TR200103028T2 - Piperazin halka içeren bileşiklerin yeni sentezi ve kristalleştirilmesi - Google Patents
Piperazin halka içeren bileşiklerin yeni sentezi ve kristalleştirilmesiInfo
- Publication number
- TR200103028T2 TR200103028T2 TR2001/03028T TR200103028T TR200103028T2 TR 200103028 T2 TR200103028 T2 TR 200103028T2 TR 2001/03028 T TR2001/03028 T TR 2001/03028T TR 200103028 T TR200103028 T TR 200103028T TR 200103028 T2 TR200103028 T2 TR 200103028T2
- Authority
- TR
- Turkey
- Prior art keywords
- phenyl
- methyl
- piperazine
- mirtazapine
- cyanopyridyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Bu bulus, piperazin halka içeren bilesikler,özellikle mirtazapinin hazirlanmasi için yönteme dogrultulmustur. Bu bulus uyarinca, mirtazapin ara maddesi 1-(3-karboksipiridil-2)-4-metil-2-fenil-piperazin, 1-(3-sianopiridil-2)-4-metil-2-fenil-piperazin molü basina yaklasik olarak 12 mole kadar baz oraninda mevcut bir baz ile 1-(3-sianopiridil-2)-4-metil-2-fenil piperazin, 1-(3-sianopiridil-2-4-metil-2-fenil-piperazin) ile potasyum kloridin oda sicakliginda en az yaklasik 130 oC de hidrolizi ile yapilabilir. Bu bulusun yöntemi ayni zamanda 2-1mino-3-hidroksimetil piridinin N-metil-1-fenil-2, 2'-iminodietil klorid ile 1-(3- hidroksimetilpiridil-2)-4-metil-2-fenil piperazin olusturmak için tepkimesi ve mirtazapin olusturmak için 1-(3-hidroksimetilpiridil-2)-fenil-4- metilpiperazine sülfürik asit eklenmesini içerir. Bu bulus ayrica ham mirtazapinden mirtazapinin yeniden krisallestirilmesi için yeni bir yöntem ile ilgilidir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13004799P | 1999-04-19 | 1999-04-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200103028T2 true TR200103028T2 (tr) | 2002-01-21 |
Family
ID=22442814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2001/03028T TR200103028T2 (tr) | 1999-04-19 | 2000-04-18 | Piperazin halka içeren bileşiklerin yeni sentezi ve kristalleştirilmesi |
Country Status (16)
Country | Link |
---|---|
JP (1) | JP2004500324A (tr) |
KR (1) | KR20020019902A (tr) |
CN (4) | CN1679586A (tr) |
CA (1) | CA2368815A1 (tr) |
CZ (1) | CZ20013658A3 (tr) |
HK (1) | HK1044116A1 (tr) |
HR (1) | HRP20010747A2 (tr) |
HU (1) | HUP0200839A3 (tr) |
IL (1) | IL146023A0 (tr) |
PL (1) | PL366289A1 (tr) |
RU (1) | RU2001128229A (tr) |
SK (1) | SK14672001A3 (tr) |
TR (1) | TR200103028T2 (tr) |
WO (1) | WO2000062782A1 (tr) |
YU (1) | YU74101A (tr) |
ZA (1) | ZA200108220B (tr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6019900A (en) * | 1999-11-24 | 2001-06-04 | Sumika Fine Chemicals Co., Ltd. | Anhydrous mirtazapine crystals and process for producing the same |
AU6474200A (en) * | 1999-12-13 | 2001-06-18 | Sumika Fine Chemicals Co., Ltd. | Process for the preparation of a pyridinemethanol compound |
US6660730B2 (en) * | 2000-11-27 | 2003-12-09 | Sumika Fine Chemicals Co., Ltd. | Anhydrous mirtazapine and process for preparing the same |
UA83666C2 (ru) * | 2003-07-10 | 2008-08-11 | Н.В. Органон | Способ получения энантиомерно чистого миртазапина |
ES2246161B1 (es) * | 2004-07-22 | 2007-04-01 | Medichem, S.A. | Proceso mejorado para la fabricacion de mirtazapina. |
JP4848704B2 (ja) * | 2004-08-24 | 2011-12-28 | 住友化学株式会社 | 2−(4−メチル−2−フェニルピペラジン−1−イル)−3−シアノピリジンの製造方法 |
JP5192707B2 (ja) | 2007-03-22 | 2013-05-08 | 住友化学株式会社 | ミルタザピンの製造方法 |
US7994314B2 (en) | 2007-04-11 | 2011-08-09 | N.V. Organon | Method for the preparation of an enantiomerically pure benzazepine |
CA2684021A1 (en) | 2007-04-11 | 2008-10-23 | N.V. Organon | A method for the preparation of an enantiomer of a tetracyclic benzazepine |
KR101485418B1 (ko) | 2013-05-29 | 2015-01-26 | 주식회사 메디켐코리아 | 고순도 미르타자핀의 제조방법 |
JP2017088564A (ja) * | 2015-11-13 | 2017-05-25 | 株式会社トクヤマ | ミルタザピンの製造方法 |
JP6571497B2 (ja) * | 2015-11-13 | 2019-09-04 | 株式会社トクヤマ | ミルタザピンの製造方法 |
CN108191873B (zh) * | 2018-01-08 | 2021-09-24 | 山东省食品药品检验研究院 | 一种盐酸米安色林的纯化方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL189199C (nl) * | 1975-04-05 | 1993-02-01 | Akzo Nv | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
-
2000
- 2000-04-18 CZ CZ20013658A patent/CZ20013658A3/cs unknown
- 2000-04-18 RU RU2001128229/04A patent/RU2001128229A/ru not_active Application Discontinuation
- 2000-04-18 IL IL14602300A patent/IL146023A0/xx unknown
- 2000-04-18 PL PL00366289A patent/PL366289A1/xx unknown
- 2000-04-18 CN CNA2005100042880A patent/CN1679586A/zh active Pending
- 2000-04-18 YU YU74101A patent/YU74101A/sh unknown
- 2000-04-18 HU HU0200839A patent/HUP0200839A3/hu unknown
- 2000-04-18 TR TR2001/03028T patent/TR200103028T2/tr unknown
- 2000-04-18 KR KR1020017013267A patent/KR20020019902A/ko not_active IP Right Cessation
- 2000-04-18 CN CN00807574A patent/CN1356903A/zh active Pending
- 2000-04-18 SK SK1467-2001A patent/SK14672001A3/sk unknown
- 2000-04-18 CN CNA2005100042908A patent/CN1680365A/zh active Pending
- 2000-04-18 JP JP2000611918A patent/JP2004500324A/ja not_active Withdrawn
- 2000-04-18 CA CA002368815A patent/CA2368815A1/en not_active Abandoned
- 2000-04-18 CN CNA2005100042895A patent/CN1680374A/zh active Pending
- 2000-04-18 WO PCT/US2000/010357 patent/WO2000062782A1/en not_active Application Discontinuation
-
2001
- 2001-10-05 ZA ZA200108220A patent/ZA200108220B/xx unknown
- 2001-10-15 HR HR20010747A patent/HRP20010747A2/hr not_active Application Discontinuation
-
2002
- 2002-07-05 HK HK02105027.4A patent/HK1044116A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
PL366289A1 (en) | 2005-01-24 |
ZA200108220B (en) | 2006-02-26 |
SK14672001A3 (sk) | 2002-11-06 |
HK1044116A1 (zh) | 2002-10-11 |
HRP20010747A2 (en) | 2002-12-31 |
IL146023A0 (en) | 2002-07-25 |
WO2000062782A1 (en) | 2000-10-26 |
CN1680365A (zh) | 2005-10-12 |
CN1680374A (zh) | 2005-10-12 |
JP2004500324A (ja) | 2004-01-08 |
KR20020019902A (ko) | 2002-03-13 |
YU74101A (sh) | 2004-09-03 |
CA2368815A1 (en) | 2000-10-26 |
CN1679586A (zh) | 2005-10-12 |
CZ20013658A3 (cs) | 2002-08-14 |
RU2001128229A (ru) | 2003-07-10 |
CN1356903A (zh) | 2002-07-03 |
HUP0200839A2 (en) | 2002-08-28 |
HUP0200839A3 (en) | 2003-05-28 |
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