ATE255103T1 - Verfahren zur herstellung von pyridinmethanol- verbindungen - Google Patents
Verfahren zur herstellung von pyridinmethanol- verbindungenInfo
- Publication number
- ATE255103T1 ATE255103T1 AT00962909T AT00962909T ATE255103T1 AT E255103 T1 ATE255103 T1 AT E255103T1 AT 00962909 T AT00962909 T AT 00962909T AT 00962909 T AT00962909 T AT 00962909T AT E255103 T1 ATE255103 T1 AT E255103T1
- Authority
- AT
- Austria
- Prior art keywords
- pyridine methanol
- producing pyridine
- methanol compounds
- compounds
- producing
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- VRWLBMGRSLQKSU-UHFFFAOYSA-N methanol;pyridine Chemical class OC.C1=CC=NC=C1 VRWLBMGRSLQKSU-UHFFFAOYSA-N 0.000 title 1
- -1 pyridinemethanol compound Chemical class 0.000 abstract 2
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 229910052987 metal hydride Inorganic materials 0.000 abstract 1
- 150000004681 metal hydrides Chemical class 0.000 abstract 1
- 229960001785 mirtazapine Drugs 0.000 abstract 1
- RONZAEMNMFQXRA-UHFFFAOYSA-N mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 abstract 1
- HJIGRHPMRXZAEJ-UHFFFAOYSA-M potassium;pyridine-2-carboxylate Chemical compound [K+].[O-]C(=O)C1=CC=CC=N1 HJIGRHPMRXZAEJ-UHFFFAOYSA-M 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP35351499 | 1999-12-13 | ||
| PCT/JP2000/005384 WO2001042239A1 (en) | 1999-12-13 | 2000-08-11 | Process for the preparation of a pyridinemethanol compound |
| PCT/JP2000/006688 WO2001042240A1 (fr) | 1999-12-13 | 2000-09-28 | Procede de preparation d'un compose pyridinemethanol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE255103T1 true ATE255103T1 (de) | 2003-12-15 |
Family
ID=18431365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00962909T ATE255103T1 (de) | 1999-12-13 | 2000-09-28 | Verfahren zur herstellung von pyridinmethanol- verbindungen |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6376668B1 (de) |
| EP (1) | EP1238977B2 (de) |
| JP (1) | JP3930736B2 (de) |
| AT (1) | ATE255103T1 (de) |
| AU (2) | AU6474200A (de) |
| CA (1) | CA2394439C (de) |
| DE (1) | DE60006857T3 (de) |
| DK (1) | DK1238977T4 (de) |
| ES (1) | ES2209985T5 (de) |
| IL (2) | IL150120A0 (de) |
| PT (1) | PT1238977E (de) |
| WO (2) | WO2001042239A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001080857A1 (en) * | 2000-04-24 | 2001-11-01 | Teva Pharmaceutical Industries Ltd. | Zolpidem hemitartrate |
| KR20030078086A (ko) | 2001-03-01 | 2003-10-04 | 테바 파마슈티컬 인더스트리즈 리미티드 | 미르타자핀 중간체의 제조방법 |
| CZ296992B6 (cs) * | 2002-10-03 | 2006-08-16 | Zentiva, A.S. | Príprava a izolace 2-substituovaných-3-pyridylkarboxylových kyselin, jejich karboxylových solí a produktu redukce |
| UA83666C2 (ru) | 2003-07-10 | 2008-08-11 | Н.В. Органон | Способ получения энантиомерно чистого миртазапина |
| US7838029B1 (en) | 2003-07-31 | 2010-11-23 | Watson Laboratories, Inc. | Mirtazapine solid dosage forms |
| TW200538100A (en) * | 2004-04-21 | 2005-12-01 | Akzo Nobel Nv | Mirtazapine salts |
| CA2684021A1 (en) | 2007-04-11 | 2008-10-23 | N.V. Organon | A method for the preparation of an enantiomer of a tetracyclic benzazepine |
| US20080255348A1 (en) * | 2007-04-11 | 2008-10-16 | N.V. Organon | Method for the preparation of an enantiomer of a tetracyclic benzazepine |
| WO2010046851A1 (en) * | 2008-10-22 | 2010-04-29 | Watson Pharma Private Limited | Process for the preparation of 1- ( 3-hydroxymethylpyrid-2 -yl ) -2 -phenyl-4-methylpiperazine and mirtazapine |
| JP6433809B2 (ja) * | 2015-02-20 | 2018-12-05 | 株式会社トクヤマ | １−（３−ヒドロキシメチルピリジル−２−）−２−フェニル−４−メチルピペラジンの製造方法 |
| RS62055B1 (sr) | 2015-02-27 | 2021-07-30 | Dechra Ltd | Stimulacija apetita, upravljanje gubitkom težine i lečenje anoreksije kod pasa i mačaka |
| JP6571497B2 (ja) * | 2015-11-13 | 2019-09-04 | 株式会社トクヤマ | ミルタザピンの製造方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL189199C (nl) | 1975-04-05 | 1993-02-01 | Akzo Nv | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
| US5196532A (en) * | 1989-02-08 | 1993-03-23 | Basf Aktiengesellschaft | Diaryl-substituted heterocyclic compounds, their preparation and drugs and cosmetics obtained therefrom |
| CN1679586A (zh) * | 1999-04-19 | 2005-10-12 | 特瓦制药工业有限公司 | 含哌嗪环化合物的新型合成和结晶方法 |
| HUP0200808A3 (en) * | 1999-04-19 | 2002-12-28 | Teva Pharma | Synthesis of piperazine ring and novel piperazine derivatives |
| JP3817424B2 (ja) † | 2000-12-28 | 2006-09-06 | キヤノン株式会社 | シート折り装置及びこれを備えた画像形成装置 |
-
2000
- 2000-08-11 WO PCT/JP2000/005384 patent/WO2001042239A1/ja not_active Ceased
- 2000-08-11 AU AU64742/00A patent/AU6474200A/en not_active Abandoned
- 2000-09-28 AT AT00962909T patent/ATE255103T1/de active
- 2000-09-28 PT PT00962909T patent/PT1238977E/pt unknown
- 2000-09-28 ES ES00962909T patent/ES2209985T5/es not_active Expired - Lifetime
- 2000-09-28 DK DK00962909.8T patent/DK1238977T4/da active
- 2000-09-28 WO PCT/JP2000/006688 patent/WO2001042240A1/ja not_active Ceased
- 2000-09-28 DE DE60006857T patent/DE60006857T3/de not_active Expired - Lifetime
- 2000-09-28 JP JP2001543539A patent/JP3930736B2/ja not_active Expired - Fee Related
- 2000-09-28 CA CA002394439A patent/CA2394439C/en not_active Expired - Fee Related
- 2000-09-28 EP EP00962909A patent/EP1238977B2/de not_active Expired - Lifetime
- 2000-09-28 AU AU74472/00A patent/AU771484B2/en not_active Ceased
- 2000-09-28 IL IL15012000A patent/IL150120A0/xx active IP Right Grant
- 2000-11-07 US US09/706,803 patent/US6376668B1/en not_active Expired - Fee Related
-
2001
- 2001-10-19 US US09/981,919 patent/US6437120B1/en not_active Expired - Fee Related
-
2002
- 2002-06-10 IL IL150120A patent/IL150120A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60006857T3 (de) | 2011-02-10 |
| IL150120A0 (en) | 2002-12-01 |
| US20020035255A1 (en) | 2002-03-21 |
| PT1238977E (pt) | 2004-03-31 |
| ES2209985T5 (es) | 2010-12-03 |
| EP1238977A1 (de) | 2002-09-11 |
| ES2209985T3 (es) | 2004-07-01 |
| EP1238977B2 (de) | 2010-07-21 |
| DK1238977T3 (da) | 2004-03-08 |
| AU771484B2 (en) | 2004-03-25 |
| US6376668B1 (en) | 2002-04-23 |
| JP3930736B2 (ja) | 2007-06-13 |
| US6437120B1 (en) | 2002-08-20 |
| DE60006857T2 (de) | 2004-08-26 |
| AU7447200A (en) | 2001-06-18 |
| IL150120A (en) | 2007-09-20 |
| EP1238977A4 (de) | 2003-02-12 |
| WO2001042239A1 (en) | 2001-06-14 |
| WO2001042240A1 (fr) | 2001-06-14 |
| CA2394439C (en) | 2007-09-11 |
| DE60006857D1 (de) | 2004-01-08 |
| DK1238977T4 (da) | 2010-10-11 |
| CA2394439A1 (en) | 2001-06-14 |
| EP1238977B1 (de) | 2003-11-26 |
| AU6474200A (en) | 2001-06-18 |
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