AU4368996A - Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands - Google Patents

Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands

Info

Publication number
AU4368996A
AU4368996A AU43689/96A AU4368996A AU4368996A AU 4368996 A AU4368996 A AU 4368996A AU 43689/96 A AU43689/96 A AU 43689/96A AU 4368996 A AU4368996 A AU 4368996A AU 4368996 A AU4368996 A AU 4368996A
Authority
AU
Australia
Prior art keywords
aminomethyl
imidazole derivatives
substituted imidazole
certain
dopamine receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU43689/96A
Inventor
Raymond F Horvath
John M Peterson
Andrew Thurkauf
Jun Yuan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurogen Corp
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/401,201 external-priority patent/US5681956A/en
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of AU4368996A publication Critical patent/AU4368996A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU43689/96A 1994-11-23 1995-11-22 Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands Abandoned AU4368996A (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US34415494A 1994-11-23 1994-11-23
US34455294A 1994-11-23 1994-11-23
US344552 1994-11-23
US344154 1994-11-23
US08/401,201 US5681956A (en) 1990-12-28 1995-03-09 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
US401201 1995-03-09
PCT/US1995/015262 WO1996016040A1 (en) 1994-11-23 1995-11-22 Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands

Publications (1)

Publication Number Publication Date
AU4368996A true AU4368996A (en) 1996-06-17

Family

ID=27407598

Family Applications (1)

Application Number Title Priority Date Filing Date
AU43689/96A Abandoned AU4368996A (en) 1994-11-23 1995-11-22 Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands

Country Status (8)

Country Link
EP (1) EP0793653A1 (en)
JP (1) JP2941950B2 (en)
CN (1) CN1088062C (en)
AU (1) AU4368996A (en)
BR (1) BR9509760A (en)
CA (1) CA2205998C (en)
MX (1) MX9703736A (en)
WO (1) WO1996016040A1 (en)

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AU3705597A (en) 1996-08-08 1998-03-06 Schering Corporation Preparation of aminomethyl-phenylimidazoles
US5905152A (en) * 1996-08-08 1999-05-18 Schering Corporation Preparation of aminomethyl-phenylimidazoles
DE19637237A1 (en) 1996-09-13 1998-03-19 Merck Patent Gmbh Piperazine derivatives
HUP0003309A3 (en) 1997-06-12 2002-02-28 Rhone Poulenc Rorer Ltd West M Imidazolyl-cyclic acetals, process for producing them and pharmaceutical compositions containing the same
TW450954B (en) * 1998-05-14 2001-08-21 Pharmacia & Amp Upjohn Company Phenylsulfonamide-phenylethylamines useful as dopamine receptors
CA2334945A1 (en) * 1998-06-12 1999-12-16 Christophe Alain Thurieau Imidazolyl derivatives
WO2000018763A2 (en) * 1998-09-29 2000-04-06 Neurogen Corporation 2-(2,3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles: dopamine receptor subtype specific ligands
US6288230B1 (en) 1998-09-29 2001-09-11 Neurogen Corporation 2-(2, 3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles: dopamine receptor subtype specific ligands
US6284759B1 (en) 1998-09-30 2001-09-04 Neurogen Corporation 2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands
NZ511018A (en) 1998-10-08 2003-09-26 Smithkline Beecham Plc Tetrahydrobenzazepine derivatives useful as modulators of dopamine D3 receptors (antipsychotic agents)
AU771199B2 (en) * 1999-01-08 2004-03-18 Neurogen Corporation 1-phenyl-4-(1-(2-aryl)cyclopropyl) methylpiperazines: dopamine receptor ligands
US6284761B1 (en) 1999-01-08 2001-09-04 Neurogen Corporation 1-phenyl-4-(1-[2-aryl]cyclopropyl)methylpiperazines: dopamine receptor ligands
AR022230A1 (en) * 1999-01-12 2002-09-04 Abbott Gmbh & Co Kg TRIAZOL COMPOUNDS, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND USE OF THE SAME TO PREPARE SUCH COMPOSITION
WO2002049993A2 (en) * 2000-09-29 2002-06-27 Neurogen Corporation High affinity small molecule c5a receptor modulators
RU2380362C2 (en) * 1999-10-11 2010-01-27 Сосьете Де Консей Де Решерш З Derivatives of five-member heterocycles, method of production and use thereof as medicinal agents
KR100822085B1 (en) * 1999-10-11 2008-04-15 소시에떼 드 꽁세이으 드 르세르세 에 따블리까시옹 시앙띠피끄 (에스.세.에르.아.에스.) 5-membered heterocycle derivatives, methods for their preparation and their use as medicaments
FR2812546B1 (en) * 2000-08-01 2008-11-21 Sod Conseils Rech Applic 5-CHAIN HETEROCYCLE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS
TWI283577B (en) * 1999-10-11 2007-07-11 Sod Conseils Rech Applic Pharmaceutical composition of imidazole derivatives acting as modulators of sodium channels and the use thereof
AU2001279294A1 (en) 2000-07-06 2002-01-21 Neurogen Corporation Melanin concentrating hormone receptor ligands
IL154222A0 (en) 2000-08-01 2003-07-31 Sod Conseils Rech Applic Imidazolyl derivatives
EP1345935A2 (en) 2000-12-21 2003-09-24 Warner-Lambert Company LLC Piperidine derivatives as subtype selective n-methyl-d-aspartate antagonists
FR2818978B1 (en) * 2000-12-28 2003-02-28 Sod Conseils Rech Applic MODULATORS OF SODIUM CHANNELS DERIVED FROM 2-PIPERIDYLIMIDAZOLES
TWI248438B (en) * 2001-04-10 2006-02-01 Sod Conseils Rech Applic Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
CN1518550A (en) 2001-06-21 2004-08-04 ʷ��˿�������ȳ�ķ���޹�˾ Imidazo [1,2-A] pyridine derivatives for prophylaxis and treatment of herpes viral infections
ATE326466T1 (en) 2001-10-05 2006-06-15 Smithkline Beecham Corp IMIDAZOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HERPES VIRUS INFECTION
WO2005011657A2 (en) 2003-07-30 2005-02-10 Xenon Pharmaceuticals Inc. Piperazine derivatives and their use as therapeutic agents
DE102004051277A1 (en) 2004-10-21 2006-04-27 Merck Patent Gmbh Heterocyclic carbonyl compounds
EP1848428A4 (en) * 2005-02-18 2012-04-18 Neurogen Corp Thiazole amides, imidazole amides and related analogues
EP1939180A1 (en) 2006-12-20 2008-07-02 sanofi-aventis Heteroarylacrylamides and their use as pharmaceuticals for the stimulation of the expression of endothelial NO synthase
EP1939181A1 (en) 2006-12-27 2008-07-02 sanofi-aventis Heteroaryl-substituted carboxamides and use thereof for the stimulation of the expression of NO synthase
JPWO2008136428A1 (en) * 2007-04-27 2010-07-29 武田薬品工業株式会社 Nitrogen-containing 5-membered heterocyclic compound
SA08290520B1 (en) 2007-08-22 2012-02-22 استرازينيكا ايه بي Cyclopropyl Amide Derivatives and Pharmaceutical Composition Comprising the Same for Treating Histamine H3 Receptors Associated Condition
TW201039825A (en) 2009-02-20 2010-11-16 Astrazeneca Ab Cyclopropyl amide derivatives 983
RU2012136148A (en) 2010-02-18 2014-03-27 Астразенека Аб NEW CRYSTAL FORM OF THE CYCLOPROPYLBENZAMIDE DERIVATIVE
CA2842362C (en) 2011-07-29 2020-06-16 Karyopharm Therapeutics, Inc. Hydrazide containing nuclear transport modulators and uses thereof
PE20141003A1 (en) * 2011-07-29 2014-09-02 Karyopharm Therapeutics Inc NUCLEAR TRANSPORTATION MODULATORS AND USES OF THEM
US9051299B2 (en) 2012-03-29 2015-06-09 Merck Sharp & Dohme Corp. Imidazolyl methyl piperidine T-type calcium channel antagonists
PT2858991T (en) 2012-05-09 2018-12-17 Biogen Ma Inc Nuclear transport modulators and uses thereof
WO2014144772A1 (en) 2013-03-15 2014-09-18 Karyopharm Therapeutics Inc. Methods of promoting wound healing using crm1 inhibitors
CA2915365C (en) 2013-06-21 2022-08-16 Karyopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
WO2015154191A1 (en) 2014-04-10 2015-10-15 Dalhousie University Treatment of parkinson's disease through arfgap1 inhibition using substituted piperazine derivatives
US10519139B2 (en) 2014-08-15 2019-12-31 Karyopharm Therapeutics Inc. Polymorphs of Selinexor
WO2017117535A1 (en) 2015-12-31 2017-07-06 Karyopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
MA43529A (en) 2015-12-31 2018-11-07 Karyopharm Therapeutics Inc NUCLEAR TRANSPORT MODULATORS AND THEIR USES
US11602530B2 (en) 2016-11-28 2023-03-14 Biogen Ma Inc. CRM1 inhibitors for treating epilepsy
IL273428B2 (en) 2017-09-22 2023-09-01 Jubilant Epipad LLC Heterocyclic compounds as pad inhibitors
KR102782563B1 (en) 2017-10-18 2025-03-14 주빌런트 에피파드 엘엘씨 Imidazo-pyridine compounds as PAD inhibitors
US11629135B2 (en) 2017-11-06 2023-04-18 Jubilant Prodell Llc Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
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CN112105610B (en) 2018-03-13 2024-01-26 朱比连特普罗德尔有限责任公司 Bicyclic compounds as inhibitors of PD1/PD-L1 interaction/activation

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DK171349B1 (en) * 1986-11-14 1996-09-16 Hoffmann La Roche Tetrahydronaphthalane derivatives, process for their preparation, medicaments containing the compounds and use of the compounds for the manufacture of medicaments
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GB9306578D0 (en) * 1993-03-30 1993-05-26 Merck Sharp & Dohme Therapeutic agents
KR100196356B1 (en) * 1993-09-28 1999-06-15 오스카 아끼히꼬 Diabetes treatment

Also Published As

Publication number Publication date
CA2205998A1 (en) 1996-05-30
JPH10502670A (en) 1998-03-10
BR9509760A (en) 1998-06-30
CN1177349A (en) 1998-03-25
MX9703736A (en) 1998-07-31
CN1088062C (en) 2002-07-24
EP0793653A1 (en) 1997-09-10
JP2941950B2 (en) 1999-08-30
WO1996016040A1 (en) 1996-05-30
CA2205998C (en) 2002-07-16

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