AR029006A1 - Derivados de heterociclos con 5 miembros, su preparacion y su uso como medicamentos - Google Patents

Derivados de heterociclos con 5 miembros, su preparacion y su uso como medicamentos

Info

Publication number
AR029006A1
AR029006A1 ARP000105353A ARP000105353A AR029006A1 AR 029006 A1 AR029006 A1 AR 029006A1 AR P000105353 A ARP000105353 A AR P000105353A AR P000105353 A ARP000105353 A AR P000105353A AR 029006 A1 AR029006 A1 AR 029006A1
Authority
AR
Argentina
Prior art keywords
methyl
derivatives
omega
hydroxyphenyl
formulas
Prior art date
Application number
ARP000105353A
Other languages
English (en)
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9912643A external-priority patent/FR2799461B1/fr
Priority claimed from FR0010151A external-priority patent/FR2812546B1/fr
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of AR029006A1 publication Critical patent/AR029006A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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Abstract

Uso de determinados derivados de oxazoles, tiazoles, imidazoles e isoxazolinas para preparar un medicamento destinado a inhibir las monoaminas oxidasas (MAO) y/o la peroxidacion lipídica y/o para actuar como moduladores de los canales de sodio. Un tema particular es la utilizacion de dichos derivados para preparar un medicamento destinado a tratar uno de los trastornos o enfermedades siguientes: enfermedad de Parkinson, demencia senil, enfermedad de Alzheimer, corea de Huntington, esclerosis amiotrofica lateral, esquizofrenia, depresion, sicosis y dolor y epilepsia. Dichos derivados tienen la formula general (1), en forma racémica, enantiomera o cualquier combinacion de las formas, en la cual Het es un heterociclo con 5 miembros que comprende 2 heteroátomos y tal que la formula General (1) corresponde exclusivamente a un de las sub-formulas siguientes, teniendo A, B, R1, R2, Omega, W, n, X e Y los significados dados en la descripcion. También se definen medicamentos de formulas generales (2), (3), (2)1, (2)2, (2)3, y (2)4, donde A, B, R1 R2, Omega, n, X e Y tienen los significados ya indicados; nuevos productos industriales de formulas (3), (3)1, (3)2, (3)3( y (3)4, donde A, B, R1, R2,Omega, n, X e Y tienen los significados ya indicados; y composiciones farmacéuticas que contienen a un compuesto de formula (2) o (3). En particular se hace referencia a los compuestos siguientes : -4-[3,5-bis(1,1-dimetiletil)-4-hidroxifenil]-N-metil-2-tiazolmetanamina; -2-[({4-[3,5-di(ter-butil)-4-hidroxifenil]-1,3-tiazol-2-il}metil)(metil)amino]acetonitrilo; -2,6-di(ter-butil)-4-(2-{[(2-hidroxietil)(metil)amino]metil}-1.3-tiazol-4-il)-fenol; -3-[3,5-bis(1,1-dimetiletil)-4-hidroxifenil]-4.5-dihidro-5-isoxazoletanol û(1R)-N-bencil-2-(1H-indol-3-il)-1-(4-fenil-1H-imidazol-2-il)etanamina; o sus sales.
ARP000105353A 1999-10-11 2000-10-11 Derivados de heterociclos con 5 miembros, su preparacion y su uso como medicamentos AR029006A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9912643A FR2799461B1 (fr) 1999-10-11 1999-10-11 Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments
FR0010151A FR2812546B1 (fr) 2000-08-01 2000-08-01 Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments
FR0011169 2000-09-01

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