DK1117297T3 - Syntetiske analoger af ecteinascidin-743 - Google Patents

Syntetiske analoger af ecteinascidin-743

Info

Publication number
DK1117297T3
DK1117297T3 DK99948484T DK99948484T DK1117297T3 DK 1117297 T3 DK1117297 T3 DK 1117297T3 DK 99948484 T DK99948484 T DK 99948484T DK 99948484 T DK99948484 T DK 99948484T DK 1117297 T3 DK1117297 T3 DK 1117297T3
Authority
DK
Denmark
Prior art keywords
substituted
unsubstituted
co2h
nhc
alkynyl
Prior art date
Application number
DK99948484T
Other languages
English (en)
Inventor
Elias J Corey
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Application granted granted Critical
Publication of DK1117297T3 publication Critical patent/DK1117297T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
DK99948484T 1998-09-30 1999-09-30 Syntetiske analoger af ecteinascidin-743 DK1117297T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/165,892 US6124292A (en) 1998-09-30 1998-09-30 Synthetic analogs of ecteinascidin-743

Publications (1)

Publication Number Publication Date
DK1117297T3 true DK1117297T3 (da) 2006-01-09

Family

ID=22600906

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99948484T DK1117297T3 (da) 1998-09-30 1999-09-30 Syntetiske analoger af ecteinascidin-743

Country Status (13)

Country Link
US (3) US6124292A (da)
EP (1) EP1117297B1 (da)
JP (1) JP4638985B2 (da)
AT (1) ATE303063T1 (da)
AU (1) AU765439B2 (da)
CA (1) CA2345297C (da)
DE (1) DE69927039T2 (da)
DK (1) DK1117297T3 (da)
ES (1) ES2249028T3 (da)
HK (1) HK1039727B (da)
MX (1) MXPA01003339A (da)
NZ (1) NZ510734A (da)
WO (1) WO2000018233A1 (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1077698B1 (en) * 1998-05-11 2005-03-02 Pharma Mar, S.A. Metabolites of ecteinascidin 743
US6124292A (en) * 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
GB9918178D0 (en) * 2000-05-15 1999-10-06 Pharma Mar Sa Synthetic methods
MY130271A (en) * 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
AU783562B2 (en) * 2000-01-19 2005-11-10 Trustees Of Columbia University In The City Of New York, The Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof
US6815544B2 (en) 2000-02-11 2004-11-09 President And Fellows Of Harvard College Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds
MXPA02007767A (es) * 2000-02-11 2002-10-23 Harvard College Proceso sintetico para un intermediario para compuestos de ecteinascidina y ftalascidina.
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
CA2406080C (en) * 2000-04-12 2011-11-29 Pharma Mar, S.A. Antitumoral ecteinascidin derivatives
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
US7420051B2 (en) * 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
JP2004529074A (ja) * 2000-11-03 2004-09-24 プレジデント アンド フェロウズ オブ ハーバード カレッジ サフラマイシン、そのアナログ、およびその使用
CA2428160C (en) * 2000-11-06 2009-10-13 Pharma Mar, S.A. Compositions for antitumor treatment containing ecteinascidin 743
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
US7183054B2 (en) * 2003-06-03 2007-02-27 President And Fellows Of Harvard College Assay for identifying biological targets of polynucleotide-binding compounds
NZ554765A (en) * 2004-10-26 2010-01-29 Pharma Mar Sa Pegylated Liposomal Doxorubicin In Combination With Ecteinescidin 743
DE602005001833T2 (de) 2004-10-29 2008-04-17 Pharma Mar S.A., Sociedad Unipersonal Zusammensetzungen enthaltend Ecteinascidin und einen Disaccharide
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
WO2009138509A1 (en) * 2008-05-16 2009-11-19 Pharma Mar, S.A. Multiple myeloma treatments
RU2010151602A (ru) * 2008-05-16 2012-06-27 Фарма Мар, С.А. (Es) Комбинированная терапия с помощью рм00104 и другого противоопухолевого средства
WO2011048210A1 (en) 2009-10-22 2011-04-28 Pharma Mar, S.A. PDGFR-α AS RESPONSE MARKER FOR PM00104 TREATMENT
WO2011147828A1 (en) 2010-05-25 2011-12-01 Pharma Mar, S.A. Synthetic process for the manufacture of ecteinascidin compounds
RU2743643C2 (ru) 2010-11-12 2021-02-20 Фарма Мар, С.А. Комбинированная терапия противоопухолевым алкалоидом
CN107522698B (zh) * 2016-06-20 2021-12-28 浙江海正药业股份有限公司 一种曲贝替定的制备方法及其中间体
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
US10597378B2 (en) 2017-09-08 2020-03-24 National Health Research Institutes Tetrahydroisoquinolines for use as MOR/NOP dual agonists
CN111518110B (zh) 2019-02-01 2023-11-03 博瑞生物医药（苏州）股份有限公司 一种海鞘素化合物及其中间体的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5937952B2 (ja) 1977-09-12 1984-09-12 正 新井 抗生物質サフラマイシンａ，ｂ，ｃ，ｄ，ｅおよびその製造法
JPS56135486A (en) 1980-03-26 1981-10-22 Tadashi Arai Antibiotic saframycin s and its preparative method
JPS5942382A (ja) * 1982-09-02 1984-03-08 Yoshitomi Pharmaceut Ind Ltd サフラシン誘導体
JPS6158593A (ja) * 1984-08-30 1986-03-25 Tadashi Arai 新規サフラマイシンａ誘導体およびその製造法
EP0233841A1 (de) * 1986-02-18 1987-08-26 Arai, Tadashi, Prof. Chinon-Derivate und Verfahren zu ihrer Herstellung
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
JPS632991A (ja) * 1986-06-23 1988-01-07 Akinori Kubo 新規イソキノリン誘導体
EP0262085A1 (de) * 1986-08-15 1988-03-30 Gesellschaft für Biotechnologische Forschung mbH (GBF) Antibiotika aus Myxococcus
EP0329606A3 (de) * 1988-02-12 1991-04-03 Ciba-Geigy Ag Neue Antibiotika aus Myxococcus
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US6124292A (en) * 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743

Also Published As

Publication number Publication date
US6348467B1 (en) 2002-02-19
AU6165099A (en) 2000-04-17
DE69927039T2 (de) 2006-06-22
EP1117297B1 (en) 2005-08-31
HK1039727A1 (en) 2002-05-10
CA2345297C (en) 2009-12-22
US6124292A (en) 2000-09-26
MXPA01003339A (es) 2002-07-02
USRE41614E1 (en) 2010-08-31
DE69927039D1 (de) 2005-10-06
AU765439B2 (en) 2003-09-18
EP1117297A1 (en) 2001-07-25
JP2002525296A (ja) 2002-08-13
WO2000018233A1 (en) 2000-04-06
JP4638985B2 (ja) 2011-02-23
ES2249028T3 (es) 2006-03-16
EP1117297A4 (en) 2002-02-27
CA2345297A1 (en) 2000-04-06
NZ510734A (en) 2003-10-31
ATE303063T1 (de) 2005-09-15
HK1039727B (zh) 2006-01-06

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