WO2006021559A3 - Verfahren zur herstellung von tiotropiumsalzen und silicium-derivate als zwischenprodukte - Google Patents

Verfahren zur herstellung von tiotropiumsalzen und silicium-derivate als zwischenprodukte Download PDF

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Publication number
WO2006021559A3
WO2006021559A3 PCT/EP2005/054131 EP2005054131W WO2006021559A3 WO 2006021559 A3 WO2006021559 A3 WO 2006021559A3 EP 2005054131 W EP2005054131 W EP 2005054131W WO 2006021559 A3 WO2006021559 A3 WO 2006021559A3
Authority
WO
WIPO (PCT)
Prior art keywords
intermediates
tiotropium salts
silicon derivatives
producing tiotropium
producing
Prior art date
Application number
PCT/EP2005/054131
Other languages
English (en)
French (fr)
Other versions
WO2006021559A2 (de
WO2006021559A8 (de
Inventor
Werner Belzer
Rainer Hamm
Monika Hofmann
Ralf Lock
Original Assignee
Boehringer Ingelheim Pharma
Werner Belzer
Rainer Hamm
Monika Hofmann
Ralf Lock
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35745545&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2006021559(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to JP2007528841A priority Critical patent/JP5173421B2/ja
Priority to BRPI0514643-7A priority patent/BRPI0514643A/pt
Priority to AU2005276432A priority patent/AU2005276432B2/en
Priority to NZ553840A priority patent/NZ553840A/en
Priority to KR1020077006836A priority patent/KR101274455B1/ko
Application filed by Boehringer Ingelheim Pharma, Werner Belzer, Rainer Hamm, Monika Hofmann, Ralf Lock filed Critical Boehringer Ingelheim Pharma
Priority to CA2573373A priority patent/CA2573373C/en
Priority to EP05801688A priority patent/EP1794158A2/de
Publication of WO2006021559A2 publication Critical patent/WO2006021559A2/de
Publication of WO2006021559A3 publication Critical patent/WO2006021559A3/de
Publication of WO2006021559A8 publication Critical patent/WO2006021559A8/de
Priority to IL181522A priority patent/IL181522A/en
Priority to IL213720A priority patent/IL213720A/en
Priority to IL213717A priority patent/IL213717A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Die Erfindung betrifft ein neues Verfahren zur Herstellung von Tiotropiumsalzen der allgemeinen Formel (1) über die entsprechende Silylverbindung worin X- die in den Ansprüchen und in der Beschreibung genannten Bedeutungen haben kann.
PCT/EP2005/054131 2004-08-26 2005-08-23 Verfahren zur herstellung von tiotropiumsalzen und silicium-derivate als zwischenprodukte WO2006021559A2 (de)

Priority Applications (10)

Application Number Priority Date Filing Date Title
EP05801688A EP1794158A2 (de) 2004-08-26 2005-08-23 Verfahren zur herstellung von tiotropiumsalzen und silicium-derivate als zwischenprodukte
BRPI0514643-7A BRPI0514643A (pt) 2004-08-26 2005-08-23 processo para a produção de sais de tiotrópio
AU2005276432A AU2005276432B2 (en) 2004-08-26 2005-08-23 Method for producing tiotropium salts and silicon derivatives as intermediates
NZ553840A NZ553840A (en) 2004-08-26 2005-08-23 Novel method for producing tiotropium salts
KR1020077006836A KR101274455B1 (ko) 2004-08-26 2005-08-23 티오트로퓸 염의 신규한 제조방법
JP2007528841A JP5173421B2 (ja) 2004-08-26 2005-08-23 チオトロピウム塩の新規な製造方法
CA2573373A CA2573373C (en) 2004-08-26 2005-08-23 Method for producing tiotropium salts and silicon derivatives as intermediates
IL181522A IL181522A (en) 2004-08-26 2007-02-22 Method for producing tiotropium salts
IL213717A IL213717A0 (en) 2004-08-26 2011-06-22 Novel method for producing tiotropium salts
IL213720A IL213720A (en) 2004-08-26 2011-06-22 Tiotropium salts

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004041253.7 2004-08-26
DE102004041253A DE102004041253A1 (de) 2004-08-26 2004-08-26 Neues Verfahren zur Herstellung von Tiotropiumsalzen

Publications (3)

Publication Number Publication Date
WO2006021559A2 WO2006021559A2 (de) 2006-03-02
WO2006021559A3 true WO2006021559A3 (de) 2006-08-17
WO2006021559A8 WO2006021559A8 (de) 2006-11-16

Family

ID=35745545

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/054131 WO2006021559A2 (de) 2004-08-26 2005-08-23 Verfahren zur herstellung von tiotropiumsalzen und silicium-derivate als zwischenprodukte

Country Status (16)

Country Link
US (2) US7491824B2 (de)
EP (1) EP1794158A2 (de)
JP (1) JP5173421B2 (de)
KR (1) KR101274455B1 (de)
CN (1) CN100532382C (de)
AR (1) AR050714A1 (de)
AU (1) AU2005276432B2 (de)
BR (1) BRPI0514643A (de)
CA (1) CA2573373C (de)
DE (1) DE102004041253A1 (de)
IL (3) IL181522A (de)
NZ (1) NZ553840A (de)
RU (1) RU2384575C2 (de)
TW (2) TWI387595B (de)
WO (1) WO2006021559A2 (de)
ZA (1) ZA200610503B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2083007B1 (de) * 2003-11-03 2013-04-24 Boehringer Ingelheim International Gmbh Tiotropiumsalze, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittelformulierungen
DK1682541T3 (da) * 2003-11-03 2010-06-28 Boehringer Ingelheim Int Fremgangsmåde til fremstilling af tiotropiumsalte
NZ563596A (en) * 2005-05-02 2011-01-28 Boehringer Ingelheim Int Crystalline form of tiotropium bromide anhydrate
KR20080024532A (ko) * 2005-06-15 2008-03-18 베링거 인겔하임 인터내셔날 게엠베하 신규한 티오트로퓸 염의 제조방법, 신규한 티오트로퓸 염및 이의 약제학적 조성물
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
US20080051582A1 (en) * 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
TR201007108A2 (tr) * 2010-08-25 2012-03-21 B�Lg�� Mahmut Yeni tiotropyum bromür kristali ve üretim yöntemi.@
US9707375B2 (en) 2011-03-14 2017-07-18 Rochester Medical Corporation, a subsidiary of C. R. Bard, Inc. Catheter grip and method
ITRM20110508A1 (it) 2011-09-27 2013-03-28 Lusochimica Spa Processo per la preparazione degli esteri della scopina.
US8680297B2 (en) 2011-10-06 2014-03-25 Drug Process Licensing Assoc., LLC Manufacturing process for tiotropium bromide
CZ304808B6 (cs) 2012-03-16 2014-11-05 Zentiva, K.S. Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu a jeho nová forma
CZ305012B6 (cs) 2012-03-30 2015-03-25 Zentiva, K.S. Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu
MX2015013845A (es) 2013-04-01 2016-05-09 Pulmatrix Inc Polvos secos de tiotropio.
WO2019129801A1 (en) 2017-12-28 2019-07-04 Linnea S.A. Process for the purification of methyl-2,2-dithienylglycolate

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003057694A1 (de) * 2002-01-12 2003-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur herstellung von scopinestern

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU591299B2 (en) * 1986-06-27 1989-11-30 Marion Laboratories, Inc. 1,7-substituted heptyne-2-ones
DE4108393A1 (de) * 1991-03-15 1992-09-17 Boehringer Ingelheim Kg Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln
US5554120A (en) * 1994-07-25 1996-09-10 Advanced Cardiovascular Systems, Inc. Polymer blends for use in making medical devices including catheters and balloons for dilatation catheters

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003057694A1 (de) * 2002-01-12 2003-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur herstellung von scopinestern

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MONTSERRAT CARBALLIDO, LUIS CASTEDO, CONCEPCIÓN GONZÁLEZ-BELLO: "Synthesis of Amino Carba Sugars and Conformationally Restricted Polyhydroxy -Amino Acids from (-)-Quinic Acid", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, no. 17, 17 August 2004 (2004-08-17), pages 3663 - 3668, XP002374123 *

Also Published As

Publication number Publication date
IL181522A0 (en) 2007-07-04
CN101001855A (zh) 2007-07-18
CA2573373A1 (en) 2006-03-02
AU2005276432A1 (en) 2006-03-02
CN100532382C (zh) 2009-08-26
RU2384575C2 (ru) 2010-03-20
WO2006021559A2 (de) 2006-03-02
US20060047120A1 (en) 2006-03-02
BRPI0514643A (pt) 2008-06-17
US8008495B2 (en) 2011-08-30
IL213717A0 (en) 2011-07-31
US20090118511A1 (en) 2009-05-07
TWI429646B (zh) 2014-03-11
KR20070046196A (ko) 2007-05-02
KR101274455B1 (ko) 2013-06-18
TWI387595B (zh) 2013-03-01
IL181522A (en) 2011-08-31
JP5173421B2 (ja) 2013-04-03
JP2008510774A (ja) 2008-04-10
IL213720A0 (en) 2011-07-31
NZ553840A (en) 2010-06-25
DE102004041253A1 (de) 2006-03-02
IL213720A (en) 2012-03-29
TW201231466A (en) 2012-08-01
CA2573373C (en) 2014-05-06
ZA200610503B (en) 2008-09-25
EP1794158A2 (de) 2007-06-13
AR050714A1 (es) 2006-11-15
WO2006021559A8 (de) 2006-11-16
RU2007110951A (ru) 2008-10-10
TW200617006A (en) 2006-06-01
AU2005276432B2 (en) 2011-11-10
US7491824B2 (en) 2009-02-17

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