WO2006004100A8 - １，２－ジヒドロピリジン－２－オン化合物の製造方法 - Google Patents

１，２－ジヒドロピリジン－２－オン化合物の製造方法

Info

Publication number
WO2006004100A8
WO2006004100A8 PCT/JP2005/012364 JP2005012364W WO2006004100A8 WO 2006004100 A8 WO2006004100 A8 WO 2006004100A8 JP 2005012364 W JP2005012364 W JP 2005012364W WO 2006004100 A8 WO2006004100 A8 WO 2006004100A8
Authority
WO
WIPO (PCT)
Prior art keywords
ring
compound
optionally substituted
dihydropyridine
producing
Prior art date
Application number
PCT/JP2005/012364
Other languages
English (en)
French (fr)
Other versions
WO2006004100A1 (ja
Inventor
Akio Kayano
Katutoshi Nishiura
Original Assignee
Eisai Co Ltd
Akio Kayano
Katutoshi Nishiura
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35782900&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2006004100(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to AU2005258378A priority Critical patent/AU2005258378B2/en
Priority to KR1020067027447A priority patent/KR101187218B1/ko
Priority to AT05758231T priority patent/ATE547405T1/de
Priority to EP05758231A priority patent/EP1772450B1/en
Priority to CA2570177A priority patent/CA2570177C/en
Priority to PL05758231T priority patent/PL1772450T3/pl
Application filed by Eisai Co Ltd, Akio Kayano, Katutoshi Nishiura filed Critical Eisai Co Ltd
Priority to JP2006528897A priority patent/JP5030206B2/ja
Priority to SI200531518T priority patent/SI1772450T1/sl
Publication of WO2006004100A1 publication Critical patent/WO2006004100A1/ja
Publication of WO2006004100A8 publication Critical patent/WO2006004100A8/ja
Priority to IL180151A priority patent/IL180151A/en
Priority to US11/649,299 priority patent/US8304548B2/en
Priority to US12/870,507 priority patent/US8772497B2/en
Priority to US14/165,365 priority patent/US9045426B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
PCT/JP2005/012364 2004-07-06 2005-07-05 １，２－ジヒドロピリジン－２－オン化合物の製造方法 WO2006004100A1 (ja)

Priority Applications (12)

Application Number Priority Date Filing Date Title
SI200531518T SI1772450T1 (sl) 2004-07-06 2005-07-05 Postopek izdelave spojine 1,2-dihidropiridin-2-on
PL05758231T PL1772450T3 (pl) 2004-07-06 2005-07-05 Sposób wytwarzania związku 1,2-dihydropirydyn-2-onu
KR1020067027447A KR101187218B1 (ko) 2004-07-06 2005-07-05 1,2-디하이드로피리딘-2-온 화합물의 제조 방법
AT05758231T ATE547405T1 (de) 2004-07-06 2005-07-05 Verfahren zur herstellung einer 1,2- dihydropyridin-2-onverbindung
EP05758231A EP1772450B1 (en) 2004-07-06 2005-07-05 Method for producing 1,2-dihydropyridine-2-one compound
CA2570177A CA2570177C (en) 2004-07-06 2005-07-05 Method for producing 1,2-dihydropyridine-2-one compound
JP2006528897A JP5030206B2 (ja) 2004-07-06 2005-07-05 １，２−ジヒドロピリジン−２−オン化合物の製造方法
AU2005258378A AU2005258378B2 (en) 2004-07-06 2005-07-05 Method for producing 1,2-dihydropyridine-2-one compound
IL180151A IL180151A (en) 2004-07-06 2006-12-18 Method for the production of a compound of 2,1-dihydropyridin-2-one
US11/649,299 US8304548B2 (en) 2004-07-06 2007-01-04 Method for producing 1, 2-dihydropyridine-2-one compound
US12/870,507 US8772497B2 (en) 2004-07-06 2010-08-27 Method for producing 1, 2-dihydropyridine-2-one compound
US14/165,365 US9045426B2 (en) 2004-07-06 2014-01-27 Method for producing 1,2-dihydropyridine-2-one compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004-198709 2004-07-06
JP2004198709 2004-07-06

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2005/012388 Continuation-In-Part WO2006004107A1 (ja) 2004-07-06 2005-07-05 １，２－ジヒドロピリジン化合物の結晶およびその製造方法

Related Child Applications (2)

Application Number Title Priority Date Filing Date
PCT/JP2005/012388 Continuation-In-Part WO2006004107A1 (ja) 2004-07-06 2005-07-05 １，２－ジヒドロピリジン化合物の結晶およびその製造方法
US11/649,299 Continuation-In-Part US8304548B2 (en) 2004-07-06 2007-01-04 Method for producing 1, 2-dihydropyridine-2-one compound

Publications (2)

Publication Number Publication Date
WO2006004100A1 WO2006004100A1 (ja) 2006-01-12
WO2006004100A8 true WO2006004100A8 (ja) 2006-02-23

Family

ID=35782900

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/JP2005/012364 WO2006004100A1 (ja) 2004-07-06 2005-07-05 １，２－ジヒドロピリジン－２－オン化合物の製造方法
PCT/JP2005/012388 WO2006004107A1 (ja) 2004-07-06 2005-07-05 １，２－ジヒドロピリジン化合物の結晶およびその製造方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/JP2005/012388 WO2006004107A1 (ja) 2004-07-06 2005-07-05 １，２－ジヒドロピリジン化合物の結晶およびその製造方法

Country Status (29)

Country Link
US (3) US8304548B2 (ja)
EP (3) EP1772450B1 (ja)
JP (3) JP5030206B2 (ja)
KR (2) KR101187218B1 (ja)
CN (7) CN104402808A (ja)
AT (1) ATE547405T1 (ja)
AU (2) AU2005258378B2 (ja)
BR (1) BRPI0510254B8 (ja)
CA (2) CA2561829C (ja)
CY (1) CY1114313T1 (ja)
DK (1) DK1764361T3 (ja)
ES (1) ES2404697T3 (ja)
HK (2) HK1102127A1 (ja)
HR (1) HRP20130363T1 (ja)
IL (2) IL180024A (ja)
JO (1) JO2832B1 (ja)
ME (1) ME01520B (ja)
MX (1) MXPA06014458A (ja)
MY (1) MY148809A (ja)
NO (1) NO339101B1 (ja)
NZ (1) NZ550720A (ja)
PL (2) PL1764361T3 (ja)
PT (1) PT1764361E (ja)
RS (1) RS52752B (ja)
RU (1) RU2323930C1 (ja)
SI (2) SI1772450T1 (ja)
TW (1) TW200606144A (ja)
WO (2) WO2006004100A1 (ja)
ZA (1) ZA200609274B (ja)

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CA2634056C (en) 2005-12-21 2014-06-10 Eisai R&D Management Co., Ltd. Amorphous form of 1,2-dihydropyridine compound
WO2007126060A1 (ja) 2006-04-28 2007-11-08 Eisai R & D Management Co., Ltd １，２－ジヒドロピリジン化合物の塩
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CN104649962A (zh) * 2013-11-25 2015-05-27 天津市汉康医药生物技术有限公司 吡仑帕奈倍半水合物化合物
CN103664756A (zh) * 2013-11-26 2014-03-26 苏州晶云药物科技有限公司 吡仑帕奈新晶型a及其制备方法
CN104706604A (zh) * 2013-12-12 2015-06-17 北京星昊医药股份有限公司 一种吡仑帕奈冻干口崩片及其制备方法
CN110452216B (zh) 2014-04-02 2022-08-26 英特穆恩公司 抗纤维化吡啶酮类
CN105085382B (zh) * 2014-05-14 2019-10-18 江苏豪森药业集团有限公司 吡仑帕奈异构体晶型及其制备方法和用途
CN103980188B (zh) * 2014-05-30 2016-01-27 浙江永宁药业股份有限公司 一种吡仑帕奈的合成方法及其中间体和中间体的合成方法
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CN105906557A (zh) * 2016-03-30 2016-08-31 北京万全德众医药生物技术有限公司 2-甲氧基-5-（吡啶-2-基）吡啶的一种合成方法
CN106389367B (zh) * 2016-11-16 2020-12-18 杭州朱养心药业有限公司 吡仑帕奈包衣片剂药物组合物
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Also Published As

Publication number Publication date
PL1772450T3 (pl) 2012-07-31
CA2561829A1 (en) 2006-01-12
RU2323930C1 (ru) 2008-05-10
EP2586771A2 (en) 2013-05-01
CN1984890A (zh) 2007-06-20
PL1764361T3 (pl) 2013-06-28
NO339101B1 (no) 2016-11-14
IL180024A (en) 2011-09-27
EP1772450A1 (en) 2007-04-11
AU2005258385A1 (en) 2006-01-12
CN101544599A (zh) 2009-09-30
BRPI0510254B1 (pt) 2019-10-29
AU2005258378A1 (en) 2006-01-12
HK1102127A1 (ja) 2007-11-09
CN1942443A (zh) 2007-04-04
CA2570177A1 (en) 2006-01-12
CN101544599B (zh) 2012-06-06
IL180151A (en) 2012-01-31
DK1764361T3 (da) 2013-05-06
AU2005258385B2 (en) 2009-11-05
EP1772450A4 (en) 2009-06-10
IL180024A0 (en) 2007-05-15
WO2006004107A1 (ja) 2006-01-12
JP2012021029A (ja) 2012-02-02
AU2005258378B2 (en) 2011-04-28
JPWO2006004100A1 (ja) 2008-04-24
EP1772450B1 (en) 2012-02-29
KR101187218B1 (ko) 2012-10-02
NO20065754L (no) 2007-04-04
CA2570177C (en) 2012-11-20
US20100324297A1 (en) 2010-12-23
NZ550720A (en) 2009-10-30
BRPI0510254B8 (pt) 2021-05-25
US9045426B2 (en) 2015-06-02
KR20070028459A (ko) 2007-03-12
ZA200609274B (en) 2008-06-25
CN102382047A (zh) 2012-03-21
PT1764361E (pt) 2013-04-23
JP5030206B2 (ja) 2012-09-19
JP5419944B2 (ja) 2014-02-19
CN1942443B (zh) 2012-05-09
HK1104999A1 (ja) 2008-02-01
JPWO2006004107A1 (ja) 2008-04-24
TW200606144A (en) 2006-02-16
CN101914057A (zh) 2010-12-15
EP1764361B1 (en) 2013-01-30
KR20070008617A (ko) 2007-01-17
US8772497B2 (en) 2014-07-08
CA2561829C (en) 2009-11-24
MY148809A (en) 2013-05-31
US20070142640A1 (en) 2007-06-21
US20140142315A1 (en) 2014-05-22
TWI346660B (ja) 2011-08-11
CY1114313T1 (el) 2016-08-31
CN102382047B (zh) 2014-04-23
US8304548B2 (en) 2012-11-06
BRPI0510254A (pt) 2007-10-23
SI1772450T1 (sl) 2012-06-29
CN104402807A (zh) 2015-03-11
RS52752B (en) 2013-08-30
ES2404697T3 (es) 2013-05-28
SI1764361T1 (sl) 2013-07-31
ME01520B (me) 2014-04-20
IL180151A0 (en) 2007-06-03
HRP20130363T1 (en) 2013-05-31
MXPA06014458A (es) 2007-03-01
KR100939743B1 (ko) 2010-02-04
EP2586771A3 (en) 2013-07-31
CN101914057B (zh) 2012-07-04
ATE547405T1 (de) 2012-03-15
EP1764361A4 (en) 2012-05-30
WO2006004100A1 (ja) 2006-01-12
JO2832B1 (en) 2014-09-15
EP1764361A1 (en) 2007-03-21
CN104402808A (zh) 2015-03-11

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