ATE46159T1 - Pyridazinone, inotrope mittel. - Google Patents

Pyridazinone, inotrope mittel.

Info

Publication number
ATE46159T1
ATE46159T1 AT85307340T AT85307340T ATE46159T1 AT E46159 T1 ATE46159 T1 AT E46159T1 AT 85307340 T AT85307340 T AT 85307340T AT 85307340 T AT85307340 T AT 85307340T AT E46159 T1 ATE46159 T1 AT E46159T1
Authority
AT
Austria
Prior art keywords
pyridazinone
inotropic agent
hydrogen
independently
whent
Prior art date
Application number
AT85307340T
Other languages
English (en)
Inventor
David Wayne Robertson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE46159T1 publication Critical patent/ATE46159T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT85307340T 1984-10-15 1985-10-14 Pyridazinone, inotrope mittel. ATE46159T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/660,836 US4617302A (en) 1984-10-15 1984-10-15 Inotropic agents
EP85307340A EP0178876B1 (de) 1984-10-15 1985-10-14 Pyridazinone, inotrope Mittel

Publications (1)

Publication Number Publication Date
ATE46159T1 true ATE46159T1 (de) 1989-09-15

Family

ID=24651171

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85307340T ATE46159T1 (de) 1984-10-15 1985-10-14 Pyridazinone, inotrope mittel.

Country Status (6)

Country Link
US (1) US4617302A (de)
EP (1) EP0178876B1 (de)
JP (1) JPS6197282A (de)
AT (1) ATE46159T1 (de)
CA (1) CA1245648A (de)
DE (1) DE3572816D1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3631085A1 (de) * 1986-09-12 1988-03-24 Boehringer Mannheim Gmbh Heterocyclisch substituierte indolinone, verfahren zu ihrer herstellung, arzneimittel sowie zwischenprodukte
DE3706427A1 (de) * 1987-02-27 1988-09-08 Boehringer Mannheim Gmbh Neue substituierte 3h-indole, zwischenprodukte, verfahren zu ihrer herstellung sowie arzneimittel
US6355648B1 (en) * 1999-05-04 2002-03-12 American Home Products Corporation Thio-oxindole derivatives
US6509334B1 (en) * 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
US6391907B1 (en) 1999-05-04 2002-05-21 American Home Products Corporation Indoline derivatives
DE60113696T2 (de) * 2000-07-05 2006-07-13 Ortho-Mcneil Pharmaceutical, Inc. Nichtpeptidische substituierte spirobenzoazepine als vasopressin antagonisten
AU2004281257C1 (en) * 2003-06-17 2010-07-01 Janssen Pharmaceutica N.V. Substituted spirobenzazepines
EP1984342A2 (de) * 2006-01-20 2008-10-29 Janssen Pharmaceutica, N.V. NEUE FESTE FORMEN VON (4R)-1-[4-(2-CHLOR-5-FLUORBENZOYL)AMINO-3-METHOXYBENZOYL]-1,2,3,5-TETRAHYDRO-SPIRO[4H-1-BENZAZEPIN-4,1ý-[2]CYCLOPENTEN]-3ý-CARBONSÄURE
AU2007299822A1 (en) * 2006-09-22 2008-03-27 Janssen Pharmaceutica N.V. Spiro benzazepines as vasopressin antagonists
DK2078022T3 (da) * 2006-09-22 2012-02-13 Janssen Pharmaceutica Nv Spirobenzazepiner anvendt som vasopressinantagonister
JOP20180029A1 (ar) * 2017-03-30 2019-01-30 Takeda Pharmaceuticals Co مركب حلقي غير متجانس
CN121013845A (zh) * 2023-03-10 2025-11-25 硕腾服务有限责任公司 磷酸二酯酶3(pde3)抑制剂

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE790106A (fr) * 1971-10-14 1973-04-13 Basf Ag Dihydropyridazones, leur preparation et leurs utilisations therapeutiques
ES8101067A1 (es) * 1978-08-25 1980-12-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona
US4258185A (en) * 1978-10-17 1981-03-24 Yoshitomi Pharmaceutical Industries, Ltd. Pyridazinone compounds
GB2031404A (en) * 1978-10-17 1980-04-23 Yoshitomi Pharmaceutical Pyridazinone compounds
US4304777A (en) * 1979-08-30 1981-12-08 Sterling Drug Inc. 6-(Pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics
US4404203A (en) * 1981-05-14 1983-09-13 Warner-Lambert Company Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
US4397854A (en) * 1981-05-14 1983-08-09 Warner-Lambert Company Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
DE3124699A1 (de) * 1981-06-24 1983-01-13 Basf Ag, 6700 Ludwigshafen Neue 2-aryl-3,4-diaza-bicyclo(4.n.0.)alken-(2)-one-(5),verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4353905A (en) * 1981-09-17 1982-10-12 Warner-Lambert Company Substituted 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones

Also Published As

Publication number Publication date
DE3572816D1 (de) 1989-10-12
JPS6197282A (ja) 1986-05-15
EP0178876B1 (de) 1989-09-06
EP0178876A1 (de) 1986-04-23
CA1245648A (en) 1988-11-29
US4617302A (en) 1986-10-14

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee