AR039172A1 - Derivados de morfolina, antagonistas de ccr3. - Google Patents
Derivados de morfolina, antagonistas de ccr3.Info
- Publication number
- AR039172A1 AR039172A1 ARP030101084A ARP030101084A AR039172A1 AR 039172 A1 AR039172 A1 AR 039172A1 AR P030101084 A ARP030101084 A AR P030101084A AR P030101084 A ARP030101084 A AR P030101084A AR 039172 A1 AR039172 A1 AR 039172A1
- Authority
- AR
- Argentina
- Prior art keywords
- morfolina
- derivatives
- ccr3 antagonists
- substituted
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Ciertos compuestos de fórmula (1): en la que: R1 representa arilo sustituido o no sustituido; Y representa -(CRnaRnb)n-; Rna y Rnb son cada uno independientemente hidrógeno o alquilo C1-6; n es un número entero de 1 a 5; R2 representa arilo sustituido o no sustituido o heteroarilo sustituido o no sustituido; cada uno de R3 y R4 representa independientemente hidrógeno o alquilo C1-6; y sales y solvatos de los mismos son antagonistas de CCR3 y, de esta forma, están indicados por su utilidad en terapia.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0207436.7A GB0207436D0 (en) | 2002-03-28 | 2002-03-28 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR039172A1 true AR039172A1 (es) | 2005-02-09 |
Family
ID=9933988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030101084A AR039172A1 (es) | 2002-03-28 | 2003-03-27 | Derivados de morfolina, antagonistas de ccr3. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1487455A1 (es) |
| JP (1) | JP2005526807A (es) |
| AR (1) | AR039172A1 (es) |
| AU (1) | AU2003226759A1 (es) |
| GB (1) | GB0207436D0 (es) |
| TW (1) | TW200400824A (es) |
| WO (1) | WO2003082292A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR028948A1 (es) | 2000-06-20 | 2003-05-28 | Astrazeneca Ab | Compuestos novedosos |
| KR101128065B1 (ko) | 2004-05-26 | 2012-04-12 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 신나미드 화합물 |
| IN2014CN03493A (es) | 2004-09-08 | 2015-07-03 | Mitsubishi Tanabe Pharma Corp | |
| US7923563B2 (en) | 2004-10-26 | 2011-04-12 | Eisai R&D Management Co., Ltd. | Amorphous object of cinnamide compound |
| AU2006282122A1 (en) * | 2005-08-26 | 2007-03-01 | Astrazeneca Ab | A combination of compounds, which can be used in the treatment of respiratory diseases, especially chronic obstructive pulmonary disease (COPD) and asthma |
| TW200744612A (en) * | 2005-08-26 | 2007-12-16 | Astrazeneca Ab | New combination |
| JP5221144B2 (ja) | 2005-11-24 | 2013-06-26 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | モルホリンタイプ・シンナミド化合物 |
| TWI370130B (en) | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
| TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
| AU2007252643A1 (en) * | 2006-05-19 | 2007-11-29 | Eisai R & D Management Co., Ltd. | Urea type cinnamide derivative |
| US7737141B2 (en) | 2006-07-28 | 2010-06-15 | Eisai R&D Management Co., Ltd. | Prodrug of cinnamide compound |
| EP2120935A4 (en) * | 2007-02-23 | 2011-06-22 | Astrazeneca Ab | NOVEL COMBINATION OF COMPOUNDS FOR THE TREATMENT OF AIRWAY DISEASES, IN PARTICULAR CHRONIC OBSTRUCTIVE BRONCHOPNEUMOPATHY (COPD) AND ASTHMA |
| US20080207900A1 (en) | 2007-02-28 | 2008-08-28 | Teiji Kimura | Two cyclic oxomorphorin derivatives |
| CA2694401C (en) | 2007-08-31 | 2012-12-04 | Eisai R&D Management Co., Ltd. | Polycyclic compound |
| US7935815B2 (en) | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69527786T2 (de) * | 1994-05-18 | 2003-04-10 | Nisshin Seifun Group Inc., Tokio/Tokyo | Diaminomethyliden-derivate |
| KR20010086045A (ko) * | 1998-11-20 | 2001-09-07 | 프리돌린 클라우스너, 롤란드 비. 보레르 | 피롤리딘 유도체-씨씨알-3 수용체 길항제 |
| CA2423305A1 (en) * | 2000-09-29 | 2002-04-04 | Glaxo Group Limited | Compounds useful in the treatment of inflammatory diseases |
-
2002
- 2002-03-28 GB GBGB0207436.7A patent/GB0207436D0/en not_active Ceased
-
2003
- 2003-03-26 TW TW092106769A patent/TW200400824A/zh unknown
- 2003-03-27 JP JP2003579829A patent/JP2005526807A/ja active Pending
- 2003-03-27 AU AU2003226759A patent/AU2003226759A1/en not_active Abandoned
- 2003-03-27 WO PCT/EP2003/003340 patent/WO2003082292A1/en not_active Application Discontinuation
- 2003-03-27 AR ARP030101084A patent/AR039172A1/es unknown
- 2003-03-27 EP EP03745296A patent/EP1487455A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003082292A1 (en) | 2003-10-09 |
| EP1487455A1 (en) | 2004-12-22 |
| TW200400824A (en) | 2004-01-16 |
| GB0207436D0 (en) | 2002-05-08 |
| JP2005526807A (ja) | 2005-09-08 |
| AU2003226759A1 (en) | 2003-10-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR039172A1 (es) | Derivados de morfolina, antagonistas de ccr3. | |
| CY1117132T1 (el) | Παραγωγο θειαζολιου | |
| CY1111706T1 (el) | Παραγωγα αρυλο- και ετεροαρυλο-πιπεριδινοκαρβοξυλικων αλατων, η παρασκευη τους και η εφαρμογη τους ως αναστολεις του ενζυμου faah | |
| CO5580746A2 (es) | Derivados de fenil-piperazina como inhibidores de la reabsorcion de la serotonina | |
| CO5580768A2 (es) | Derivados de 4,5-diariltiazol como ligandos cb-1 | |
| EA200800285A1 (ru) | Новые производные 2,4-дианилинопиримидинов, их получение, лекарственные средства, фармацевтические композиции, содержащие указанные производные, и их применение, в частности, в качестве ингибиторов ikk | |
| CY1106237T1 (el) | Ετepοκυκλικα παραγωγα με 5 μελη στο δακτυλιο και εφαρμογη αυτων ως παρεμποδιστων της μονοαμινο οξυδασης | |
| HUP9802859A2 (hu) | Acil-amino-szalicilsav-amid-származékok és alkalmazásuk peszticidként | |
| EA200970311A1 (ru) | ПРОИЗВОДНЫЕ 2-АРИЛ-6-ФЕНИЛИМИДАЗО[1,2-α]ПИРИДИНОВ, ИХ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ В ТЕРАПИИ | |
| EA200401285A1 (ru) | Меченные радиоактивными изотопами производные хинолина и хинолинона и их применение в качестве лигандов метаботропного глутаматного рецептора | |
| AR049784A1 (es) | Derivados sustituidos de morfolina y tiomorfolina | |
| EA200600509A1 (ru) | Соединения пиримидотиофена | |
| ECSP045369A (es) | Derivados de n-[fenil(piperidin-2-il)metil]benzamida, su preparacion y su aplicacion en terapeutica | |
| UY26899A1 (es) | Derivados de pirazol fusionados | |
| CO4520230A1 (es) | Derivados de [3-(4-fenilpiperacin-1-il) propilamino, tio y oxilo]-piridina, pirimidina y benceno como antagonistas de alfa 1- adrenoceptores | |
| DK1117297T3 (da) | Syntetiske analoger af ecteinascidin-743 | |
| ECSP045278A (es) | Compuestos de oxo-azabicíclicos | |
| AR024939A1 (es) | Compuestos derivados de hidantoina,tiohidantoina, pirimidinonas, tioxopirimidinonas, intermedirios, proceso para su preparacion y su uso de los mismos | |
| AR042362A1 (es) | Derivados de 3h-quinazolin-4-ona, proceso de obtencion y composiciones farmaceuticas que los contienen | |
| WO2003082861A3 (en) | Morpholinyl-urea derivatives for use of the treatment of inflammatory diseases | |
| ATE402185T1 (de) | Verfahren für fluorcytidinderivate | |
| AR040133A1 (es) | Derivados de n-acilamino bencil eter | |
| HUP0201475A2 (hu) | Heteroarilamidin-, metilamidin- és guanidinszármazékok, előállításuk és alkalmazásuk, valamint e vegyületeket tartalmazó gyógyászati készítmények | |
| CO5580721A2 (es) | Composicion fungicida basada en al menos un derivado de piridilmetilbenzamida y al menos un derivado de ditiocarbamato | |
| AR034206A1 (es) | Un procedimiento para la preparacion de mesilatos de derivados de piperazina y dichos mesilatos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |