EA199700046A1 - Бис-(2-галоидэтил)аминофенилзамещенные производные дистамицина - Google Patents

Бис-(2-галоидэтил)аминофенилзамещенные производные дистамицина

Info

Publication number
EA199700046A1
EA199700046A1 EA199700046A EA199700046A EA199700046A1 EA 199700046 A1 EA199700046 A1 EA 199700046A1 EA 199700046 A EA199700046 A EA 199700046A EA 199700046 A EA199700046 A EA 199700046A EA 199700046 A1 EA199700046 A1 EA 199700046A1
Authority
EA
Eurasian Patent Office
Prior art keywords
haloidethyl
distamicine
bis
derivatives
aminophenyl substituted
Prior art date
Application number
EA199700046A
Other languages
English (en)
Other versions
EA000033B1 (ru
Inventor
Паоло Коззи
Итало Берия
Лаура Каполонго
Кристина Францетти
Original Assignee
Фармация Энд Апджон С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармация Энд Апджон С.П.А. filed Critical Фармация Энд Апджон С.П.А.
Publication of EA199700046A1 publication Critical patent/EA199700046A1/ru
Publication of EA000033B1 publication Critical patent/EA000033B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Описываются новые противоопухолевые и противовирусные агенты формулы 1в которой n обозначает 2, 3 или 4; один из R и Rобозначает водород, C-C-алкил, CFили C-C-алкокси, а другой независимо обозначает CF, C-C-алкил или C-C-алкокси; и X обозначает водород; или их соли.
EA199700046A 1995-07-21 1996-06-19 Бис-(2-галоидэтил)аминофенилзамещенные производные дистамицина и их применение в качестве противоопухолевого и противовирусного средства EA000033B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9514993.6A GB9514993D0 (en) 1995-07-21 1995-07-21 Site specific phenyl nitrogen mustards
PCT/EP1996/002659 WO1997003957A1 (en) 1995-07-21 1996-06-19 Bis-(2-haloethyl)aminophenyl substituted distamycin derivatives as antitumor and antiviral agents

Publications (2)

Publication Number Publication Date
EA199700046A1 true EA199700046A1 (ru) 1997-12-30
EA000033B1 EA000033B1 (ru) 1998-02-26

Family

ID=10778062

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700046A EA000033B1 (ru) 1995-07-21 1996-06-19 Бис-(2-галоидэтил)аминофенилзамещенные производные дистамицина и их применение в качестве противоопухолевого и противовирусного средства

Country Status (18)

Country Link
EP (1) EP0787126A1 (ru)
JP (1) JPH10506410A (ru)
KR (1) KR970706251A (ru)
CN (1) CN1159183A (ru)
AR (1) AR003456A1 (ru)
AU (1) AU6357996A (ru)
BR (1) BR9606528A (ru)
CA (1) CA2199635A1 (ru)
EA (1) EA000033B1 (ru)
GB (1) GB9514993D0 (ru)
HU (1) HUP9702393A3 (ru)
IL (1) IL120342A0 (ru)
MX (1) MX9701949A (ru)
NO (1) NO971142L (ru)
PL (1) PL319352A1 (ru)
TW (1) TW367325B (ru)
WO (1) WO1997003957A1 (ru)
ZA (1) ZA965028B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635417B1 (en) 1996-07-31 2003-10-21 California Institute Of Technology Complex formation between DSDNA and oligomer of cyclic heterocycles
JP2001513759A (ja) 1996-02-26 2001-09-04 カリフォルニア・インスティチュート・オブ・テクノロジー 二本鎖ｄｎａの副溝において結合する改良されたポリアミド
US5998140A (en) * 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
GB9623522D0 (en) * 1996-11-11 1997-01-08 Pharmacia & Upjohn Spa Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9816652D0 (en) * 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9907414D0 (en) 1999-03-31 1999-05-26 Cancer Res Campaign Tech Improvements relating to prodrugs
US6559125B1 (en) 2000-01-28 2003-05-06 California Institute Of Technology Polyamide-alkylator conjugates and related products and method
US20030236198A1 (en) 2001-06-13 2003-12-25 Genesoft, Inc. Antipathogenic benzamide compounds
ATE425753T1 (de) 2002-08-02 2009-04-15 Genesoft Pharmaceuticals Inc Biaryl-verbindungen mit antiinfektiver wirkung
US7265129B2 (en) 2002-10-25 2007-09-04 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
JP2006509027A (ja) 2002-12-10 2006-03-16 オーシェント ファーマシューティカルズ コーポレーション （ピロールカルボキサミド）−（ベンズアミド）−（イミダゾールカルボキサミド）モチーフを有する抗菌化合物
EP2792355A1 (en) 2013-04-17 2014-10-22 Albert-Ludwigs-Universität Freiburg Compounds for use as bromodomain inhibitors
CN115414356A (zh) * 2022-09-27 2022-12-02 广西科技大学 一种茚并吡咯类衍生物在制备抗肿瘤药物组合物中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8612218D0 (en) * 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents

Also Published As

Publication number Publication date
CA2199635A1 (en) 1997-02-06
NO971142D0 (no) 1997-03-12
HUP9702393A3 (en) 1998-05-28
JPH10506410A (ja) 1998-06-23
EP0787126A1 (en) 1997-08-06
TW367325B (en) 1999-08-21
WO1997003957A1 (en) 1997-02-06
KR970706251A (ko) 1997-11-03
GB9514993D0 (en) 1995-09-20
AR003456A1 (es) 1998-08-05
CN1159183A (zh) 1997-09-10
IL120342A0 (en) 1997-06-10
EA000033B1 (ru) 1998-02-26
ZA965028B (en) 1997-01-23
MX9701949A (es) 1997-06-28
AU6357996A (en) 1997-02-18
HUP9702393A2 (hu) 1998-04-28
PL319352A1 (en) 1997-08-04
BR9606528A (pt) 1997-12-23
NO971142L (no) 1997-03-12

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU