FR2823208B1 - Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments - Google Patents

Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments

Info

Publication number
FR2823208B1
FR2823208B1 FR0104943A FR0104943A FR2823208B1 FR 2823208 B1 FR2823208 B1 FR 2823208B1 FR 0104943 A FR0104943 A FR 0104943A FR 0104943 A FR0104943 A FR 0104943A FR 2823208 B1 FR2823208 B1 FR 2823208B1
Authority
FR
France
Prior art keywords
chain
medicaments
preparation
application
heterocycle derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR0104943A
Other languages
English (en)
Other versions
FR2823208A1 (fr
Inventor
Jeremiah Harnett
Dennis Bigg
Anne Marie Liberatore
Alain Rolland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority to FR0104943A priority Critical patent/FR2823208B1/fr
Priority to TW091105848A priority patent/TWI248438B/zh
Priority to MYPI20021232A priority patent/MY142094A/en
Priority to JP2002581412A priority patent/JP4422964B2/ja
Priority to HU0303799A priority patent/HU228192B1/hu
Priority to PCT/FR2002/001218 priority patent/WO2002083656A2/fr
Priority to AU2002307980A priority patent/AU2002307980B2/en
Priority to CZ2003-3054A priority patent/CZ304550B6/cs
Priority to IL15812102A priority patent/IL158121A0/xx
Priority to PL372297A priority patent/PL211939B1/pl
Priority to RU2003132471/04A priority patent/RU2288224C2/ru
Priority to KR1020037013243A priority patent/KR100865809B1/ko
Priority to NZ528645A priority patent/NZ528645A/en
Priority to CA2443403A priority patent/CA2443403C/fr
Priority to CNB02807937XA priority patent/CN1284777C/zh
Priority to DE60232959T priority patent/DE60232959D1/de
Priority to MXPA03009194A priority patent/MXPA03009194A/es
Priority to ES02761921T priority patent/ES2328467T3/es
Priority to BRPI0208703-0A priority patent/BRPI0208703B1/pt
Priority to EP02761921A priority patent/EP1379514B1/fr
Priority to BRPI0208703-0A priority patent/BR0208703A/pt
Priority to ARP020101330A priority patent/AR036329A1/es
Publication of FR2823208A1 publication Critical patent/FR2823208A1/fr
Priority to IL158121A priority patent/IL158121A/en
Priority to ZA200307750A priority patent/ZA200307750B/en
Priority to IS6979A priority patent/IS2724B/is
Priority to NO20034524A priority patent/NO326051B1/no
Application granted granted Critical
Publication of FR2823208B1 publication Critical patent/FR2823208B1/fr
Priority to US10/915,001 priority patent/US7291641B2/en
Priority to US10/575,249 priority patent/US20070054900A1/en
Priority to HK05102380A priority patent/HK1070055A1/xx
Priority to US13/053,092 priority patent/US8288560B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR0104943A 1999-10-11 2001-04-10 Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments Expired - Lifetime FR2823208B1 (fr)

Priority Applications (30)

Application Number Priority Date Filing Date Title
FR0104943A FR2823208B1 (fr) 2001-04-10 2001-04-10 Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments
TW091105848A TWI248438B (en) 2001-04-10 2002-03-26 Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
MYPI20021232A MY142094A (en) 2001-04-10 2002-04-05 5-membered heterocycles, preparation and application thereof as medicaments
BRPI0208703-0A BRPI0208703B1 (pt) 2001-04-10 2002-04-09 A 5-chain heterocyclic compound, pharmaceutical composition and use of a compound
PCT/FR2002/001218 WO2002083656A2 (fr) 2001-04-10 2002-04-09 Derives d'heterocycles a 5 chainons et leur utilisation en tant qu'inhibiteurs de la mao et/ou peroxydation lipidique, leur preparation et leur application comme medicaments
AU2002307980A AU2002307980B2 (en) 2001-04-10 2002-04-09 5-membered heterocycles, preparation and use thereof as mao inhibitors and lipid peroxidation inhibitors, preparation thereof and use thereof as medicaments
CZ2003-3054A CZ304550B6 (cs) 2001-04-10 2002-04-09 Deriváty heterocyklů s 5 atomy kruhu, jejich příprava a jejich použití jako léčiv
IL15812102A IL158121A0 (en) 2001-04-10 2002-04-09 5-membered heterocycles, preparation and application thereof as medicaments
PL372297A PL211939B1 (pl) 2001-04-10 2002-04-09 Pochodne 4-6-członowych związków heterocyklicznych, kompozycje farmaceutyczne je zawierające i ich zastosowanie jako leków
RU2003132471/04A RU2288224C2 (ru) 2001-04-10 2002-04-09 Производные 5-членных гетероциклов, их получение и применение в качестве лекарственных средств
KR1020037013243A KR100865809B1 (ko) 2001-04-10 2002-04-09 5-원 헤테로사이클, 이의 제조 방법 및 의약으로서의 이의용도
NZ528645A NZ528645A (en) 2001-04-10 2002-04-09 5-membered heterocycles, preparation and application thereof as medicaments
CA2443403A CA2443403C (fr) 2001-04-10 2002-04-09 Derives d'heterocycles a 5 chainons et leur utilisation en tant qu'inhibiteurs de la mao et/ou peroxydation lipidique, leur preparation et leur application comme medicaments
CNB02807937XA CN1284777C (zh) 2001-04-10 2002-04-09 5元杂环化合物、它们的制备和作为药物的应用
DE60232959T DE60232959D1 (de) 2001-04-10 2002-04-09 Fünfgliederige heteroringderative und deren verwender lipidperoxidierung
MXPA03009194A MXPA03009194A (es) 2001-04-10 2002-04-09 DERIVADOS DE HETEROCICLOS DE 5 MIEMBROS, SU PREPARACIoN Y SU APLICACIoN COMO MEDICAMENTOS.
JP2002581412A JP4422964B2 (ja) 2001-04-10 2002-04-09 ５員複素環誘導体、その製造法及びその医薬としての使用
HU0303799A HU228192B1 (en) 2001-04-10 2002-04-09 5-membered heterocycles and application thereof as medicaments
EP02761921A EP1379514B1 (fr) 2001-04-10 2002-04-09 Derives d'heterocycles a 5 chainons, leur preparation et leur application comme medicaments
BRPI0208703-0A BR0208703A (pt) 2001-04-10 2002-04-09 composto, composição farmacêutica e utilização de um composto
ES02761921T ES2328467T3 (es) 2001-04-10 2002-04-09 Derivados heterociclicos de 5 miembros, su preparacion y su aplicacion como medicamentos.
ARP020101330A AR036329A1 (es) 2001-04-10 2002-04-10 Compuesto derivado de tiazol, imidazol y oxazol, composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento
IL158121A IL158121A (en) 2001-04-10 2003-09-25 5-membered heterocycles, pharmaceutical compositions comprising them and uses thereof for the manufacture of medicaments
ZA200307750A ZA200307750B (en) 2001-04-10 2003-10-03 5-Membered heterocycles, preparation and use thereof as MAO inhibitors and lipid peroxidation inhibitors, preparation thereof and use thereof as medicaments.
IS6979A IS2724B (is) 2001-04-10 2003-10-08 5-hluta heteróhringir, framleiðsla og notkun þeirra sem lyfja
NO20034524A NO326051B1 (no) 2001-04-10 2003-10-09 5-leddete heterocykler, medikament og anvendelse derav, samt farmasoytisk preparat.
US10/915,001 US7291641B2 (en) 1999-10-11 2004-08-10 Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
US10/575,249 US20070054900A1 (en) 1999-10-11 2004-10-08 4-Phenlthiazole and 4-phenylimidizole derivatives and their use as medicaments for the treatment of neurodegenerative diseases, pain and epilepsy
HK05102380A HK1070055A1 (en) 2001-04-10 2005-03-18 5-Membered heterocycles, preparation and application thereof as medicaments
US13/053,092 US8288560B2 (en) 1999-10-11 2011-03-21 Derivatives of heterocycles with 5 members, their preparation and their use as medicaments

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0104943A FR2823208B1 (fr) 2001-04-10 2001-04-10 Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments

Publications (2)

Publication Number Publication Date
FR2823208A1 FR2823208A1 (fr) 2002-10-11
FR2823208B1 true FR2823208B1 (fr) 2004-03-19

Family

ID=8862216

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0104943A Expired - Lifetime FR2823208B1 (fr) 1999-10-11 2001-04-10 Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments

Country Status (2)

Country Link
FR (1) FR2823208B1 (fr)
ZA (1) ZA200307750B (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5326770A (en) * 1992-07-17 1994-07-05 The Du Pont Merck Pharmaceutical Company Monoamine oxidase-B (MAO-B) inhibitory 5-substituted 2,4-thiazolidinediones useful in treating memory disorders of mammals
AU7135996A (en) * 1995-10-11 1997-04-30 Synthelabo Oxazolidin-2-one derivatives, preparation method therefor and therapeutical use thereof
TWI283577B (en) * 1999-10-11 2007-07-11 Sod Conseils Rech Applic Pharmaceutical composition of imidazole derivatives acting as modulators of sodium channels and the use thereof

Also Published As

Publication number Publication date
FR2823208A1 (fr) 2002-10-11
ZA200307750B (en) 2004-07-26

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