MX9701949A - Derivados de distamicina substituidos con bis-(2-haloetil) aminofenilo como agentes antitumorales y antivirales. - Google Patents
Derivados de distamicina substituidos con bis-(2-haloetil) aminofenilo como agentes antitumorales y antivirales.Info
- Publication number
- MX9701949A MX9701949A MX9701949A MX9701949A MX9701949A MX 9701949 A MX9701949 A MX 9701949A MX 9701949 A MX9701949 A MX 9701949A MX 9701949 A MX9701949 A MX 9701949A MX 9701949 A MX9701949 A MX 9701949A
- Authority
- MX
- Mexico
- Prior art keywords
- antitumor
- haloethyl
- bis
- antiviral agents
- distamycin derivatives
- Prior art date
Links
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- 239000003443 antiviral agent Substances 0.000 title abstract 2
- UPBAOYRENQEPJO-UHFFFAOYSA-N n-[5-[[5-[(3-amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-formamido-1-methylpyrrole-2-carboxamide Chemical class CN1C=C(NC=O)C=C1C(=O)NC1=CN(C)C(C(=O)NC2=CN(C)C(C(=O)NCCC(N)=N)=C2)=C1 UPBAOYRENQEPJO-UHFFFAOYSA-N 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
Abstract
Se describen novedosos agentes antitumorales y antivirales de formula (Y), en donde n es 2, 3 o 4; uno de R y R1 es hidrogeno, alquilo de 1 a 4 átomos de carbono, CF3 o alcoxi de 1 a 4 átomos de carbono y el oro es independientemente CF3, alquilo de 1 a 4 átomos de carbono o alcoxi de 1 a 4 átomos de carbono; y X es halogeno; y las sales de los mismos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9514993.6 | 1995-07-21 | ||
| GBGB9514993.6A GB9514993D0 (en) | 1995-07-21 | 1995-07-21 | Site specific phenyl nitrogen mustards |
| PCT/EP1996/002659 WO1997003957A1 (en) | 1995-07-21 | 1996-06-19 | Bis-(2-haloethyl)aminophenyl substituted distamycin derivatives as antitumor and antiviral agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MXPA97001949A MXPA97001949A (es) | 1997-06-01 |
| MX9701949A true MX9701949A (es) | 1997-06-28 |
Family
ID=10778062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9701949A MX9701949A (es) | 1995-07-21 | 1996-06-19 | Derivados de distamicina substituidos con bis-(2-haloetil) aminofenilo como agentes antitumorales y antivirales. |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0787126A1 (es) |
| JP (1) | JPH10506410A (es) |
| KR (1) | KR970706251A (es) |
| CN (1) | CN1159183A (es) |
| AR (1) | AR003456A1 (es) |
| AU (1) | AU6357996A (es) |
| BR (1) | BR9606528A (es) |
| CA (1) | CA2199635A1 (es) |
| EA (1) | EA000033B1 (es) |
| GB (1) | GB9514993D0 (es) |
| HU (1) | HUP9702393A3 (es) |
| IL (1) | IL120342A0 (es) |
| MX (1) | MX9701949A (es) |
| NO (1) | NO971142D0 (es) |
| PL (1) | PL319352A1 (es) |
| TW (1) | TW367325B (es) |
| WO (1) | WO1997003957A1 (es) |
| ZA (1) | ZA965028B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6635417B1 (en) | 1996-07-31 | 2003-10-21 | California Institute Of Technology | Complex formation between DSDNA and oligomer of cyclic heterocycles |
| JP2001513759A (ja) | 1996-02-26 | 2001-09-04 | カリフォルニア・インスティチュート・オブ・テクノロジー | 二本鎖ｄｎａの副溝において結合する改良されたポリアミド |
| US5998140A (en) * | 1996-07-31 | 1999-12-07 | The Scripps Research Institute | Complex formation between dsDNA and oligomer of cyclic heterocycles |
| GB9623522D0 (en) * | 1996-11-11 | 1997-01-08 | Pharmacia & Upjohn Spa | Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents |
| GB9816652D0 (en) * | 1998-07-30 | 1998-09-30 | Pharmacia & Upjohn Spa | Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents |
| GB9907414D0 (en) * | 1999-03-31 | 1999-05-26 | Cancer Res Campaign Tech | Improvements relating to prodrugs |
| US6559125B1 (en) | 2000-01-28 | 2003-05-06 | California Institute Of Technology | Polyamide-alkylator conjugates and related products and method |
| WO2002101007A2 (en) | 2001-06-13 | 2002-12-19 | Genesoft Pharmaceuticals, Inc | Antipathogenic benzamide compounds |
| AU2003258022A1 (en) | 2002-08-02 | 2004-02-23 | Genesoft Pharmaceuticals, Inc. | Biaryl compounds having anti-infective activity |
| WO2004039318A2 (en) | 2002-10-25 | 2004-05-13 | Genesoft Pharmaceuticals, Inc. | Anti-infective biaryl compounds |
| EP1587529A4 (en) | 2002-12-10 | 2009-08-12 | Oscient Pharmaceuticals Corp | ANTIBACTERIAL COMPOUNDS WITH (PYROCARBOXAMIDE) - (BENZAMID) - (IMIDAZOLE CARBOXAMIDE) MOTIVE |
| EP2792355A1 (en) | 2013-04-17 | 2014-10-22 | Albert-Ludwigs-Universität Freiburg | Compounds for use as bromodomain inhibitors |
| CN115414356A (zh) * | 2022-09-27 | 2022-12-02 | 广西科技大学 | 一种茚并吡咯类衍生物在制备抗肿瘤药物组合物中的应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8612218D0 (en) * | 1986-05-20 | 1986-06-25 | Erba Farmitalia | Site specific alkylating agents |
-
1995
- 1995-07-21 GB GBGB9514993.6A patent/GB9514993D0/en active Pending
-
1996
- 1996-06-13 ZA ZA965028A patent/ZA965028B/xx unknown
- 1996-06-18 TW TW085107334A patent/TW367325B/zh active
- 1996-06-19 WO PCT/EP1996/002659 patent/WO1997003957A1/en not_active Ceased
- 1996-06-19 EA EA199700046A patent/EA000033B1/ru not_active IP Right Cessation
- 1996-06-19 HU HU9702393A patent/HUP9702393A3/hu unknown
- 1996-06-19 CN CN96190784A patent/CN1159183A/zh active Pending
- 1996-06-19 MX MX9701949A patent/MX9701949A/es unknown
- 1996-06-19 AU AU63579/96A patent/AU6357996A/en not_active Abandoned
- 1996-06-19 JP JP9506209A patent/JPH10506410A/ja active Pending
- 1996-06-19 EP EP96922849A patent/EP0787126A1/en not_active Withdrawn
- 1996-06-19 CA CA002199635A patent/CA2199635A1/en not_active Abandoned
- 1996-06-19 PL PL96319352A patent/PL319352A1/xx unknown
- 1996-06-19 IL IL12034296A patent/IL120342A0/xx unknown
- 1996-06-19 BR BR9606528A patent/BR9606528A/pt not_active Application Discontinuation
- 1996-07-15 AR ARP960103583A patent/AR003456A1/es unknown
- 1996-09-19 KR KR1019970701796A patent/KR970706251A/ko not_active Withdrawn
-
1997
- 1997-03-12 NO NO971142A patent/NO971142D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1159183A (zh) | 1997-09-10 |
| AU6357996A (en) | 1997-02-18 |
| EP0787126A1 (en) | 1997-08-06 |
| GB9514993D0 (en) | 1995-09-20 |
| NO971142L (no) | 1997-03-12 |
| KR970706251A (ko) | 1997-11-03 |
| ZA965028B (en) | 1997-01-23 |
| CA2199635A1 (en) | 1997-02-06 |
| AR003456A1 (es) | 1998-08-05 |
| JPH10506410A (ja) | 1998-06-23 |
| HUP9702393A2 (hu) | 1998-04-28 |
| TW367325B (en) | 1999-08-21 |
| PL319352A1 (en) | 1997-08-04 |
| WO1997003957A1 (en) | 1997-02-06 |
| EA199700046A1 (ru) | 1997-12-30 |
| NO971142D0 (no) | 1997-03-12 |
| EA000033B1 (ru) | 1998-02-26 |
| BR9606528A (pt) | 1997-12-23 |
| HUP9702393A3 (en) | 1998-05-28 |
| IL120342A0 (en) | 1997-06-10 |
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