CY1106237T1 - Ετepοκυκλικα παραγωγα με 5 μελη στο δακτυλιο και εφαρμογη αυτων ως παρεμποδιστων της μονοαμινο οξυδασης - Google Patents

Ετepοκυκλικα παραγωγα με 5 μελη στο δακτυλιο και εφαρμογη αυτων ως παρεμποδιστων της μονοαμινο οξυδασης

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Publication number
CY1106237T1
CY1106237T1 CY20061101600T CY061101600T CY1106237T1 CY 1106237 T1 CY1106237 T1 CY 1106237T1 CY 20061101600 T CY20061101600 T CY 20061101600T CY 061101600 T CY061101600 T CY 061101600T CY 1106237 T1 CY1106237 T1 CY 1106237T1
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CY
Cyprus
Prior art keywords
specifically
radical
alkyl
general formula
cycloalkyl
Prior art date
Application number
CY20061101600T
Other languages
English (en)
Inventor
Pierre-Etienne Chabrier De Lassauniere
Jeremiah Harnett
Dennis Bigg
Jacques Pommier
Jacques Lannoy
Anne-Marie Liberatore
Christophe Thurieau
Original Assignee
Societe De Conseils De Recherches Et D´ Applications Scientifiques (S.C.R.A.S.)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9912643A external-priority patent/FR2799461B1/fr
Priority claimed from FR0010151A external-priority patent/FR2812546B1/fr
Application filed by Societe De Conseils De Recherches Et D´ Applications Scientifiques (S.C.R.A.S.) filed Critical Societe De Conseils De Recherches Et D´ Applications Scientifiques (S.C.R.A.S.)
Publication of CY1106237T1 publication Critical patent/CY1106237T1/el

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Abstract

Η εφεύρεση αφορά ενώσεις του γενικού τύπου (I) οι οποίες είναι δυνατόν να χρησιμοποιηθούν δια την παραγωγή ενός φαρμάκου δια την παρεμπόδιση της μονοαμίνο οξυδάσης (ΜΑΟ) και/ή δια τη λιπιδική υπεροξείδωση και/ή δια τη δράση ως τροποποιητών των αυλακών νατρίου. Το προκύπτον φάρμακο χρησιμοποιείται ιδιαιτέρως δια τη φαρμακευτική αγωγή της ασθενείας του Parkinson, της γεροντικής άνοιας, της ασθενείας του Alzheimer, της χορίας του Huntington, της αμυοτροφικής πλαγίας σκληρώσεως, της σχιζοφρένειας, της καταθλίψεως, της ψυχώσεως, του πόνου και της επιληψίας. Οι ενώσεις της εφευρέσεως αντιστοιχούν εις το γενικό τύπο (I) εις τον οποίο το Het είναι ένας 5μελής ετερόκυκλος που περιέχει δυο ετεροάτομα και είναι τέτοιος ώστε ο γενικός τύπος (I) να αντιστοιχεί αποκλειστικά σε έναν από τους υπο-τύπους (I)1, (I)2, (I)3 και (I)4, όπου το Α παριστά ειδικώς ένα υποκατεστημένο φαινύλ ή διφαινύλο ριζικό, το Β παριστά ειδικώς Η ή ένα αλκύλο ριζικό, το Χ παριστά ειδικώς ΝΗ ή S, το Υ παριστά Ο ή S, το n είναι ένας ακέραιος αριθμός από 0 έως 6, το R<1> και το R<2> παριστούν ανεξαρτήτως το εν του άλλου ειδικώς ριζικά που εκλέγονται από τα επόμενα : ένα άτομο υδρογόνου ή ένα αλκύλο ή κυκλοαλκύλο ριζικό και το ΩΜΕΓΑ παριστά NR<46>R<47> ή OR<48>, R<46> και R<47> που παριστούν ειδικώς ριζικά που εκλέγονται από τα επόμενα : ένα άτομο υδρογόνου και ένα αλκύλο , κυκλοαλκύλο , αλκυνύλο , κυανοαλκύλ αλκοξυκαρβονύλ , αραλκοξυκαρβονύλ ή (κυκλοοαλκύλ) οξυκαρβονύλο ριζικό και όπου το R<48> παριστά ένα άτομο υδρογόνου ή ένα αλκύλ , αλκυνύλ ή κυανοϋλαλκυνύλο ριζικό.
CY20061101600T 1999-10-11 2006-11-08 Ετepοκυκλικα παραγωγα με 5 μελη στο δακτυλιο και εφαρμογη αυτων ως παρεμποδιστων της μονοαμινο οξυδασης CY1106237T1 (el)

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Application Number Priority Date Filing Date Title
FR9912643A FR2799461B1 (fr) 1999-10-11 1999-10-11 Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments
FR0010151A FR2812546B1 (fr) 2000-08-01 2000-08-01 Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments
FR0011169 2000-09-01
PCT/FR2000/002805 WO2001026656A2 (fr) 1999-10-11 2000-10-10 Derives d'heterocycles a 5 chainons et leur application comme inhibiteurs de monoamine oxydase

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US8288560B2 (en) 2012-10-16
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ES2544856T3 (es) 2015-09-04
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PL215580B1 (pl) 2013-12-31
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US20110172434A1 (en) 2011-07-14
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EP1228760A3 (fr) 2004-01-28
WO2001026656A2 (fr) 2001-04-19
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DE60030574D1 (de) 2006-10-19
RU2002112227A (ru) 2004-01-27
EP1223933B1 (fr) 2006-09-06
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US20080146627A1 (en) 2008-06-19
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