ES8603458A1 - Un procedimiento para preparar una 3-r1-4-r2-5-q-6-r-2(1h)-piridinona - Google Patents
Un procedimiento para preparar una 3-r1-4-r2-5-q-6-r-2(1h)-piridinonaInfo
- Publication number
- ES8603458A1 ES8603458A1 ES533877A ES533877A ES8603458A1 ES 8603458 A1 ES8603458 A1 ES 8603458A1 ES 533877 A ES533877 A ES 533877A ES 533877 A ES533877 A ES 533877A ES 8603458 A1 ES8603458 A1 ES 8603458A1
- Authority
- ES
- Spain
- Prior art keywords
- pyridinones
- pyridinyl
- cardiotonic agents
- hydroxyphenyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR UNA 3-R1-4-R2-5-Q-6-R-2(1H)-PIRIDINONA. CONSISTE EN CALENTAR A UNA TEMPERATURA DE 150 A 250JC UNA 3,4-DIHIDRO-3-R1-4-R2-5-Q-6-R-2(1H)-PIRIDINONA DE FORMULA (II) EN UN SOLVENTE INERTE ADECUADO EN PRESENCIA DE AZUFRE PARA OBTENER UNA 3-R1-4-R2-5-Q-6-R-2(1H)-PIRIDINONA DE FORMULA (I). SIENDO: R ALQUEILO INFERIOR; R1 Y R2 SON H O METILO; Y Q ES 4(O3)-HIDROXIFENILO), 4(O3)-METOXIFENILO, Y OTROS. LA 3-R1-4-R2-5-Q-6-R-2(1H)-PIRIDINONA EN DONDE Q ES 4(O3)-METOXIFENILO SE PUEDE ESCINDIR POR CALENTAMIENTO EN PRESENCIA DE YODURO DE LITIO PARA PREPARAR EL CORRESPONDIENTE COMPUESTO EN EL QUE Q ES 4(O3)-HIDROXIFENILO. EL SOLVENTE INERTE ES UNA MEZCLA ENTECTICA DE DIFENIL Y DIFENIL ETER. SE UTILIZAN COMO CARDIOTONICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/442,623 US4431651A (en) | 1982-11-18 | 1982-11-18 | 2-Pyridinones and their use as cardiotonic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
ES533877A0 ES533877A0 (es) | 1985-12-16 |
ES8603458A1 true ES8603458A1 (es) | 1985-12-16 |
Family
ID=23757512
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES533877A Expired ES8603458A1 (es) | 1982-11-18 | 1984-06-29 | Un procedimiento para preparar una 3-r1-4-r2-5-q-6-r-2(1h)-piridinona |
Country Status (5)
Country | Link |
---|---|
US (1) | US4431651A (es) |
JP (1) | JPS59106462A (es) |
CA (1) | CA1195980A (es) |
ES (1) | ES8603458A1 (es) |
ZA (1) | ZA838502B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4515797A (en) * | 1981-09-08 | 1985-05-07 | Sterling Drug Inc. | 3-Amino-5-(hydroxy- and/or aminophenyl)-6-(lower-alkyl)-2(1H)-pyridinones and cardiotonic use thereof |
US4465686A (en) * | 1981-09-08 | 1984-08-14 | Sterling Drug Inc. | 5-(Hydroxy- and/or amino-phenyl)-6-(lower-alkyl)-2-(1H)-pyridinones, their cardiotonic use and preparation |
US20040067955A1 (en) * | 2002-09-06 | 2004-04-08 | Fujisawa Pharmaceutical Co. Ltd. | Pyridazinone compound and pharmaceutical use thereof |
PE20060285A1 (es) | 2004-03-30 | 2006-05-08 | Aventis Pharma Inc | Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp) |
US8946434B2 (en) | 2010-07-16 | 2015-02-03 | N30 Pharmaceuticals, Inc. | Dihydropyridin-2(1H)-one compound as S-nirtosoglutathione reductase inhibitors and neurokinin-3 receptor antagonists |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3718743A (en) * | 1970-11-19 | 1973-02-27 | Merck & Co Inc | 5-phenyl-2-piperidones and 5-phenyl-2-thiopiperidones in compositions and methods for treating pain, fever and inflammation |
US4004012A (en) * | 1975-10-14 | 1977-01-18 | Sterling Drug Inc. | 3-Cyano-5-(pyridinyl)-2(1H)-pyridinones |
US4072746A (en) * | 1975-10-14 | 1978-02-07 | Sterling Drug Inc. | 3-Amino-5-(pyridinyl)-2(1H)-pyridinones |
US4297360A (en) * | 1980-03-28 | 1981-10-27 | Sterling Drug Inc. | 5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use |
-
1982
- 1982-11-18 US US06/442,623 patent/US4431651A/en not_active Expired - Fee Related
-
1983
- 1983-11-15 ZA ZA838502A patent/ZA838502B/xx unknown
- 1983-11-17 CA CA000441427A patent/CA1195980A/en not_active Expired
- 1983-11-18 JP JP58217647A patent/JPS59106462A/ja active Pending
-
1984
- 1984-06-29 ES ES533877A patent/ES8603458A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
US4431651A (en) | 1984-02-14 |
ES533877A0 (es) | 1985-12-16 |
ZA838502B (en) | 1984-07-25 |
CA1195980A (en) | 1985-10-29 |
JPS59106462A (ja) | 1984-06-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UA7140A1 (uk) | Спосіб отримання похідних піридіну | |
ES8704481A1 (es) | Procedimiento para la preparacion de nuevos derivados de pi-colina | |
ES8401959A1 (es) | Un procedimiento para la produccion de un derivado de carbostirilo. | |
ES466483A1 (es) | Un procedimiento para la preparacion de derivados de azol | |
ES8603458A1 (es) | Un procedimiento para preparar una 3-r1-4-r2-5-q-6-r-2(1h)-piridinona | |
ES8800910A1 (es) | Un procedimiento para la preparacion de nuevas quinazolindionas | |
ES8604520A1 (es) | Procedimiento para preparar derivados de 2(1h)-piridona | |
ES8609302A1 (es) | Un procedimiento para la preparacion de 4-amino-2-fenilqui- nolinas | |
ES8502435A1 (es) | Un metodo para preparar 2(1h)-piridinonas | |
ES8601138A1 (es) | Un procedimiento para preparar derivados de 5-(piridinil o fenil)-2(1h)-piridinona | |
ES8801895A1 (es) | Procedimiento para la obtencion de benzamidas | |
ES8602352A1 (es) | Procedimiento para preparar derivados de 2-alcoxiaminosulfo-nilbencenosulfonilurea | |
IL77009A0 (en) | Biphenylyloxy and biphenylylalkoxy aryl acyl urea derivatives,processes for the preparation thereof and pesticidal compositions containing the same | |
IE40762L (en) | Substituted phenylureas as herbicides | |
ES8506301A1 (es) | Un procedimiento para preparar 2-alcoxi-5-(piridinil) piridinas | |
IE780982L (en) | 4-hydroxythiazoline-2-thiones. | |
ES8703847A1 (es) | Procedimiento para la obtencion de derivados de sulfonilgua-nidinopirimidina | |
ES448781A1 (es) | Un procedimiento para preparar isocianuratos de hidroximeti-lo-hidroxialcohilo mixtos. | |
ES8703855A1 (es) | Procedimiento para la obtencion de derivados de sulfonilgua-nidinotriazina | |
IL50983A (en) | 5-alkylureido-1,3,4-thiadiazol-2-yl-sulphonyl-acetic-acid derivatives,process for the preparation of said compound and herbicidal compositions containing the same | |
HK77290A (en) | Process for preparing 2-acyl-3,4-dialkoxyanilines | |
ES449530A1 (es) | Un procedimiento para la preparacion de nuevos derivados de piridona. | |
ZA773350B (en) | New 1-substituted derivatives of 2,2-diphenylcyclopropane | |
ES8707722A1 (es) | Un procedimiento para la preparacion de quinazolinonas | |
JPS5379888A (en) | 2,2- or 3,3-dl-substituted-imidazo 1,3 |