AR029006A1 - Derivados de heterociclos con 5 miembros, su preparacion y su uso como medicamentos - Google Patents
Derivados de heterociclos con 5 miembros, su preparacion y su uso como medicamentosInfo
- Publication number
- AR029006A1 AR029006A1 ARP000105353A ARP000105353A AR029006A1 AR 029006 A1 AR029006 A1 AR 029006A1 AR P000105353 A ARP000105353 A AR P000105353A AR P000105353 A ARP000105353 A AR P000105353A AR 029006 A1 AR029006 A1 AR 029006A1
- Authority
- AR
- Argentina
- Prior art keywords
- methyl
- derivatives
- omega
- hydroxyphenyl
- formulas
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 4
- 229940079593 drug Drugs 0.000 title abstract 2
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 102000010909 Monoamine Oxidase Human genes 0.000 abstract 2
- 108010062431 Monoamine oxidase Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- QJTZUFDRYUDSHO-XMMPIXPASA-N (1r)-n-benzyl-2-(1h-indol-3-yl)-1-(5-phenyl-1h-imidazol-2-yl)ethanamine Chemical compound C=1NC([C@@H](CC=2C3=CC=CC=C3NC=2)NCC=2C=CC=CC=2)=NC=1C1=CC=CC=C1 QJTZUFDRYUDSHO-XMMPIXPASA-N 0.000 abstract 1
- YNOPFGAHCQHUAY-UHFFFAOYSA-N 2-tert-butyl-4-[2-[[2-hydroxyethyl(methyl)amino]methyl]-1,3-thiazol-4-yl]phenol Chemical compound CN(CCO)Cc1nc(cs1)-c1ccc(O)c(c1)C(C)(C)C YNOPFGAHCQHUAY-UHFFFAOYSA-N 0.000 abstract 1
- 206010016936 Folliculitis Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000034189 Sclerosis Diseases 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- 108010052164 Sodium Channels Proteins 0.000 abstract 1
- 102000018674 Sodium Channels Human genes 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002460 imidazoles Chemical class 0.000 abstract 1
- 150000002547 isoxazolines Chemical class 0.000 abstract 1
- 230000003859 lipid peroxidation Effects 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000002916 oxazoles Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 150000003557 thiazoles Chemical class 0.000 abstract 1
- -1 {4- [3,5-di (tert-butyl) -4-hydroxyphenyl] -1,3-thiazol-2-yl} methyl Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
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- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A61K31/42—Oxazoles
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- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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- A61K31/425—Thiazoles
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- A61K31/425—Thiazoles
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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Abstract
Uso de determinados derivados de oxazoles, tiazoles, imidazoles e isoxazolinas para preparar un medicamento destinado a inhibir las monoaminas oxidasas (MAO) y/o la peroxidacion lipídica y/o para actuar como moduladores de los canales de sodio. Un tema particular es la utilizacion de dichos derivados para preparar un medicamento destinado a tratar uno de los trastornos o enfermedades siguientes: enfermedad de Parkinson, demencia senil, enfermedad de Alzheimer, corea de Huntington, esclerosis amiotrofica lateral, esquizofrenia, depresion, sicosis y dolor y epilepsia. Dichos derivados tienen la formula general (1), en forma racémica, enantiomera o cualquier combinacion de las formas, en la cual Het es un heterociclo con 5 miembros que comprende 2 heteroátomos y tal que la formula General (1) corresponde exclusivamente a un de las sub-formulas siguientes, teniendo A, B, R1, R2, Omega, W, n, X e Y los significados dados en la descripcion. También se definen medicamentos de formulas generales (2), (3), (2)1, (2)2, (2)3, y (2)4, donde A, B, R1 R2, Omega, n, X e Y tienen los significados ya indicados; nuevos productos industriales de formulas (3), (3)1, (3)2, (3)3( y (3)4, donde A, B, R1, R2,Omega, n, X e Y tienen los significados ya indicados; y composiciones farmacéuticas que contienen a un compuesto de formula (2) o (3). En particular se hace referencia a los compuestos siguientes : -4-[3,5-bis(1,1-dimetiletil)-4-hidroxifenil]-N-metil-2-tiazolmetanamina; -2-[({4-[3,5-di(ter-butil)-4-hidroxifenil]-1,3-tiazol-2-il}metil)(metil)amino]acetonitrilo; -2,6-di(ter-butil)-4-(2-{[(2-hidroxietil)(metil)amino]metil}-1.3-tiazol-4-il)-fenol; -3-[3,5-bis(1,1-dimetiletil)-4-hidroxifenil]-4.5-dihidro-5-isoxazoletanol û(1R)-N-bencil-2-(1H-indol-3-il)-1-(4-fenil-1H-imidazol-2-il)etanamina; o sus sales.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9912643A FR2799461B1 (fr) | 1999-10-11 | 1999-10-11 | Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments |
FR0010151A FR2812546B1 (fr) | 2000-08-01 | 2000-08-01 | Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments |
FR0011169 | 2000-09-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR029006A1 true AR029006A1 (es) | 2003-06-04 |
Family
ID=27248695
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000105353A AR029006A1 (es) | 1999-10-11 | 2000-10-11 | Derivados de heterociclos con 5 miembros, su preparacion y su uso como medicamentos |
Country Status (27)
Country | Link |
---|---|
US (4) | US20070021390A1 (es) |
EP (3) | EP1223933B1 (es) |
JP (1) | JP4972263B2 (es) |
KR (2) | KR20070068491A (es) |
CN (1) | CN100488506C (es) |
AR (1) | AR029006A1 (es) |
AT (2) | ATE338547T1 (es) |
AU (1) | AU783129B2 (es) |
BR (1) | BR0014649A (es) |
CA (1) | CA2388505C (es) |
CY (1) | CY1106237T1 (es) |
CZ (1) | CZ304331B6 (es) |
DE (1) | DE60030574T2 (es) |
DK (2) | DK1589007T3 (es) |
ES (2) | ES2270873T3 (es) |
HK (1) | HK1049957B (es) |
HU (1) | HU228254B1 (es) |
IL (3) | IL148896A0 (es) |
MX (1) | MXPA02003665A (es) |
MY (1) | MY145388A (es) |
NO (1) | NO331874B1 (es) |
NZ (2) | NZ518304A (es) |
PL (1) | PL215580B1 (es) |
PT (2) | PT1589007E (es) |
RU (1) | RU2271355C2 (es) |
TW (2) | TWI283577B (es) |
WO (1) | WO2001026656A2 (es) |
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2000
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- 2000-10-10 WO PCT/FR2000/002805 patent/WO2001026656A2/fr active Application Filing
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- 2000-10-10 CZ CZ2002-1292A patent/CZ304331B6/cs not_active IP Right Cessation
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- 2000-10-10 KR KR1020027004578A patent/KR100731698B1/ko not_active IP Right Cessation
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2003
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- 2007-02-20 US US11/708,531 patent/US20070179153A1/en not_active Abandoned
- 2007-08-08 IL IL185118A patent/IL185118A0/en not_active IP Right Cessation
- 2007-12-11 US US12/001,439 patent/US7956075B2/en not_active Expired - Fee Related
-
2011
- 2011-03-21 US US13/053,092 patent/US8288560B2/en not_active Expired - Fee Related
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