DE69927039D1 - Synthetische analoge des ecteinascidin-743 - Google Patents

Synthetische analoge des ecteinascidin-743

Info

Publication number
DE69927039D1
DE69927039D1 DE69927039T DE69927039T DE69927039D1 DE 69927039 D1 DE69927039 D1 DE 69927039D1 DE 69927039 T DE69927039 T DE 69927039T DE 69927039 T DE69927039 T DE 69927039T DE 69927039 D1 DE69927039 D1 DE 69927039D1
Authority
DE
Germany
Prior art keywords
substituted
unsubstituted
co2h
nhc
alkynyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69927039T
Other languages
English (en)
Other versions
DE69927039T2 (de
Inventor
J Corey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard College
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Application granted granted Critical
Publication of DE69927039D1 publication Critical patent/DE69927039D1/de
Publication of DE69927039T2 publication Critical patent/DE69927039T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69927039T 1998-09-30 1999-09-30 Synthetische analoge des ecteinascidin-743 Expired - Lifetime DE69927039T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/165,892 US6124292A (en) 1998-09-30 1998-09-30 Synthetic analogs of ecteinascidin-743
US165892 1998-09-30
PCT/US1999/022405 WO2000018233A1 (en) 1998-09-30 1999-09-30 Synthetic analogs of ecteinascidin-743

Publications (2)

Publication Number Publication Date
DE69927039D1 true DE69927039D1 (de) 2005-10-06
DE69927039T2 DE69927039T2 (de) 2006-06-22

Family

ID=22600906

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69927039T Expired - Lifetime DE69927039T2 (de) 1998-09-30 1999-09-30 Synthetische analoge des ecteinascidin-743

Country Status (13)

Country Link
US (3) US6124292A (de)
EP (1) EP1117297B1 (de)
JP (1) JP4638985B2 (de)
AT (1) ATE303063T1 (de)
AU (1) AU765439B2 (de)
CA (1) CA2345297C (de)
DE (1) DE69927039T2 (de)
DK (1) DK1117297T3 (de)
ES (1) ES2249028T3 (de)
HK (1) HK1039727B (de)
MX (1) MXPA01003339A (de)
NZ (1) NZ510734A (de)
WO (1) WO2000018233A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL139607A0 (en) * 1998-05-11 2002-02-10 Pharma Mar Sa Metabolites of ecteinascidin 743
US6124292A (en) * 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
GB9918178D0 (en) * 2000-05-15 1999-10-06 Pharma Mar Sa Synthetic methods
MY130271A (en) * 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
EP1254140A4 (de) * 2000-01-19 2003-03-12 Univ Columbia Verbindungen der saframycin-ecteinascidin-serie, verwendungen und synthesen davon
US6815544B2 (en) 2000-02-11 2004-11-09 President And Fellows Of Harvard College Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds
NZ520635A (en) * 2000-02-11 2004-05-28 Harvard College Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds
IL152094A (en) * 2000-04-12 2011-10-31 Pharma Mar Sa History of actinacidin and pharmaceutical preparations containing them as anti-cancer substances
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
US7420051B2 (en) * 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
JP2004529074A (ja) 2000-11-03 2004-09-24 プレジデント アンド フェロウズ オブ ハーバード カレッジ サフラマイシン、そのアナログ、およびその使用
PL361389A1 (en) * 2000-11-06 2004-10-04 Pharma Mar, S.A. Effective antitumour treatments
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
US7183054B2 (en) * 2003-06-03 2007-02-27 President And Fellows Of Harvard College Assay for identifying biological targets of polynucleotide-binding compounds
PT1827500E (pt) * 2004-10-26 2009-08-05 Pharma Mar Sa Doxorrubicina pegilada lipossomal em combinação com ecteinescidina 743
DK1658848T3 (da) 2004-10-29 2007-11-26 Pharma Mar Sa Formuleringer omfattende ecteinascidin og et disaccharid
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
JP2011520846A (ja) * 2008-05-16 2011-07-21 ファルマ・マール・ソシエダード・アノニマ 多発性骨髄腫の治療
KR20110025178A (ko) * 2008-05-16 2011-03-09 파르마 마르 에스.에이. Ｐｍ00104 및 다른 항종양제를 이용한 복합 치료법
WO2011048210A1 (en) 2009-10-22 2011-04-28 Pharma Mar, S.A. PDGFR-α AS RESPONSE MARKER FOR PM00104 TREATMENT
US9428524B2 (en) 2010-05-25 2016-08-30 Pharma Mar, S.A. Synthetic process for the manufacture of ecteinascidin compounds
SI2786753T1 (sl) 2010-11-12 2019-05-31 Pharma Mar S.A. Kombinacijska terapija s protitumorskim antibiotikom
CN107522698B (zh) * 2016-06-20 2021-12-28 浙江海正药业股份有限公司 一种曲贝替定的制备方法及其中间体
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
US10597378B2 (en) 2017-09-08 2020-03-24 National Health Research Institutes Tetrahydroisoquinolines for use as MOR/NOP dual agonists
CN111518110B (zh) * 2019-02-01 2023-11-03 博瑞生物医药（苏州）股份有限公司 一种海鞘素化合物及其中间体的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5937952B2 (ja) 1977-09-12 1984-09-12 正 新井 抗生物質サフラマイシンａ，ｂ，ｃ，ｄ，ｅおよびその製造法
JPS56135486A (en) 1980-03-26 1981-10-22 Tadashi Arai Antibiotic saframycin s and its preparative method
JPS5942382A (ja) * 1982-09-02 1984-03-08 Yoshitomi Pharmaceut Ind Ltd サフラシン誘導体
JPS6158593A (ja) * 1984-08-30 1986-03-25 Tadashi Arai 新規サフラマイシンａ誘導体およびその製造法
EP0233841A1 (de) * 1986-02-18 1987-08-26 Arai, Tadashi, Prof. Chinon-Derivate und Verfahren zu ihrer Herstellung
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
JPS632991A (ja) * 1986-06-23 1988-01-07 Akinori Kubo 新規イソキノリン誘導体
EP0262085A1 (de) * 1986-08-15 1988-03-30 Gesellschaft für Biotechnologische Forschung mbH (GBF) Antibiotika aus Myxococcus
EP0329606A3 (de) * 1988-02-12 1991-04-03 Ciba-Geigy Ag Neue Antibiotika aus Myxococcus
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US6124292A (en) * 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743

Also Published As

Publication number Publication date
ES2249028T3 (es) 2006-03-16
US6124292A (en) 2000-09-26
DE69927039T2 (de) 2006-06-22
NZ510734A (en) 2003-10-31
EP1117297A4 (de) 2002-02-27
HK1039727B (zh) 2006-01-06
USRE41614E1 (en) 2010-08-31
HK1039727A1 (en) 2002-05-10
WO2000018233A1 (en) 2000-04-06
EP1117297A1 (de) 2001-07-25
CA2345297A1 (en) 2000-04-06
DK1117297T3 (da) 2006-01-09
US6348467B1 (en) 2002-02-19
AU6165099A (en) 2000-04-17
JP2002525296A (ja) 2002-08-13
CA2345297C (en) 2009-12-22
AU765439B2 (en) 2003-09-18
JP4638985B2 (ja) 2011-02-23
EP1117297B1 (de) 2005-08-31
ATE303063T1 (de) 2005-09-15
MXPA01003339A (es) 2002-07-02

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