BR0213814A - Processos para a fabricação de 3-hidroxi-n, 1,6-trialquil-4-oxo-1, 4-diidro piridino-2-carboxamida - Google Patents

Processos para a fabricação de 3-hidroxi-n, 1,6-trialquil-4-oxo-1, 4-diidro piridino-2-carboxamida

Info

Publication number
BR0213814A
BR0213814A BR0213814-0A BR0213814A BR0213814A BR 0213814 A BR0213814 A BR 0213814A BR 0213814 A BR0213814 A BR 0213814A BR 0213814 A BR0213814 A BR 0213814A
Authority
BR
Brazil
Prior art keywords
oxo
dihydropyridine
trialkyl
carboxamide
hydroxy
Prior art date
Application number
BR0213814-0A
Other languages
English (en)
Inventor
Tim Fat Tam
Wanren Li
Original Assignee
Apotex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apotex Inc filed Critical Apotex Inc
Publication of BR0213814A publication Critical patent/BR0213814A/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/40Oxygen atoms attached in positions 3 and 4, e.g. maltol

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

"PROCESSOS PARA A FABRICAçãO DE 3-HIDROXI-N,1,6-TRIALQUIL-4-OXO-1,4-DIIDRO PIRIDINO-2-CARBOXAMIDA". A presente invenção refere-se a um novo processo para a preparçaão de 3-hidroxi-N,1,6-trialquil-4-oxo-1,4-diidro piridino-2-carboxamida de fórmula I. O pr<0>Cesso compreende oxidação TEMPO de um álcool primário de 3-O-protegido-2-hidroxi metil-6-alquil-4H-piran-4-ona de fórmula III para ácido 6-alquil-4-oxo-4H-piran-2-carboxílico 3-O-protegido de fórmula II. Reação de composto de fórmula II com metilamina e 1,1-carbonil diimidazol em um solvente inerte proporciona N,1,6-trialquil-4-oxo-1,4-diidro piridino-2-carboxamida 3-O-protegida, que é desprotegida para render 3-hidroxi-N,1,6-trialquil-4-oxo-1,4-diidro piridino-2-carboxamida de fórmula I.
BR0213814-0A 2001-11-02 2002-10-30 Processos para a fabricação de 3-hidroxi-n, 1,6-trialquil-4-oxo-1, 4-diidro piridino-2-carboxamida BR0213814A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/985,269 US6426418B1 (en) 2001-11-02 2001-11-02 Processes for the manufacturing of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxamide
PCT/CA2002/001623 WO2003037867A1 (en) 2001-11-02 2002-10-30 Processes for the manufacturing of 3-hydroxy-n,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxamide

Publications (1)

Publication Number Publication Date
BR0213814A true BR0213814A (pt) 2004-10-19

Family

ID=25531334

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0213814-0A BR0213814A (pt) 2001-11-02 2002-10-30 Processos para a fabricação de 3-hidroxi-n, 1,6-trialquil-4-oxo-1, 4-diidro piridino-2-carboxamida

Country Status (11)

Country Link
US (3) US6426418B1 (pt)
EP (1) EP1440061B1 (pt)
KR (1) KR20050056908A (pt)
CN (1) CN1282645C (pt)
AT (1) ATE359272T1 (pt)
BR (1) BR0213814A (pt)
DE (1) DE60219501D1 (pt)
ES (1) ES2284925T3 (pt)
MX (1) MXPA04004063A (pt)
PL (1) PL368722A1 (pt)
WO (1) WO2003037867A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6426418B1 (en) * 2001-11-02 2002-07-30 Apotex, Inc. Processes for the manufacturing of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxamide
NZ529657A (en) * 2003-11-20 2004-07-30 Apotex Inc Iron chelating cycloalkyl derivatives of 3-hydroxy-4-pyridinones
CA2488034C (en) * 2004-11-19 2009-10-06 Apotex Inc. Process for the manufacture of 3-hydroxy-n-alkyl-1-cycloalkyl-6-alkyl-4-oxo-1,4-dihydropyridine-2-carboxamide and its related analogues
JP5586602B2 (ja) 2008-07-25 2014-09-10 ビーブ・ヘルスケア・カンパニー 化合物
AU2009325128B2 (en) 2008-12-11 2015-01-29 Shionogi & Co., Ltd. Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates
KR101682058B1 (ko) 2008-12-11 2016-12-02 비이브 헬쓰케어 컴퍼니 카르바모일피리돈 hiv 인테그라제 억제제를 위한 제조방법 및 중간체
JP5629268B2 (ja) * 2008-12-11 2014-11-19 塩野義製薬株式会社 マルトールエーテルの製造方法および中間体
TWI518084B (zh) 2009-03-26 2016-01-21 鹽野義製藥股份有限公司 哌喃酮與吡啶酮衍生物之製造方法
TWI582097B (zh) 2010-03-23 2017-05-11 Viiv醫療保健公司 製備胺甲醯吡啶酮衍生物及中間體之方法
CN105153421B (zh) * 2015-07-28 2017-10-13 辽宁石油化工大学 一种制备四甲基哌啶氮氧自由基聚合物方法
CN105294413B (zh) * 2015-09-17 2017-04-12 浙江工业大学 一种铁盐催化醇氧化制备醛/酮的方法
AR113748A1 (es) 2017-10-06 2020-06-10 Shionogi & Co Proceso estereoselectivo para preparar derivados de piridona policíclicos sustituidos
CN109438405B (zh) * 2018-12-24 2023-04-07 广东莱佛士制药技术有限公司 一种3-(苄氧基)-4-氧代-4h-吡喃-2-羧酸的合成方法
EP4301732A1 (en) * 2021-03-01 2024-01-10 Orion Corporation Process for the preparation of a cyp11a1 inhibitor and intermediates thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3468915A (en) 1966-04-18 1969-09-23 Pfizer & Co C Novel 2-substituted-6-methylpyromeconic acids
GR78491B (pt) 1982-03-24 1984-09-27 Nat Res Dev
GB9217099D0 (en) 1992-08-12 1992-09-23 British Tech Group Pharmaceutical compositions
DE59611243D1 (de) 1995-09-29 2005-08-11 Novartis Ag Hydroxypyridinone
GB9711093D0 (en) 1997-05-29 1997-07-23 British Tech Group Novel orally active iron (III) chelators
EP1070039A1 (en) * 1998-04-09 2001-01-24 Merck & Co., Inc. Oxidation process using tempo
US6426418B1 (en) * 2001-11-02 2002-07-30 Apotex, Inc. Processes for the manufacturing of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxamide

Also Published As

Publication number Publication date
CN1282645C (zh) 2006-11-01
EP1440061A1 (en) 2004-07-28
ES2284925T3 (es) 2007-11-16
EP1440061B1 (en) 2007-04-11
KR20050056908A (ko) 2005-06-16
MXPA04004063A (es) 2004-07-08
WO2003037867A1 (en) 2003-05-08
DE60219501D1 (de) 2007-05-24
CN1578769A (zh) 2005-02-09
US6426418B1 (en) 2002-07-30
US6476229B1 (en) 2002-11-05
US6472532B1 (en) 2002-10-29
ATE359272T1 (de) 2007-05-15
PL368722A1 (en) 2005-04-04

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B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]