WO2006021559A8 - Verfahren zur herstellung von tiotropiumsalzen und silicium-derivate als zwischenprodukte - Google Patents
Verfahren zur herstellung von tiotropiumsalzen und silicium-derivate als zwischenprodukteInfo
- Publication number
- WO2006021559A8 WO2006021559A8 PCT/EP2005/054131 EP2005054131W WO2006021559A8 WO 2006021559 A8 WO2006021559 A8 WO 2006021559A8 EP 2005054131 W EP2005054131 W EP 2005054131W WO 2006021559 A8 WO2006021559 A8 WO 2006021559A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- intermediates
- tiotropium salts
- silicon derivatives
- producing tiotropium
- producing
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical class O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 1
- -1 silyl compound Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05801688A EP1794158A2 (de) | 2004-08-26 | 2005-08-23 | Verfahren zur herstellung von tiotropiumsalzen und silicium-derivate als zwischenprodukte |
NZ553840A NZ553840A (en) | 2004-08-26 | 2005-08-23 | Novel method for producing tiotropium salts |
BRPI0514643-7A BRPI0514643A (pt) | 2004-08-26 | 2005-08-23 | processo para a produção de sais de tiotrópio |
CA2573373A CA2573373C (en) | 2004-08-26 | 2005-08-23 | Method for producing tiotropium salts and silicon derivatives as intermediates |
JP2007528841A JP5173421B2 (ja) | 2004-08-26 | 2005-08-23 | チオトロピウム塩の新規な製造方法 |
AU2005276432A AU2005276432B2 (en) | 2004-08-26 | 2005-08-23 | Method for producing tiotropium salts and silicon derivatives as intermediates |
KR1020077006836A KR101274455B1 (ko) | 2004-08-26 | 2005-08-23 | 티오트로퓸 염의 신규한 제조방법 |
IL181522A IL181522A (en) | 2004-08-26 | 2007-02-22 | Method for producing tiotropium salts |
IL213720A IL213720A (en) | 2004-08-26 | 2011-06-22 | Tiotropium salts |
IL213717A IL213717A0 (en) | 2004-08-26 | 2011-06-22 | Novel method for producing tiotropium salts |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004041253.7 | 2004-08-26 | ||
DE102004041253A DE102004041253A1 (de) | 2004-08-26 | 2004-08-26 | Neues Verfahren zur Herstellung von Tiotropiumsalzen |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2006021559A2 WO2006021559A2 (de) | 2006-03-02 |
WO2006021559A3 WO2006021559A3 (de) | 2006-08-17 |
WO2006021559A8 true WO2006021559A8 (de) | 2006-11-16 |
Family
ID=35745545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2005/054131 WO2006021559A2 (de) | 2004-08-26 | 2005-08-23 | Verfahren zur herstellung von tiotropiumsalzen und silicium-derivate als zwischenprodukte |
Country Status (16)
Country | Link |
---|---|
US (2) | US7491824B2 (de) |
EP (1) | EP1794158A2 (de) |
JP (1) | JP5173421B2 (de) |
KR (1) | KR101274455B1 (de) |
CN (1) | CN100532382C (de) |
AR (1) | AR050714A1 (de) |
AU (1) | AU2005276432B2 (de) |
BR (1) | BRPI0514643A (de) |
CA (1) | CA2573373C (de) |
DE (1) | DE102004041253A1 (de) |
IL (3) | IL181522A (de) |
NZ (1) | NZ553840A (de) |
RU (1) | RU2384575C2 (de) |
TW (2) | TWI429646B (de) |
WO (1) | WO2006021559A2 (de) |
ZA (1) | ZA200610503B (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20050485A1 (es) * | 2003-11-03 | 2005-10-05 | Boehringer Ingelheim Int | Nuevas sales de tiotropio, procedimiento para su preparacion, asi como formulaciones medicamentosas que las contienen |
CN100549010C (zh) * | 2003-11-03 | 2009-10-14 | 贝林格尔.英格海姆国际有限公司 | 制备噻托铵盐类的方法,噻托铵盐类及含有该盐类的医药制剂 |
CA2606549A1 (en) * | 2005-05-02 | 2006-11-09 | Boehringer Ingelheim International Gmbh | Crystalline forms of tiotropium bromide |
EP1896026B1 (de) * | 2005-06-15 | 2013-10-09 | Boehringer Ingelheim International GmbH | Verfahren zur herstellung von tiotropium salzen, tiotropium salze und pharmazeutische mischungen |
DE102005035112A1 (de) * | 2005-07-27 | 2007-02-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen |
US20080051582A1 (en) * | 2006-07-10 | 2008-02-28 | Sicor Inc. | Process for the preparation of tiotropium bromide |
TR201007108A2 (tr) * | 2010-08-25 | 2012-03-21 | B�Lg�� Mahmut | Yeni tiotropyum bromür kristali ve üretim yöntemi.@ |
US9707375B2 (en) | 2011-03-14 | 2017-07-18 | Rochester Medical Corporation, a subsidiary of C. R. Bard, Inc. | Catheter grip and method |
ITRM20110508A1 (it) | 2011-09-27 | 2013-03-28 | Lusochimica Spa | Processo per la preparazione degli esteri della scopina. |
US8680297B2 (en) | 2011-10-06 | 2014-03-25 | Drug Process Licensing Assoc., LLC | Manufacturing process for tiotropium bromide |
CZ304808B6 (cs) | 2012-03-16 | 2014-11-05 | Zentiva, K.S. | Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu a jeho nová forma |
CZ305012B6 (cs) | 2012-03-30 | 2015-03-25 | Zentiva, K.S. | Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu |
JP6473738B2 (ja) | 2013-04-01 | 2019-02-20 | パルマトリックス,インコーポレイテッド | チオトロピウム乾燥粉末 |
WO2019129801A1 (en) | 2017-12-28 | 2019-07-04 | Linnea S.A. | Process for the purification of methyl-2,2-dithienylglycolate |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ220791A (en) * | 1986-06-27 | 1990-08-28 | Marion Laboratories Inc | 1-phenyl-7-aminohept-5-yn-2-one derivatives |
DE4108393A1 (de) * | 1991-03-15 | 1992-09-17 | Boehringer Ingelheim Kg | Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln |
US5554120A (en) * | 1994-07-25 | 1996-09-10 | Advanced Cardiovascular Systems, Inc. | Polymer blends for use in making medical devices including catheters and balloons for dilatation catheters |
DE10200943A1 (de) * | 2002-01-12 | 2003-07-24 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Scopinestern |
-
2004
- 2004-08-26 DE DE102004041253A patent/DE102004041253A1/de not_active Withdrawn
-
2005
- 2005-08-23 EP EP05801688A patent/EP1794158A2/de not_active Ceased
- 2005-08-23 RU RU2007110951/04A patent/RU2384575C2/ru not_active IP Right Cessation
- 2005-08-23 NZ NZ553840A patent/NZ553840A/en not_active IP Right Cessation
- 2005-08-23 CA CA2573373A patent/CA2573373C/en not_active Expired - Fee Related
- 2005-08-23 WO PCT/EP2005/054131 patent/WO2006021559A2/de active Application Filing
- 2005-08-23 AU AU2005276432A patent/AU2005276432B2/en not_active Ceased
- 2005-08-23 JP JP2007528841A patent/JP5173421B2/ja not_active Expired - Fee Related
- 2005-08-23 US US11/209,323 patent/US7491824B2/en not_active Expired - Fee Related
- 2005-08-23 CN CNB2005800272058A patent/CN100532382C/zh not_active Expired - Fee Related
- 2005-08-23 KR KR1020077006836A patent/KR101274455B1/ko not_active IP Right Cessation
- 2005-08-23 BR BRPI0514643-7A patent/BRPI0514643A/pt not_active Application Discontinuation
- 2005-08-25 TW TW101111178A patent/TWI429646B/zh not_active IP Right Cessation
- 2005-08-25 TW TW094129119A patent/TWI387595B/zh not_active IP Right Cessation
- 2005-08-26 AR ARP050103567A patent/AR050714A1/es unknown
-
2006
- 2006-12-14 ZA ZA200610503A patent/ZA200610503B/xx unknown
-
2007
- 2007-02-22 IL IL181522A patent/IL181522A/en not_active IP Right Cessation
-
2009
- 2009-01-05 US US12/348,481 patent/US8008495B2/en not_active Expired - Fee Related
-
2011
- 2011-06-22 IL IL213717A patent/IL213717A0/en not_active IP Right Cessation
- 2011-06-22 IL IL213720A patent/IL213720A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
TW201231466A (en) | 2012-08-01 |
IL181522A (en) | 2011-08-31 |
JP2008510774A (ja) | 2008-04-10 |
ZA200610503B (en) | 2008-09-25 |
CA2573373C (en) | 2014-05-06 |
RU2384575C2 (ru) | 2010-03-20 |
BRPI0514643A (pt) | 2008-06-17 |
TWI387595B (zh) | 2013-03-01 |
US20090118511A1 (en) | 2009-05-07 |
JP5173421B2 (ja) | 2013-04-03 |
IL181522A0 (en) | 2007-07-04 |
IL213720A0 (en) | 2011-07-31 |
EP1794158A2 (de) | 2007-06-13 |
TW200617006A (en) | 2006-06-01 |
AR050714A1 (es) | 2006-11-15 |
US7491824B2 (en) | 2009-02-17 |
WO2006021559A3 (de) | 2006-08-17 |
IL213720A (en) | 2012-03-29 |
WO2006021559A2 (de) | 2006-03-02 |
US8008495B2 (en) | 2011-08-30 |
CN101001855A (zh) | 2007-07-18 |
TWI429646B (zh) | 2014-03-11 |
IL213717A0 (en) | 2011-07-31 |
DE102004041253A1 (de) | 2006-03-02 |
KR20070046196A (ko) | 2007-05-02 |
NZ553840A (en) | 2010-06-25 |
KR101274455B1 (ko) | 2013-06-18 |
CN100532382C (zh) | 2009-08-26 |
RU2007110951A (ru) | 2008-10-10 |
AU2005276432B2 (en) | 2011-11-10 |
US20060047120A1 (en) | 2006-03-02 |
CA2573373A1 (en) | 2006-03-02 |
AU2005276432A1 (en) | 2006-03-02 |
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