HUP9702393A2 - bisz(2-Halogén-etil)-amino-fenil szubsztituált distamycinszármazékok, tumorellenes és vírusellenes hatóanyagok - Google Patents

bisz(2-Halogén-etil)-amino-fenil szubsztituált distamycinszármazékok, tumorellenes és vírusellenes hatóanyagok

Info

Publication number
HUP9702393A2
HUP9702393A2 HU9702393A HUP9702393A HUP9702393A2 HU P9702393 A2 HUP9702393 A2 HU P9702393A2 HU 9702393 A HU9702393 A HU 9702393A HU P9702393 A HUP9702393 A HU P9702393A HU P9702393 A2 HUP9702393 A2 HU P9702393A2
Authority
HU
Hungary
Prior art keywords
antitumor
antiviral agents
haloethyl
bis
carbon
Prior art date
Application number
HU9702393A
Other languages
English (en)
Inventor
Italo Beria
Laura Capolongo
Paolo Cozzi
Cristina Franzetti
Original Assignee
Pharmacia & Upjohn S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn S.P.A. filed Critical Pharmacia & Upjohn S.P.A.
Publication of HUP9702393A2 publication Critical patent/HUP9702393A2/hu
Publication of HUP9702393A3 publication Critical patent/HUP9702393A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány tárgya az (I) általánős képletű vegyület vagygyógyszerészetileg elfőgadható sói, ahől az általánős képletben n jelentése 2, 3 vagy 4 egész szám, R és R1 egyikének jelentése hidrőgénatőm, 1-4 szénatőmős alkilcső-pőrt, triflűőr-metil-csőpőrt vagy 1-4 szénatőmős alkőxicsőpőrt és amásik jelentése egymástól függetlenül triflűőr-metil-csőpőrt, 1-4szénatőmős alkilcsőpőrt vagy 1-4 szénatőmős alkőxicsőpőrt, és X jelentése halőgénatőm. A találmány szerinti vegyületek gyógyszerészetben vírűsellenesszerként, illetve daganatellenes szerként alkalmazhatók. ŕ
HU9702393A 1995-07-21 1996-06-19 Bis(2-haloethyl)aminophenyl substituted distamycin derivatives as antitumor and antiviral agents HUP9702393A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9514993.6A GB9514993D0 (en) 1995-07-21 1995-07-21 Site specific phenyl nitrogen mustards

Publications (2)

Publication Number Publication Date
HUP9702393A2 true HUP9702393A2 (hu) 1998-04-28
HUP9702393A3 HUP9702393A3 (en) 1998-05-28

Family

ID=10778062

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9702393A HUP9702393A3 (en) 1995-07-21 1996-06-19 Bis(2-haloethyl)aminophenyl substituted distamycin derivatives as antitumor and antiviral agents

Country Status (18)

Country Link
EP (1) EP0787126A1 (hu)
JP (1) JPH10506410A (hu)
KR (1) KR970706251A (hu)
CN (1) CN1159183A (hu)
AR (1) AR003456A1 (hu)
AU (1) AU6357996A (hu)
BR (1) BR9606528A (hu)
CA (1) CA2199635A1 (hu)
EA (1) EA000033B1 (hu)
GB (1) GB9514993D0 (hu)
HU (1) HUP9702393A3 (hu)
IL (1) IL120342A0 (hu)
MX (1) MX9701949A (hu)
NO (1) NO971142L (hu)
PL (1) PL319352A1 (hu)
TW (1) TW367325B (hu)
WO (1) WO1997003957A1 (hu)
ZA (1) ZA965028B (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635417B1 (en) 1996-07-31 2003-10-21 California Institute Of Technology Complex formation between DSDNA and oligomer of cyclic heterocycles
AU734715B2 (en) 1996-02-26 2001-06-21 California Institute Of Technology Improved polyamides for binding in the minor groove of double stranded DNA
US5998140A (en) 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
GB9623522D0 (en) * 1996-11-11 1997-01-08 Pharmacia & Upjohn Spa Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9816652D0 (en) * 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9907414D0 (en) * 1999-03-31 1999-05-26 Cancer Res Campaign Tech Improvements relating to prodrugs
US6559125B1 (en) 2000-01-28 2003-05-06 California Institute Of Technology Polyamide-alkylator conjugates and related products and method
WO2002101007A2 (en) 2001-06-13 2002-12-19 Genesoft Pharmaceuticals, Inc Antipathogenic benzamide compounds
WO2004012736A1 (en) 2002-08-02 2004-02-12 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
US7265129B2 (en) 2002-10-25 2007-09-04 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
US7129214B2 (en) 2002-12-10 2006-10-31 Oscient Pharmaceuticals Corporation Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif
EP2792355A1 (en) 2013-04-17 2014-10-22 Albert-Ludwigs-Universität Freiburg Compounds for use as bromodomain inhibitors
CN115414356A (zh) * 2022-09-27 2022-12-02 广西科技大学 一种茚并吡咯类衍生物在制备抗肿瘤药物组合物中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8612218D0 (en) * 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents

Also Published As

Publication number Publication date
IL120342A0 (en) 1997-06-10
AU6357996A (en) 1997-02-18
JPH10506410A (ja) 1998-06-23
AR003456A1 (es) 1998-08-05
EA000033B1 (ru) 1998-02-26
NO971142D0 (no) 1997-03-12
KR970706251A (ko) 1997-11-03
MX9701949A (es) 1997-06-28
GB9514993D0 (en) 1995-09-20
EP0787126A1 (en) 1997-08-06
TW367325B (en) 1999-08-21
PL319352A1 (en) 1997-08-04
ZA965028B (en) 1997-01-23
WO1997003957A1 (en) 1997-02-06
NO971142L (no) 1997-03-12
HUP9702393A3 (en) 1998-05-28
CN1159183A (zh) 1997-09-10
EA199700046A1 (ru) 1997-12-30
CA2199635A1 (en) 1997-02-06
BR9606528A (pt) 1997-12-23

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