BR0014649A - Utilização de um produto, medicamento, composto e composição farmacêutica - Google Patents

Utilização de um produto, medicamento, composto e composição farmacêutica

Info

Publication number
BR0014649A
BR0014649A BR0014649-8A BR0014649A BR0014649A BR 0014649 A BR0014649 A BR 0014649A BR 0014649 A BR0014649 A BR 0014649A BR 0014649 A BR0014649 A BR 0014649A
Authority
BR
Brazil
Prior art keywords
mainly
alkyl
radical
general formula
hydrogen atom
Prior art date
Application number
BR0014649-8A
Other languages
English (en)
Inventor
Pierre-Etienne Chabrier De Lassauniere
Jeremiah Harnett
Dennis Bigg
Jacques Pommier
Jacques Lannoy
Anne-Marie Liberatore
Christophe Thurieau
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9912643A external-priority patent/FR2799461B1/fr
Priority claimed from FR0010151A external-priority patent/FR2812546B1/fr
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of BR0014649A publication Critical patent/BR0014649A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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Abstract

"UTILIZAçãO DE UM PRODUTO, MEDICAMENTO, COMPOSTO E COMPOSIçãO FARMACêUTICA". Os compostos de fórmula geral ( I ) podem ser utilizados para preparar um medicamento destinado a inibir as monoamina oxidases ( MAO ) e/ou peroxidação lipídica e/ou a agir como moduladores dos canais sódicos. Em particular, o medicamento preparado será destinado para tratar a doença de Parkinson, as demências senis, a doença de Alzheimer, a coréia de Huntington, a esclerose lateral amiotrófica, a esquizofrenia, as depressões, as psicoses, a dor e a epilepsia. Os compostos da invenção apresentam a fórmula geral ( I ) em que Het é um heterociclo com 5 membros comportando 2 heteroátomos e tal que a fórmula geral ( I ) corresponda exclusivamente a uma das sub-fórmulas ( I )~ 1~, ( I )~ 2~, ( I )~ 3~, ( I )~ 4~ em que A representa principalmente um radical fenila ou bifenila substituído, B representa principalmente H ou um radical alquila, X representa principalmente NH ou S, Y representa O ou S, n é um número inteiro de O a 6, R^ 1^ e R^ 2^ representam, independentemente, principalmente, radicais selecionados dentre um átomo de hidrogênio ou radical alquila ou cicloalquila, e <87> representa NR^ 46^R^ 47^ ou OR^ 48^, R^ 46^ e R^ 47^ representando, principalmente, radicais selecionados dentre um átomo de hidrogênio e um radical alquila, cicloalquila, alquinila, cianoalquila alcoxicarbonila, aralcaxicarbonila ou ( cicloalquil ) oxicarbonila e R ^ 48^ representando um átomo de hidrogênio ou um radical alquila, alquinila ou cianoalquila.
BR0014649-8A 1999-10-11 2000-10-10 Utilização de um produto, medicamento, composto e composição farmacêutica BR0014649A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9912643A FR2799461B1 (fr) 1999-10-11 1999-10-11 Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments
FR0010151A FR2812546B1 (fr) 2000-08-01 2000-08-01 Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments
FR0011169 2000-09-01
PCT/FR2000/002805 WO2001026656A2 (fr) 1999-10-11 2000-10-10 Derives d'heterocycles a 5 chainons et leur application comme inhibiteurs de monoamine oxydase

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US7956075B2 (en) 2011-06-07
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US20070021390A1 (en) 2007-01-25
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EP1223933B1 (fr) 2006-09-06
DE60030574D1 (de) 2006-10-19
AU7796500A (en) 2001-04-23
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CY1106237T1 (el) 2011-06-08
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EP1223933A2 (fr) 2002-07-24
WO2001026656A3 (fr) 2002-04-18
NO20021689D0 (no) 2002-04-10
IL148896A0 (en) 2002-09-12
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US20080146627A1 (en) 2008-06-19
ATE522213T1 (de) 2011-09-15
CZ20021292A3 (cs) 2002-10-16
ES2270873T3 (es) 2007-04-16
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MXPA02003665A (es) 2003-10-14
US8288560B2 (en) 2012-10-16
DK1589007T3 (en) 2015-08-10
EP1228760A2 (fr) 2002-08-07
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AU783129B2 (en) 2005-09-29
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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]