PT97169A - Processo para a preparacao de composicoes farmaceuticas inibidora das enzimas 5-lipxigenase e ciclo-oxigenase contendo derivados de 3,5-di-terc-butil-4-hidroxifenilmetileno de tiazolidinonas, oxazolidinona e imidazolidinonas 2-substituidas - Google Patents

Processo para a preparacao de composicoes farmaceuticas inibidora das enzimas 5-lipxigenase e ciclo-oxigenase contendo derivados de 3,5-di-terc-butil-4-hidroxifenilmetileno de tiazolidinonas, oxazolidinona e imidazolidinonas 2-substituidas

Info

Publication number
PT97169A
PT97169A PT97169A PT9716991A PT97169A PT 97169 A PT97169 A PT 97169A PT 97169 A PT97169 A PT 97169A PT 9716991 A PT9716991 A PT 9716991A PT 97169 A PT97169 A PT 97169A
Authority
PT
Portugal
Prior art keywords
imidazolidinones
lipxygenase
hydroxyphenylenean
terc
oxygenase
Prior art date
Application number
PT97169A
Other languages
English (en)
Other versions
PT97169B (pt
Inventor
Wiaczeslaw Antin Cetenko
David Thomas Connor
Jagadish Chandra Sircar
Roderick Joseph Sorenson
Paul Charles Unangst
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of PT97169A publication Critical patent/PT97169A/pt
Publication of PT97169B publication Critical patent/PT97169B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/96—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/40—One oxygen atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/46—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT97169A 1990-03-27 1991-03-27 Processo para a preparacao de composicoes farmaceuticas inibidora das enzimas 5-lipxigenase e ciclo-oxigenase contendo derivados de 3,5-di-terc-butil-4-hidroxifenilmetileno de tiazolidinonas, oxazolidinona e imidazolidinonas 2-substituidas PT97169B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49993790A 1990-03-27 1990-03-27
US07/640,711 US5143928A (en) 1990-03-27 1991-01-18 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents

Publications (2)

Publication Number Publication Date
PT97169A true PT97169A (pt) 1991-12-31
PT97169B PT97169B (pt) 1998-07-31

Family

ID=27053353

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97169A PT97169B (pt) 1990-03-27 1991-03-27 Processo para a preparacao de composicoes farmaceuticas inibidora das enzimas 5-lipxigenase e ciclo-oxigenase contendo derivados de 3,5-di-terc-butil-4-hidroxifenilmetileno de tiazolidinonas, oxazolidinona e imidazolidinonas 2-substituidas

Country Status (20)

Country Link
US (3) US5143928A (pt)
EP (1) EP0449216B1 (pt)
JP (1) JP3028628B2 (pt)
KR (1) KR0156533B1 (pt)
CN (1) CN1055180A (pt)
AT (1) ATE133945T1 (pt)
AU (1) AU640468B2 (pt)
CA (1) CA2039056C (pt)
DE (1) DE69116909T2 (pt)
DK (1) DK0449216T3 (pt)
ES (1) ES2082875T3 (pt)
FI (1) FI103508B (pt)
GR (1) GR3019272T3 (pt)
HK (1) HK1005186A1 (pt)
HU (1) HU911001D0 (pt)
IE (1) IE911006A1 (pt)
IL (1) IL97403A0 (pt)
NO (1) NO302294B1 (pt)
NZ (1) NZ237565A (pt)
PT (1) PT97169B (pt)

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US6444685B1 (en) 2000-07-17 2002-09-03 Wyeth N-(4-sulfonylaryl)Cyclylamine 2-hydroxyethylamines as beta-3 adrenergic receptor agonists
US6525202B2 (en) 2000-07-17 2003-02-25 Wyeth Cyclic amine phenyl beta-3 adrenergic receptor agonists
US6452014B1 (en) 2000-12-22 2002-09-17 Geron Corporation Telomerase inhibitors and methods of their use
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CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
MXPA02010430A (es) * 2001-11-27 2003-06-02 Warner Lambert Co Inhibidores aminotransferasa dependientes de aminoacidos de cadena ramificada y su uso en el tratamiento de las enfermedades neurodegenerativas.
DK1567112T3 (da) * 2002-11-22 2009-02-09 Smithkline Beecham Corp Thiazolidin-4-oner til at hæmme hYAK3-proteiner
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JP4570857B2 (ja) * 2003-03-31 2010-10-27 富士フイルム株式会社 感光性組成物及び平版印刷版原版
PT1889198E (pt) 2005-04-28 2015-03-06 Proteus Digital Health Inc Sistema fármaco-informático
CN100384828C (zh) * 2005-05-08 2008-04-30 山东大学 (z)-5-[[(3,5-二叔丁基)-4-羟基苯基]亚甲基]-2-亚氨基-4-噻唑啉酮甲磺酸盐的制备方法
TW200716580A (en) * 2005-06-08 2007-05-01 Smithkline Beecham Corp (5Z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5H)-one
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
US20100286041A1 (en) * 2007-03-22 2010-11-11 Smithkline Beecham Corporation (5z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5h)-one
FR2919608B1 (fr) * 2007-08-01 2012-10-05 Univ Rennes Derives d'imidazolones,procede de preparation et applications biologiques
WO2010095940A2 (en) 2009-02-20 2010-08-26 To-Bbb Holding B.V. Glutathione-based drug delivery system
US11033523B2 (en) 2009-04-29 2021-06-15 Amarin Pharmaceuticals Ireland Limited Pharmaceutical compositions comprising EPA and a cardiovascular agent and methods of using the same
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CN102000487B (zh) * 2010-10-19 2012-09-05 上海海事大学 一种捕捉二氧化碳的方法
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JP6453224B2 (ja) 2012-11-05 2019-01-16 コミッサリア ア レネルジ アトミック エ オー エネルジス アルテルナティヴスＣｏｍｍｉｓｓａｒｉａｔ Ａ Ｌ‘Ｅｎｅｒｇｉｅ Ａｔｏｍｉｑｕｅ Ｅｔ Ａｕｘ Ｅｎｅｒｇｉｅｓ Ａｌｔｅｒｎａｔｉｖｅｓ インビボで血液がんの幹細胞を排除するため、および血液がんの再発を防ぐための、チロシンキナーゼ阻害剤のような抗がん剤と、好ましくはチアゾリジンジオンであるｓｔａｔ５アンタゴニストとの組み合わせ

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Also Published As

Publication number Publication date
ES2082875T3 (es) 1996-04-01
FI103508B1 (fi) 1999-07-15
KR0156533B1 (ko) 1998-11-16
AU7372191A (en) 1991-10-03
JPH04221371A (ja) 1992-08-11
CA2039056C (en) 2001-09-18
EP0449216A1 (en) 1991-10-02
NO911231L (no) 1991-09-30
US5290800A (en) 1994-03-01
HU911001D0 (en) 1991-10-28
DE69116909T2 (de) 1996-06-13
AU640468B2 (en) 1993-08-26
HK1005186A1 (en) 1998-12-24
GR3019272T3 (en) 1996-06-30
CA2039056A1 (en) 1991-09-28
PT97169B (pt) 1998-07-31
FI911443A0 (fi) 1991-03-25
FI911443A (fi) 1991-09-28
US5494927A (en) 1996-02-27
IL97403A0 (en) 1992-06-21
CN1055180A (zh) 1991-10-09
JP3028628B2 (ja) 2000-04-04
US5143928A (en) 1992-09-01
NO911231D0 (no) 1991-03-26
NZ237565A (en) 1993-02-25
KR910016724A (ko) 1991-11-05
DE69116909D1 (de) 1996-03-21
EP0449216B1 (en) 1996-02-07
NO302294B1 (no) 1998-02-16
FI103508B (fi) 1999-07-15
DK0449216T3 (da) 1996-07-01
ATE133945T1 (de) 1996-02-15
IE911006A1 (en) 1991-10-09

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