TW367325B - Site specific phenyl nitrogen mustards, process for preparing them and pharmaceutical composition containing them - Google Patents

Site specific phenyl nitrogen mustards, process for preparing them and pharmaceutical composition containing them

Info

Publication number
TW367325B
TW367325B TW085107334A TW85107334A TW367325B TW 367325 B TW367325 B TW 367325B TW 085107334 A TW085107334 A TW 085107334A TW 85107334 A TW85107334 A TW 85107334A TW 367325 B TW367325 B TW 367325B
Authority
TW
Taiwan
Prior art keywords
preparing
pharmaceutical composition
composition containing
site specific
nitrogen mustards
Prior art date
Application number
TW085107334A
Other languages
Chinese (zh)
Inventor
Paolo Cozzi
Italo Beria
Laura Capolongo
Cristina Franzetti
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Application granted granted Critical
Publication of TW367325B publication Critical patent/TW367325B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

The invention relates to a novel antitumor and antiviral agents of formula (I) wherein n is 3; X is chlorine; one of R and R1 is hydrogen or C1-C4alkyl and the other is C1-C4alkyl; and the pharmaceutically acceptable salts thereof are disclosed.
TW085107334A 1995-07-21 1996-06-18 Site specific phenyl nitrogen mustards, process for preparing them and pharmaceutical composition containing them TW367325B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9514993.6A GB9514993D0 (en) 1995-07-21 1995-07-21 Site specific phenyl nitrogen mustards

Publications (1)

Publication Number Publication Date
TW367325B true TW367325B (en) 1999-08-21

Family

ID=10778062

Family Applications (1)

Application Number Title Priority Date Filing Date
TW085107334A TW367325B (en) 1995-07-21 1996-06-18 Site specific phenyl nitrogen mustards, process for preparing them and pharmaceutical composition containing them

Country Status (18)

Country Link
EP (1) EP0787126A1 (en)
JP (1) JPH10506410A (en)
KR (1) KR970706251A (en)
CN (1) CN1159183A (en)
AR (1) AR003456A1 (en)
AU (1) AU6357996A (en)
BR (1) BR9606528A (en)
CA (1) CA2199635A1 (en)
EA (1) EA000033B1 (en)
GB (1) GB9514993D0 (en)
HU (1) HUP9702393A3 (en)
IL (1) IL120342A0 (en)
MX (1) MX9701949A (en)
NO (1) NO971142D0 (en)
PL (1) PL319352A1 (en)
TW (1) TW367325B (en)
WO (1) WO1997003957A1 (en)
ZA (1) ZA965028B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635417B1 (en) 1996-07-31 2003-10-21 California Institute Of Technology Complex formation between DSDNA and oligomer of cyclic heterocycles
AU734715B2 (en) 1996-02-26 2001-06-21 California Institute Of Technology Improved polyamides for binding in the minor groove of double stranded DNA
US5998140A (en) * 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
GB9623522D0 (en) * 1996-11-11 1997-01-08 Pharmacia & Upjohn Spa Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9816652D0 (en) * 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9907414D0 (en) * 1999-03-31 1999-05-26 Cancer Res Campaign Tech Improvements relating to prodrugs
US6559125B1 (en) 2000-01-28 2003-05-06 California Institute Of Technology Polyamide-alkylator conjugates and related products and method
WO2002101007A2 (en) 2001-06-13 2002-12-19 Genesoft Pharmaceuticals, Inc Antipathogenic benzamide compounds
WO2004012736A1 (en) 2002-08-02 2004-02-12 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
EP1562931A2 (en) 2002-10-25 2005-08-17 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
JP2006509027A (en) 2002-12-10 2006-03-16 オーシェント ファーマシューティカルズ コーポレーション Antibacterial compound having (pyrrolecarboxamide)-(benzamide)-(imidazolecarboxamide) motif
EP2792355A1 (en) 2013-04-17 2014-10-22 Albert-Ludwigs-Universität Freiburg Compounds for use as bromodomain inhibitors
CN115414356A (en) * 2022-09-27 2022-12-02 广西科技大学 Application of indenopyrrole derivatives in preparation of antitumor pharmaceutical composition

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8612218D0 (en) * 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents

Also Published As

Publication number Publication date
KR970706251A (en) 1997-11-03
GB9514993D0 (en) 1995-09-20
HUP9702393A2 (en) 1998-04-28
EP0787126A1 (en) 1997-08-06
WO1997003957A1 (en) 1997-02-06
MX9701949A (en) 1997-06-28
IL120342A0 (en) 1997-06-10
CN1159183A (en) 1997-09-10
ZA965028B (en) 1997-01-23
AU6357996A (en) 1997-02-18
HUP9702393A3 (en) 1998-05-28
NO971142L (en) 1997-03-12
NO971142D0 (en) 1997-03-12
BR9606528A (en) 1997-12-23
EA000033B1 (en) 1998-02-26
EA199700046A1 (en) 1997-12-30
JPH10506410A (en) 1998-06-23
AR003456A1 (en) 1998-08-05
CA2199635A1 (en) 1997-02-06
PL319352A1 (en) 1997-08-04

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