DE60116855D1 - Oxy- und aminosubstituierte tetrahydrofurylderivate mit antitumoraktivität - Google Patents
Oxy- und aminosubstituierte tetrahydrofurylderivate mit antitumoraktivitätInfo
- Publication number
- DE60116855D1 DE60116855D1 DE60116855T DE60116855T DE60116855D1 DE 60116855 D1 DE60116855 D1 DE 60116855D1 DE 60116855 T DE60116855 T DE 60116855T DE 60116855 T DE60116855 T DE 60116855T DE 60116855 D1 DE60116855 D1 DE 60116855D1
- Authority
- DE
- Germany
- Prior art keywords
- substituted
- unsubstituted
- alkenyl
- alkyl
- antitumoractivity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0003629 | 2000-02-16 | ||
GB0003629A GB0003629D0 (en) | 2000-02-16 | 2000-02-16 | Antitumour agent |
GB0021774 | 2000-09-05 | ||
GB0021774A GB0021774D0 (en) | 2000-09-05 | 2000-09-05 | Anti-tumour compound |
PCT/GB2001/000655 WO2001060810A1 (en) | 2000-02-16 | 2001-02-16 | Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60116855D1 true DE60116855D1 (de) | 2006-04-13 |
DE60116855T2 DE60116855T2 (de) | 2006-09-14 |
Family
ID=26243662
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60116855T Expired - Lifetime DE60116855T2 (de) | 2000-02-16 | 2001-02-16 | Oxy- und aminosubstituierte tetrahydrofurylderivate mit antitumoraktivität |
Country Status (17)
Country | Link |
---|---|
US (1) | US6864283B2 (de) |
EP (1) | EP1255746B1 (de) |
JP (1) | JP2003523338A (de) |
KR (1) | KR20020092958A (de) |
CN (1) | CN1318409C (de) |
AT (1) | ATE316524T1 (de) |
AU (2) | AU3387301A (de) |
BR (1) | BR0108448A (de) |
CA (1) | CA2400612C (de) |
CZ (1) | CZ20022791A3 (de) |
DE (1) | DE60116855T2 (de) |
ES (1) | ES2256199T3 (de) |
IL (1) | IL151241A (de) |
MX (1) | MXPA02007995A (de) |
PL (1) | PL357193A1 (de) |
RU (1) | RU2002124591A (de) |
WO (1) | WO2001060810A1 (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001060810A1 (en) | 2000-02-16 | 2001-08-23 | Pharma Mar, S.A. | Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity |
CN102229585A (zh) * | 2011-04-26 | 2011-11-02 | 中国人民解放军第二军医大学 | 具有抗肿瘤活性的γ-丁内酯聚酮类化合物 |
JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5583160A (en) * | 1989-02-03 | 1996-12-10 | The Biomembrane Institute | Methylsphingosine used to treat apoptosis |
CA2007507C (en) | 1989-02-03 | 1998-05-19 | Yasuyuki Igarashi | Sphingosine and n-methyl-sphingosine as inhibitor of cell growth |
US6107520A (en) * | 1997-04-15 | 2000-08-22 | The Board Of Trustees Of The University Of Illinois | Spisulosine compounds |
WO2001060810A1 (en) | 2000-02-16 | 2001-08-23 | Pharma Mar, S.A. | Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity |
-
2001
- 2001-02-16 WO PCT/GB2001/000655 patent/WO2001060810A1/en active IP Right Grant
- 2001-02-16 EP EP01905903A patent/EP1255746B1/de not_active Expired - Lifetime
- 2001-02-16 CZ CZ20022791A patent/CZ20022791A3/cs unknown
- 2001-02-16 ES ES01905903T patent/ES2256199T3/es not_active Expired - Lifetime
- 2001-02-16 JP JP2001560195A patent/JP2003523338A/ja active Pending
- 2001-02-16 AT AT01905903T patent/ATE316524T1/de not_active IP Right Cessation
- 2001-02-16 AU AU3387301A patent/AU3387301A/xx active Pending
- 2001-02-16 AU AU2001233873A patent/AU2001233873B2/en not_active Ceased
- 2001-02-16 KR KR1020027010697A patent/KR20020092958A/ko not_active Application Discontinuation
- 2001-02-16 RU RU2002124591/04A patent/RU2002124591A/ru not_active Application Discontinuation
- 2001-02-16 PL PL01357193A patent/PL357193A1/xx not_active Application Discontinuation
- 2001-02-16 MX MXPA02007995A patent/MXPA02007995A/es active IP Right Grant
- 2001-02-16 DE DE60116855T patent/DE60116855T2/de not_active Expired - Lifetime
- 2001-02-16 CA CA2400612A patent/CA2400612C/en not_active Expired - Fee Related
- 2001-02-16 CN CNB018080421A patent/CN1318409C/zh not_active Expired - Fee Related
- 2001-02-16 US US10/203,918 patent/US6864283B2/en not_active Expired - Fee Related
- 2001-02-16 BR BR0108448-8A patent/BR0108448A/pt not_active IP Right Cessation
-
2002
- 2002-08-13 IL IL151241A patent/IL151241A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE60116855T2 (de) | 2006-09-14 |
RU2002124591A (ru) | 2004-01-10 |
CA2400612C (en) | 2010-05-11 |
EP1255746B1 (de) | 2006-01-25 |
AU2001233873B2 (en) | 2006-03-02 |
ATE316524T1 (de) | 2006-02-15 |
MXPA02007995A (es) | 2003-05-23 |
ES2256199T3 (es) | 2006-07-16 |
BR0108448A (pt) | 2003-04-01 |
US6864283B2 (en) | 2005-03-08 |
WO2001060810A1 (en) | 2001-08-23 |
EP1255746A1 (de) | 2002-11-13 |
WO2001060810B1 (en) | 2001-11-29 |
KR20020092958A (ko) | 2002-12-12 |
CA2400612A1 (en) | 2001-08-23 |
IL151241A (en) | 2006-10-31 |
JP2003523338A (ja) | 2003-08-05 |
PL357193A1 (en) | 2004-07-26 |
CN1318409C (zh) | 2007-05-30 |
AU3387301A (en) | 2001-08-27 |
CN1423642A (zh) | 2003-06-11 |
US20030092738A1 (en) | 2003-05-15 |
CZ20022791A3 (cs) | 2003-02-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |