ES8604177A1 - Un procedimiento para preparar nuevos derivados de isoxazol fenil-alifaticos - Google Patents

Un procedimiento para preparar nuevos derivados de isoxazol fenil-alifaticos

Info

Publication number
ES8604177A1
ES8604177A1 ES545773A ES545773A ES8604177A1 ES 8604177 A1 ES8604177 A1 ES 8604177A1 ES 545773 A ES545773 A ES 545773A ES 545773 A ES545773 A ES 545773A ES 8604177 A1 ES8604177 A1 ES 8604177A1
Authority
ES
Spain
Prior art keywords
substituted
alkyl
antiviral agents
aliphatic
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545773A
Other languages
English (en)
Other versions
ES545773A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of ES8604177A1 publication Critical patent/ES8604177A1/es
Publication of ES545773A0 publication Critical patent/ES545773A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ISOXAZOL FENIL-ALIFATICOS Y DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE X ES OXIGENO; R, R1, R2, R3, R4 Y R5 PUEDEN SER VARIOS TIPOS DE RADICALES; Y N VALE 3 A 9. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN DERIVADO DE METAL ALCALINO DE 3-R-4-R4-5-METILISOXAZOL, EN LAS QUE HAL ES BROMO O YODO, R ES ALQUILO O HIDROXIALQUILO DE 1,A 3 ATOMOS DE CARBONO, R1, R2, R3 Y R4 SON HIDROGENO, ALQUILO O HIDROXIALQUILO DE 1 A 3 ATOMOS DE CARBONO, M ES N-1 Y R5 TIENE EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIVIRA
ES545773A 1983-08-29 1985-07-31 Un procedimiento para preparar nuevos derivados de isoxazol fenil-alifaticos Expired ES8604177A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52758383A 1983-08-29 1983-08-29
US62430284A 1984-06-25 1984-06-25

Publications (2)

Publication Number Publication Date
ES8604177A1 true ES8604177A1 (es) 1986-01-16
ES545773A0 ES545773A0 (es) 1986-01-16

Family

ID=27062451

Family Applications (3)

Application Number Title Priority Date Filing Date
ES535459A Granted ES535459A0 (es) 1983-08-29 1984-08-28 Un procedimiento para preparar nuevos derivados de isoxazol fenil-alifaticos
ES545774A Expired ES8604178A1 (es) 1983-08-29 1985-07-31 Un procedimiento para preparar nuevos derivados de isoxazol fenil-alifaticos
ES545773A Expired ES8604177A1 (es) 1983-08-29 1985-07-31 Un procedimiento para preparar nuevos derivados de isoxazol fenil-alifaticos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES535459A Granted ES535459A0 (es) 1983-08-29 1984-08-28 Un procedimiento para preparar nuevos derivados de isoxazol fenil-alifaticos
ES545774A Expired ES8604178A1 (es) 1983-08-29 1985-07-31 Un procedimiento para preparar nuevos derivados de isoxazol fenil-alifaticos

Country Status (15)

Country Link
EP (1) EP0137242B1 (es)
KR (1) KR890005147B1 (es)
AU (1) AU570066B2 (es)
CA (1) CA1238912A (es)
DE (1) DE3485714D1 (es)
DK (1) DK409784A (es)
ES (3) ES535459A0 (es)
FI (1) FI81348C (es)
GR (1) GR80237B (es)
IE (1) IE842211L (es)
IL (1) IL72752A (es)
NO (1) NO159274C (es)
NZ (1) NZ209209A (es)
PH (1) PH19602A (es)
PT (1) PT79134B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469885A (en) * 1983-05-09 1984-09-04 G. D. Searle & Co. Halogenated protease inhibitors
ZA846525B (en) * 1983-08-29 1985-04-24 Sterling Drug Inc (substituted)phenyl-aliphatic-isoxazoles useful as antiviral agents and preparation thereof
CA1299176C (en) * 1985-07-02 1992-04-21 Guy Dominic Diana Process for preparing isoxazole and furan derivatives
US4843087A (en) * 1983-08-29 1989-06-27 Sterling Drug Inc. Di-heterocyclic compounds and their use as antiviral agents
US4861791A (en) * 1983-08-29 1989-08-29 Sterling Drug Inc. Dihydro-oxazolyl substituted-phenyl-aliphatic lower alkyl and their use as antiviral agents
US5002960A (en) * 1983-08-29 1991-03-26 Sterling Drug, Inc. N-haloalkyl-4-(isoxazol-5-yl)alkoxy benzamides
LV5506A3 (lv) * 1985-05-17 1994-03-10 Chem Pharm Forsch Gmbh Izoksazola atvasinajumu iegusanas panemiens
FI83782C (fi) * 1985-05-17 1991-08-26 Chemie Linz Ag Foerfarande foer framstaellning av farmakologiskt vaerdefulla substituerande isoxazolderivat.
US5051437A (en) * 1986-06-24 1991-09-24 Sterling Drug Inc. Thiazolylphenoxyalkylisoxazoles, related compounds, and their use as antiviral agents
MY102282A (en) * 1987-01-28 1992-05-15 Cl Pharma Isoxazole derivatives with antiviral activities and pharmaceutical products containing these.
US4992433A (en) * 1987-11-23 1991-02-12 Janssen Pharmaceutica N.V. Novel pyridazinamine derivatives
GB8807275D0 (en) * 1988-03-26 1988-04-27 Synphar Lab Inc Chemical compounds
US5070090A (en) * 1989-05-15 1991-12-03 Janssen Pharmaceutica N.V. Antipicorpaviral herterocyclic-substituted morpholinyl alkylphenol ethers
GB8911158D0 (en) * 1989-05-16 1989-07-05 Janssen Pharmaceutica Nv Antiviral pyridazinamines
US4942241A (en) * 1989-08-21 1990-07-17 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
NZ234760A (en) * 1989-08-18 1991-09-25 Sterling Drug Inc Antiviral oxazole compounds and compositions
US5175178A (en) * 1989-08-21 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5110821A (en) * 1989-08-18 1992-05-05 Sterling Drug Inc. 1,3,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US4945164A (en) * 1989-08-18 1990-07-31 Sterling Drug Inc. 1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof
IT1247509B (it) * 1991-04-19 1994-12-17 Univ Cagliari Composti di sintesi atti all'impiego nella terapia delle infezioni da rhinovirus
US5175177A (en) * 1991-07-17 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5453433A (en) * 1994-05-13 1995-09-26 Sterling Winthrop Inc. Thiadiazoles and antipicornaviral compositions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268678A (en) * 1979-09-04 1981-05-19 Sterling Drug Inc. 4-(Arylaliphatic)isoxazoles
US4451476A (en) * 1982-12-13 1984-05-29 Sterling Drug Inc. Isoxazoles as antiviral agents

Also Published As

Publication number Publication date
GR80237B (en) 1985-01-02
IL72752A (en) 1988-05-31
FI843392A0 (fi) 1984-08-28
CA1238912A (en) 1988-07-05
DK409784A (da) 1985-03-01
ES545773A0 (es) 1986-01-16
NZ209209A (en) 1988-02-12
DK409784D0 (da) 1984-08-28
NO159274B (no) 1988-09-05
KR890005147B1 (ko) 1989-12-14
ES8604178A1 (es) 1986-01-16
IL72752A0 (en) 1984-11-30
FI843392A (fi) 1985-03-01
NO159274C (no) 1988-12-14
ES8602777A1 (es) 1985-12-01
NO843425L (no) 1985-03-01
FI81348B (fi) 1990-06-29
IE842211L (en) 1985-02-28
KR850001753A (ko) 1985-04-01
FI81348C (fi) 1990-10-10
EP0137242B1 (en) 1992-05-13
EP0137242A3 (en) 1986-10-01
ES535459A0 (es) 1985-12-01
PH19602A (en) 1986-05-27
DE3485714D1 (de) 1992-06-17
EP0137242A2 (en) 1985-04-17
PT79134B (en) 1986-08-19
AU3199884A (en) 1985-03-07
PT79134A (en) 1984-09-01
AU570066B2 (en) 1988-03-03
ES545774A0 (es) 1986-01-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603