of aldonolactones, aldarolactones, and aldarodilactones using gas sparging
EP1773839A1 (de) * 2004-06-30 2007-04-18 E.I. Dupont De Nemours And Company Synthese von aldonolactonen,aldarolactonen und aldarodilactonen mittels azeotroper destillation
JP2008509154A (ja) * 2004-08-06 2008-03-27 トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド 新規なスタチン薬剤組成物および関連治療方法
NZ552390A (en) * 2004-08-06 2010-01-29 Transform Pharmaceuticals Inc Novel fenofibrate formulations and related methods of treatment
US20090042979A1 (en) * 2004-08-06 2009-02-12 Transform Pharmaceuticals Inc. Novel Statin Pharmaceutical Compositions and Related Methods of Treatment
JO2897B1 (en) 2004-11-05 2015-09-15 نوفارتيس ايه جي Organic compounds
DK2018153T3 (da) 2006-04-26 2012-07-23 Rosemont Pharmaceuticals Ltd Flydende orale sammensætninger
JP2009114121A (ja) * 2007-11-06 2009-05-28 Kaneka Corp シンバスタチンの製造方法
CN101704808A (zh) * 2009-11-20 2010-05-12 西南合成制药股份有限公司 制备他汀类化合物的内酯化方法
CN103172603B (zh) * 2011-12-22 2014-12-17 北大方正集团有限公司 一种高选择性酯化处理洛伐他汀酸的洛伐他汀提取方法
CN103172602B (zh) * 2011-12-22 2015-04-29 北大方正集团有限公司 一种纯化洛伐他汀的方法
CN102875505B (zh) * 2012-08-02 2015-08-05 丽珠集团新北江制药股份有限公司 一种美伐他汀的提取精制工艺

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588820A (en) 1984-06-11 1986-05-13 Merck & Co., Inc. Process for epimerization at C6 of 3,4,5,6-tetrahydro-2H-pyran-2-one
US4820850A (en) 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US4916239A (en) 1988-07-19 1990-04-10 Merck & Co., Inc. Process for the lactonization of mevinic acids and analogs thereof
US5159104A (en) * 1991-05-01 1992-10-27 Merck & Co., Inc. Process to simvastatin ester
US5393893A (en) * 1993-11-08 1995-02-28 Apotex, Inc. Process for producing simvastatin and analogs thereof
IN186880B (de) * 1997-10-28 2001-12-01 Ranbaxy Lab Ltd
ZA9810764B (en) * 1998-04-22 1999-08-13 Ranbaxy Lab Ltd An improved process of lactonization in the preparation of statins.
SI20072A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
JP2000106835A (ja) * 1998-09-30 2000-04-18 Gunze Ltd 紅麹及びその製造法
SI20527A (sl) * 1999-06-29 2001-10-31 Kaneka Corporation Postopek za selektivno laktonizacijo

Also Published As

Publication number Publication date
US6649775B2 (en) 2003-11-18
CN1193022C (zh) 2005-03-16
DE60226203T2 (de) 2009-05-14
JP2003096071A (ja) 2003-04-03
CN1406938A (zh) 2003-04-02
EP1288212A1 (de) 2003-03-05
KR100407758B1 (ko) 2003-12-01
ATE393151T1 (de) 2008-05-15
EP1288212B1 (de) 2008-04-23
KR20030018202A (ko) 2003-03-06
US20030050482A1 (en) 2003-03-13
WO2003018570A1 (en) 2003-03-06

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