PL366289A1 - Novel synthesis and crystallization of piperazine ring-containing compounds - Google Patents
Novel synthesis and crystallization of piperazine ring-containing compoundsInfo
- Publication number
- PL366289A1 PL366289A1 PL00366289A PL36628900A PL366289A1 PL 366289 A1 PL366289 A1 PL 366289A1 PL 00366289 A PL00366289 A PL 00366289A PL 36628900 A PL36628900 A PL 36628900A PL 366289 A1 PL366289 A1 PL 366289A1
- Authority
- PL
- Poland
- Prior art keywords
- crystallization
- containing compounds
- piperazine ring
- novel synthesis
- synthesis
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 238000002425 crystallisation Methods 0.000 title 1
- 230000008025 crystallization Effects 0.000 title 1
- 125000004193 piperazinyl group Chemical group 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13004799P | 1999-04-19 | 1999-04-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL366289A1 true PL366289A1 (en) | 2005-01-24 |
Family
ID=22442814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL00366289A PL366289A1 (en) | 1999-04-19 | 2000-04-18 | Novel synthesis and crystallization of piperazine ring-containing compounds |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JP2004500324A (en) |
| KR (1) | KR20020019902A (en) |
| CN (4) | CN1680374A (en) |
| CA (1) | CA2368815A1 (en) |
| CZ (1) | CZ20013658A3 (en) |
| HK (1) | HK1044116A1 (en) |
| HR (1) | HRP20010747A2 (en) |
| HU (1) | HUP0200839A3 (en) |
| IL (1) | IL146023A0 (en) |
| PL (1) | PL366289A1 (en) |
| RU (1) | RU2001128229A (en) |
| SK (1) | SK14672001A3 (en) |
| TR (1) | TR200103028T2 (en) |
| WO (1) | WO2000062782A1 (en) |
| YU (1) | YU74101A (en) |
| ZA (1) | ZA200108220B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001038329A1 (en) | 1999-11-24 | 2001-05-31 | Sumika Fine Chemicals Co., Ltd. | Anhydrous mirtazapine crystals and process for producing the same |
| AU6474200A (en) * | 1999-12-13 | 2001-06-18 | Sumika Fine Chemicals Co., Ltd. | Process for the preparation of a pyridinemethanol compound |
| US6660730B2 (en) * | 2000-11-27 | 2003-12-09 | Sumika Fine Chemicals Co., Ltd. | Anhydrous mirtazapine and process for preparing the same |
| UA83666C2 (en) * | 2003-07-10 | 2008-08-11 | Н.В. Органон | Method for the preparation of enantiomerically pure mirtazapine |
| ES2246161B1 (en) * | 2004-07-22 | 2007-04-01 | Medichem, S.A. | IMPROVED PROCESS FOR THE MANUFACTURE OF MIRTAZAPINE. |
| JP4848704B2 (en) * | 2004-08-24 | 2011-12-28 | 住友化学株式会社 | Process for producing 2- (4-methyl-2-phenylpiperazin-1-yl) -3-cyanopyridine |
| JP5192707B2 (en) * | 2007-03-22 | 2013-05-08 | 住友化学株式会社 | Manufacturing method of mirtazapine |
| US7994314B2 (en) | 2007-04-11 | 2011-08-09 | N.V. Organon | Method for the preparation of an enantiomerically pure benzazepine |
| MX2009010967A (en) | 2007-04-11 | 2009-12-15 | Organon Nv | A method for the preparation of mirtazapine. |
| KR101485418B1 (en) | 2013-05-29 | 2015-01-26 | 주식회사 메디켐코리아 | A synthetic method of high purity mirtazapine |
| JP6571497B2 (en) * | 2015-11-13 | 2019-09-04 | 株式会社トクヤマ | Manufacturing method of mirtazapine |
| JP2017088564A (en) * | 2015-11-13 | 2017-05-25 | 株式会社トクヤマ | Manufacturing method of mirtazapine |
| CN108191873B (en) * | 2018-01-08 | 2021-09-24 | 山东省食品药品检验研究院 | A kind of purification method of mianserin hydrochloride |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL189199C (en) * | 1975-04-05 | 1993-02-01 | Akzo Nv | PROCESS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS WITH ACTION ON THE CENTRAL NERVOUS SYSTEM BASED ON BENZ (ARYL) AZEPINE DERIVATIVES, THE PHARMACEUTICAL PREPARATIONS OBTAINED, AND METHOD FOR PREPARING THE PRODUCT TO BE USED. |
-
2000
- 2000-04-18 CZ CZ20013658A patent/CZ20013658A3/en unknown
- 2000-04-18 CN CNA2005100042895A patent/CN1680374A/en active Pending
- 2000-04-18 HK HK02105027.4A patent/HK1044116A1/en unknown
- 2000-04-18 CN CN00807574A patent/CN1356903A/en active Pending
- 2000-04-18 SK SK1467-2001A patent/SK14672001A3/en unknown
- 2000-04-18 HR HR20010747A patent/HRP20010747A2/en not_active Application Discontinuation
- 2000-04-18 RU RU2001128229/04A patent/RU2001128229A/en not_active Application Discontinuation
- 2000-04-18 KR KR1020017013267A patent/KR20020019902A/en not_active Abandoned
- 2000-04-18 JP JP2000611918A patent/JP2004500324A/en not_active Withdrawn
- 2000-04-18 CN CNA2005100042880A patent/CN1679586A/en active Pending
- 2000-04-18 YU YU74101A patent/YU74101A/en unknown
- 2000-04-18 TR TR2001/03028T patent/TR200103028T2/en unknown
- 2000-04-18 PL PL00366289A patent/PL366289A1/en unknown
- 2000-04-18 HU HU0200839A patent/HUP0200839A3/en unknown
- 2000-04-18 WO PCT/US2000/010357 patent/WO2000062782A1/en not_active Application Discontinuation
- 2000-04-18 IL IL14602300A patent/IL146023A0/en unknown
- 2000-04-18 CA CA002368815A patent/CA2368815A1/en not_active Abandoned
- 2000-04-18 CN CNA2005100042908A patent/CN1680365A/en active Pending
-
2001
- 2001-10-05 ZA ZA200108220A patent/ZA200108220B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1044116A1 (en) | 2002-10-11 |
| IL146023A0 (en) | 2002-07-25 |
| CN1680374A (en) | 2005-10-12 |
| HRP20010747A2 (en) | 2002-12-31 |
| CN1356903A (en) | 2002-07-03 |
| TR200103028T2 (en) | 2002-01-21 |
| JP2004500324A (en) | 2004-01-08 |
| CN1680365A (en) | 2005-10-12 |
| SK14672001A3 (en) | 2002-11-06 |
| CN1679586A (en) | 2005-10-12 |
| HUP0200839A3 (en) | 2003-05-28 |
| WO2000062782A1 (en) | 2000-10-26 |
| CZ20013658A3 (en) | 2002-08-14 |
| CA2368815A1 (en) | 2000-10-26 |
| ZA200108220B (en) | 2006-02-26 |
| YU74101A (en) | 2004-09-03 |
| KR20020019902A (en) | 2002-03-13 |
| RU2001128229A (en) | 2003-07-10 |
| HUP0200839A2 (en) | 2002-08-28 |
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