ATE359272T1 - Verfahren zur herstellung von 3-hydroxy-n-1,6- - Google Patents
Verfahren zur herstellung von 3-hydroxy-n-1,6-Info
- Publication number
- ATE359272T1 ATE359272T1 AT02771927T AT02771927T ATE359272T1 AT E359272 T1 ATE359272 T1 AT E359272T1 AT 02771927 T AT02771927 T AT 02771927T AT 02771927 T AT02771927 T AT 02771927T AT E359272 T1 ATE359272 T1 AT E359272T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- oxo
- hydroxy
- dihydropyridine
- trialkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/40—Oxygen atoms attached in positions 3 and 4, e.g. maltol
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/985,269 US6426418B1 (en) | 2001-11-02 | 2001-11-02 | Processes for the manufacturing of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE359272T1 true ATE359272T1 (de) | 2007-05-15 |
Family
ID=25531334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02771927T ATE359272T1 (de) | 2001-11-02 | 2002-10-30 | Verfahren zur herstellung von 3-hydroxy-n-1,6- |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US6426418B1 (de) |
| EP (1) | EP1440061B1 (de) |
| KR (1) | KR20050056908A (de) |
| CN (1) | CN1282645C (de) |
| AT (1) | ATE359272T1 (de) |
| BR (1) | BR0213814A (de) |
| DE (1) | DE60219501D1 (de) |
| ES (1) | ES2284925T3 (de) |
| MX (1) | MXPA04004063A (de) |
| PL (1) | PL368722A1 (de) |
| WO (1) | WO2003037867A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6426418B1 (en) * | 2001-11-02 | 2002-07-30 | Apotex, Inc. | Processes for the manufacturing of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxamide |
| NZ529657A (en) * | 2003-11-20 | 2004-07-30 | Apotex Inc | Iron chelating cycloalkyl derivatives of 3-hydroxy-4-pyridinones |
| CA2488034C (en) * | 2004-11-19 | 2009-10-06 | Apotex Inc. | Process for the manufacture of 3-hydroxy-n-alkyl-1-cycloalkyl-6-alkyl-4-oxo-1,4-dihydropyridine-2-carboxamide and its related analogues |
| KR101695807B1 (ko) | 2008-07-25 | 2017-01-13 | 비이브 헬쓰케어 컴퍼니 | 화합물 |
| US8710249B2 (en) * | 2008-12-11 | 2014-04-29 | Shionogi & Co., Ltd. | Maltol ether processes and intermediates |
| US8624023B2 (en) | 2008-12-11 | 2014-01-07 | Shionogi & Co., Ltd. | Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates |
| ES2763540T3 (es) | 2008-12-11 | 2020-05-29 | Viiv Healthcare Co | Intermedios para inhibidores de la integrasa del VIH de carbamoilpiridona |
| TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Ｖｉｉｖ醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
| CN105153421B (zh) * | 2015-07-28 | 2017-10-13 | 辽宁石油化工大学 | 一种制备四甲基哌啶氮氧自由基聚合物方法 |
| CN105294413B (zh) * | 2015-09-17 | 2017-04-12 | 浙江工业大学 | 一种铁盐催化醇氧化制备醛/酮的方法 |
| EP3693373A4 (de) | 2017-10-06 | 2021-11-03 | Shionogi & Co., Ltd. | Verfahren zur stereoselektiven herstellung von substituierten polycyclischen pyridonderivaten |
| CN109438405B (zh) * | 2018-12-24 | 2023-04-07 | 广东莱佛士制药技术有限公司 | 一种3-(苄氧基)-4-氧代-4h-吡喃-2-羧酸的合成方法 |
| CN117279893A (zh) * | 2021-03-01 | 2023-12-22 | 奥仁公司 | 用于制备cyp11a1抑制剂及其中间体的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3468915A (en) | 1966-04-18 | 1969-09-23 | Pfizer & Co C | Novel 2-substituted-6-methylpyromeconic acids |
| GR78491B (de) | 1982-03-24 | 1984-09-27 | Nat Res Dev | |
| GB9217099D0 (en) | 1992-08-12 | 1992-09-23 | British Tech Group | Pharmaceutical compositions |
| PT768302E (pt) | 1995-09-29 | 2005-11-30 | Novartis Ag | Novas hidroxipiridinonas |
| GB9711093D0 (en) | 1997-05-29 | 1997-07-23 | British Tech Group | Novel orally active iron (III) chelators |
| CA2327890A1 (en) * | 1998-04-09 | 1999-10-21 | Merck & Co., Inc. | Oxidation process using tempo |
| US6426418B1 (en) * | 2001-11-02 | 2002-07-30 | Apotex, Inc. | Processes for the manufacturing of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxamide |
-
2001
- 2001-11-02 US US09/985,269 patent/US6426418B1/en not_active Expired - Fee Related
-
2002
- 2002-03-19 US US10/100,133 patent/US6472532B1/en not_active Expired - Fee Related
- 2002-03-19 US US10/100,107 patent/US6476229B1/en not_active Expired - Fee Related
- 2002-10-30 CN CNB028215672A patent/CN1282645C/zh not_active Expired - Fee Related
- 2002-10-30 MX MXPA04004063A patent/MXPA04004063A/es active IP Right Grant
- 2002-10-30 AT AT02771927T patent/ATE359272T1/de not_active IP Right Cessation
- 2002-10-30 DE DE60219501T patent/DE60219501D1/de not_active Expired - Lifetime
- 2002-10-30 KR KR1020047006656A patent/KR20050056908A/ko not_active Application Discontinuation
- 2002-10-30 WO PCT/CA2002/001623 patent/WO2003037867A1/en active IP Right Grant
- 2002-10-30 ES ES02771927T patent/ES2284925T3/es not_active Expired - Lifetime
- 2002-10-30 PL PL02368722A patent/PL368722A1/xx not_active Application Discontinuation
- 2002-10-30 EP EP02771927A patent/EP1440061B1/de not_active Expired - Lifetime
- 2002-10-30 BR BR0213814-0A patent/BR0213814A/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA04004063A (es) | 2004-07-08 |
| CN1282645C (zh) | 2006-11-01 |
| US6426418B1 (en) | 2002-07-30 |
| DE60219501D1 (de) | 2007-05-24 |
| KR20050056908A (ko) | 2005-06-16 |
| ES2284925T3 (es) | 2007-11-16 |
| EP1440061B1 (de) | 2007-04-11 |
| WO2003037867A1 (en) | 2003-05-08 |
| US6476229B1 (en) | 2002-11-05 |
| EP1440061A1 (de) | 2004-07-28 |
| PL368722A1 (en) | 2005-04-04 |
| CN1578769A (zh) | 2005-02-09 |
| US6472532B1 (en) | 2002-10-29 |
| BR0213814A (pt) | 2004-10-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE262488T1 (de) | Verfahren zur herstellung von silicoaluminophosphat-molekularsieben | |
| ATE353081T1 (de) | Verfahren zur herstellung von duloxetin und deren verwendeten zwischenprodukten | |
| DE60316688D1 (de) | Dehydrophenylahistine und analoge davon sowie ein verfahren zur herstellung von dehydrophenylahistinen und analogen davon | |
| ATE359272T1 (de) | Verfahren zur herstellung von 3-hydroxy-n-1,6- | |
| ATE422200T1 (de) | Verfahren zur herstellung substituierter nikotinsäureester | |
| DE60202203D1 (de) | Neues verfahren zur herstellung von oxabispidinen | |
| ATE521600T1 (de) | Verfahren zur herstellung von statinen | |
| ATE407127T1 (de) | Verfahren zur herstellung von beraprost und dessen salzen | |
| ATE457972T1 (de) | Verfahren zur herstellung von 7-amino-syn-3,5- dihydroxyheptansäurederivaten und zwischenverbindungen diesesverfahrens und deren herestellung | |
| DE60105441D1 (de) | Verfahren zur herstellung von pantoprazol und zwischenprodukte dieses verfahrens | |
| ATE266618T1 (de) | Verfahren zur herstellung von zwischenprodukten für pestizide | |
| DE60015563D1 (de) | Verfahren zur herstellung von benzoperhydroisoindolen | |
| ATE310735T1 (de) | Verfahren zur herstellung von spirocyclischen tetronsäurederivaten | |
| DE60107292D1 (de) | Verfahren zur herstellung von (+)-trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidin | |
| DE60104704D1 (de) | Verfahren zur herstellung einer substituierten imidazopyridinverbindung | |
| ATE363460T1 (de) | Verfahren zur herstellung von fluorhalogenalkanen | |
| ATE380171T1 (de) | Verfahren zur herstellung von terbinafine | |
| ATE299862T1 (de) | Verfahren zur herstellung von ketiminen | |
| DE60014103D1 (de) | Verfahren zur herstellung von debromohymenialdisin und deren analogen | |
| ATE244706T1 (de) | Enantiomere von mercaptolactonen und verfahren zu ihrer herstellung | |
| ATE387421T1 (de) | Verfahren zur herstellung von michael-addukten | |
| ATE301637T1 (de) | Verfahren zur herstellung von n-geschützten azetidin-2-carbonsäuren | |
| ATE240937T1 (de) | Gamma-oxohomophenylalanin derivate und ein verfahren zur herstellung von homophenylalanin derivaten durch reduktion derselben | |
| ATE260883T1 (de) | Verfahren zur herstellung von atropasäureethylester | |
| DE50311011D1 (de) | Verfahren zur herstellung von makrocyclischen ketonen durch dieckmann-kondensation in der gasphase |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |