TR201007108A2 - Yeni tiotropyum bromür kristali ve üretim yöntemi.@ - Google Patents

Yeni tiotropyum bromür kristali ve üretim yöntemi.@

Info

Publication number
TR201007108A2
TR201007108A2 TR2010/07108A TR201007108A TR201007108A2 TR 201007108 A2 TR201007108 A2 TR 201007108A2 TR 2010/07108 A TR2010/07108 A TR 2010/07108A TR 201007108 A TR201007108 A TR 201007108A TR 201007108 A2 TR201007108 A2 TR 201007108A2
Authority
TR
Turkey
Prior art keywords
production method
tiotropium bromide
bromide crystal
new tiotropium
new
Prior art date
Application number
TR2010/07108A
Other languages
English (en)
Inventor
B�Lg�� Mahmut
Original Assignee
B�Lg�� Mahmut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by B�Lg�� Mahmut filed Critical B�Lg�� Mahmut
Priority to TR2010/07108A priority Critical patent/TR201007108A2/tr
Priority to PCT/TR2011/000196 priority patent/WO2012026906A1/en
Priority to EP11773329.5A priority patent/EP2609096A1/en
Publication of TR201007108A2 publication Critical patent/TR201007108A2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Abstract

Mevcut buluş, (la, 2p, 4p, 5a, 7|3)-7-[(hidroksidi-2-tienilasetil)oksi]-9,9-dim til-3-oksa-9-azoniatrisiklo[3.3.1.0 ^"^İnonan-bromid'in yeni bir kristal formuna ve bu kristal formu imal etmeye yönelik yeni bir yöntem ile ilgilidir.
TR2010/07108A 2010-08-25 2010-08-25 Yeni tiotropyum bromür kristali ve üretim yöntemi.@ TR201007108A2 (tr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
TR2010/07108A TR201007108A2 (tr) 2010-08-25 2010-08-25 Yeni tiotropyum bromür kristali ve üretim yöntemi.@
PCT/TR2011/000196 WO2012026906A1 (en) 2010-08-25 2011-08-23 New tiotropium bromide crystal and its production method
EP11773329.5A EP2609096A1 (en) 2010-08-25 2011-08-23 New tiotropium bromide crystal and its production method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TR2010/07108A TR201007108A2 (tr) 2010-08-25 2010-08-25 Yeni tiotropyum bromür kristali ve üretim yöntemi.@

Publications (1)

Publication Number Publication Date
TR201007108A2 true TR201007108A2 (tr) 2012-03-21

Family

ID=44903330

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2010/07108A TR201007108A2 (tr) 2010-08-25 2010-08-25 Yeni tiotropyum bromür kristali ve üretim yöntemi.@

Country Status (3)

Country Link
EP (1) EP2609096A1 (tr)
TR (1) TR201007108A2 (tr)
WO (1) WO2012026906A1 (tr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
TR201111589A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür susuz kristal formu.
EP2897955B1 (en) * 2012-09-11 2019-11-06 Bilgic, Mahmut New tiotropium bromide crystalline form
CN104341413A (zh) * 2013-07-29 2015-02-11 天津金耀集团有限公司 一种无水噻托溴铵的新晶型
CN104341412A (zh) * 2013-07-29 2015-02-11 天津金耀集团有限公司 一种无水噻托溴铵结晶的制备方法
EP3414243A1 (en) * 2016-02-11 2018-12-19 Sima Patent Ve Lisanslama Hizmetleri Ltd. STI Crystalline form of tiotropium bromide anhydrate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
ME00412B (me) * 2001-06-22 2011-10-10 Boehringer Ingelheim Pharma Kristalni antiholinergik , postupak za njegovo pripremanje i njegova primjena u proizvodnji lijeka
DE102004041253A1 (de) * 2004-08-26 2006-03-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen
CN1271073C (zh) * 2004-10-26 2006-08-23 江苏正大天晴药业股份有限公司 结晶性抗胆碱能药噻托溴铵晶体
AU2006243239A1 (en) * 2005-05-02 2006-11-09 Boehringer Ingelheim International Gmbh Crystalline forms of tiotropium bromide
CN101166738B (zh) * 2005-05-02 2011-06-01 贝林格尔·英格海姆国际有限公司 噻托溴铵的新晶型

Also Published As

Publication number Publication date
EP2609096A1 (en) 2013-07-03
WO2012026906A1 (en) 2012-03-01

Similar Documents

Publication Publication Date Title
TR201007108A2 (tr) Yeni tiotropyum bromür kristali ve üretim yöntemi.@
MA35898B1 (fr) Anticorps anti-lrp5 et leurs procédés d&#39;utilisation
FR2981643B1 (fr) Procede de preparation d&#39;un materiau composite silicium/carbone, materiau ainsi prepare, et electrode notamment electrode negative, comprenant ce materiau.
MA37538A2 (fr) Anticorps et immunoconjugués anti-ly6e et procédés d&#39;utilisation
MA35712B1 (fr) Anticorps anti-htra1 et leurs procédés d&#39;utilisation
AU332502S (en) Cloth
MY178142A (en) Anti-phf-tau antibodies and their uses
EA201890942A1 (ru) Мультивалентные вакцины с синтетическими наноносителями
MX2012010488A (es) Formula infantil para el optimo crecimiento, proteccion gastrointestinal y proteccion inmunologica de infantes.
FI20125353A (fi) Turverakenteet
BR112015008824A2 (pt) linhagens melhoradas de microalgas e processo das mesmas
IN2014KN00892A (tr)
AU348239S (en) Starfish nightlight
IN2014KN02745A (tr)
FR2972572B1 (fr) Procede de preparation d&#39;une electrode a air, ladite electrode ainsi obtenue et ses utilisations
IN2014KN00893A (tr)
MX361998B (es) Procedimiento de preparacion de derivados de acido 4-haloalquil-3-mercapto-2 sustituido-hidroxibenzoico.
TR201002520A2 (tr) Tiotropyum bromür imalat metodu.
TR201111589A2 (tr) Tiotropyum bromür susuz kristal formu.
WO2014009204A8 (de) Oxasilacyclen und verfahren zu deren herstellung
TR201005222A2 (tr) Tiotropyum bromür sentez yöntemi
RU2012144245A (ru) Способ получения 1-(адамантил-1)-пиридиний бромида
RU2011119424A (ru) Поли-n,n-диаллиласпарагиновая кислота
RU2011151198A (ru) Масса для изготовления облицовочной плитки
UA69411U (en) Piece of clothing omophorion