FR2799461B1 - Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments - Google Patents
Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicamentsInfo
- Publication number
- FR2799461B1 FR2799461B1 FR9912643A FR9912643A FR2799461B1 FR 2799461 B1 FR2799461 B1 FR 2799461B1 FR 9912643 A FR9912643 A FR 9912643A FR 9912643 A FR9912643 A FR 9912643A FR 2799461 B1 FR2799461 B1 FR 2799461B1
- Authority
- FR
- France
- Prior art keywords
- chain
- medicaments
- preparation
- application
- heterocycle derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (49)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9912643A FR2799461B1 (fr) | 1999-10-11 | 1999-10-11 | Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments |
TW089121109A TWI283577B (en) | 1999-10-11 | 2000-10-09 | Pharmaceutical composition of imidazole derivatives acting as modulators of sodium channels and the use thereof |
TW093132951A TWI292316B (en) | 1999-10-11 | 2000-10-09 | Pharmaceutical composition of thiazole derivatives intended to inhibit mao and/or lipidic peroxidation and/or to act as modulators of sodium channels and the use thereof |
NZ518304A NZ518304A (en) | 1999-10-11 | 2000-10-10 | 5-membered heterocycle derivatives, their production and use to inhibit monoamine oxydases (MAO) and/or lipidic peroxidation and/or to act as modulators of the sodium channels |
AT00967988T ATE338547T1 (de) | 1999-10-11 | 2000-10-10 | Fünfgliedrige derivate von heterozyklen und ihre verwendung als monoaminoxidase-inhibitoren |
RU2005112774/04A RU2380362C2 (ru) | 1999-10-11 | 2000-10-10 | Производные пятичленных гетероциклов, способ их получения и их применение в качестве лекарственных средств |
HU0203841A HU228254B1 (en) | 1999-10-11 | 2000-10-10 | 5-membered heteroaromatic compound and pharmaceutical compositions containing it |
AT02076763T ATE522213T1 (de) | 1999-10-11 | 2000-10-10 | Fünfgliedrige-heteroringderivate , ihre herstellung und ihre verwendung als arzneimittel |
KR1020077013941A KR20070068491A (ko) | 1999-10-11 | 2000-10-10 | 5-원 헤테로사이클 유도체, 이의 제조 방법 및의약으로서의 이의 용도 |
IL14889600A IL148896A0 (en) | 1999-10-11 | 2000-10-10 | 5-membered heterocycle derivatives, production thereof and use thereof as medicaments |
ES00967988T ES2270873T3 (es) | 1999-10-11 | 2000-10-10 | Derivados de heterociclos de 5 miembros y su aplicacion como inhibidores de monoamina oxidasa. |
MYPI20004725A MY145388A (en) | 1999-10-11 | 2000-10-10 | 5-membered heterocycle derivatives, production thereof and sue thereof as medicaments |
CNA2009101297620A CN101559053A (zh) | 1999-10-11 | 2000-10-10 | 5-元杂环衍生物、其制备及其作为药物的用途 |
EP02076763A EP1228760B1 (fr) | 1999-10-11 | 2000-10-10 | Dérivés d'hétérocycles à 5 chaînons, leur préparation et leur application à titre de médicaments |
EP05076749.0A EP1589007B1 (fr) | 1999-10-11 | 2000-10-10 | Dérivés d'hétérocycles à 5 chainons, leur préparation et leur application comme médicaments |
NZ533429A NZ533429A (en) | 1999-10-11 | 2000-10-10 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
MXPA02003665A MXPA02003665A (es) | 1999-10-11 | 2000-10-10 | Derivados de heterociclos de 5 miembros, su preparacion y su uso como medicamentos. |
AU77965/00A AU783129B2 (en) | 1999-10-11 | 2000-10-10 | 5-membered heterocycle derivatives, production thereof and use thereof as medicaments |
PL355147A PL215580B1 (pl) | 1999-10-11 | 2000-10-10 | 4-[2-(aminometylo)-1,3-tiazol-4-ilo]-2,6-di(tert-butylo) fenol i jego zastosowanie jako leku |
PT50767490T PT1589007E (pt) | 1999-10-11 | 2000-10-10 | Derivados de heterociclos de cinco membros, sua preparação e sua aplicação como medicamentos |
CA2388505A CA2388505C (fr) | 1999-10-11 | 2000-10-10 | Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments |
DK00967988T DK1223933T3 (da) | 1999-10-11 | 2000-10-10 | 5-leddet derivater af heterocyklusser og deres anvendelse som monoaminoxidaseinhibitorer |
DK05076749.0T DK1589007T3 (en) | 1999-10-11 | 2000-10-10 | 5-link heterocycle derivatives, their preparation and use as pharmaceuticals |
EP00967988A EP1223933B1 (fr) | 1999-10-11 | 2000-10-10 | Dérivés d'hétérocycles à 5 chainons et leur application comme inhibiteurs de monoamine oxydase |
PCT/FR2000/002805 WO2001026656A2 (fr) | 1999-10-11 | 2000-10-10 | Derives d'heterocycles a 5 chainons et leur application comme inhibiteurs de monoamine oxydase |
ES02076763T ES2370274T3 (es) | 1999-10-11 | 2000-10-10 | Derivados de heterociclos de 5 miembros, su preparación y su aplicación como medicamentos. |
CNB008158479A CN100488506C (zh) | 1999-10-11 | 2000-10-10 | 5-元杂环衍生物、其制备及其作为药物的用途 |
PT00967988T PT1223933E (pt) | 1999-10-11 | 2000-10-10 | Derivados de heterociclos com 5 membros e sua utilização como inibidores de monoamina oxidase |
JP2001529718A JP4972263B2 (ja) | 1999-10-11 | 2000-10-10 | 5員複素環誘導体、その製造方法及びその医薬としての使用 |
DE60030574T DE60030574T2 (de) | 1999-10-11 | 2000-10-10 | Fünfgliedrige derivate von heterozyklen und ihre verwendung als monoaminoxidase-inhibitoren |
KR1020027004578A KR100731698B1 (ko) | 1999-10-11 | 2000-10-10 | 5-원 헤테로사이클 유도체, 이의 제조 방법 및의약으로서의 이의 용도 |
ES05076749.0T ES2544856T3 (es) | 1999-10-11 | 2000-10-10 | Derivados de heterociclos de 5 miembros, su preparación y su aplicación como medicamentos |
RU2002112227/15A RU2271355C2 (ru) | 1999-10-11 | 2000-10-10 | Производные пятичленных гетероциклов, способ их получения и их применение в качестве лекарственных средств |
BR0014649-8A BR0014649A (pt) | 1999-10-11 | 2000-10-10 | Utilização de um produto, medicamento, composto e composição farmacêutica |
CZ2002-1292A CZ304331B6 (cs) | 1999-10-11 | 2000-10-10 | Použití thiazolových derivátů pro přípravu léčiva |
ARP000105353A AR029006A1 (es) | 1999-10-11 | 2000-10-11 | Derivados de heterociclos con 5 miembros, su preparacion y su uso como medicamentos |
IL148896A IL148896A (en) | 1999-10-11 | 2002-03-26 | Use of thiazole derivatives for drug preparation, pharmaceutical preparations containing them and one such compound |
NO20021689A NO331874B1 (no) | 1999-10-11 | 2002-04-10 | 4-[2(aminometyl)-1,3-tiazol-4-yl]-2,6-di(tert-butyl)fenol, anvendelse som medikamenter samt anvendelse for behandling av sykdom. |
HK03101645.4A HK1049957B (zh) | 1999-10-11 | 2003-03-06 | 5-元雜環衍生物、其製備及其作為藥物的用途 |
US10/681,002 US20040132788A1 (en) | 1999-10-11 | 2003-10-08 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
US10/915,001 US7291641B2 (en) | 1999-10-11 | 2004-08-10 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
US10/575,249 US20070054900A1 (en) | 1999-10-11 | 2004-10-08 | 4-Phenlthiazole and 4-phenylimidizole derivatives and their use as medicaments for the treatment of neurodegenerative diseases, pain and epilepsy |
US11/256,901 US20070021390A1 (en) | 1999-10-11 | 2005-10-24 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
CY20061101600T CY1106237T1 (el) | 1999-10-11 | 2006-11-08 | Ετepοκυκλικα παραγωγα με 5 μελη στο δακτυλιο και εφαρμογη αυτων ως παρεμποδιστων της μονοαμινο οξυδασης |
US11/708,531 US20070179153A1 (en) | 1999-10-11 | 2007-02-20 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
IL185118A IL185118A0 (en) | 1999-10-11 | 2007-08-08 | 5-membered heterocycle derivatives,production thereof and use thereof as medicaments |
US12/001,439 US7956075B2 (en) | 1999-10-11 | 2007-12-11 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
RU2009136591/04A RU2530882C2 (ru) | 1999-10-11 | 2009-10-02 | Производные пятичленных гетероциклов, способ их получения и их применение в качестве лекарственных средств |
US13/053,092 US8288560B2 (en) | 1999-10-11 | 2011-03-21 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9912643A FR2799461B1 (fr) | 1999-10-11 | 1999-10-11 | Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2799461A1 FR2799461A1 (fr) | 2001-04-13 |
FR2799461B1 true FR2799461B1 (fr) | 2002-01-04 |
Family
ID=9550778
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR9912643A Expired - Lifetime FR2799461B1 (fr) | 1999-10-11 | 1999-10-11 | Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments |
Country Status (3)
Country | Link |
---|---|
CN (1) | CN101559053A (fr) |
ES (1) | ES2370274T3 (fr) |
FR (1) | FR2799461B1 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN110240557B (zh) * | 2018-03-08 | 2023-05-09 | 广东东阳光药业有限公司 | 吡咯烷酰胺衍生物及其用途 |
CN111018802B (zh) * | 2019-12-03 | 2021-07-06 | 湖北大学 | 具有抗帕金森氏症的化合物、制备方法及其应用 |
CN113912528B (zh) * | 2020-07-07 | 2023-06-09 | 广东东阳光药业有限公司 | 吡咯烷酰胺衍生物的盐及其用途 |
CN115959977B (zh) * | 2022-12-28 | 2024-06-11 | 陕西泰合利华工业有限公司 | 一种1,1,1-三(3,5-二甲氧基甲基-4-羟基苯基)乙烷的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
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DE3941438A1 (de) * | 1989-12-15 | 1991-06-20 | Hoechst Ag | Neue 2-substituierte 4-(3-alkyl-5-tert.-butyl-4-hydroxy-phenyl)-thiazole, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung |
FR2764889B1 (fr) * | 1997-06-20 | 2000-09-01 | Sod Conseils Rech Applic | Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
CA2302294A1 (fr) * | 1997-08-28 | 1999-03-04 | Harlan Edgar Shannon | Procede de traitement d'une douleur |
-
1999
- 1999-10-11 FR FR9912643A patent/FR2799461B1/fr not_active Expired - Lifetime
-
2000
- 2000-10-10 ES ES02076763T patent/ES2370274T3/es not_active Expired - Lifetime
- 2000-10-10 CN CNA2009101297620A patent/CN101559053A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
CN101559053A (zh) | 2009-10-21 |
FR2799461A1 (fr) | 2001-04-13 |
ES2370274T3 (es) | 2011-12-14 |
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